CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

EMBO Journal

Volumn 31, Issue 10, 2012, Pages 2309-2321

  Gu, Peili ^a   Min, Jin Na ^a   Wang, Yang ^a   Huang, Chenhui ^b   Peng, Tao ^c   Chai, Weihang ^b   Chang, Sandy ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

DNA damage; DNA replication; mouse model; stem cell; telomere

Indexed keywords

PROTEIN; PROTEIN CONSERVED TELOMERE MAINTENANCE COMPONENT 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHROMOSOME LOSS; CHROMOSOME REPLICATION; CONTROLLED STUDY; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GENE DELETION; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELOMERE;

ANIMALS; DNA REPLICATION; GENE DELETION; MICE; MICE, KNOCKOUT; STEM CELLS; TELOMERE; TELOMERE-BINDING PROTEINS;

MAMMALIA; MUS;

EID: 84861198042     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.96     Document Type: Article

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