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Volumn 45, Issue 7, 2015, Pages 1892-1905

Inhibitory receptors as targets for cancer immunotherapy

Author keywords

Cancer immunotherapy; CTLA4; Inhibitory receptors; LAG3; PD1

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MONOCLONAL ANTIBODY; PROTEIN DERIVATIVE; CD223 ANTIGEN; LEUKOCYTE ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84935432896     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344413     Document Type: Review
Times cited : (119)

References (147)
  • 1
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R. et al., Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 2009. 10: 29-37.
    • (2009) Nat. Immunol. , vol.10 , pp. 29-37
    • Blackburn, S.D.1    Shin, H.2    Haining, W.N.3    Zou, T.4    Workman, C.J.5    Polley, A.6    Betts, M.R.7
  • 2
    • 84856733781 scopus 로고    scopus 로고
    • Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization
    • Baitsch, L., Legat, A., Barba, L., Fuertes Marraco, S. A., Rivals, J. P., Baumgaertner, P., Christiansen-Jucht, C. et al., Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. PLoS One 2012. 7: e30852.
    • (2012) PLoS One , vol.7 , pp. e30852
    • Baitsch, L.1    Legat, A.2    Barba, L.3    Fuertes Marraco, S.A.4    Rivals, J.P.5    Baumgaertner, P.6    Christiansen-Jucht, C.7
  • 3
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M. et al., Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004. 10: 942-949.
    • (2004) Nat. Med. , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6    Evdemon-Hogan, M.7
  • 4
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • Shevach, E. M., Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009. 30: 636-645.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 5
    • 84890814629 scopus 로고    scopus 로고
    • Breakthrough of the year 2013. Cancer immunotherapy
    • Couzin-Frankel, J., Breakthrough of the year 2013. Cancer immunotherapy. Science 2013. 342: 1432-1433.
    • (2013) Science , vol.342 , pp. 1432-1433
    • Couzin-Frankel, J.1
  • 8
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    • Matsuzaki, J., Gnjatic, S., Mhawech-Fauceglia, P., Beck, A., Miller, A., Tsuji, T., Eppolito, C. et al., Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc. Natl. Acad. Sci. USA 2010. 107: 7875-7880.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 7875-7880
    • Matsuzaki, J.1    Gnjatic, S.2    Mhawech-Fauceglia, P.3    Beck, A.4    Miller, A.5    Tsuji, T.6    Eppolito, C.7
  • 9
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D. M., The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 2012. 12: 252-264.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 10
    • 84890281406 scopus 로고    scopus 로고
    • Adverse events to monoclonal antibodies used for cancer therapy: focus on hypersensitivity responses
    • Baldo, B. A., Adverse events to monoclonal antibodies used for cancer therapy: focus on hypersensitivity responses. Oncoimmunology 2013. 2: e26333.
    • (2013) Oncoimmunology , vol.2 , pp. e26333
    • Baldo, B.A.1
  • 11
  • 13
    • 84880733312 scopus 로고    scopus 로고
    • Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology
    • Kalos, M. and June, C. H., Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology. Immunity 2013. 39: 49-60.
    • (2013) Immunity , vol.39 , pp. 49-60
    • Kalos, M.1    June, C.H.2
  • 14
    • 84880721353 scopus 로고    scopus 로고
    • Dendritic-cell-based therapeutic cancer vaccines
    • Palucka, K. and Banchereau, J., Dendritic-cell-based therapeutic cancer vaccines. Immunity 2013. 39: 38-48.
    • (2013) Immunity , vol.39 , pp. 38-48
    • Palucka, K.1    Banchereau, J.2
  • 15
    • 84903700330 scopus 로고    scopus 로고
    • Co-inhibitory pathways and their importance in immune regulation
    • Murakami, N. and Riella, L. V., Co-inhibitory pathways and their importance in immune regulation. Transplantation 2014. 98: 3-14.
    • (2014) Transplantation , vol.98 , pp. 3-14
    • Murakami, N.1    Riella, L.V.2
  • 17
    • 84870483850 scopus 로고    scopus 로고
    • Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal
    • Lu, Y., Schneider, H. and Rudd, C. E., Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal. Blood 2012. 120: 4560-4570.
    • (2012) Blood , vol.120 , pp. 4560-4570
    • Lu, Y.1    Schneider, H.2    Rudd, C.E.3
  • 18
    • 33646578505 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression
    • Oderup, C., Cederbom, L., Makowska, A., Cilio, C. M. and Ivars, F., Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression. Immunology 2006. 118: 240-249.
    • (2006) Immunology , vol.118 , pp. 240-249
    • Oderup, C.1    Cederbom, L.2    Makowska, A.3    Cilio, C.M.4    Ivars, F.5
  • 19
    • 48249103057 scopus 로고    scopus 로고
    • Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
    • Onishi, Y., Fehervari, Z., Yamaguchi, T. and Sakaguchi, S., Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. USA 2008. 105: 10113-10118.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 10113-10118
    • Onishi, Y.1    Fehervari, Z.2    Yamaguchi, T.3    Sakaguchi, S.4
  • 20
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi, O. S., Zheng, Y., Nakamura, K., Attridge, K., Manzotti, C., Schmidt, E. M., Baker, J. et al., Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 2011. 332: 600-603.
