Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk

Oncotarget

Volumn 6, Issue 40, 2015, Pages 42468-42477

  Walsh, Kyle M ^a,b   Codd, Veryan ^c,d   Rice, Terri ^a   Nelson, Christopher P ^c,d   Smirnov, Ivan V ^a   McCoy, Lucie S ^a   Hansen, Helen M ^a   Elhauge, Edward ^a   Ojha, Juhi ^a   Francis, Stephen S ^a   Madsen, Nils R ^a   Bracci, Paige M ^a   Pico, Alexander R ^e   Molinaro, Annette M ^a   Tihan, Tarik ^a   Berger, Mitchel S ^a   Chang, Susan M ^a   Prados, Michael D ^a   Jenkins, Robert B ^f   Wiemels, Joseph L ^a,b   Samani, Nilesh J ^c,d   Wiencke, John K ^a,b   Wrensch, Margaret R ^a,b   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d GLENFIELD HOSPITAL   (United Kingdom)

^e GLADSTONE INSTITUTES   (United States)

^f Mayo Clinic College of Medicine   (United States)

Author keywords

CST complex; Glioma; Single nucleotide polymorphism; Telomerase; Telomere

Indexed keywords

DNA; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; AGE DISTRIBUTION; AGING; ARTICLE; CANCER GENETICS; CANCER RISK; CARCINOGENESIS; CASE CONTROL STUDY; CELLULAR PARAMETERS; COHORT ANALYSIS; CONTROLLED STUDY; CTC1 GENE; GENE; GENETIC ASSOCIATION; GENOME SIZE; GENOTYPE; GLIOMA; HUMAN; LEUKOCYTE TELOMERE LENGTH; MAJOR CLINICAL STUDY; MENDELIAN RANDOMIZATION ANALYSIS; OBFC1 GENE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TELOMERE HOMEOSTASIS; TERC GENE; TERT GENE; BRAIN TUMOR; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; LEUKOCYTE; MALE; METABOLISM; STATISTICAL MODEL; TELOMERE;

ADULT; BRAIN NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLIOMA; HUMANS; LEUKOCYTES; MALE; MODELS, STATISTICAL; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TELOMERE;

EID: 84952332384     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6468     Document Type: Article

References (39)

