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Volumn 31, Issue 4, 2016, Pages 440-450

Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis

Author keywords

Animal models; Aortic stenosis; Apo(a); Lipoprotein(a); Oxidized phospholipids

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID;

EID: 84969592223     PISSN: 02684705     EISSN: 15317080     Source Type: Journal    
DOI: 10.1097/HCO.0000000000000300     Document Type: Review
Times cited : (54)

References (95)
  • 1
    • 84911913843 scopus 로고    scopus 로고
    • Calcific aortic valve disease: A consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease
    • Yutzey KE, Demer LL, Body SC, et al. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol 2014; 34:2387-2393.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 2387-2393
    • Yutzey, K.E.1    Demer, L.L.2    Body, S.C.3
  • 2
    • 84907363577 scopus 로고    scopus 로고
    • Aortic-valve stenosis - From patients at risk to severe valve obstruction
    • Otto CM, Prendergast B. Aortic-valve stenosis - from patients at risk to severe valve obstruction. N Engl J Med 2014; 371:744-756.
    • (2014) N Engl J Med , vol.371 , pp. 744-756
    • Otto, C.M.1    Prendergast, B.2
  • 3
    • 84938085871 scopus 로고    scopus 로고
    • Calcification in aortic stenosis. the skeleton key
    • Pawade TA, Newby DE, Dweck MR. Calcification in aortic stenosis. The skeleton key. J Am Coll Cardiol 2015; 66:561-577. Excellent review article on the role of calcification in aortic stenosis.
    • (2015) J Am Coll Cardiol , vol.66 , pp. 561-577
    • Pawade, T.A.1    Newby, D.E.2    Dweck, M.R.3
  • 4
    • 20344364674 scopus 로고    scopus 로고
    • A randomized trial of intensive lipidlowering therapy in calcific aortic stenosis
    • Cowell SJ, Newby DE, Prescott RJ, et al. A randomized trial of intensive lipidlowering therapy in calcific aortic stenosis. N Engl J Med 2005; 352:2389-2397.
    • (2005) N Engl J Med , vol.352 , pp. 2389-2397
    • Cowell, S.J.1    Newby, D.E.2    Prescott, R.J.3
  • 5
    • 52649120889 scopus 로고    scopus 로고
    • Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
    • Rossebo AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008; 359:1343-1356.
    • (2008) N Engl J Med , vol.359 , pp. 1343-1356
    • Rossebo, A.B.1    Pedersen, T.R.2    Boman, K.3
  • 6
    • 74949091630 scopus 로고    scopus 로고
    • Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: Results of the aortic stenosis progression observation: Measuring effects of rosuvastatin (ASTRONOMER) trial
    • Chan KL, Teo K, Dumesnil JG, et al. Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial. Circulation 2010; 121:306-314.
    • (2010) Circulation , vol.121 , pp. 306-314
    • Chan, K.L.1    Teo, K.2    Dumesnil, J.G.3
  • 7
    • 50949124650 scopus 로고    scopus 로고
    • Prognosis and risk factors in patients with asymptomatic aortic stenosis and their modulation by atorvastatin (20 mg)
    • Dichtl W, Alber HF, Feuchtner GM, et al. Prognosis and risk factors in patients with asymptomatic aortic stenosis and their modulation by atorvastatin (20 mg). Am J Cardiol 2008; 102:743-748.
    • (2008) Am J Cardiol , vol.102 , pp. 743-748
    • Dichtl, W.1    Alber, H.F.2    Feuchtner, G.M.3
  • 8
    • 0028865042 scopus 로고
    • Correlation between lipoprotein(a) and aortic valve sclerosis assessed by echocardiography (the JMS Cardiac Echo and Cohort Study)
    • Gotoh T, Kuroda T, Yamasawa M, et al. Correlation between lipoprotein(a) and aortic valve sclerosis assessed by echocardiography (the JMS Cardiac Echo and Cohort Study). Am J Cardiol 1995; 76:928-932.
    • (1995) Am J Cardiol , vol.76 , pp. 928-932
    • Gotoh, T.1    Kuroda, T.2    Yamasawa, M.3
  • 9
    • 0031051128 scopus 로고    scopus 로고
    • Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study
    • Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol 1997; 29:630-634.
    • (1997) J Am Coll Cardiol , vol.29 , pp. 630-634
    • Stewart, B.F.1    Siscovick, D.2    Lind, B.K.3
  • 10
    • 0037260393 scopus 로고    scopus 로고
    • Lipoprotein(a), Chlamydia pneumoniae, leptin and tissue plasminogen activator as risk markers for valvular aortic stenosis
    • Glader CA, Birgander LS, Soderberg S, et al. Lipoprotein(a), Chlamydia pneumoniae, leptin and tissue plasminogen activator as risk markers for valvular aortic stenosis. Eur Heart J 2003; 24:198-208.