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5    Schmidt, E.M.6    Baker, J.7
  • 21
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach, D. R., Krummel, M. F. and Allison, J. P., Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996. 271: 1734-1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 22
    • 79953241540 scopus 로고    scopus 로고
    • Melanoma drug wins US approval
    • Ledford, H., Melanoma drug wins US approval. Nature 2011. 471: 561.
    • (2011) Nature , vol.471 , pp. 561
    • Ledford, H.1
  • 23
    • 84884271914 scopus 로고    scopus 로고
    • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
    • Simpson, T. R., Li, F., Montalvo-Ortiz, W., Sepulveda, M. A., Bergerhoff, K., Arce, F., Roddie, C. et al., Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J. Exp. Med. 2013. 210: 1695-1710.
    • (2013) J. Exp. Med. , vol.210 , pp. 1695-1710
    • Simpson, T.R.1    Li, F.2    Montalvo-Ortiz, W.3    Sepulveda, M.A.4    Bergerhoff, K.5    Arce, F.6    Roddie, C.7
  • 24
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • Ribas, A., Kefford, R., Marshall, M. A., Punt, C. J., Haanen, J. B., Marmol, M., Garbe, C. et al., Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J. Clin. Oncol. 2013. 31: 616-622.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3    Punt, C.J.4    Haanen, J.B.5    Marmol, M.6    Garbe, C.7
  • 27
    • 84885591238 scopus 로고    scopus 로고
    • Treatment with ipilimumab: a case report of complete response in a metastatic malignant melanoma patient
    • Addeo, A. and Rinaldi, C. R., Treatment with ipilimumab: a case report of complete response in a metastatic malignant melanoma patient. Case Rep. Oncol. 2013. 6: 285-288.
    • (2013) Case Rep. Oncol. , vol.6 , pp. 285-288
    • Addeo, A.1    Rinaldi, C.R.2
  • 28
    • 84928917822 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
    • Schadendorf, D., Hodi, F. S., Robert, C., Weber, J. S., Margolin, K., Hamid, O., Patt, D. et al., Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma. J. Clin. Oncol. 2015. 33: 1889-1894.
    • (2015) J. Clin. Oncol. , vol.33 , pp. 1889-1894
    • Schadendorf, D.1    Hodi, F.S.2    Robert, C.3    Weber, J.S.4    Margolin, K.5    Hamid, O.6    Patt, D.7
  • 30
    • 84874100871 scopus 로고    scopus 로고
    • CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria
    • Barnes, M. J., Griseri, T., Johnson, A. M., Young, W., Powrie, F. and Izcue, A., CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria. Mucosal. Immunol. 2013. 6: 324-334.
    • (2013) Mucosal. Immunol. , vol.6 , pp. 324-334
    • Barnes, M.J.1    Griseri, T.2    Johnson, A.M.3    Young, W.4    Powrie, F.5    Izcue, A.6
  • 31
    • 55949123945 scopus 로고    scopus 로고
    • FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation
    • Mancardi, D. A., Iannascoli, B., Hoos, S., England, P., Daeron, M. and Bruhns, P., FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. J. Clin. Invest. 2008. 118: 3738-3750.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3738-3750
    • Mancardi, D.A.1    Iannascoli, B.2    Hoos, S.3    England, P.4    Daeron, M.5    Bruhns, P.6
  • 32
    • 84903517715 scopus 로고    scopus 로고
    • Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies
    • Furness, A. J., Vargas, F. A., Peggs, K. S. and Quezada, S. A., Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies. Trends Immunol. 2014. 35: 290-298.
    • (2014) Trends Immunol. , vol.35 , pp. 290-298
    • Furness, A.J.1    Vargas, F.A.2    Peggs, K.S.3    Quezada, S.A.4
  • 33
    • 10744234019 scopus 로고    scopus 로고
    • Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques
    • Keler, T., Halk, E., Vitale, L., O'Neill, T., Blanset, D., Lee, S., Srinivasan, M. et al., Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques. J. Immunol. 2003. 171: 6251-6259.
    • (2003) J. Immunol. , vol.171 , pp. 6251-6259
    • Keler, T.1    Halk, E.2    Vitale, L.3    O'Neill, T.4    Blanset, D.5    Lee, S.6    Srinivasan, M.7
  • 34
    • 82155168544 scopus 로고    scopus 로고
    • A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
    • Hamid, O., Schmidt, H., Nissan, A., Ridolfi, L., Aamdal, S., Hansson, J., Guida, M. et al., A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J. Transl. Med. 2011. 9: 204.
