메뉴 건너뛰기




Volumn 66, Issue 5, 2015, Pages 561-577

Calcification in aortic stenosis: The skeleton key

Author keywords

aortic valve; calcification of; calcinosis; calcium; computed tomography; diphosphonates; positron emission tomography

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; AUTOTAXIN; BETA CATENIN; BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN 2; DENOSUMAB; FETUIN A; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84938085871     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.05.066     Document Type: Review
Times cited : (289)

References (109)
  • 1
    • 33748453667 scopus 로고    scopus 로고
    • Burden of valvular heart diseases: A population-based study
    • V.T. Nkomo, J.M. Gardin, T.N. Skelton, and et al. Burden of valvular heart diseases: a population-based study Lancet 368 2006 1005 1011
    • (2006) Lancet , vol.368 , pp. 1005-1011
    • Nkomo, V.T.1    Gardin, J.M.2    Skelton, T.N.3
  • 2
    • 84880059080 scopus 로고    scopus 로고
    • Aortic stenosis in the elderly: Disease prevalence and number of candidates for transcatheter aortic valve replacement: A meta-analysis and modeling study
    • R.L. Osnabrugge, D. Mylotte, S.J. Head, and et al. Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study J Am Coll Cardiol 62 2013 1002 1012
    • (2013) J Am Coll Cardiol , vol.62 , pp. 1002-1012
    • Osnabrugge, R.L.1    Mylotte, D.2    Head, S.J.3
  • 3
    • 80054937214 scopus 로고    scopus 로고
    • Calcific aortic valve disease: Not simply a degenerative process. A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease - 2011 update
    • N.M. Rajamannan, F.J. Evans, E. Aikawa, and et al. Calcific aortic valve disease: not simply a degenerative process. A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: calcific aortic valve disease - 2011 update Circulation 124 2011 1783 1791
    • (2011) Circulation , vol.124 , pp. 1783-1791
    • Rajamannan, N.M.1    Evans, F.J.2    Aikawa, E.3
  • 4
    • 79957674758 scopus 로고    scopus 로고
    • Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification
    • S.E. New, and E. Aikawa Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification Circ Res 108 2011 1381 1391
    • (2011) Circ Res , vol.108 , pp. 1381-1391
    • New, S.E.1    Aikawa, E.2
  • 5
    • 77952537064 scopus 로고    scopus 로고
    • Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium
    • G. Thanassoulis, J.M. Massaro, R. Cury, and et al. Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium J Am Coll Cardiol 55 2010 2491 2498
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2491-2498
    • Thanassoulis, G.1    Massaro, J.M.2    Cury, R.3
  • 6
    • 0031051128 scopus 로고    scopus 로고
    • Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study
    • B.F. Stewart, D. Siscovick, B.K. Lind, and et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study J Am Coll Cardiol 29 1997 630 634
    • (1997) J Am Coll Cardiol , vol.29 , pp. 630-634
    • Stewart, B.F.1    Siscovick, D.2    Lind, B.K.3
  • 7
    • 68949156524 scopus 로고    scopus 로고
    • Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk factors: Results of the longitudinal population-based KORA/MONICA survey
    • J. Stritzke, P. Linsel-Nitschke, M.R. Markus, and et al. Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk factors: results of the longitudinal population-based KORA/MONICA survey Eur Heart J 30 2009 2044 2053
    • (2009) Eur Heart J , vol.30 , pp. 2044-2053
    • Stritzke, J.1    Linsel-Nitschke, P.2    Markus, M.R.3
  • 8
    • 0027477812 scopus 로고
    • Progression of aortic valve dysfunction in 51 adult patients with congenital bicuspid aortic valve: Assessment and follow up by Doppler echocardiography
    • R.T. Pachulski, and K.L. Chan Progression of aortic valve dysfunction in 51 adult patients with congenital bicuspid aortic valve: assessment and follow up by Doppler echocardiography Br Heart J 69 1993 237 240
    • (1993) Br Heart J , vol.69 , pp. 237-240
    • Pachulski, R.T.1    Chan, K.L.2
  • 9
    • 84908689210 scopus 로고    scopus 로고
    • Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis
    • J.G. Smith, K. Luk, C.A. Schulz, et al. for the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Extracoronary Calcium Working Group Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis JAMA 312 2014 1764 1771
    • (2014) JAMA , vol.312 , pp. 1764-1771
    • Smith, J.G.1    Luk, K.2    Schulz, C.A.3
  • 10
    • 84873513160 scopus 로고    scopus 로고
    • Genetic associations with valvular calcification and aortic stenosis
    • G. Thanassoulis, C.Y. Campbell, D.S. Owens, et al. for the CHARGE Extracoronary Calcium Working Group Genetic associations with valvular calcification and aortic stenosis N Engl J Med 368 2013 503 512
    • (2013) N Engl J Med , vol.368 , pp. 503-512
    • Thanassoulis, G.1    Campbell, C.Y.2    Owens, D.S.3
  • 11
    • 0027991976 scopus 로고
    • Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies
    • C.M. Otto, J. Kuusisto, D.D. Reichenbach, and et al. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies Circulation 90 1994 844 853
    • (1994) Circulation , vol.90 , pp. 844-853
    • Otto, C.M.1    Kuusisto, J.2    Reichenbach, D.D.3
  • 12
    • 0034711505 scopus 로고    scopus 로고
    • Apoptosis regulates human vascular calcification in vitro: Evidence for initiation of vascular calcification by apoptotic bodies
    • D. Proudfoot, J.N. Skepper, L. Hegyi, and et al. Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies Circ Res 87 2000 1055 1062
    • (2000) Circ Res , vol.87 , pp. 1055-1062
    • Proudfoot, D.1    Skepper, J.N.2    Hegyi, L.3
  • 13
    • 0017282062 scopus 로고
    • Calcification of matrix vesicles in human aortic valve and aortic media
    • K.M. Kim Calcification of matrix vesicles in human aortic valve and aortic media Fed Proc 35 1976 156 162
    • (1976) Fed Proc , vol.35 , pp. 156-162
    • Kim, K.M.1
  • 14
    • 21844438685 scopus 로고    scopus 로고
    • Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: A vicious cycle of inflammation and arterial calcification?