    • (2003) Eur Heart J , vol.24 , pp. 198-208
    • Glader, C.A.1    Birgander, L.S.2    Soderberg, S.3
  • 11
    • 35448974103 scopus 로고    scopus 로고
    • Effects of serum levels of novel atherosclerotic risk factors on aortic valve calcification
    • Bozbas H, Yildirir A, Atar I, et al. Effects of serum levels of novel atherosclerotic risk factors on aortic valve calcification. J Heart Valve Dis 2007; 16:387-393.
    • (2007) J Heart Valve Dis , vol.16 , pp. 387-393
    • Bozbas, H.1    Yildirir, A.2    Atar, I.3
  • 12
    • 84893333521 scopus 로고    scopus 로고
    • Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population
    • Kamstrup PR, Tybjaerg-Hansen A, Nordestgaard BG. Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population. J Am Coll Cardiol 2014; 63:470-477. Mendelian randomization analysis within the CGPS and CCHS cohorts (n=77 680) demonstrating an Lp(a) dose dependent risk for aortic valve stenosis, with a hazard ratio of 1.6 for each 10-fold increase in genetically determined Lp(a) levels associated with the LPA SNPs rs10455872 and rs3798220 or kringle IV type 2 repeats.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 470-477
    • Kamstrup, P.R.1    Tybjaerg-Hansen, A.2    Nordestgaard, B.G.3
  • 13
    • 84941029258 scopus 로고    scopus 로고
    • Elevated lipoprotein( a) does not cause low-grade inflammation despite causal association with aortic valve stenosis and myocardial infarction: A study of 100, 578 individuals from the general population
    • Langsted A, Varbo A, Kamstrup PR, Nordestgaard BG. Elevated lipoprotein( a) does not cause low-grade inflammation despite causal association with aortic valve stenosis and myocardial infarction: a study of 100, 578 individuals from the general population. J Clin Endocrinol Metab 2015; 100:2690-2699.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 2690-2699
    • Langsted, A.1    Varbo, A.2    Kamstrup, P.R.3    Nordestgaard, B.G.4
  • 14
    • 84903123480 scopus 로고    scopus 로고
    • Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: A prospective Mendelian randomization study and replication in a case-control cohort
    • Arsenault BJ, Boekholdt SM, Dube MP, et al. Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective Mendelian randomization study and replication in a case-control cohort. Circ Cardiovasc Genet 2014; 7:304-310.
    • (2014) Circ Cardiovasc Genet , vol.7 , pp. 304-310
    • Arsenault, B.J.1    Boekholdt, S.M.2    Dube, M.P.3
  • 15
    • 84942416178 scopus 로고    scopus 로고
    • Lipoprotein(a) levels are associated with aortic valve calcification in asymptomatic patients with familial hypercholesterolaemia
    • Vongpromek R, Bos S, Ten Kate GJ, et al. Lipoprotein(a) levels are associated with aortic valve calcification in asymptomatic patients with familial hypercholesterolaemia. J Intern Med 2015; 278:166-173.
    • (2015) J Intern Med , vol.278 , pp. 166-173
    • Vongpromek, R.1    Bos, S.2    Ten Kate, G.J.3
  • 16
    • 84941056473 scopus 로고    scopus 로고
    • Oxidized phospholipids, lipoprotein(a), and progression of calcific aortic valve stenosis
    • Capoulade R, Chan KL, Yeang C, et al. Oxidized phospholipids, lipoprotein(a), and progression of calcific aortic valve stenosis. J Am Coll Cardiol 2015; 66:1236-1246. This study demonstrated that elevated Lp(a) (>58.5 mg/dl) as well as OxPL-apoB (>5.50 nM) are each associated with 1.5 times faster progression of aortic valve stenosis and a two-fold increased risk of AVR and death, in a secondary analysis of 220 patients from the ASTRONOMER trial followed for an average of 3.5 years.
    • (2015) J Am Coll Cardiol , vol.66 , pp. 1236-1246
    • Capoulade, R.1    Chan, K.L.2    Yeang, C.3
  • 17
    • 84873513160 scopus 로고    scopus 로고
    • Genetic associations with valvular calcification and aortic stenosis
    • Thanassoulis G, Campbell CY, Owens DS, et al. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med 2013; 368:503-512.
    • (2013) N Engl J Med , vol.368 , pp. 503-512
    • Thanassoulis, G.1    Campbell, C.Y.2    Owens, D.S.3
  • 18
    • 84908689210 scopus 로고    scopus 로고
    • Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis
    • Smith JG, Luk K, Schulz CA, et al. Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis. JAMA 2014; 312:1764-1771.
    • (2014) JAMA , vol.312 , pp. 1764-1771
    • Smith, J.G.1    Luk, K.2    Schulz, C.A.3
  • 19
    • 84960119350 scopus 로고    scopus 로고
    • 'LDL-C'=LDL-C+Lp(a)-C: Implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering
    • Yeang C, Witztum JL, Tsimikas S. 'LDL-C'=LDL-C+Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol 2015; 26:169-178.
