Fragrant unsaturated aldehydes elicit activation of the keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress

Antioxidants and Redox Signaling

Volumn 11, Issue 5, 2009, Pages 949-962

  Masutani, Hiroshi ^a,c   Otsuki, Ryoko ^a   Yamaguchi, Yoshimi ^a   Takenaka, Masahiro ^a   Kanoh, Nobue ^b   Takatera, Koji ^b   Kunimoto, Yuji ^b   Yodoi, Junji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Research and Development Rockfield Co Ltd   (Japan)

^c NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 HEXENAL; 2,4 OCTADIENAL; 2,6 NONADIENAL; ALDEHYDE DERIVATIVE; ARTEMISIA PRINCEPS EXTRACT; CINNAMALDEHYDE; CITRAL; HYDROGEN PEROXIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PERILLA FRUTESCENS EXTRACT; PERILLALDEHYDE; PLANT EXTRACT; SAFRANAL; SULFORAPHANE; THIOREDOXIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ALDEHYDE; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; PRIMER DNA; SIGNAL PEPTIDE;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE; CHROMATIN IMMUNOPRECIPITATION; METABOLISM; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECIES DIFFERENCE; WESTERN BLOTTING;

ARTEMISIA PRINCEPS; PERILLA FRUTESCENS;

ALDEHYDES; BASE SEQUENCE; BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PLANT EXTRACTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECIES SPECIFICITY; THIOREDOXINS; UP-REGULATION;

EID: 64549130036     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2008.2292     Document Type: Article

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