    • I. Nadra, J.C. Mason, P. Philippidis, and et al. Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ Res 96 2005 1248 1256
    • (2005) Circ Res , vol.96 , pp. 1248-1256
    • Nadra, I.1    Mason, J.C.2    Philippidis, P.3
  • 15
    • 33846593363 scopus 로고    scopus 로고
    • Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis
    • L.M. Moura, S.F. Ramos, J.L. Zamorano, and et al. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis J Am Coll Cardiol 49 2007 554 561
    • (2007) J Am Coll Cardiol , vol.49 , pp. 554-561
    • Moura, L.M.1    Ramos, S.F.2    Zamorano, J.L.3
  • 16
    • 0037024284 scopus 로고    scopus 로고
    • Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve
    • N.M. Rajamannan, M. Subramaniam, M. Springett, and et al. Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve Circulation 105 2002 2660 2665
    • (2002) Circulation , vol.105 , pp. 2660-2665
    • Rajamannan, N.M.1    Subramaniam, M.2    Springett, M.3
  • 17
    • 33750703971 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis in old hypercholesterolemic mice
    • R.M. Weiss, M. Ohashi, J.D. Miller, and et al. Calcific aortic valve stenosis in old hypercholesterolemic mice Circulation 114 2006 2065 2069
    • (2006) Circulation , vol.114 , pp. 2065-2069
    • Weiss, R.M.1    Ohashi, M.2    Miller, J.D.3
  • 18
    • 20344364674 scopus 로고    scopus 로고
    • A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis
    • Impact on Regression (SALTIRE) Investigators
    • S.J. Cowell, D.E. Newby, R.J. Prescott, et al. for the Scottish Aortic Stenosis and Lipid Lowering Trial Impact on Regression (SALTIRE) Investigators A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis N Engl J Med 352 2005 2389 2397
    • (2005) N Engl J Med , vol.352 , pp. 2389-2397
    • Cowell, S.J.1    Newby, D.E.2    Prescott, R.J.3
  • 19
    • 74949091630 scopus 로고    scopus 로고
    • Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: Results of the aortic stenosis progression observation: Measuring effects of rosuvastatin (ASTRONOMER) trial
    • K.L. Chan, K. Teo, J.G. Dumesnil, et al. for the ASTRONOMER Investigators Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: results of the aortic stenosis progression observation: measuring effects of rosuvastatin (ASTRONOMER) trial Circulation 121 2010 306 314
    • (2010) Circulation , vol.121 , pp. 306-314
    • Chan, K.L.1    Teo, K.2    Dumesnil, J.G.3
  • 20
    • 52649120889 scopus 로고    scopus 로고
    • Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
    • A.B. Rossebø, T.R. Pedersen, K. Boman, et al. for the SEAS Investigators Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis N Engl J Med 359 2008 1343 1356
    • (2008) N Engl J Med , vol.359 , pp. 1343-1356
    • Rossebø, A.B.1    Pedersen, T.R.2    Boman, K.3
  • 21
    • 84930339080 scopus 로고    scopus 로고
    • Impact of statins on serial coronary calcification during atheroma progression and regression
    • R. Puri, S.J. Nicholls, M. Shao, and et al. Impact of statins on serial coronary calcification during atheroma progression and regression J Am Coll Cardiol 65 2015 1273 1282
    • (2015) J Am Coll Cardiol , vol.65 , pp. 1273-1282
    • Puri, R.1    Nicholls, S.J.2    Shao, M.3
  • 22
    • 84863646913 scopus 로고    scopus 로고
    • Impact of metabolic syndrome on progression of aortic stenosis: Influence of age and statin therapy
    • R. Capoulade, M.A. Clavel, J.G. Dumesnil, et al. for the ASTRONOMER Investigators Impact of metabolic syndrome on progression of aortic stenosis: influence of age and statin therapy J Am Coll Cardiol 60 2012 216 223
    • (2012) J Am Coll Cardiol , vol.60 , pp. 216-223
    • Capoulade, R.1    Clavel, M.A.2    Dumesnil, J.G.3
  • 23
    • 0035916929 scopus 로고    scopus 로고
    • Bone formation and inflammation in cardiac valves
    • E.R. Mohler 3rd, F. Gannon, C. Reynolds, and et al. Bone formation and inflammation in cardiac valves Circulation 103 2001 1522 1528
    • (2001) Circulation , vol.103 , pp. 1522-1528
    • Mohler, E.R.1    Gannon, F.2    Reynolds, C.3
  • 24
    • 84900547836 scopus 로고    scopus 로고
    • Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase
    • R.N. El Accaoui, S.T. Gould, G.P. Hajj, and et al. Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase Am J Physiol Heart Circ Physiol 306 2014 H1302 H1313
    • (2014) Am J Physiol Heart Circ Physiol , vol.306 , pp. H1302-H1313
    • El Accaoui, R.N.1    Gould, S.T.2    Hajj, G.P.3
  • 25
    • 0037159283 scopus 로고    scopus 로고
    • Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma
    • K.D. O'Brien, D.M. Shavelle, M.T. Caulfield, and et al. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma Circulation 106 2002 2224 2230
    • (2002) Circulation , vol.106 , pp. 2224-2230
    • O'Brien, K.D.1    Shavelle, D.M.2    Caulfield, M.T.3
  • 26
    • 79955541355 scopus 로고    scopus 로고
    • (Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis
    • T. Peltonen, J. Napankangas, P. Ohtonen, and et al. (Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis Atherosclerosis 216 2011 35 43
    • (2011) Atherosclerosis , vol.216 , pp. 35-43
    • Peltonen, T.1    Napankangas, J.2    Ohtonen, P.3
  • 27
    • 84888064712 scopus 로고    scopus 로고
    • Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis
    • R. Capoulade, M.A. Clavel, P. Mathieu, and et al. Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis Eur J Clin Invest 43 2013 1262 1272
    • (2013) Eur J Clin Invest , vol.43 , pp. 1262-1272
    • Capoulade, R.1    Clavel, M.A.2    Mathieu, P.3
  • 28
    • 0033662188 scopus 로고    scopus 로고
    • CBFA1: A molecular switch in osteoblast biology
    • P. Ducy CBFA1: a molecular switch in osteoblast biology Dev Dyn 219 2000 461 471
    • (2000) Dev Dyn , vol.219 , pp. 461-471
    • Ducy, P.1
  • 29
    • 0038711036 scopus 로고    scopus 로고
    • Human aortic valve calcification is associated with an osteoblast phenotype
    • N.M. Rajamannan, M. Subramaniam, D. Rickard, and et al. Human aortic valve calcification is associated with an osteoblast phenotype Circulation 107 2003 2181 2184
    • (2003) Circulation , vol.107 , pp. 2181-2184
    • Rajamannan, N.M.1    Subramaniam, M.2    Rickard, D.3
  • 30
    • 53849089554 scopus 로고    scopus 로고
    • Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulation
    • V. Pohjolainen, P. Taskinen, Y. Soini, and et al. Noncollagenous bone matrix proteins as a part of calcific aortic valve disease regulation Hum Pathol 39 2008 1695 1701
    • (2008) Hum Pathol , vol.39 , pp. 1695-1701
    • Pohjolainen, V.1    Taskinen, P.2    Soini, Y.3
  • 32
    • 36348976915 scopus 로고    scopus 로고
    • The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology
    • A.C. Liu, V.R. Joag, and A.I. Gotlieb The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology Am J Pathol 171 2007 1407 1418
    • (2007) Am J Pathol , vol.171 , pp. 1407-1418
    • Liu, A.C.1    Joag, V.R.2    Gotlieb, A.I.3
  • 33
    • 37349065459 scopus 로고    scopus 로고
    • Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    • E. Aikawa, M. Nahrendorf, J.L. Figueiredo, and et al. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo Circulation 116 2007 2841 2850
    • (2007) Circulation , vol.116 , pp. 2841-2850
    • Aikawa, E.1    Nahrendorf, M.2    Figueiredo, J.L.3
  • 34
    • 84855393451 scopus 로고    scopus 로고
    • Look more closely at the valve: Imaging calcific aortic valve disease
    • E. Aikawa, and C.M. Otto Look more closely at the valve: imaging calcific aortic valve disease Circulation 125 2012 9 11
    • (2012) Circulation , vol.125 , pp. 9-11
    • Aikawa, E.1    Otto, C.M.2
  • 35
    • 0028180137 scopus 로고
    • TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify
    • K.E. Watson, K. Bostrom, R. Ravindranath, and et al. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify J Clin Invest 93 1994 2106 2113
    • (1994) J Clin Invest , vol.93 , pp. 2106-2113
    • Watson, K.E.1    Bostrom, K.2    Ravindranath, R.3
  • 36
    • 33846320026 scopus 로고    scopus 로고
    • Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification
    • Y. Tintut, and L. Demer Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification J Investig Med 54 2006 395 401
    • (2006) J Investig Med , vol.54 , pp. 395-401
    • Tintut, Y.1    Demer, L.2
  • 37
    • 24644467759 scopus 로고    scopus 로고
    • Mutations in NOTCH1 cause aortic valve disease
    • V. Garg, A.N. Muth, J.F. Ransom, and et al. Mutations in NOTCH1 cause aortic valve disease Nature 437 2005 270 274
    • (2005) Nature , vol.437 , pp. 270-274
    • Garg, V.1    Muth, A.N.2    Ransom, J.F.3
  • 38
    • 70350580660 scopus 로고    scopus 로고
    • Notch1 represses osteogenic pathways in aortic valve cells
    • V. Nigam, and D. Srivastava Notch1 represses osteogenic pathways in aortic valve cells J Mol Cell Cardiol 47 2009 828 834
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 828-834
    • Nigam, V.1    Srivastava, D.2
  • 39
    • 0028906991 scopus 로고
    • Atherosclerotic calcification: Relation to developmental osteogenesis
    • K. Boström, K.E. Watson, W.P. Stanford, and et al. Atherosclerotic calcification: relation to developmental osteogenesis Am J Cardiol 75 1995 88B 91B
    • (1995) Am J Cardiol , vol.75 , pp. 88B-91B
    • Boström, K.1    Watson, K.E.2    Stanford, W.P.3
  • 40
    • 70349135494 scopus 로고    scopus 로고
    • Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: Role of Smad1 and extracellular signal-regulated kinase 1/2
    • X. Yang, X. Meng, X. Su, and et al. Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2 J Thorac Cardiovasc Surg 138 2009 1008 1015
    • (2009) J Thorac Cardiovasc Surg , vol.138 , pp. 1008-1015
    • Yang, X.1    Meng, X.2    Su, X.3
  • 41
    • 58949103283 scopus 로고    scopus 로고
    • Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2
    • X. Yang, D.A. Fullerton, X. Su, and et al. Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2 J Am Coll Cardiol 53 2009 491 500
    • (2009) J Am Coll Cardiol , vol.53 , pp. 491-500
    • Yang, X.1    Fullerton, D.A.2    Su, X.3
  • 42
    • 33646466212 scopus 로고    scopus 로고
    • Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation
    • F.C. Caira, S.R. Stock, T.G. Gleason, and et al. Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation J Am Coll Cardiol 47 2006 1707 1712
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1707-1712
    • Caira, F.C.1    Stock, S.R.2    Gleason, T.G.3