    • (2015) Curr Opin Lipidol , vol.26 , pp. 169-178
    • Yeang, C.1    Witztum, J.L.2    Tsimikas, S.3
  • 20
    • 33846593363 scopus 로고    scopus 로고
    • Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis
    • Moura LM, Ramos SF, Zamorano JL, et al. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J Am Coll Cardiol 2007; 49:554-561.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 554-561
    • Moura, L.M.1    Ramos, S.F.2    Zamorano, J.L.3
  • 21
    • 82155197192 scopus 로고    scopus 로고
    • Lipid lowering on progression of mild to moderate aortic stenosis: Meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients
    • Teo KK, Corsi DJ, Tam JW, et al. Lipid lowering on progression of mild to moderate aortic stenosis: meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients. Can J Cardiol 2011; 27:800-808.
    • (2011) Can J Cardiol , vol.27 , pp. 800-808
    • Teo, K.K.1    Corsi, D.J.2    Tam, J.W.3
  • 22
    • 50949107980 scopus 로고    scopus 로고
    • Stage-related effect of statin treatment on the progression of aortic valve sclerosis and stenosis
    • Antonini-Canterin F, Hirsu M, Popescu BA, et al. Stage-related effect of statin treatment on the progression of aortic valve sclerosis and stenosis. Am J Cardiol 2008; 102:738-742.
    • (2008) Am J Cardiol , vol.102 , pp. 738-742
    • Antonini-Canterin, F.1    Hirsu, M.2    Popescu, B.A.3
  • 23
    • 84919752308 scopus 로고    scopus 로고
    • Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
    • Postmus I, Trompet S, Deshmukh HA, et al. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun 2014; 5:1-10.
    • (2014) Nat Commun , vol.5 , pp. 1-10
    • Postmus, I.1    Trompet, S.2    Deshmukh, H.A.3
  • 24
    • 84885031446 scopus 로고    scopus 로고
    • Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment
    • Donnelly LA, van Zuydam NR, Zhou K, et al. Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment. Pharmacogenet Genomics 2013; 23:518-525.
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 518-525
    • Donnelly, L.A.1    Van Zuydam, N.R.2    Zhou, K.3
  • 25
    • 84860271201 scopus 로고    scopus 로고
    • Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: Importance of Lp(a)
    • Deshmukh HA, Colhoun HM, Johnson T, et al. Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). J Lipid Res 2012; 53:1000-1011.
    • (2012) J Lipid Res , vol.53 , pp. 1000-1011
    • Deshmukh, H.A.1    Colhoun, H.M.2    Johnson, T.3
  • 26
    • 78649888517 scopus 로고    scopus 로고
    • Lipoprotein(a) as a cardiovascular risk factor: Current status
    • Nordestgaard BG, Chapman MJ, Ray K, et al. Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J 2010; 31:2844-2853.
    • (2010) Eur Heart J , vol.31 , pp. 2844-2853
    • Nordestgaard, B.G.1    Chapman, M.J.2    Ray, K.3
  • 28
    • 84973092131 scopus 로고    scopus 로고
    • Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B-100 and lipoprotein(a)
    • (in press)
    • Yeang C, Hung MY, Byun YS, et al. Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B-100 and lipoprotein(a). J Clin Lipidol. (in press).
    • J Clin Lipidol
    • Yeang, C.1    Hung, M.Y.2    Byun, Y.S.3
  • 29
    • 84868206439 scopus 로고    scopus 로고
    • Calcific aortic stenosis: A disease of the valve and the myocardium
    • Dweck MR, Boon NA, Newby DE. Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol 2012; 60:1854-1863.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 1854-1863
    • Dweck, M.R.1    Boon, N.A.2    Newby, D.E.3
  • 30
    • 0032936072 scopus 로고    scopus 로고
    • Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves
    • Olsson M, Thyberg J, Nilsson J. Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves. Arterioscler Thromb Vasc Biol 1999; 19:1218-1222.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 1218-1222
    • Olsson, M.1    Thyberg, J.2    Nilsson, J.3
  • 31
    • 0029872345 scopus 로고    scopus 로고
    • Apolipoproteins B, (a), and e accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis
    • O'Brien KD, Reichenbach DD, Marcovina SM, et al. Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis. Arterioscler Thromb Vasc Biol 1996; 16:523-532.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 523-532
    • O'Brien, K.D.1    Reichenbach, D.D.2    Marcovina, S.M.3
  • 32
    • 0027991976 scopus 로고
    • Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies
    • Otto CM, Kuusisto J, Reichenbach DD, et al. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 1994; 90:844-853.
    • (1994) Circulation , vol.90 , pp. 844-853
    • Otto, C.M.1    Kuusisto, J.2    Reichenbach, D.D.3
  • 33
    • 0001173793 scopus 로고    scopus 로고
    • Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice
    • Lou XJ, Boonmark NW, Horrigan FT, et al. Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice. Proc Natl Acad Sci U S A 1998; 95:12591-12595.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 12591-12595
    • Lou, X.J.1    Boonmark, N.W.2    Horrigan, F.T.3
  • 34
    • 1842326803 scopus 로고    scopus 로고
    • Lipoprotein(a) vascular accumulation in mice. in vivo analysis of the role of lysine binding sites using recombinant adenovirus
    • Hughes SD, Lou XJ, Ighani S, et al. Lipoprotein(a) vascular accumulation in mice. In vivo analysis of the role of lysine binding sites using recombinant adenovirus. J Clin Invest 1997; 100:1493-1500.
