Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region

Oncotarget

Volumn 7, Issue 19, 2016, Pages 27267-27279

  Liu, Xiongxiong ^a,b,c   Sun, Chao ^a,b   Liu, Bingtao ^a,b,c,d   Jin, Xiaodong ^a,b,c   Li, Ping ^a,b,c   Zheng, Xiaogang ^a,b,c,d   Zhao, Ting ^a,b,c   Li, Feifei ^a,b,c,d   Li, Qiang ^a,b,c  

^a INSTITUTE OF MODERN PHYSICS   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Genistein; Keap1 Nrf2; Methylation; Oxidative stress; Selective radiosensitivity

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; GENISTEIN; GLUTATHIONE; HEME OXYGENASE 1; MESSENGER RNA; PEPTIDES AND PROTEINS; PROTEIN CARBONYL; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; KEAP1 PROTEIN, HUMAN; KELCH LIKE ECH ASSOCIATED PROTEIN 1;

A549 CELL LINE; APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE; HUMAN; HUMAN CELL; IC50; KEAP1 GENE; LUNG FIBROBLAST; NON SMALL CELL LUNG CANCER; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN LOCALIZATION; RADIATION PROTECTION; RADIOSENSITIZATION; TRANSCRIPTION TERMINATION; A-549 CELL LINE; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; RADIATION RESPONSE; RADIATION TOLERANCE; X RAY;

A549 CELLS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE; CELL SURVIVAL; DNA METHYLATION; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENISTEIN; HUMANS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; LUNG NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; RADIATION TOLERANCE; X-RAYS;

EID: 84968928038     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8403     Document Type: Article

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