  • 43
    • 79952134815 scopus 로고    scopus 로고
    • β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells
    • J.H. Chen, W.L. Chen, K.L. Sider, and et al. β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells Arterioscl Thromb Vasc Biol 31 2011 590 597
    • (2011) Arterioscl Thromb Vasc Biol , vol.31 , pp. 590-597
    • Chen, J.H.1    Chen, W.L.2    Sider, K.L.3
  • 45
    • 0033815524 scopus 로고    scopus 로고
    • Rate of bone loss is associated with mortality in older women: A prospective study
    • D.M. Kado, W.S. Browner, T. Blackwell, and et al. Rate of bone loss is associated with mortality in older women: a prospective study J Bone Miner Res 15 2000 1974 1980
    • (2000) J Bone Miner Res , vol.15 , pp. 1974-1980
    • Kado, D.M.1    Browner, W.S.2    Blackwell, T.3
  • 46
    • 84916217846 scopus 로고    scopus 로고
    • Inverse association between bone mineral density and risk of aortic stenosis in men and women in EPIC-Norfolk prospective study
    • R. Pfister, G. Michels, S.J. Sharp, and et al. Inverse association between bone mineral density and risk of aortic stenosis in men and women in EPIC-Norfolk prospective study Int J Cardiol 178 2015 29 30
    • (2015) Int J Cardiol , vol.178 , pp. 29-30
    • Pfister, R.1    Michels, G.2    Sharp, S.J.3
  • 47
    • 28944433579 scopus 로고    scopus 로고
    • Aortic valve calcification: Association with bone mineral density and cardiovascular risk factors
    • Y. Aksoy, C. Yagmur, G.O. Tekin, and et al. Aortic valve calcification: association with bone mineral density and cardiovascular risk factors Coron Artery Dis 16 2005 379 383
    • (2005) Coron Artery Dis , vol.16 , pp. 379-383
    • Aksoy, Y.1    Yagmur, C.2    Tekin, G.O.3
  • 48
    • 44649133999 scopus 로고    scopus 로고
    • Vascular calcification: Pathobiology of a multifaceted disease
    • L.L. Demer, and Y. Tintut Vascular calcification: pathobiology of a multifaceted disease Circulation 117 2008 2938 2948
    • (2008) Circulation , vol.117 , pp. 2938-2948
    • Demer, L.L.1    Tintut, Y.2
  • 49
    • 70149123804 scopus 로고    scopus 로고
    • Vascular calcification and bone disease: The calcification paradox
    • V. Persy, and P. D'Haese Vascular calcification and bone disease: the calcification paradox Trends Mol Med 15 2009 405 416
    • (2009) Trends Mol Med , vol.15 , pp. 405-416
    • Persy, V.1    D'Haese, P.2
  • 50
    • 0032526023 scopus 로고    scopus 로고
    • Osteitis deformans (Paget's disease) and calcific disease of the heart valves
    • H.N. Hultgren Osteitis deformans (Paget's disease) and calcific disease of the heart valves Am J Cardiol 81 1998 1461 1464
    • (1998) Am J Cardiol , vol.81 , pp. 1461-1464
    • Hultgren, H.N.1
  • 51
    • 0347004546 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor κb ligand and osteoprotegerin regulate aortic valve calcification
    • J.J. Kaden, S. Bickelhaupt, R. Grobholz, and et al. Receptor activator of nuclear factor κB ligand and osteoprotegerin regulate aortic valve calcification J Mol Cell Cardiol 36 2004 57 66
    • (2004) J Mol Cell Cardiol , vol.36 , pp. 57-66
    • Kaden, J.J.1    Bickelhaupt, S.2    Grobholz, R.3
  • 52
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    • N. Bucay, I. Sarosi, C.R. Dunstan, and et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification Genes Dev 12 1998 1260 1268
    • (1998) Genes Dev , vol.12 , pp. 1260-1268
    • Bucay, N.1    Sarosi, I.2    Dunstan, C.R.3
  • 53
    • 0030929793 scopus 로고    scopus 로고
    • Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients
    • F. Parhami, A.D. Morrow, J. Balucan, and et al. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients Arterioscl Thromb Vasc Biol 17 1997 680 687
    • (1997) Arterioscl Thromb Vasc Biol , vol.17 , pp. 680-687
    • Parhami, F.1    Morrow, A.D.2    Balucan, J.3
  • 54
    • 0036668481 scopus 로고    scopus 로고
    • Vascular calcification and osteoporosis: Inflammatory responses to oxidized lipids
    • L.L. Demer Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids Int J Epidemiol 31 2002 737 741
    • (2002) Int J Epidemiol , vol.31 , pp. 737-741
    • Demer, L.L.1
  • 55
    • 84875843626 scopus 로고    scopus 로고
    • Vitamin K-dependent carboxylation of matrix Gla-protein: A crucial switch to control ectopic mineralization
    • L.J. Schurgers, J. Uitto, and C.P. Reutelingsperger Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization Trends Mol Med 19 2013 217 226
    • (2013) Trends Mol Med , vol.19 , pp. 217-226
    • Schurgers, L.J.1    Uitto, J.2    Reutelingsperger, C.P.3
  • 56
  • 57
    • 35448937699 scopus 로고    scopus 로고
    • Systemic and local levels of fetuin-A in calcific aortic valve stenosis
    • J.J. Kaden, J.O. Reinöhl, B. Blesch, and et al. Systemic and local levels of fetuin-A in calcific aortic valve stenosis Int J Mol Med 20 2007 193 197
    • (2007) Int J Mol Med , vol.20 , pp. 193-197
    • Kaden, J.J.1    Reinöhl, J.O.2    Blesch, B.3
  • 58
    • 68949097676 scopus 로고    scopus 로고
    • Association of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients
    • R. Koos, V. Brandenburg, A.H. Mahnken, and et al. Association of fetuin-A levels with the progression of aortic valve calcification in non-dialyzed patients Eur Heart J 30 2009 2054 2061