    • (1997) J Clin Invest , vol.100 , pp. 1493-1500
    • Hughes, S.D.1    Lou, X.J.2    Ighani, S.3
  • 36
    • 84884160203 scopus 로고    scopus 로고
    • Determinants of binding of oxidized phospholipids on apolipoprotein(a) and lipoprotein(a)
    • Leibundgut G, Scipione C, Yin H, et al. Determinants of binding of oxidized phospholipids on apolipoprotein(a) and lipoprotein(a). J Lipid Res 2013; 54:2815-2830.
    • (2013) J Lipid Res , vol.54 , pp. 2815-2830
    • Leibundgut, G.1    Scipione, C.2    Yin, H.3
  • 37
    • 84863807794 scopus 로고    scopus 로고
    • Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia
    • Arai K, Orsoni A, Mallat Z, et al. Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia. J Lipid Res 2012; 53:1670-1678.
    • (2012) J Lipid Res , vol.53 , pp. 1670-1678
    • Arai, K.1    Orsoni, A.2    Mallat, Z.3
  • 38
    • 84871360826 scopus 로고    scopus 로고
    • Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia
    • Yoshida H, Shoda T, Yanai H, et al. Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia. Atherosclerosis 2013; 226:161-164.
    • (2013) Atherosclerosis , vol.226 , pp. 161-164
    • Yoshida, H.1    Shoda, T.2    Yanai, H.3
  • 39
    • 59049086968 scopus 로고    scopus 로고
    • A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma
    • Bergmark C, Dewan A, Orsoni A, et al. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J Lipid Res 2008; 49:2230-2239.
    • (2008) J Lipid Res , vol.49 , pp. 2230-2239
    • Bergmark, C.1    Dewan, A.2    Orsoni, A.3
  • 40
    • 77952547617 scopus 로고    scopus 로고
    • Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts
    • Edelstein C, Pfaffinger D, Yang M, et al. Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts. Biochim Biophys Acta 2010; 1801:738-745.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 738-745
    • Edelstein, C.1    Pfaffinger, D.2    Yang, M.3
  • 41
    • 84859598048 scopus 로고    scopus 로고
    • Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction
    • Leibundgut G, Arai K, Orsoni A, et al. Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction. J Am Coll Cardiol 2012; 59:1426-1437.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1426-1437
    • Leibundgut, G.1    Arai, K.2    Orsoni, A.3
  • 42
    • 65349142018 scopus 로고    scopus 로고
    • Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: Results from the Dallas Heart Study
    • Tsimikas S, Clopton P, Brilakis ES, et al. Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study. Circulation 2009; 119:1711-1719.
    • (2009) Circulation , vol.119 , pp. 1711-1719
    • Tsimikas, S.1    Clopton, P.2    Brilakis, E.S.3
  • 43
    • 84933049780 scopus 로고    scopus 로고
    • Heritability of biomarkers of oxidized lipoproteins: Twin pair study
    • Rao F, Schork AJ, Maihofer AX, et al. Heritability of biomarkers of oxidized lipoproteins: twin pair study. Arterioscler Thromb Vasc Biol 2015; 35:1704-1711.
    • (2015) Arterioscler Thromb Vasc Biol , vol.35 , pp. 1704-1711
    • Rao, F.1    Schork, A.J.2    Maihofer, A.X.3
  • 44
    • 84933059481 scopus 로고    scopus 로고
    • Relationship of oxidized phospholipids on apolipoprotein B-100 to cardiovascular outcomes in patients treated with intensive versus moderate atorvastatin therapy: The TNT trial
    • Byun YS, Lee JH, Arsenault BJ, et al. Relationship of oxidized phospholipids on apolipoprotein B-100 to cardiovascular outcomes in patients treated with intensive versus moderate atorvastatin therapy: the TNT trial. J Am Coll Cardiol 2015; 65:1286-1295.
    • (2015) J Am Coll Cardiol , vol.65 , pp. 1286-1295
    • Byun, Y.S.1    Lee, J.H.2    Arsenault, B.J.3
  • 45
    • 77950020917 scopus 로고    scopus 로고
    • The I4399M variant of apolipoprotein( a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles
    • Arai K, Luke MM, Koschinsky ML, et al. The I4399M variant of apolipoprotein( a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis 2010; 209:498-503.