    • (2011) J. Transl. Med. , vol.9 , pp. 204
    • Hamid, O.1    Schmidt, H.2    Nissan, A.3    Ridolfi, L.4    Aamdal, S.5    Hansson, J.6    Guida, M.7
  • 35
    • 84880664259 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
    • Holmgaard, R. B., Zamarin, D., Munn, D. H., Wolchok, J. D. and Allison, J. P., Indoleamine 2, 3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J. Exp. Med. 2013. 210: 1389-1402.
    • (2013) J. Exp. Med. , vol.210 , pp. 1389-1402
    • Holmgaard, R.B.1    Zamarin, D.2    Munn, D.H.3    Wolchok, J.D.4    Allison, J.P.5
  • 38
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte, M. J., Keir, M. E., Phamduy, T. B., Sharpe, A. H. and Freeman, G. J., Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007. 27: 111-122.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 39
    • 77950283280 scopus 로고    scopus 로고
    • Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
    • Hino, R., Kabashima, K., Kato, Y., Yagi, H., Nakamura, M., Honjo, T., Okazaki, T. et al., Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer 2010. 116: 1757-1766.
    • (2010) Cancer , vol.116 , pp. 1757-1766
    • Hino, R.1    Kabashima, K.2    Kato, Y.3    Yagi, H.4    Nakamura, M.5    Honjo, T.6    Okazaki, T.7
  • 40
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • Hamanishi, J., Mandai, M., Iwasaki, M., Okazaki, T., Tanaka, Y., Yamaguchi, K., Higuchi, T. et al., Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc. Natl. Acad. Sci. USA 2007. 104: 3360-3365.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 3360-3365
    • Hamanishi, J.1    Mandai, M.2    Iwasaki, M.3    Okazaki, T.4    Tanaka, Y.5    Yamaguchi, K.6    Higuchi, T.7
  • 41
    • 84894478745 scopus 로고    scopus 로고
    • Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer
    • Maine, C. J., Aziz, N. H., Chatterjee, J., Hayford, C., Brewig, N., Whilding, L., George, A. J. et al., Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer. Cancer Immunol. Immunother. 2014. 63: 215-224.
    • (2014) Cancer Immunol. Immunother. , vol.63 , pp. 215-224
    • Maine, C.J.1    Aziz, N.H.2    Chatterjee, J.3    Hayford, C.4    Brewig, N.5    Whilding, L.6    George, A.J.7
  • 42
  • 43
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C. et al., Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 2002. 8: 793-800.
    • (2002) Nat. Med. , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6    Roche, P.C.7
  • 44
    • 3142688997 scopus 로고    scopus 로고
    • SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
    • Chemnitz, J. M., Parry, R. V., Nichols, K. E., June, C. H. and Riley, J. L., SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J. Immunol. 2004. 173: 945-954.
    • (2004) J. Immunol. , vol.173 , pp. 945-954
    • Chemnitz, J.M.1    Parry, R.V.2    Nichols, K.E.3    June, C.H.4    Riley, J.L.5
  • 45
    • 0037111483 scopus 로고    scopus 로고
    • Expression of programmed death 1 ligands by murine T cells and APC
    • Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T. et al., Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 2002. 169: 5538-5545.
    • (2002) J. Immunol. , vol.169 , pp. 5538-5545
    • Yamazaki, T.1    Akiba, H.2    Iwai, H.3    Matsuda, H.4    Aoki, M.5    Tanno, Y.6    Shin, T.7
  • 46
    • 84922085652 scopus 로고    scopus 로고
    • Pembrolizumab: first global approval
    • Poole, R. M., Pembrolizumab: first global approval. Drugs 2014. 74: 1973-1981.
    • (2014) Drugs , vol.74 , pp. 1973-1981
    • Poole, R.M.1
  • 49
    • 84907521155 scopus 로고    scopus 로고
    • A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer
    • Seiwert, T. Y., Burtness, B., Weiss, J., Gluck, I., Eder, J. P., Pai, S. I., Dolled-Filhart, M. et al., A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer. ASCO Meeting Abstracts 2014. 32: 6011.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 6011
    • Seiwert, T.Y.1    Burtness, B.2    Weiss, J.3    Gluck, I.4    Eder, J.P.5    Pai, S.I.6    Dolled-Filhart, M.7
  • 51
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian, S. L., Sznol, M., McDermott, D. F., Kluger, H. M., Carvajal, R. D., Sharfman, W. H., Brahmer, J. R. et al., Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J. Clin. Oncol. 2014. 32: 1020-1030.