    • (2009) Eur Heart J , vol.30 , pp. 2054-2061
    • Koos, R.1    Brandenburg, V.2    Mahnken, A.H.3
  • 59
    • 84938088869 scopus 로고    scopus 로고
    • Reduced fetuin a serum level is associated with faster progression and increased valvular calcification in elderly patients with aortic stenosis
    • D. Mohty, N. Côté, P. Pibarot, and et al. Reduced fetuin a serum level is associated with faster progression and increased valvular calcification in elderly patients with aortic stenosis J Clin Exp Cardiol 2 2011 147
    • (2011) J Clin Exp Cardiol , vol.2 , pp. 147
    • Mohty, D.1    Côté, N.2    Pibarot, P.3
  • 60
    • 84906307730 scopus 로고    scopus 로고
    • Circulating levels of matrix GLA protein and progression of aortic stenosis: A substudy of the Aortic Stenosis Progression Observation: Measuring Effects of rosuvastatin (ASTRONOMER) trial
    • R. Capoulade, N. Côté, P. Mathieu, et al. for the ASTRONOMER Investigators Circulating levels of matrix GLA protein and progression of aortic stenosis: a substudy of the Aortic Stenosis Progression Observation: Measuring Effects of rosuvastatin (ASTRONOMER) trial Can J Cardiol 30 2014 1088 1095
    • (2014) Can J Cardiol , vol.30 , pp. 1088-1095
    • Capoulade, R.1    Côté, N.2    Mathieu, P.3
  • 61
    • 84859652051 scopus 로고    scopus 로고
    • ATP acts as a survival signal and prevents the mineralization of aortic valve
    • N. Côté, D. El Husseini, A. Pépin, and et al. ATP acts as a survival signal and prevents the mineralization of aortic valve J Mol Cell Cardiol 52 2012 1191 1202
    • (2012) J Mol Cell Cardiol , vol.52 , pp. 1191-1202
    • Côté, N.1    El Husseini, D.2    Pépin, A.3
  • 62
    • 84901234969 scopus 로고    scopus 로고
    • P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: Implication for calcific aortic valve disease
    • D. El Husseini, M.C. Boulanger, A. Mahmut, and et al. P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: implication for calcific aortic valve disease J Mol Cell Cardiol 72 2014 146 156
    • (2014) J Mol Cell Cardiol , vol.72 , pp. 146-156
    • El Husseini, D.1    Boulanger, M.C.2    Mahmut, A.3
  • 63
    • 58449135145 scopus 로고    scopus 로고
    • Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice
    • H. Baumgartner, J. Hung, J. Bermejo, and et al. Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice Eur J Echocardiogr 22 2009 1 25
    • (2009) Eur J Echocardiogr , vol.22 , pp. 1-25
    • Baumgartner, H.1    Hung, J.2    Bermejo, J.3
  • 64
    • 0034739287 scopus 로고    scopus 로고
    • Predictors of outcome in severe, asymptomatic aortic stenosis
    • R. Rosenhek, T. Binder, G. Porenta, and et al. Predictors of outcome in severe, asymptomatic aortic stenosis N Engl J Med 343 2000 611 617
    • (2000) N Engl J Med , vol.343 , pp. 611-617
    • Rosenhek, R.1    Binder, T.2    Porenta, G.3
  • 65
    • 84875814770 scopus 로고    scopus 로고
    • Prognostic stratification by conventional echocardiography of patients with aortic stenosis: The "cAIMAN-ECHO score."
    • G. Cioffi, C. Mazzone, P. Faggiano, and et al. Prognostic stratification by conventional echocardiography of patients with aortic stenosis: the "CAIMAN-ECHO score." Echocardiography 30 2013 367 377
    • (2013) Echocardiography , vol.30 , pp. 367-377
    • Cioffi, G.1    Mazzone, C.2    Faggiano, P.3
  • 66
    • 3242675955 scopus 로고    scopus 로고
    • Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography
    • D. Messika-Zeitoun, M.C. Aubry, D. Detaint, and et al. Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography Circulation 110 2004 356 362
    • (2004) Circulation , vol.110 , pp. 356-362
    • Messika-Zeitoun, D.1    Aubry, M.C.2    Detaint, D.3
  • 67
    • 84938055100 scopus 로고    scopus 로고
    • 18F-NaF is a predictor of progression and outcome in aortic valve disease (abstr)
    • W. Jenkins, M. Dweck, A. Shah, and et al. 18F-NaF is a predictor of progression and outcome in aortic valve disease (abstr) J Am Coll Cardiol 63 Suppl 12 2014 A995
    • (2014) J Am Coll Cardiol , vol.63 , pp. A995
    • Jenkins, W.1    Dweck, M.2    Shah, A.3
  • 68
    • 33644967579 scopus 로고    scopus 로고
    • Aortic valve calcification as an incidental finding at CT of the elderly: Severity and location as predictors of aortic stenosis
    • F. Liu, C.A. Coursey, C. Grahame-Clarke, and et al. Aortic valve calcification as an incidental finding at CT of the elderly: severity and location as predictors of aortic stenosis AJR Am J Roentgenol 186 2006 342 349
    • (2006) AJR Am J Roentgenol , vol.186 , pp. 342-349
    • Liu, F.1    Coursey, C.A.2    Grahame-Clarke, C.3
  • 69
    • 33748942068 scopus 로고    scopus 로고
    • Prevalence and clinical importance of aortic valve calcification detected incidentally on CT scans: Comparison with echocardiography
    • R. Koos, H.P. Kühl, G. Mühlenbruch, and et al. Prevalence and clinical importance of aortic valve calcification detected incidentally on CT scans: comparison with echocardiography Radiology 241 2006 76 82
    • (2006) Radiology , vol.241 , pp. 76-82
    • Koos, R.1    Kühl, H.P.2    Mühlenbruch, G.3
  • 70
    • 84874545201 scopus 로고    scopus 로고