    • (2010) Atherosclerosis , vol.209 , pp. 498-503
    • Arai, K.1    Luke, M.M.2    Koschinsky, M.L.3
  • 46
    • 43049116177 scopus 로고    scopus 로고
    • The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans
    • Ky B, Burke A, Tsimikas S, et al. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol 2008; 51:1653-1662.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1653-1662
    • Ky, B.1    Burke, A.2    Tsimikas, S.3
  • 47
    • 45449120489 scopus 로고    scopus 로고
    • Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: Volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study
    • Choi SH, Chae A, Miller E, et al. Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study. J Am Coll Cardiol 2008; 52:24-32.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 24-32
    • Choi, S.H.1    Chae, A.2    Miller, E.3
  • 48
    • 33646190667 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: Effect of pravastatin
    • Rodenburg J, Vissers MN, Wiegman A, et al. Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin. J Am Coll Cardiol 2006; 47:1803-1810.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1803-1810
    • Rodenburg, J.1    Vissers, M.N.2    Wiegman, A.3
  • 49
    • 4544346640 scopus 로고    scopus 로고
    • High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial
    • Tsimikas S, Witztum JL, Miller ER, et al. High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation 2004; 110:1406-1412.
    • (2004) Circulation , vol.110 , pp. 1406-1412
    • Tsimikas, S.1    Witztum, J.L.2    Miller, E.R.3
  • 50
    • 78149340053 scopus 로고    scopus 로고
    • Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet
    • Faghihnia N, Tsimikas S, Miller ER, et al. Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet. J Lipid Res 2010; 51:3324-3330.
    • (2010) J Lipid Res , vol.51 , pp. 3324-3330
    • Faghihnia, N.1    Tsimikas, S.2    Miller, E.R.3
  • 51
    • 70349295182 scopus 로고    scopus 로고
    • Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: A randomized clinical trial
    • Budoff MJ, Ahmadi N, Gul KM, et al. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev Med 2009; 49:101-107.
    • (2009) Prev Med , vol.49 , pp. 101-107
    • Budoff, M.J.1    Ahmadi, N.2    Gul, K.M.3
  • 52
    • 1542373714 scopus 로고    scopus 로고
    • Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a)
    • Silaste ML, Rantala M, Alfthan G, et al. Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arterioscler Thromb Vasc Biol 2004; 24:498-503.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 498-503
    • Silaste, M.L.1    Rantala, M.2    Alfthan, G.3
  • 53
    • 84944152398 scopus 로고    scopus 로고
    • Antisense therapy targeting apolipoprotein( a): A randomised, double-blind, placebo-controlled phase 1 study
    • Tsimikas S, Viney NJ, Hughes SG, et al. Antisense therapy targeting apolipoprotein( a): a randomised, double-blind, placebo-controlled phase 1 study. Lancet 2015; 386:1472-1483.
    • (2015) Lancet , vol.386 , pp. 1472-1483
    • Tsimikas, S.1    Viney, N.J.2    Hughes, S.G.3
  • 54
    • 79251580687 scopus 로고    scopus 로고
    • Oxidation-specific epitopes are dangerassociated molecular patterns recognized by pattern recognition receptors of innate immunity
    • Miller YI, Choi S-H, Wiesner P, et al. Oxidation-specific epitopes are dangerassociated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res 2011; 108:235-248.
    • (2011) Circ Res , vol.108 , pp. 235-248
    • Miller, Y.I.1    Choi, S.-H.2    Wiesner, P.3
  • 55
    • 84897018581 scopus 로고    scopus 로고
    • The influence of innate and adaptive immune responses on atherosclerosis
    • Witztum JL, Lichtman AH. The influence of innate and adaptive immune responses on atherosclerosis. Annu Rev Pathol 2014; 9:73-102.
    • (2014) Annu Rev Pathol , vol.9 , pp. 73-102
    • Witztum, J.L.1    Lichtman, A.H.2
  • 56
    • 0037896283 scopus 로고    scopus 로고
    • Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins
    • Horkko S, Bird DA, Miller E, et al. Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. J Clin Invest 1999; 103:117-128.
    • (1999) J Clin Invest , vol.103 , pp. 117-128
    • Horkko, S.1    Bird, D.A.2    Miller, E.3
  • 57
    • 0029957467 scopus 로고    scopus 로고
    • Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma
    • Palinski W, Horkko S, Miller E, et al. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma. J Clin Invest 1996; 98:800-814.
    • (1996) J Clin Invest , vol.98 , pp. 800-814
    • Palinski, W.1    Horkko, S.2    Miller, E.3
  • 58
    • 0036510381 scopus 로고    scopus 로고
    • Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation
    • Friedman P, Horkko S, Steinberg D, et al. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem 2002; 277:7010-7020.
    • (2002) J Biol Chem , vol.277 , pp. 7010-7020
    • Friedman, P.1    Horkko, S.2    Steinberg, D.3
  • 59
    • 0032950484 scopus 로고    scopus 로고
    • Autoantibodies to OxLDL are decreased in individuals with borderline hypertension
    • Wu R, de Faire U, Lemne C, et al. Autoantibodies to OxLDL are decreased in individuals with borderline hypertension. Hypertension 1999; 33: 53-59.