1. Wrensch M, Jenkins RB, Chang JS, Yeh RF, Xiao Y, Decker PA, Ballman KV, Berger M, Buckner JC, Chang S, Giannini C, Halder C, Kollmeyer TM, Kosel ML, LaChance DH, McCoy L, et al. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet. 2009; 41:905-908.
2. Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, Simon M, Marie Y, Boisselier B, Delattre JY, Hoang-Xuan K, El Hallani S, Idbaih A, Zelenika D, Andersson U, Henriksson R, et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet. 2009; 41:899-904.
3. Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, et al. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014; 46:731-735.
4. Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, Hottenga JJ, Fischer K, Esko T, Surakka I, Broer L, Nyholt DR, Mateo Leach I, Salo P, Hagg S, Matthews MK, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013; 45:422-427, 427e421-422.
5. Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H and de Lange T. Mammalian telomeres end in a large duplex loop. Cell. 1999; 97:503-514.
6. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Walston J, Kimura M and Aviv A. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol. 2007; 165:14-21.
7. Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M, Beveridge AJ, Rafelt S, Moore J, Nelson C, Soranzo N, Zhai G, Valdes AM, Blackburn H, Mateo Leach I, de Boer RA, Kimura M, et al. Common variants near TERC are associated with mean telomere length. Nat Genet. 2010; 42:197-199.
8. Wilson WR, Herbert KE, Mistry Y, Stevens SE, Patel HR, Hastings RA, Thompson MM and Williams B. Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease. Eur Heart J. 2008; 29:2689-2694.
9. Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, Kimura M, Skurnick J, Awad G and Aviv A. Telomere length in the newborn. Pediatr Res. 2002; 52:377-381.
10. Mangino M, Hwang SJ, Spector TD, Hunt SC, Kimura M, Fitzpatrick AL, Christiansen L, Petersen I, Elbers CC, Harris T, Chen W, Srinivasan SR, Kark JD, Benetos A, El Shamieh S, Visvikis-Siest S, et al. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet. 2012; 21:5385-5394.
11. Wang S, Chen Y, Qu F, He S, Huang X, Jiang H, Jin T, Wan S and Xing J. Association between leukocyte telomere length and glioma risk: a case-control study. Neuro Oncol. 2014; 16:505-512.
12. Walcott F, Rajaraman P, Gadalla SM, Inskip PD, Purdue MP, Albanes D, Orr E, De Vivo I and Savage SA. Telomere length and risk of glioma. Cancer Epidemiol. 2013; 37:935-938.
13. Iles MM, Bishop DT, Taylor JC, Hayward NK, Brossard M, Cust AE, Dunning AM, Lee JE, Moses EK, Akslen LA, Andresen PA, Avril MF, Azizi E, Scarra GB, Brown KM, Debniak T, et al. The effect on melanoma risk of genes previously associated with telomere length. J Natl Cancer Inst. 2014; 106.
14. Zhang C, Doherty JA, Burgess S, Hung RJ, Lindstrom S, Kraft P, Gong J, Amos CI, Sellers TA, Monteiro AN, Chenevix-Trench G, Bickeboller H, Risch A, Brennan P, McKay JD, Houlston RS, et al. Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study. Hum Mol Genet. 2015; 24:5356-5366.
15. Ma H, Zhou Z, Wei S, Liu Z, Pooley KA, Dunning AM, Svenson U, Roos G, Hosgood HD, 3rd, Shen M and Wei Q. Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One. 2011; 6:e20466.
16. Wentzensen IM, Mirabello L, Pfeiffer RM and Savage SA. The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011; 20:1238-1250.
17. Hou L, Zhang X, Gawron AJ and Liu J. Surrogate tissue telomere length and cancer risk: shorter or longer? Cancer Lett. 2012; 319(:130-135.
18. Hou L, Joyce BT, Gao T, Liu L, Zheng Y, Penedo FJ, Liu S, Zhang W, Bergan R, Dai Q, Vokonas P, Hoxha M, Schwartz J and Baccarelli A. Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort. EBioMedicine. 2015; 2:591-596.
19. Blackburn EH. Walking the walk from genes through telomere maintenance to cancer risk. Cancer Prev Res (Phila). 2011; 4:473-475.
20. Gray R and Wheatley K. How to avoid bias when comparing bone marrow transplantation with chemotherapy. Bone Marrow Transplant. 1991; 7 Suppl 3:9-12.
21. Daniali L, Benetos A, Susser E, Kark JD, Labat C, Kimura M, Desai K, Granick M and Aviv A. Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun. 2013; 4:1597.
22. Jansen H, Samani NJ and Schunkert H. Mendelian randomization studies in coronary artery disease. Eur Heart J. 2014; 35:1917-1924.
23. De Semir D, Nosrati M, Li S and Kashani-Sabet M. Telomerase: going beyond the ends. Cell Cycle. 2007; 6:546-549.
24. Vannier JB, Sarek G and Boulton SJ. RTEL1: functions of a disease-associated helicase. Trends Cell Biol. 2014; 24:416-425.
25. Walsh KM, Rice T, Decker PA, Kosel ML, Kollmeyer T, Hansen HM, Zheng S, McCoy LS, Bracci PM, Anderson E, Hsuang G, Wiemels JL, Pico AR, Smirnov I, Molinaro AM, Tihan T, et al. Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis. Neuro Oncol. 2013; 15:1041-1047.
26. Eckel-Passow JE, Lachance DH, Molinaro AM, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, et al. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med. 2015; 372:2499-2508.
27. Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA, Jr., Friedman AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, Mandahl N, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A. 2013; 110:6021-6026.
28. Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan RP, Choi S, Hong C, He D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh KM, Myong S, Song JS, et al. Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer. Science. 2015; 348:1036-1039.
29. Wang D, Hu E, Wu P, Yuan W, Xu S, Sun Z, Shi H, Yuan J, Li G and Zhao S. Genetic variant near TERC influencing the risk of gliomas with older age at diagnosis in a Chinese population. J Neurooncol. 2015; 124:57-64.
30. Chen LY, Redon S and Lingner J. The human CST complex is a terminator of telomerase activity. Nature. 2012; 488:540-544.
31. Bainbridge MN, Armstrong GN, Gramatges MM, Bertuch AA, Jhangiani SN, Doddapaneni H, Lewis L, Tombrello J, Tsavachidis S, Liu Y, Jalali A, Plon SE, Lau CC, Parsons DW, Claus EB, Barnholtz-Sloan J, et al. Germline mutations in shelterin complex genes are associated with familial glioma. J Natl Cancer Inst. 2015; 107.
32. Walsh KM, Wiencke JK, Lachance DH, Wiemels JL, Molinaro AM, Eckel-Passow JE, Jenkins RB and Wrensch MR. Telomere maintenance and the etiology of adult glioma. Neuro Oncol. 2015; 17:1445-1452.
33. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature. 2007; 447:661-678.
34. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008; 455:1061-1068.
35. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA and Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006; 38:904-909.
36. Levy D, Neuhausen SL, Hunt SC, Kimura M, Hwang SJ, Chen W, Bis JC, Fitzpatrick AL, Smith E, Johnson AD, Gardner JP, Srinivasan SR, Schork N, Rotter JI, Herbig U, Psaty BM, et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A. 2010; 107:9293-9298.
37. Howie BN, Donnelly P and Marchini J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 2009; 5:e1000529.
38. Abecasis GR, Altshuler D, Auton A, Brooks LD, Durbin RM, Gibbs RA, Hurles ME and McVean GA. A map of human genome variation from population-scale sequencing. Nature. 2010; 467:1061-1073.
39. Marchini J and Howie B. Genotype imputation for genome-wide association studies. Nat Rev Genet. 2010; 11:499-511.