    • Sex differences in aortic valve calcification measured by multidetector computed tomography in aortic stenosis
    • S.R. Aggarwal, M.A. Clavel, D. Messika-Zeitoun, and et al. Sex differences in aortic valve calcification measured by multidetector computed tomography in aortic stenosis Circ Cardiovasc Imaging 6 2013 40 47
    • (2013) Circ Cardiovasc Imaging , vol.6 , pp. 40-47
    • Aggarwal, S.R.1    Clavel, M.A.2    Messika-Zeitoun, D.3
  • 71
    • 84890066949 scopus 로고    scopus 로고
    • Small valve area with low-gradient aortic stenosis: Beware the hard hearted
    • M.R. Dweck, C. Chin, and D.E. Newby Small valve area with low-gradient aortic stenosis: beware the hard hearted J Am Coll Cardiol 62 2013 2339 2340
    • (2013) J Am Coll Cardiol , vol.62 , pp. 2339-2340
    • Dweck, M.R.1    Chin, C.2    Newby, D.E.3
  • 72
    • 84890039575 scopus 로고    scopus 로고
    • The complex nature of discordant severe calcified aortic valve disease grading: New insights from combined Doppler echocardiographic and computed tomographic study
    • M.A. Clavel, D. Messika-Zeitoun, P. Pibarot, and et al. The complex nature of discordant severe calcified aortic valve disease grading: new insights from combined Doppler echocardiographic and computed tomographic study J Am Coll Cardiol 62 2013 2329 2338
    • (2013) J Am Coll Cardiol , vol.62 , pp. 2329-2338
    • Clavel, M.A.1    Messika-Zeitoun, D.2    Pibarot, P.3
  • 73
    • 84908022512 scopus 로고    scopus 로고
    • Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis: Results of an international registry study
    • M.A. Clavel, P. Pibarot, D. Messika-Zeitoun, and et al. Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis: results of an international registry study J Am Coll Cardiol 64 2014 1202 1213
    • (2014) J Am Coll Cardiol , vol.64 , pp. 1202-1213
    • Clavel, M.A.1    Pibarot, P.2    Messika-Zeitoun, D.3
  • 74
    • 33746394181 scopus 로고    scopus 로고
    • Aortic valve calcification as quantified with multislice computed tomography predicts short-term clinical outcome in patients with asymptomatic aortic stenosis
    • G.M. Feuchtner, S. Müller, W. Grander, and et al. Aortic valve calcification as quantified with multislice computed tomography predicts short-term clinical outcome in patients with asymptomatic aortic stenosis J Heart Valve Dis 15 2006 494 498
    • (2006) J Heart Valve Dis , vol.15 , pp. 494-498
    • Feuchtner, G.M.1    Müller, S.2    Grander, W.3
  • 75
    • 16644373342 scopus 로고    scopus 로고
    • Aortic valve calcification as a marker for aortic stenosis severity: Assessment on 16-MDCT
    • R. Koos, A.H. Mahnken, A.M. Sinha, and et al. Aortic valve calcification as a marker for aortic stenosis severity: assessment on 16-MDCT AJR Am J Roentgenol 183 2004 1813 1818
    • (2004) AJR Am J Roentgenol , vol.183 , pp. 1813-1818
    • Koos, R.1    Mahnken, A.H.2    Sinha, A.M.3
  • 76
    • 33847014811 scopus 로고    scopus 로고
    • Aortic valve calcification: Determinants and progression in the population
    • D. Messika-Zeitoun, L.F. Bielak, P.A. Peyser, and et al. Aortic valve calcification: determinants and progression in the population Arterioscl Thromb Vasc Biol 27 2007 642 648
    • (2007) Arterioscl Thromb Vasc Biol , vol.27 , pp. 642-648
    • Messika-Zeitoun, D.1    Bielak, L.F.2    Peyser, P.A.3
  • 77
    • 84900423536 scopus 로고    scopus 로고
    • 18F-NaF uptake is a marker of active calcification and disease progression in patients with aortic stenosis
    • M.R. Dweck, W.S. Jenkins, A.T. Vesey, and et al. 18F-NaF uptake is a marker of active calcification and disease progression in patients with aortic stenosis Circ Cardiovasc Imaging 7 2014 371 378
    • (2014) Circ Cardiovasc Imaging , vol.7 , pp. 371-378
    • Dweck, M.R.1    Jenkins, W.S.2    Vesey, A.T.3
  • 78
    • 84930226120 scopus 로고    scopus 로고
    • Haemodynamic and anatomic progression of aortic stenosis
    • V. Nguyen, C. Cimadevilla, C. Estellat, and et al. Haemodynamic and anatomic progression of aortic stenosis Heart 101 2015 943 947
    • (2015) Heart , vol.101 , pp. 943-947
    • Nguyen, V.1    Cimadevilla, C.2    Estellat, C.3
  • 79
    • 84855387134 scopus 로고    scopus 로고
    • Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis
    • M.R. Dweck, C. Jones, N.V. Joshi, and et al. Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis Circulation 125 2012 76 86
    • (2012) Circulation , vol.125 , pp. 76-86
    • Dweck, M.R.1    Jones, C.2    Joshi, N.V.3
  • 80
    • 79958841743 scopus 로고    scopus 로고
    • Imaging of the aortic valve using fluorodeoxyglucose positron emission tomography: Increased valvular fluorodeoxyglucose uptake in aortic stenosis
    • G. Marincheva-Savcheva, S. Subramanian, S. Qadir, and et al. Imaging of the aortic valve using fluorodeoxyglucose positron emission tomography: increased valvular fluorodeoxyglucose uptake in aortic stenosis J Am Coll Cardiol 57 2011 2507 2515
    • (2011) J Am Coll Cardiol , vol.57 , pp. 2507-2515
    • Marincheva-Savcheva, G.1    Subramanian, S.2    Qadir, S.3
  • 81
    • 84878844007 scopus 로고    scopus 로고
    • Aortic stenosis, atherosclerosis, and skeletal bone: Is there a common link with calcification and inflammation?