    • (1999) Hypertension , vol.33 , pp. 53-59
    • Wu, R.1    De Faire, U.2    Lemne, C.3
  • 60
    • 77956495725 scopus 로고    scopus 로고
    • Oxidation-specific biomarkers, lipoprotein( a), and risk of fatal and nonfatal coronary events
    • Tsimikas S, Mallat Z, Talmud PJ, et al. Oxidation-specific biomarkers, lipoprotein( a), and risk of fatal and nonfatal coronary events. J Am Coll Cardiol 2010; 56:946-955.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 946-955
    • Tsimikas, S.1    Mallat, Z.2    Talmud, P.J.3
  • 61
    • 34547627109 scopus 로고    scopus 로고
    • Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: Prospective results from the Bruneck study
    • Kiechl S, Willeit J, Mayr M, et al. Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol 2007; 27:1788-1795.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1788-1795
    • Kiechl, S.1    Willeit, J.2    Mayr, M.3
  • 62
    • 75349112389 scopus 로고    scopus 로고
    • Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium
    • Ahmadi N, Tsimikas S, Hajsadeghi F, et al. Relation of oxidative biomarkers, vascular dysfunction, and progression of coronary artery calcium. Am J Cardiol 2010; 105:459-466.
    • (2010) Am J Cardiol , vol.105 , pp. 459-466
    • Ahmadi, N.1    Tsimikas, S.2    Hajsadeghi, F.3
  • 63
    • 33646902155 scopus 로고    scopus 로고
    • Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: Five-year prospective results from the Bruneck study
    • Tsimikas S, Kiechl S, Willeit J, et al. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. J Am Coll Cardiol 2006; 47:2219-2228.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 2219-2228
    • Tsimikas, S.1    Kiechl, S.2    Willeit, J.3
  • 64
    • 21444447949 scopus 로고    scopus 로고
    • Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease
    • Tsimikas S, Brilakis ES, Miller ER, et al. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med 2005; 353:46-57.
    • (2005) N Engl J Med , vol.353 , pp. 46-57
    • Tsimikas, S.1    Brilakis, E.S.2    Miller, E.R.3
  • 65
    • 0037419857 scopus 로고    scopus 로고
    • Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes
    • Tsimikas S, Bergmark C, Beyer RW, et al. Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. J Am Coll Cardiol 2003; 41:360-370.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 360-370
    • Tsimikas, S.1    Bergmark, C.2    Beyer, R.W.3
  • 66
    • 4544261604 scopus 로고    scopus 로고
    • Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): Short-term and long-term immunologic responses to oxidized low-density lipoprotein
    • Tsimikas S, Lau HK, Han KR, et al. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation 2004; 109:3164-3170.
    • (2004) Circulation , vol.109 , pp. 3164-3170
    • Tsimikas, S.1    Lau, H.K.2    Han, K.R.3
  • 67
    • 0035882483 scopus 로고    scopus 로고
    • Oxidative stress modulates osteoblastic differentiation of vascular and bone cells
    • Mody N, Parhami F, Sarafian TA, Demer LL. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 2001; 31:509-519.
    • (2001) Free Radic Biol Med , vol.31 , pp. 509-519
    • Mody, N.1    Parhami, F.2    Sarafian, T.A.3    Demer, L.L.4
  • 68
    • 70449718871 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling
    • Maziere C, Louvet L, Gomila C, et al. Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling. J Cell Physiol 2009; 221:572-578.
    • (2009) J Cell Physiol , vol.221 , pp. 572-578
    • Maziere, C.1    Louvet, L.2    Gomila, C.3
  • 69
    • 84857650449 scopus 로고    scopus 로고
    • Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis
    • Derwall M, Malhotra R, Lai CS, et al. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol 2012; 32:613-622.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 613-622
    • Derwall, M.1    Malhotra, R.2    Lai, C.S.3
  • 70
    • 79953731953 scopus 로고    scopus 로고
    • Oxidative modification of lipoproteins: Mechanisms, role in inflammation and potential clinical applications in cardiovascular disease
    • Tsimikas S, Miller YI. Oxidative modification of lipoproteins: mechanisms, role in inflammation and potential clinical applications in cardiovascular disease. Curr Pharm Des 2011; 17:27-37.
    • (2011) Curr Pharm des , vol.17 , pp. 27-37
    • Tsimikas, S.1    Miller, Y.I.2
  • 71
    • 75649087741 scopus 로고    scopus 로고
    • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    • Stewart CR, Stuart LM, Wilkinson K, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 2010; 11:155-161.
    • (2010) Nat Immunol , vol.11 , pp. 155-161
    • Stewart, C.R.1    Stuart, L.M.2    Wilkinson, K.3
  • 72
    • 77951479702 scopus 로고    scopus 로고
    • Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: Novel point of convergence between electrophilic and unfolded protein stress pathways
    • Afonyushkin T, Oskolkova OV, Philippova M, et al. Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways. Arterioscler Thromb Vasc Biol 2010; 30:1007-1013.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1007-1013
    • Afonyushkin, T.1    Oskolkova, O.V.2    Philippova, M.3
  • 73
    • 33947321122 scopus 로고    scopus 로고
    • Inflammatory profile of oxidized phospholipids
    • Bochkov VN. Inflammatory profile of oxidized phospholipids. Thromb Haemost 2007; 97:348-354.
