Lipid Lowering on Progression of Mild to Moderate Aortic Stenosis: Meta-analysis of the Randomized Placebo-Controlled Clinical Trials on 2344 Patients

Canadian Journal of Cardiology

Volumn 27, Issue 6, 2011, Pages 800-808

  Teo, Koon K ^a   Corsi, Daniel J ^a   Tam, James W ^b   Dumesnil, Jean G ^c   Chan, Kwan L ^d  

^a MCMASTER UNIVERSITY   (Canada)

^b ST BONIFACE GENERAL HOSPITAL   (Canada)

^c LAVAL UNIVERSITY   (Canada)

^d UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; ATORVASTATIN; EZETIMIBE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; ROSUVASTATIN; SIMVASTATIN;

ADULT; AGED; AORTA STENOSIS; AORTA VALVE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; HEART VALVE SURGERY; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; RANDOMIZED CONTROLLED TRIAL;

AORTIC VALVE; AORTIC VALVE STENOSIS; DISEASE PROGRESSION; ECHOCARDIOGRAPHY; HUMANS; HYPOLIPIDEMIC AGENTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 82155197192     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2011.03.012     Document Type: Article

References (31)

1. Stewart B.F., Siscovick D., Lind B.K., et al. Clinical factors associated with calcific aortic valve disease: Cardiovascular Health Study. J Am Coll Cardiol 1997, 29:630-634.
2. Nkomo V.T., Gardin J.M., Skelton T.N., et al. Burden of valvular heart disease: a population-based study. Lancet 2006, 368:1005-1011.
3. Lindroos M., Kupari M., Heikkila J., et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol 1993, 21:1220-1225.
4. Otto C.M., Burwash I.G., Legget M.E., et al. Prospective study of asymptomatic valvular aortic stenosis: clinical, echocardiographic, and exercise predictors of outcome. Circulation 1997, 9:2262-2270.
5. Pellikka P.A., Sarano M.E., Nishimura R.A., et al. Outcome of 622 adults with asymptomatic hemodynamically significant aortic stenosis during prolonged follow-up. Circulation 2005, 24:3290-3295.
6. Otto C., Kuusisto J., Reichenback D.D., et al. Characterization of the early lesion of "degenerative" valvular aortic stenosis: histological and immunohistochemical studies. Circulation 1994, 90:844-853.
7. Rajamannan N.M., Subramaniam M., Caira F., et al. Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valve via the Lrp5 receptor pathway. Circulation 2005, 112(suppl):I-229-I-234.
8. Miller J.D., Weiss R.M., Serrano K.M., et al. Lowering plasma cholesterol levels halts progression of aortic valve disease in mice. Circulation 2009, 119:2693-2701.
9. Wilmhurst P.T., Stevenson R.N., Griffiths H., et al. A case-control investigation of the relation between hyperlipidemia and calcific aortic valve stenosis. Heart 1997, 78:475-479.
10. Ghani M., Burwash I., Woodend K., et al. Case-controlled study to assess risk factors for aortic stenosis in congenitally bicuspid aortic valve. Am J Cardiol 2001, 88:690-693.
11. Novaro G.M., Tiong I.J., Pearce G.L., et al. Effect of hydroxymethylglutaryl coenzyme A reductase inhibitors on the progression of calcific aortic stenosis. Circulation 2001, 104:2005-2009.
12. Rosenhek R., Rader F., Loho N., et al. Statins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis. Circulation 2004, 110:1291-1295.
13. Kawaguchi A., Miyatake K., Yutani C., et al. Characteristic cardiovascular manifestation in homozygous and heterozygous familial hypercholesterolemia. Am Heart J 1999, 137:410-418.
14. Moura L.M., Ramos S.F., Somorano J.L., et al. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J Am Coll Cardiol 2007, 49:554-561.
15. Shavelle D.M., Takasu J., Budoff M.J., et al. HMG CoA reductase inhibitor (statin) and aortic valve calcification. Lancet 2002, 359:1125-1126.
16. Aronow W.S., Ahn C., Kronzon I., et al. Association of coronary risk factors and the use of statins with progression of mild valvular aortic stenosis in odler persons. Am J Cardiol 2001, 88:693-695.
17. Rossebo A.B., Pedersen T.R., Boman K., et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008, 359:1343-1356. SEAS Investigators.
18. Chan K.L., Teo K., Dumesnil J.G., et al. Effect of lipid lowering with rosuvastatin on progression of aortic stensosis. Results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial. Circulation 2010, 121:306-314. ASTRONOMER Investigators.
19. Cowell S.J., Newby D.E., Prescott R.J., et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005, 352:2389-2397. Scottish Aortic Stenosis and Lipid Lowering Trial, Impact on Regression (SALTIRE) Investigators.
20. Dichtl W., Alber H.F., Feuchtner G.M., et al. Prognosis and risk factors in patients with asymptomatic aortic stenosis and their modulation by atorvastatin (20 mg). Am J Cardiol 2008, 102:743-748.
21. Rosenthal R. Parametric measures of effect size. The Handbook of Research Synthesis 1994, Russell Sage Foundation, New York. H. Cooper, L.V. Hedges (Eds.).
22. Hartung J., Knapp G., Sinha B.K. Statistical Meta-Analysis with Application 2008, Wiley, Hoboken, NJ.
23. Mantel N., Haenszel W. Statistical aspects of the analysis of data from retrospective studies of diseases. J Natl Cancer Inst 1959, 22:719-749.
24. Robins J., Greenland S., Breslow N.E. A general estimator for the variance of the Mantel-Haenszel odds ratio. Am J Epidemiol 1986, 124:719-723.
25. Otto C.M., Pearlman A.S., Gardner C.L. Hemodynamic progression of aortic stenosis in adults assessed by Doppler echocardiography. J Am Coll Cardiol 1989, 13:545-550.
26. Faggiano P., Ghizzoni G., Sorgato A., et al. Rate of progression of valvular aortic stenosis is adults. Am J Cardiol 1992, 70:229-233.
27. Rosenhek R., Binder T., Porenta G., et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med 2000, 343:611-617.
28. Brener S.J., Duffy C.L., Thomas J.D., et al. Progression of aortic stenosis in 394 patients: relation to changes in myocardial and mitral valve dysfunction. J Am Coll Cardiol 1995, 25:305-310.
29. Peter M., Hoffman A., Parker C., et al. Progression of aortic stenosis. Role of age and concomitant coronary artery disease. Chest 1993, 103:1715-1719.
30. Roger V.L., Tajik A.J., Bailey K.R., et al. Progression of aortic stenosis in adults: new appraisal using Doppler echocardiography. Am Heart J 1990, 119:331-338.
31. Bonow R.O., Carabello B.A., Kanu C., et al. ACC/AHA 2006 Guidelines for the Management of Patients with Valvular Heart Disease: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease). Circulation 2006, 114:450-527.