    • M.R. Dweck, H.J. Khaw, G.K. Sng, and et al. Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation? Eur Heart J 34 2013 1567 1574
    • (2013) Eur Heart J , vol.34 , pp. 1567-1574
    • Dweck, M.R.1    Khaw, H.J.2    Sng, G.K.3
  • 82
    • 34548748759 scopus 로고    scopus 로고
    • The prevalence of inflammation in carotid atherosclerosis: Analysis with fluorodeoxyglucose-positron emission tomography
    • N. Tahara, H. Kai, H. Nakaura, and et al. The prevalence of inflammation in carotid atherosclerosis: analysis with fluorodeoxyglucose-positron emission tomography Eur Heart J 28 2007 2243 2248
    • (2007) Eur Heart J , vol.28 , pp. 2243-2248
    • Tahara, N.1    Kai, H.2    Nakaura, H.3
  • 83
    • 33750445273 scopus 로고    scopus 로고
    • 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients
    • 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients J Am Coll Cardiol 48 2006 1818 1824
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1818-1824
    • Tawakol, A.1    Migrino, R.Q.2    Bashian, G.G.3
  • 84
    • 33750448287 scopus 로고    scopus 로고
    • Simvastatin attenuates plaque inflammation: Evaluation by fluorodeoxyglucose positron emission tomography
    • N. Tahara, H. Kai, M. Ishibashi, and et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography J Am Coll Cardiol 48 2006 1825 1831
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1825-1831
    • Tahara, N.1    Kai, H.2    Ishibashi, M.3
  • 85
    • 84936873830 scopus 로고    scopus 로고
    • Identifying active vascular micro-calcification by 18F-sodium fluoride positron emission tomography
    • A. Irkle, A.T. Vesey, D.Y. Lewis, and et al. Identifying active vascular micro-calcification by 18F-sodium fluoride positron emission tomography Nat Commun 6 2015 7495
    • (2015) Nat Commun , vol.6 , pp. 7495
    • Irkle, A.1    Vesey, A.T.2    Lewis, D.Y.3
  • 86
    • 52649161365 scopus 로고    scopus 로고
    • Calcific aortic stenosis - Time to look more closely at the valve
    • C.M. Otto Calcific aortic stenosis - time to look more closely at the valve N Engl J Med 359 2008 1395 1398
    • (2008) N Engl J Med , vol.359 , pp. 1395-1398
    • Otto, C.M.1
  • 87
    • 0035036363 scopus 로고    scopus 로고
    • Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption
    • P.A. Price, S.A. Faus, and M.K. Williamson Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption Arterioscl Thromb Vasc Biol 21 2001 817 824
    • (2001) Arterioscl Thromb Vasc Biol , vol.21 , pp. 817-824
    • Price, P.A.1    Faus, S.A.2    Williamson, M.K.3
  • 88
    • 0014684354 scopus 로고
    • Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
    • H. Fleisch, R.G. Russell, and M.D. Francis Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo Science 165 1969 1262 1264
    • (1969) Science , vol.165 , pp. 1262-1264
    • Fleisch, H.1    Russell, R.G.2    Francis, M.D.3
  • 89
    • 0016710478 scopus 로고
    • The effect of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on a rabbit model of athero-arteriosclerosis
    • I.Y. Rosenblum, L. Flora, and R. Eisenstein The effect of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on a rabbit model of athero-arteriosclerosis Atherosclerosis 22 1975 411 424
    • (1975) Atherosclerosis , vol.22 , pp. 411-424
    • Rosenblum, I.Y.1    Flora, L.2    Eisenstein, R.3
  • 90
    • 0018134775 scopus 로고
    • The effect of agents interfering with soft tissue calcification and cell proliferation on calcific fibrous-fatty plaques in rabbits
    • D.M. Kramsch, and C.T. Chan The effect of agents interfering with soft tissue calcification and cell proliferation on calcific fibrous-fatty plaques in rabbits Circ Res 42 1978 562 571
    • (1978) Circ Res , vol.42 , pp. 562-571
    • Kramsch, D.M.1    Chan, C.T.2
  • 91
    • 0028842688 scopus 로고
    • Inhibition of antigen-presenting cell function by alendronate in vitro
    • P. Sansoni, G. Passeri, F. Fagnoni, and et al. Inhibition of antigen-presenting cell function by alendronate in vitro J Bone Miner Res 10 1995 1719 1725
    • (1995) J Bone Miner Res , vol.10 , pp. 1719-1725
    • Sansoni, P.1    Passeri, G.2    Fagnoni, F.3
  • 92
    • 4944239035 scopus 로고    scopus 로고
    • An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
    • E. Giraudo, M. Inoue, and D. Hanahan An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis J Clin Invest 114 2004 623 633
    • (2004) J Clin Invest , vol.114 , pp. 623-633
    • Giraudo, E.1    Inoue, M.2    Hanahan, D.3
  • 93
    • 34547574668 scopus 로고    scopus 로고
    • Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line
    • T.J. Lai, S.F. Hsu, T.M. Li, and et al. Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line Acta Pharmacologica Sinica 28 2007 1231 1235
    • (2007) Acta Pharmacologica Sinica , vol.28 , pp. 1231-1235
    • Lai, T.J.1    Hsu, S.F.2    Li, T.M.3
  • 94
    • 79151484966 scopus 로고    scopus 로고
    • Bisphosphonates prevent oxidized low- density lipoprotein-induced expression of osteogenic markers in aortic valve myofibroblasts (abstr)
    • S. Elmariah, G. Cimmino, V. Fuster, and et al. Bisphosphonates prevent oxidized low- density lipoprotein-induced expression of osteogenic markers in aortic valve myofibroblasts (abstr) J Am Coll Cardiol 55 Suppl 10A 2010 A149
    • (2010) J Am Coll Cardiol , vol.55 , pp. A149
    • Elmariah, S.1    Cimmino, G.2    Fuster, V.3
  • 95
    • 78349248623 scopus 로고    scopus 로고
    • Bisphosphonate use and prevalence of valvular and vascular calcification in women: MESA (The Multi-Ethnic Study of Atherosclerosis)
    • S. Elmariah, J.A.C. Delaney, K.D. O'Brien, and et al. Bisphosphonate use and prevalence of valvular and vascular calcification in women: MESA (The Multi-Ethnic Study of Atherosclerosis) J Am Coll Cardiol 56 2010 1752 1759
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1752-1759
    • Elmariah, S.1    Delaney, J.A.C.2    O'Brien, K.D.3
  • 96
    • 79251526533 scopus 로고    scopus 로고
    • Effect of bisphosphonates on the progression of degenerative aortic stenosis
    • A.L. Innasimuthu, and W.E. Katz Effect of bisphosphonates on the progression of degenerative aortic stenosis Echocardiography 28 2011 1 7
    • (2011) Echocardiography , vol.28 , pp. 1-7
    • Innasimuthu, A.L.1    Katz, W.E.2
  • 97
    • 67649381813 scopus 로고    scopus 로고
    • Osteoporosis treatment and progression of aortic stenosis
    • A.H. Skolnick, M. Osranek, P. Formica, and et al. Osteoporosis treatment and progression of aortic stenosis Am J Cardiol 104 2009 122 124
    • (2009) Am J Cardiol , vol.104 , pp. 122-124
    • Skolnick, A.H.1    Osranek, M.2    Formica, P.3
  • 98
    • 78149428225 scopus 로고    scopus 로고
    • Bisphosphonates in calcific aortic stenosis: Association with slower progression in mild disease-a pilot retrospective study
    • G. Sterbakova, V. Vyskocil, and K. Linhartova Bisphosphonates in calcific aortic stenosis: association with slower progression in mild disease-a pilot retrospective study Cardiology 117 2010 184 189
    • (2010) Cardiology , vol.117 , pp. 184-189
    • Sterbakova, G.1    Vyskocil, V.2    Linhartova, K.3
  • 99
    • 33750451970 scopus 로고    scopus 로고
    • Mechanisms of the in vivo inhibition of calcification of bioprosthetic porcine aortic valve cusps and aortic wall with triglycidylamine/mercapto bisphosphonate
    • H.S. Rapoport, J.M. Connolly, J. Fulmer, and et al. Mechanisms of the in vivo inhibition of calcification of bioprosthetic porcine aortic valve cusps and aortic wall with triglycidylamine/mercapto bisphosphonate Biomaterials 28 2007 690 699
    • (2007) Biomaterials , vol.28 , pp. 690-699
    • Rapoport, H.S.1    Connolly, J.M.2    Fulmer, J.3
  • 100
    • 84859590070 scopus 로고    scopus 로고
    • Do bisphosphonates slow the progression of aortic stenosis?
