Hepatic DNA Methylation Is Affected by Hepatocellular Carcinoma Risk in Patients with and without Hepatitis Virus

Digestive Diseases

Volumn 33, Issue 6, 2015, Pages 745-750

  Nishida, Naoshi ^a   Iwanishi, Mina ^a   Minami, Tomohiro ^a   Chishina, Hirokazu ^a   Arizumi, Tadaaki ^a   Takita, Masahiro ^a   Kitai, Satoshi ^a   Yada, Norihisa ^a   Ida, Hiroshi ^a   Hagiwara, Satoru ^a   Minami, Yasunori ^a   Ueshima, Kazuomi ^a   Sakurai, Toshiharu ^a   Kitano, Masayuki ^a   Kudo, Masatoshi ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aging; Background liver; Diabetes mellitus; DNA methylation; Hepatocellular carcinoma

Indexed keywords

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; HEPATITIS; HEPATITIS VIRUS; HUMAN; LIVER CELL CARCINOMA; MALE; PRIORITY JOURNAL; AGE; CARCINOMA, HEPATOCELLULAR; COMPLICATION; GENETICS; LIVER; LIVER NEOPLASMS; METABOLISM; MIDDLE AGED; RISK FACTOR; VIROLOGY; VIRUS HEPATITIS;

ADULT; AGE FACTORS; AGED; CARCINOMA, HEPATOCELLULAR; DNA METHYLATION; FEMALE; HEPATITIS VIRUSES; HEPATITIS, VIRAL, HUMAN; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; RISK FACTORS;

EID: 84945138701     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000439098     Document Type: Article

References (31)

1. Kudo M: Surveillance, diagnosis, treatment, and outcome of liver cancer in Japan. Liver Cancer 2015; 4: 39-50.
2. Kawanaka M, Nishino K, Nakamura J, Oka T, Urata N, Goto D, Suehiro M, Kawamoto H, Kudo M, Yamada G: Quantitative levels of hepatitis B virus DNA and surface antigen and the risk of hepatocellular carcinoma in patients with hepatitis B receiving long-term nucleos(t)ide analogue therapy. Liver Cancer 2014; 3: 41-52.
3. Webster DP, Klenerman P, Dusheiko GM: Hepatitis C. Lancet 2015; 385: 1124-1135.
4. Kudo M: Treatment of advanced hepatocellular carcinoma with emphasis on hepatic arterial infusion chemotherapy and molecular targeted therapy. Liver Cancer 2012; 1: 62-70.
5. Tateishi R, Okanoue T, Fujiwara N, Okita K, Kiyosawa K, Omata M, Kumada H, Hayashi N, Koike K: Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study. J Gastroenterol 2015; 50: 350-360.
6. Honda T, Miyaaki H, Ichikawa T, Taura N, Miuma S, Shibata H, Isomoto H, Takeshima F, Nakao K: Clinical characteristics of hepatocellular carcinoma in elderly patients. Oncol Lett 2011; 2: 851-854.
7. Michelotti GA, Machado MV, Diehl AM: NAFLD, NASH and liver cancer. Nat Rev Gastroenterol Hepatol 2013; 10: 656-665.
8. Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A: Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 2008; 47: 908-918.
9. Nishida N, Kudo M: Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma. Oncology 2013; 84(suppl 1):93-97.
10. Nishida N, Kudo M, Nagasaka T, Ikai I, Goel A: Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. Hepatology 2012; 56: 994-1003.
11. Nishida N, Kudo M: Alteration of epigenetic profile in human hepatocellular carcinoma and its clinical implications. Liver Cancer 2014; 3: 417-427.
12. Lim SO, Gu JM, Kim MS, Kim HS, Park YN, Park CK, Cho JW, Park YM, Jung G: Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology 2008; 135: 2128-2140, 2140.e1-e8.
13. OHagan HM, Wang W, Sen S, Destefano Shields C, Lee SS, Zhang YW, Clements EG, Cai Y, Van Neste L, Easwaran H, Casero RA, Sears CL, Baylin SB: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell 2011; 20: 606-619.
14. Nishida N, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Kudo M: Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxydeoxyguanosine in human hepatocarcinogenesis. Dig Dis 2013; 31: 459-466.
15. Bonomini F, Rodella LF, Rezzani R: Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis 2015; 6: 109-120.
16. Nishida N, Kudo M: Oxidative stress and epigenetic instability in human hepatocarcinogenesis. Dig Dis 2013; 31: 447-453.
17. Szabo G, Petrasek J: Inflammasome activation and function in liver disease. Nat Rev Gastroenterol Hepatol 2015; 12: 387-400.
18. Shen J, Wang S, Zhang YJ, Wu HC, Kibriya MG, Jasmine F, Ahsan H, Wu DP, Siegel AB, Remotti H, Santella RM: Exploring genomewide DNA methylation profiles altered in hepatocellular carcinoma using infinium HumanMethylation 450 BeadChips. Epigenetics 2013; 8: 34-43.
19. Nishida N, Nishimura T, Nakai T, Chishina H, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Kudo M: Genome-wide profiling of DNA methylation and tumor progression in human hepatocellular carcinoma. Dig Dis 2014; 32: 658-663.
20. Kew MC: Hepatic iron overload and hepatocellular carcinoma. Liver Cancer 2014; 3: 31-40.
21. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR: Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res 2007; 67: 4586-4594.
22. Nishida N, Goel A: Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review. Curr Genomics 2011; 12: 130-137.
23. Nishida N, Chishina H, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Kudo M: Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking. Dig Dis 2014; 32: 740-746.
24. Rongrui L, Na H, Zongfang L, Fanpu J, Shiwen J: Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis. Curr Pharm Des 2014; 20: 1715-1725.
25. Nishida N, Kudo M, Nishimura T, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Yokomichi N, Nagasaka T, Goel A: Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma. PLoS One 2013; 8:e72312.
26. Shibata T, Aburatani H: Exploration of liver cancer genomes. Nat Rev Gastroenterol Hepatol 2014; 11: 340-349.
27. Watanabe Y, Yamamoto H, Oikawa R, Toyota M, Yamamoto M, Kokudo N, Tanaka S, Arii S, Yotsuyanagi H, Koike K, Itoh F: DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences. Genome Res 2015; 25: 328-337.
28. Mann DA: Epigenetics in liver disease. Hepatology 2014; 60: 1418-1425.
29. Murphy SK, Yang H, Moylan CA, Pang H, Dellinger A, Abdelmalek MF, Garrett ME, Ashley-Koch A, Suzuki A, Tillmann HL, Hauser MA, Diehl AM: Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 1076-1087.
30. Zeybel M, Hardy T, Robinson SM, Fox C, Anstee QM, Ness T, Masson S, Mathers JC, French J, White S, Mann J: Differential DNA methylation of genes involved in fibrosis progression in non-Alcoholic fatty liver disease and alcoholic liver disease. Clin Epigenetics 2015; 7: 25.
31. Herceg Z, Paliwal A: Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome. Mutat Res 2011; 727: 55-61.