    • (2014) J. Clin. Oncol. , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3    Kluger, H.M.4    Carvajal, R.D.5    Sharfman, W.H.6    Brahmer, J.R.7
  • 53
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles, T., Eder, J. P., Fine, G. D., Braiteh, F. S., Loriot, Y., Cruz, C., Bellmunt, J. et al., MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014. 515: 558-562.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3    Braiteh, F.S.4    Loriot, Y.5    Cruz, C.6    Bellmunt, J.7
  • 55
    • 84880264878 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC)
    • Cho, D. C., Sosman, J. A., Sznol, M., Gordon, M. S., Hollebecque, A., Hamid, O., McDermott, D. F. et al., Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstracts 2013. 31: 4505.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 4505
    • Cho, D.C.1    Sosman, J.A.2    Sznol, M.3    Gordon, M.S.4    Hollebecque, A.5    Hamid, O.6    McDermott, D.F.7
  • 56
    • 84951279998 scopus 로고    scopus 로고
    • Antibody dependent cellular cytotoxicity (ADCC) activity of a novel anti-PD-L1 antibody, avelumab (MSB0010718C), on human tumor cells
    • Boyerinas, B., Jochems, C., Fantini, M., Heery, C. R., Gulley, J. L., Tsang, K. Y. and Schlom, J., Antibody dependent cellular cytotoxicity (ADCC) activity of a novel anti-PD-L1 antibody, avelumab (MSB0010718C), on human tumor cells. Cancer Immunol. Res. 2015.
    • (2015) Cancer Immunol. Res.
    • Boyerinas, B.1    Jochems, C.2    Fantini, M.3    Heery, C.R.4    Gulley, J.L.5    Tsang, K.Y.6    Schlom, J.7
  • 57
    • 84905991829 scopus 로고    scopus 로고
    • Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): correlation of tumor PD-L1 expression with outcome [abstract]
    • Daud, A. I., Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): correlation of tumor PD-L1 expression with outcome [abstract]. Proc. Ann. Meeting AACR. 2014. CT104.
    • (2014) Proc. Ann. Meeting AACR. , pp. CT104
    • Daud, A.I.1
  • 58
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai, Y., Ishida, M., Tanaka, Y., Okazaki, T., Honjo, T. and Minato, N., Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA 2002. 99: 12293-12297.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 60
    • 84927176839 scopus 로고    scopus 로고
    • Correlation of T-cell inflamed phenotype with mesenchymal subtype, expression of PD-L1, and other immune checkpoints in head and neck cancer
    • Saloura, V., Zuo, Z., Koeppen, H., Keck, M. K., Khattri, A., Boe, M., Hegde, P. S. et al., Correlation of T-cell inflamed phenotype with mesenchymal subtype, expression of PD-L1, and other immune checkpoints in head and neck cancer. ASCO Meeting Abstracts 2014. 32: 6009.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 6009
    • Saloura, V.1    Zuo, Z.2    Koeppen, H.3    Keck, M.K.4    Khattri, A.5    Boe, M.6    Hegde, P.S.7
  • 61
    • 84935474357 scopus 로고    scopus 로고
    • PD-L1 expression as a predictive biomarker in cancer immunotherapy
    • Patel, S. P. and Kurzrock, R., PD-L1 expression as a predictive biomarker in cancer immunotherapy. Mol. Cancer Ther. 2015. 14: 847-856.
    • (2015) Mol. Cancer Ther. , vol.14 , pp. 847-856
    • Patel, S.P.1    Kurzrock, R.2
  • 63
    • 0027979962 scopus 로고
    • Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand
    • Huard, B., Gaulard, P., Faure, F., Hercend, T. and Triebel, F., Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand. Immunogenetics 1994. 39: 213-217.
    • (1994) Immunogenetics , vol.39 , pp. 213-217
    • Huard, B.1    Gaulard, P.2    Faure, F.3    Hercend, T.4    Triebel, F.5
  • 64
    • 0036686408 scopus 로고    scopus 로고
    • Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3)
    • Workman, C. J., Rice, D. S., Dugger, K. J., Kurschner, C. and Vignali, D. A., Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur. J. Immunol. 2002. 32: 2255-2263.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2255-2263
    • Workman, C.J.1    Rice, D.S.2    Dugger, K.J.3    Kurschner, C.4    Vignali, D.A.5
  • 66
    • 2142815854 scopus 로고    scopus 로고
    • Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo
    • Workman, C. J., Cauley, L. S., Kim, I. J., Blackman, M. A., Woodland, D. L. and Vignali, D. A., Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J. Immunol. 2004. 172: 5450-5455.
    • (2004) J. Immunol. , vol.172 , pp. 5450-5455
    • Workman, C.J.1    Cauley, L.S.2    Kim, I.J.3    Blackman, M.A.4    Woodland, D.L.5    Vignali, D.A.6
  • 67
    • 11844269957 scopus 로고    scopus 로고
    • Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223)
    • Workman, C. J. and Vignali, D. A., Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J. Immunol. 2005. 174: 688-695.
    • (2005) J. Immunol. , vol.174 , pp. 688-695
    • Workman, C.J.1    Vignali, D.A.2
  • 68
    • 0037111520 scopus 로고    scopus 로고
    • Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3
    • Workman, C. J., Dugger, K. J. and Vignali, D. A., Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3. J. Immunol. 2002. 169: 5392-5395.