    • (2007) Thromb Haemost , vol.97 , pp. 348-354
    • Bochkov, V.N.1
  • 74
    • 84948968674 scopus 로고    scopus 로고
    • Mechanistic insights into Lp(a)-induced IL-8 expression: A role for oxidized phospholipid modification of apo(a)
    • Scipione CA, Sayegh SE, Romagnuolo R, et al. Mechanistic insights into Lp(a)-induced IL-8 expression: a role for oxidized phospholipid modification of apo(a). J Lipid Res 2015; 56:2273-2285. The authors show that apo(a) containing OxPL induces proinflammatory IL-8 expression, whereas mutant apo(a) and apo(a) treated with Lp-PLA2, both lacking OxPL, do not upregulate this cytokine. This is one example of how OxPL reflects the biological activity of Lp(a).
    • (2015) J Lipid Res , vol.56 , pp. 2273-2285
    • Scipione, C.A.1    Sayegh, S.E.2    Romagnuolo, R.3
  • 75
    • 2942726266 scopus 로고    scopus 로고
    • Regulatory role of endothelium in the expression of genes affecting arterial calcification
    • Cola C, Almeida M, Li D, et al. Regulatory role of endothelium in the expression of genes affecting arterial calcification. Biochem Biophys Res Commun 2004; 320:424-427.
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 424-427
    • Cola, C.1    Almeida, M.2    Li, D.3
  • 76
    • 79953295363 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4
    • Su X, Ao L, Shi Y, et al. Oxidized low density lipoprotein induces bone morphogenetic protein-2 in coronary artery endothelial cells via Toll-like receptors 2 and 4. J Biol Chem 2011; 286:12213-12220.
    • (2011) J Biol Chem , vol.286 , pp. 12213-12220
    • Su, X.1    Ao, L.2    Shi, Y.3
  • 77
    • 84884673552 scopus 로고    scopus 로고
    • Ox-LDL induces PiT-1 expression in human aortic valve interstitial cells
    • Nadlonek NA, Lee JH, Weyant MJ, et al. ox-LDL induces PiT-1 expression in human aortic valve interstitial cells. J Surg Res 2013; 184:6-9.
    • (2013) J Surg Res , vol.184 , pp. 6-9
    • Nadlonek, N.A.1    Lee, J.H.2    Weyant, M.J.3
  • 78
    • 80054097795 scopus 로고    scopus 로고
    • Nuclear factor of activated T cells mediates oxidised LDL-induced calcification of vascular smooth muscle cells
    • Goettsch C, Rauner M, Hamann C, et al. Nuclear factor of activated T cells mediates oxidised LDL-induced calcification of vascular smooth muscle cells. Diabetologia 2011; 54:2690-2701.
    • (2011) Diabetologia , vol.54 , pp. 2690-2701
    • Goettsch, C.1    Rauner, M.2    Hamann, C.3
  • 79
    • 84892682658 scopus 로고    scopus 로고
    • Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signaling
    • Liao L, Zhou Q, Song Y, et al. Ceramide mediates Ox-LDL-induced human vascular smooth muscle cell calcification via p38 mitogen-activated protein kinase signaling. PLoS One 2013; 8:1-10.
    • (2013) PLoS One , vol.8 , pp. 1-10
    • Liao, L.1    Zhou, Q.2    Song, Y.3
  • 80
    • 84918790945 scopus 로고    scopus 로고
    • Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis
    • Syvaranta S, Alanne-Kinnunen M, Oorni K, et al. Potential pathological roles for oxidized low-density lipoprotein and scavenger receptors SR-AI, CD36, and LOX-1 in aortic valve stenosis. Atherosclerosis 2014; 235:398-407.
    • (2014) Atherosclerosis , vol.235 , pp. 398-407
    • Syvaranta, S.1    Alanne-Kinnunen, M.2    Oorni, K.3
  • 81
    • 33747423277 scopus 로고    scopus 로고
    • Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice
    • Bennett BJ, Scatena M, Kirk EA, et al. Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice. Arterioscler Thromb Vasc Biol 2006; 26:2117-2124.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2117-2124
    • Bennett, B.J.1    Scatena, M.2    Kirk, E.A.3
  • 82
    • 38349133382 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice
    • Morony S, Tintut Y, Zhang Z, et al. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation 2008; 117:411-420.
    • (2008) Circulation , vol.117 , pp. 411-420
    • Morony, S.1    Tintut, Y.2    Zhang, Z.3
  • 83
    • 0030929793 scopus 로고    scopus 로고
    • Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients
    • Parhami F, Morrow AD, Balucan J, et al. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol 1997; 17:680-687.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 680-687
    • Parhami, F.1    Morrow, A.D.2    Balucan, J.3
  • 84
    • 79952192503 scopus 로고    scopus 로고
    • Decorin GAG synthesis and TGF-beta signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cells
    • Yan J, Stringer SE, Hamilton A, et al. Decorin GAG synthesis and TGF-beta signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2011; 31:608-615.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 608-615
    • Yan, J.1    Stringer, S.E.2    Hamilton, A.3
  • 85
    • 0025310826 scopus 로고
    • Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein
    • Palinski W, Yla-Herttuala S, Rosenfeld ME, et al. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. Arteriosclerosis 1990; 10:325-335.