    • O. Aksoy, A. Cam, S.S. Goel, and et al. Do bisphosphonates slow the progression of aortic stenosis? J Am Coll Cardiol 59 2012 1452 1459
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1452-1459
    • Aksoy, O.1    Cam, A.2    Goel, S.S.3
  • 101
    • 84865762097 scopus 로고    scopus 로고
    • Osteoporosis is a major confounder in observational studies investigating bisphosphonate therapy in aortic stenosis
    • M.R. Dweck, and D.E. Newby Osteoporosis is a major confounder in observational studies investigating bisphosphonate therapy in aortic stenosis J Am Coll Cardiol 60 2012 1027
    • (2012) J Am Coll Cardiol , vol.60 , pp. 1027
    • Dweck, M.R.1    Newby, D.E.2
  • 102
    • 69049083492 scopus 로고    scopus 로고
    • Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    • S.R. Cummings, J. San Martin, M.R. McClung, et al. for the FREEDOM Trial Denosumab for prevention of fractures in postmenopausal women with osteoporosis N Engl J Med 361 2009 756 765
    • (2009) N Engl J Med , vol.361 , pp. 756-765
    • Cummings, S.R.1    San Martin, J.2    McClung, M.R.3
  • 103
    • 68449102008 scopus 로고    scopus 로고
    • Inhibition of receptor activator of NF-κB ligand by denosumab attenuates vascular calcium deposition in mice
    • S. Helas, C. Goettsch, M. Schoppet, and et al. Inhibition of receptor activator of NF-κB ligand by denosumab attenuates vascular calcium deposition in mice Am J Pathol 175 2009 473 478
    • (2009) Am J Pathol , vol.175 , pp. 473-478
    • Helas, S.1    Goettsch, C.2    Schoppet, M.3
  • 105
    • 84864284460 scopus 로고    scopus 로고
    • Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats
    • N. Côté, D. El Husseini, A. Pépin, and et al. Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats Eur J Pharmacol 689 2012 139 146
    • (2012) Eur J Pharmacol , vol.689 , pp. 139-146
    • Côté, N.1    El Husseini, D.2    Pépin, A.3
  • 106
    • 84926451410 scopus 로고    scopus 로고
    • What is the ultimate test that lowering lipoprotein(a) is beneficial for cardiovascular disease and aortic stenosis?
    • M.Y. Hung, and S. Tsimikas What is the ultimate test that lowering lipoprotein(a) is beneficial for cardiovascular disease and aortic stenosis? Curr Opin Lipidol 25 2014 423 430
    • (2014) Curr Opin Lipidol , vol.25 , pp. 423-430
    • Hung, M.Y.1    Tsimikas, S.2
  • 107
    • 0041384266 scopus 로고    scopus 로고
    • Aortic valve calcification on computed tomography predicts the severity of aortic stenosis
    • S.J. Cowell, D.E. Newby, J. Burton, and et al. Aortic valve calcification on computed tomography predicts the severity of aortic stenosis Clin Radiol 58 2003 712 716
    • (2003) Clin Radiol , vol.58 , pp. 712-716
    • Cowell, S.J.1    Newby, D.E.2    Burton, J.3
  • 108
    • 79953893341 scopus 로고    scopus 로고
    • Measurement of aortic valve calcification using multislice computed tomography: Correlation with haemodynamic severity of aortic stenosis and clinical implication for patients with low ejection fraction
    • C. Cueff, J.M. Serfaty, C. Cimadevilla, and et al. Measurement of aortic valve calcification using multislice computed tomography: correlation with haemodynamic severity of aortic stenosis and clinical implication for patients with low ejection fraction Heart 97 2011 721 726
    • (2011) Heart , vol.97 , pp. 721-726
    • Cueff, C.1    Serfaty, J.M.2    Cimadevilla, C.3
  • 109
    • 84887153861 scopus 로고    scopus 로고
    • Incremental prognostic value of cardiac computed tomography angiography in asymptomatic aortic stenosis: Significance of aortic valve calcium score
    • H. Utsunomiya, H. Yamamoto, T. Kitagawa, and et al. Incremental prognostic value of cardiac computed tomography angiography in asymptomatic aortic stenosis: significance of aortic valve calcium score Int J Cardiol 168 2013 5205 5211
    • (2013) Int J Cardiol , vol.168 , pp. 5205-5211
    • Utsunomiya, H.1    Yamamoto, H.2    Kitagawa, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.