    • (2002) J. Immunol. , vol.169 , pp. 5392-5395
    • Workman, C.J.1    Dugger, K.J.2    Vignali, D.A.3
  • 69
    • 33846551969 scopus 로고    scopus 로고
    • Metalloproteases regulate T-cell proliferation and effector function via LAG-3
    • Li, N., Wang, Y., Forbes, K., Vignali, K. M., Heale, B. S., Saftig, P., Hartmann, D. et al., Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 2007. 26: 494-504.
    • (2007) EMBO J. , vol.26 , pp. 494-504
    • Li, N.1    Wang, Y.2    Forbes, K.3    Vignali, K.M.4    Heale, B.S.5    Saftig, P.6    Hartmann, D.7
  • 70
    • 9144255487 scopus 로고    scopus 로고
    • Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223
    • Li, N., Workman, C. J., Martin, S. M. and Vignali, D. A., Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223). J. Immunol. 2004. 173: 6806-6812.
    • (2004) J. Immunol. , vol.173 , pp. 6806-6812
    • Li, N.1    Workman, C.J.2    Martin, S.M.3    Vignali, D.A.4
  • 71
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo, S. R., Turnis, M. E., Goldberg, M. V., Bankoti, J., Selby, M., Nirschl, C. J., Bettini, M. L. et al., Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 2012. 72: 917-927.
    • (2012) Cancer Res. , vol.72 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3    Bankoti, J.4    Selby, M.5    Nirschl, C.J.6    Bettini, M.L.7
  • 72
    • 84899748384 scopus 로고    scopus 로고
    • PD-1 identifies the patient-specific CD8(+) tumor-reactive repertoire infiltrating human tumors
    • Gros, A., Robbins, P. F., Yao, X., Li, Y. F., Turcotte, S., Tran, E., Wunderlich, J. R. et al., PD-1 identifies the patient-specific CD8(+) tumor-reactive repertoire infiltrating human tumors. J. Clin. Invest. 2014. 124: 2246-2259.
    • (2014) J. Clin. Invest. , vol.124 , pp. 2246-2259
    • Gros, A.1    Robbins, P.F.2    Yao, X.3    Li, Y.F.4    Turcotte, S.5    Tran, E.6    Wunderlich, J.R.7
  • 73
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran, M. A., Montalvo, W., Yagita, H. and Allison, J. P., PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc. Natl. Acad. Sci. USA 2010. 107: 4275-4280.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 75
    • 85016652335 scopus 로고    scopus 로고
    • Peripheral blood and tumor biomarkers in patients with advanced melanoma treated with combination nivolumab (anti-PD-1, BMS-936558, ONO-4538) and ipilimumab
    • Callahan, M., Horak, C., Curran, M., Hollman, T., Schaer, D., Yuan, J., Lesokhin, A. et al., Peripheral blood and tumor biomarkers in patients with advanced melanoma treated with combination nivolumab (anti-PD-1, BMS-936558, ONO-4538) and ipilimumab. J. Immunother. Cancer 2013. 1: O6.
    • (2013) J. Immunother. Cancer , vol.1 , pp. O6
    • Callahan, M.1    Horak, C.2    Curran, M.3    Hollman, T.4    Schaer, D.5    Yuan, J.6    Lesokhin, A.7
  • 76
    • 84907498833 scopus 로고    scopus 로고
    • Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in advanced melanoma (MEL)
    • LBA9003
    • Sznol, M., Kluger, H. M., Callahan, M. K., Postow, M. A., Gordon, R. A., Segal, N. H., Rizvi, N. A. et al., Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in advanced melanoma (MEL). ASCO Meeting Abstracts 2014. 32: LBA9003.
    • (2014) ASCO Meeting Abstracts , vol.32
    • Sznol, M.1    Kluger, H.M.2    Callahan, M.K.3    Postow, M.A.4    Gordon, R.A.5    Segal, N.H.6    Rizvi, N.A.7
  • 78
    • 84883207410 scopus 로고    scopus 로고
    • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
    • Le, D. T., Lutz, E., Uram, J. N., Sugar, E. A., Onners, B., Solt, S., Zheng, L. et al., Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J. Immunother. 2013. 36: 382-389.
    • (2013) J. Immunother. , vol.36 , pp. 382-389
    • Le, D.T.1    Lutz, E.2    Uram, J.N.3    Sugar, E.A.4    Onners, B.5    Solt, S.6    Zheng, L.7
  • 79
    • 84860436621 scopus 로고    scopus 로고
    • Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial
    • van den Eertwegh, A. J., Versluis, J., van den Berg, H. P., Santegoets, S. J., van Moorselaar, R. J., van der Sluis, T. M., Gall, H. E. et al., Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol. 2012. 13: 509-517.
