Decorin GAG synthesis and TGF-β signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 3, 2011, Pages 608-615

  Yan, Jianyun ^a   Stringer, Sally E ^a   Hamilton, Andrew ^a   Charlton Menys, Valentine ^a   Götting, Christian ^b   Müller, Benjamin ^b   Aeschlimann, Daniel ^c   Alexander, M Yvonne ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

calcification; glycosominoglycan; molecular biology; oxidized lipids; vascular biology

Indexed keywords

ALKALINE PHOSPHATASE; CHONDROITIN; DECORIN; DECORIN GLYCOSAMINOGLYCAN; DERMATAN SULFATE; GLYCOSAMINOGLYCAN; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR MSX2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ADENOVIRUS; ADULT; ARTICLE; BIOSYNTHESIS; BLOOD VESSEL CALCIFICATION; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; OSTEOBLAST; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ALKALINE PHOSPHATASE; CALCINOSIS; CELLS, CULTURED; DECORIN; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; LIPOPROTEINS, LDL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OSTEOGENESIS; OXIDATIVE STRESS; PENTOSYLTRANSFERASES; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79952192503     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.220749     Document Type: Article

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