Review: The HSP90 molecular chaperone - An enigmatic ATPase

Biopolymers

Volumn 105, Issue 8, 2016, Pages 594-607

  Pearl, Laurence H ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

ATP; client protein; cochaperone; conformational change; molecular chaperones

Indexed keywords

ADENOSINETRIPHOSPHATE; STEROID HORMONES;

BIOLOGICAL FUNCTIONS; CANCER THERAPEUTICS; COCHAPERONE; CONFORMATIONAL CHANGE; CONFORMATIONAL CYCLE; MOLECULAR CHAPERONES; PHARMACOLOGICAL INHIBITION; STEROID HORMONE RECEPTORS;

PROTEINS;

ADENOSINE TRIPHOSPHATASE; AHA1 PROTEIN; CELL CYCLE PROTEIN 37; CHAPERONE; HEAT SHOCK PROTEIN 90; PROTEIN P23; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIMERIZATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; TETRATRICOPEPTIDE REPEAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; METABOLISM;

ADENOSINE TRIPHOSPHATASES; ANIMALS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; PROTEIN CONFORMATION; PROTEOLYSIS;

EID: 84969523556     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22835     Document Type: Review

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