    • (2012) Lancet Oncol. , vol.13 , pp. 509-517
    • van den Eertwegh, A.J.1    Versluis, J.2    van den Berg, H.P.3    Santegoets, S.J.4    van Moorselaar, R.J.5    van der Sluis, T.M.6    Gall, H.E.7
  • 80
    • 84908664534 scopus 로고    scopus 로고
    • Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial
    • Hodi, F. S., Lee, S., McDermott, D. F., Rao, U. N., Butterfield, L. H., Tarhini, A. A., Leming, P. et al., Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial. JAMA 2014. 312: 1744-1753.
    • (2014) JAMA , vol.312 , pp. 1744-1753
    • Hodi, F.S.1    Lee, S.2    McDermott, D.F.3    Rao, U.N.4    Butterfield, L.H.5    Tarhini, A.A.6    Leming, P.7
  • 81
    • 57049185731 scopus 로고    scopus 로고
    • The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation
    • Xu, Y., Hunt, N. H. and Bao, S., The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation. Cell Res. 2008. 18: 1220-1229.
    • (2008) Cell Res. , vol.18 , pp. 1220-1229
    • Xu, Y.1    Hunt, N.H.2    Bao, S.3
  • 82
    • 0028263504 scopus 로고
    • Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
    • Dranoff, G., Crawford, A. D., Sadelain, M., Ream, B., Rashid, A., Bronson, R. T., Dickersin, G. R. et al., Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science 1994. 264: 713-716.
    • (1994) Science , vol.264 , pp. 713-716
    • Dranoff, G.1    Crawford, A.D.2    Sadelain, M.3    Ream, B.4    Rashid, A.5    Bronson, R.T.6    Dickersin, G.R.7
  • 85
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi, N. A., Hellmann, M. D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J. J., Lee, W. et al., Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015. 348: 124-128.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3    Kvistborg, P.4    Makarov, V.5    Havel, J.J.6    Lee, W.7
  • 86
    • 67650340774 scopus 로고    scopus 로고
    • Newcastle disease virus: a promising vector for viral therapy, immune therapy, and gene therapy of cancer
    • Schirrmacher, V. and Fournier, P., Newcastle disease virus: a promising vector for viral therapy, immune therapy, and gene therapy of cancer. Methods Mol. Biol. 2009. 542: 565-605.
    • (2009) Methods Mol. Biol. , vol.542 , pp. 565-605
    • Schirrmacher, V.1    Fournier, P.2
  • 87
    • 84897476768 scopus 로고    scopus 로고
    • Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
    • Zamarin, D., Holmgaard, R. B., Subudhi, S. K., Park, J. S., Mansour, M., Palese, P., Merghoub, T. et al., Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci. Transl. Med. 2014. 6: 226ra232.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 226ra232
    • Zamarin, D.1    Holmgaard, R.B.2    Subudhi, S.K.3    Park, J.S.4    Mansour, M.5    Palese, P.6    Merghoub, T.7
  • 88
    • 0037203867 scopus 로고    scopus 로고
    • Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    • Monney, L., Sabatos, C. A., Gaglia, J. L., Ryu, A., Waldner, H., Chernova, T., Manning, S. et al., Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002. 415: 536-541.
    • (2002) Nature , vol.415 , pp. 536-541
    • Monney, L.1    Sabatos, C.A.2    Gaglia, J.L.3    Ryu, A.4    Waldner, H.5    Chernova, T.6    Manning, S.7
  • 90
    • 84922391334 scopus 로고    scopus 로고
    • Tim-3: an emerging target in the cancer immunotherapy landscape
    • Anderson, A. C., Tim-3: an emerging target in the cancer immunotherapy landscape. Cancer Immunol. Res. 2014. 2: 393-398.
    • (2014) Cancer Immunol. Res. , vol.2 , pp. 393-398
    • Anderson, A.C.1
  • 91
    • 77957723967 scopus 로고    scopus 로고
    • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
    • Fourcade, J., Sun, Z., Benallaoua, M., Guillaume, P., Luescher, I. F., Sander, C., Kirkwood, J. M. et al., Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J. Exp. Med. 2010. 207: 2175-2186.
    • (2010) J. Exp. Med. , vol.207 , pp. 2175-2186
    • Fourcade, J.1    Sun, Z.2    Benallaoua, M.3    Guillaume, P.4    Luescher, I.F.5    Sander, C.6    Kirkwood, J.M.7
  • 92
    • 84859701005 scopus 로고    scopus 로고
    • IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
    • Yang, Z. Z., Grote, D. M., Ziesmer, S. C., Niki, T., Hirashima, M., Novak, A. J., Witzig, T. E. et al., IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma. J. Clin. Invest. 2012. 122: 1271-1282.
    • (2012) J. Clin. Invest. , vol.122 , pp. 1271-1282
    • Yang, Z.Z.1    Grote, D.M.2    Ziesmer, S.C.3    Niki, T.4    Hirashima, M.5    Novak, A.J.6    Witzig, T.E.7
  • 93
    • 84857159981 scopus 로고    scopus 로고
    • TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression
    • Gao, X., Zhu, Y., Li, G., Huang, H., Zhang, G., Wang, F., Sun, J. et al., TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. PLoS One 2012. 7: e30676.