    • (1990) Arteriosclerosis , vol.10 , pp. 325-335
    • Palinski, W.1    Yla-Herttuala, S.2    Rosenfeld, M.E.3
  • 86
    • 0037022278 scopus 로고    scopus 로고
    • Monocyte/macrophage regulation of vascular calcification in vitro
    • Tintut Y, Patel J, Territo M, et al. Monocyte/macrophage regulation of vascular calcification in vitro. Circulation 2002; 105:650-655.
    • (2002) Circulation , vol.105 , pp. 650-655
    • Tintut, Y.1    Patel, J.2    Territo, M.3
  • 87
    • 0029620828 scopus 로고
    • Enhanced association of platelet-activating factor acetylhydrolase with lipoprotein (a) in comparison with low density lipoprotein
    • Blencowe C, Hermetter A, Kostner GM, Deigner HP. Enhanced association of platelet-activating factor acetylhydrolase with lipoprotein (a) in comparison with low density lipoprotein. J Biol Chem 1995; 270:31151-31157.
    • (1995) J Biol Chem , vol.270 , pp. 31151-31157
    • Blencowe, C.1    Hermetter, A.2    Kostner, G.M.3    Deigner, H.P.4
  • 88
    • 84893258971 scopus 로고    scopus 로고
    • Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: Implications for valve mineralization
    • Mahmut A, Boulanger MC, El Husseini D, et al. Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralization. J Am Coll Cardiol 2014; 63:460-469.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 460-469
    • Mahmut, A.1    Boulanger, M.C.2    El Husseini, D.3
  • 89
    • 84940655915 scopus 로고    scopus 로고
    • Autotaxin derived from lipoprotein( a) and valve interstitial cells promotes inflammation and mineralization of the aortic valve
    • Bouchareb R, Mahmut A, Nsaibia MJ, et al. Autotaxin derived from lipoprotein( a) and valve interstitial cells promotes inflammation and mineralization of the aortic valve. Circulation 2015; 132:677-690. This study demonstrated that Lp(a) is present in stenotic human aortic valves and co-localized with OxPL, Lp-PLA2, and autotaxin (an enzyme that hydrolyzes lysophosphatidylcholine to LPA). LPA induces calcification by VIC in vitro and promotes aortic valve calcification in a mouse model of aortic valve stenosis. These findings add to the understanding of how Lp(a) and its lipid cargo mediate calcific aortic valve stenosis.
    • (2015) Circulation , vol.132 , pp. 677-690
    • Bouchareb, R.1    Mahmut, A.2    Nsaibia, M.J.3
  • 90
    • 79958147911 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis: Methods, models, and mechanisms
    • Miller JD, Weiss RM, Heistad DD. Calcific aortic valve stenosis: methods, models, and mechanisms. Circ Res 2011; 108:1392-1412.
    • (2011) Circ Res , vol.108 , pp. 1392-1412
    • Miller, J.D.1    Weiss, R.M.2    Heistad, D.D.3
  • 91
    • 67249120424 scopus 로고    scopus 로고
    • Lowering plasma cholesterol levels halts progression of aortic valve disease in mice
    • Miller JD, Weiss RM, Serrano KM, et al. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 2009; 119:2693-2701.
    • (2009) Circulation , vol.119 , pp. 2693-2701
    • Miller, J.D.1    Weiss, R.M.2    Serrano, K.M.3
  • 92
    • 21744452833 scopus 로고    scopus 로고
    • High-level lipoprotein [a] expression in transgenic mice: Evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins
    • Schneider M, Witztum JL, Young SG, et al. High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res 2005; 46:769-778.
    • (2005) J Lipid Res , vol.46 , pp. 769-778
    • Schneider, M.1    Witztum, J.L.2    Young, S.G.3
  • 93
    • 84886070404 scopus 로고    scopus 로고
    • Relationship of apolipoproteins A-1 and B, and lipoprotein(a) to cardiovascular outcomes: The AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes)
    • Albers JJ, Slee A, O'Brien KD, et al. Relationship of apolipoproteins A-1 and B, and lipoprotein(a) to cardiovascular outcomes: the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes). J Am Coll Cardiol 2013; 62:1575-1579.
    • (2013) J Am Coll Cardiol , vol.62 , pp. 1575-1579
    • Albers, J.J.1    Slee, A.2    O'Brien, K.D.3
  • 94
    • 78549235583 scopus 로고    scopus 로고
    • Safety of anacetrapib in patients with or at high risk for coronary heart disease
    • Cannon CP, Shah S, Dansky HM, et al. Safety of anacetrapib in patients with or at high risk for coronary heart disease. N Engl J Med 2010; 363:2406-2415.
    • (2010) N Engl J Med , vol.363 , pp. 2406-2415
    • Cannon, C.P.1    Shah, S.2    Dansky, H.M.3


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