Shifting Fitness and Epistatic Landscapes Reflect Trade-offs along an Evolutionary Pathway

Journal of Molecular Biology

Volumn 428, Issue 13, 2016, Pages 2730-2743

  Steinberg, Barrett ^a,b   Ostermeier, Marc ^a  

^a Johns Hopkins University   (United States)

^b EDITAS MEDICINE   (United States)

Author keywords

beta lactamase; epistasis; fitness landscape; protein evolution

Indexed keywords

AMPICILLIN; BETA LACTAMASE; CEFOTAXIME; PENICILLINASE; PROTEIN; AMINO ACID;

ADAPTATION; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; EPISTASIS; GENE MUTATION; GENETIC BACKGROUND; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; MUTATION RATE; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; ALLELE; AMPICILLIN RESISTANCE; BIOLOGICAL MODEL; EVOLUTION; GENETICS; MUTATION; SIGNAL TRANSDUCTION;

ADAPTATION, PHYSIOLOGICAL; ALLELES; AMINO ACIDS; AMPICILLIN RESISTANCE; BETA-LACTAMASES; BIOLOGICAL EVOLUTION; EPISTASIS, GENETIC; MODELS, GENETIC; MUTATION; PROTEIN STABILITY; PROTEINS; SIGNAL TRANSDUCTION;

EID: 84969504564     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2016.04.033     Document Type: Article

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