    • (2012) PLoS One , vol.7 , pp. e30676
    • Gao, X.1    Zhu, Y.2    Li, G.3    Huang, H.4    Zhang, G.5    Wang, F.6    Sun, J.7
  • 94
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K. and Anderson, A. C., Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 2010. 207: 2187-2194.
    • (2010) J. Exp. Med. , vol.207 , pp. 2187-2194
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3    Blazar, B.R.4    Kuchroo, V.K.5    Anderson, A.C.6
  • 95
    • 79955977180 scopus 로고    scopus 로고
    • Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
    • Zhou, Q., Munger, M. E., Veenstra, R. G., Weigel, B. J., Hirashima, M., Munn, D. H., Murphy, W. J. et al., Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood 2011. 117: 4501-4510.
    • (2011) Blood , vol.117 , pp. 4501-4510
    • Zhou, Q.1    Munger, M.E.2    Veenstra, R.G.3    Weigel, B.J.4    Hirashima, M.5    Munn, D.H.6    Murphy, W.J.7
  • 98
    • 84865422909 scopus 로고    scopus 로고
    • Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
    • Chiba, S., Baghdadi, M., Akiba, H., Yoshiyama, H., Kinoshita, I., Dosaka-Akita, H., Fujioka, Y. et al., Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nat. Immunol. 2012. 13: 832-842.
    • (2012) Nat. Immunol. , vol.13 , pp. 832-842
    • Chiba, S.1    Baghdadi, M.2    Akiba, H.3    Yoshiyama, H.4    Kinoshita, I.5    Dosaka-Akita, H.6    Fujioka, Y.7
  • 99
    • 17744388105 scopus 로고    scopus 로고
    • Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
    • Hoek, R. M., Ruuls, S. R., Murphy, C. A., Wright, G. J., Goddard, R., Zurawski, S. M., Blom, B. et al., Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 2000. 290: 1768-1771.
    • (2000) Science , vol.290 , pp. 1768-1771
    • Hoek, R.M.1    Ruuls, S.R.2    Murphy, C.A.3    Wright, G.J.4    Goddard, R.5    Zurawski, S.M.6    Blom, B.7
  • 100
    • 84859162348 scopus 로고    scopus 로고
    • CD200R signaling in tumor tolerance and inflammation: a tricky balance
    • Rygiel, T. P. and Meyaard, L., CD200R signaling in tumor tolerance and inflammation: a tricky balance. Curr. Opin. Immunol. 2012. 24: 233-238.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 233-238
    • Rygiel, T.P.1    Meyaard, L.2
  • 101
    • 84893438154 scopus 로고    scopus 로고
    • Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation
    • Adhikary, G., Grun, D., Kerr, C., Balasubramanian, S., Rorke, E. A., Vemuri, M., Boucher, S. et al., Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. PLoS One 2013. 8: e84324.
    • (2013) PLoS One , vol.8 , pp. e84324
    • Adhikary, G.1    Grun, D.2    Kerr, C.3    Balasubramanian, S.4    Rorke, E.A.5    Vemuri, M.6    Boucher, S.7
  • 103
    • 79955847224 scopus 로고    scopus 로고
    • CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia
    • Coles, S. J., Wang, E. C., Man, S., Hills, R. K., Burnett, A. K., Tonks, A. and Darley, R. L., CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 2011. 25: 792-799.
    • (2011) Leukemia , vol.25 , pp. 792-799
    • Coles, S.J.1    Wang, E.C.2    Man, S.3    Hills, R.K.4    Burnett, A.K.5    Tonks, A.6    Darley, R.L.7
  • 104
    • 84884942789 scopus 로고    scopus 로고
    • CD200 flow cytometric assessment and semiquantitative immunohistochemical staining distinguishes hairy cell leukemia from hairy cell leukemia-variant and other B-cell lymphoproliferative disorders
    • Pillai, V., Pozdnyakova, O., Charest, K., Li, B., Shahsafaei, A. and Dorfman, D. M., CD200 flow cytometric assessment and semiquantitative immunohistochemical staining distinguishes hairy cell leukemia from hairy cell leukemia-variant and other B-cell lymphoproliferative disorders. Am. J. Clin. Pathol. 2013. 140: 536-543.
    • (2013) Am. J. Clin. Pathol. , vol.140 , pp. 536-543
    • Pillai, V.1    Pozdnyakova, O.2    Charest, K.3    Li, B.4    Shahsafaei, A.5    Dorfman, D.M.6
  • 105
    • 0041832335 scopus 로고    scopus 로고
    • Characterization of the CD200 receptor family in mice and humans and their interactions with CD200
    • Wright, G. J., Cherwinski, H., Foster-Cuevas, M., Brooke, G., Puklavec, M. J., Bigler, M., Song, Y. et al., Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 2003. 171: 3034-3046.
