Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25+ cells

Journal of Immunological Methods

Volumn 405, Issue , 2014, Pages 57-66

  Peraino, Jaclyn Stromp ^a   Zhang, Huiping ^a   Rajasekera, Priyani V ^a   Wei, Min ^a   Madsen, Joren C ^a   Sachs, David H ^a   Huang, Christene A ^a   Wang, Zhirui ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Diphtheria toxin; Fusion toxin; Human IL 2; Pichia pastoris expression; Regulatory T cell

Indexed keywords

DENILEUKIN DIFTITOX; DIPHTHERIA TOXIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ARTICLE; BINDING AFFINITY; CD25+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; T CELL DEPLETION; WESTERN BLOTTING;

PICHIA PASTORIS;

DIPHTHERIA TOXIN; FUSION TOXIN; HUMAN IL-2; PICHIA PASTORIS EXPRESSION; REGULATORY T CELL;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING, COMPETITIVE; BLOTTING, WESTERN; CELL PROLIFERATION; DIPHTHERIA TOXIN; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA; PICHIA; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; T-LYMPHOCYTES, REGULATORY;

EID: 84897116498     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2014.01.008     Document Type: Article

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