    • (2003) J. Immunol. , vol.171 , pp. 3034-3046
    • Wright, G.J.1    Cherwinski, H.2    Foster-Cuevas, M.3    Brooke, G.4    Puklavec, M.J.5    Bigler, M.6    Song, Y.7
  • 106
    • 84890429833 scopus 로고    scopus 로고
    • Cure of metastatic growth of EMT6 tumor cells in mice following manipulation of CD200:CD200R signaling
    • Gorczynski, R. M., Chen, Z., Khatri, I., Podnos, A. and Yu, K., Cure of metastatic growth of EMT6 tumor cells in mice following manipulation of CD200:CD200R signaling. Breast Cancer Res. Treat. 2013. 142: 271-282.
    • (2013) Breast Cancer Res. Treat. , vol.142 , pp. 271-282
    • Gorczynski, R.M.1    Chen, Z.2    Khatri, I.3    Podnos, A.4    Yu, K.5
  • 107
    • 84919494669 scopus 로고    scopus 로고
    • The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function
    • Johnston, R. J., Comps-Agrar, L., Hackney, J., Yu, X., Huseni, M., Yang, Y., Park, S. et al., The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell 2014. 26: 923-937.
    • (2014) Cancer Cell , vol.26 , pp. 923-937
    • Johnston, R.J.1    Comps-Agrar, L.2    Hackney, J.3    Yu, X.4    Huseni, M.5    Yang, Y.6    Park, S.7
  • 108
    • 57849101994 scopus 로고    scopus 로고
    • The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
    • Yu, X., Harden, K., Gonzalez, L. C., Francesco, M., Chiang, E., Irving, B., Tom, I. et al., The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 2009. 10: 48-57.
    • (2009) Nat. Immunol. , vol.10 , pp. 48-57
    • Yu, X.1    Harden, K.2    Gonzalez, L.C.3    Francesco, M.4    Chiang, E.5    Irving, B.6    Tom, I.7
  • 110
  • 112
    • 84898681799 scopus 로고    scopus 로고
    • Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
    • Joller, N., Lozano, E., Burkett, P. R., Patel, B., Xiao, S., Zhu, C., Xia, J. et al., Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 2014. 40: 569-581.
    • (2014) Immunity , vol.40 , pp. 569-581
    • Joller, N.1    Lozano, E.2    Burkett, P.R.3    Patel, B.4    Xiao, S.5    Zhu, C.6    Xia, J.7
  • 114
    • 74949125667 scopus 로고    scopus 로고
    • BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
    • Derre, L., Rivals, J. P., Jandus, C., Pastor, S., Rimoldi, D., Romero, P., Michielin, O. et al., BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J. Clin. Invest. 2010. 120: 157-167.
    • (2010) J. Clin. Invest. , vol.120 , pp. 157-167
    • Derre, L.1    Rivals, J.P.2    Jandus, C.3    Pastor, S.4    Rimoldi, D.5    Romero, P.6    Michielin, O.7
  • 115
    • 84865029272 scopus 로고    scopus 로고
    • The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy
    • Pasero, C., Speiser, D. E., Derre, L. and Olive, D., The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy. Curr. Opin. Pharmacol. 2012. 12: 478-485.
    • (2012) Curr. Opin. Pharmacol. , vol.12 , pp. 478-485
    • Pasero, C.1    Speiser, D.E.2    Derre, L.3    Olive, D.4
  • 116
    • 70349560843 scopus 로고    scopus 로고
    • High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia
    • M'Hidi, H., Thibult, M. L., Chetaille, B., Rey, F., Bouadallah, R., Nicollas, R., Olive, D. et al., High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Am. J. Clin. Pathol. 2009. 132: 589-596.
    • (2009) Am. J. Clin. Pathol. , vol.132 , pp. 589-596
    • M'Hidi, H.1    Thibult, M.L.2    Chetaille, B.3    Rey, F.4    Bouadallah, R.5    Nicollas, R.6    Olive, D.7
  • 117
    • 0034667773 scopus 로고    scopus 로고
    • Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor
    • Morel, Y., Schiano de Colella, J. M., Harrop, J., Deen, K. C., Holmes, S. D., Wattam, T. A., Khandekar, S. S. et al., Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. J. Immunol. 2000. 165: 4397-4404.
    • (2000) J. Immunol. , vol.165 , pp. 4397-4404
    • Morel, Y.1    Schiano de Colella, J.M.2    Harrop, J.3    Deen, K.C.4    Holmes, S.D.5    Wattam, T.A.6    Khandekar, S.S.7
  • 118
    • 33846479499 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation
    • Krieg, C., Boyman, O., Fu, Y. X. and Kaye, J., B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation. Nat. Immunol. 2007. 8: 162-171.
    • (2007) Nat. Immunol. , vol.8 , pp. 162-171
    • Krieg, C.1    Boyman, O.2    Fu, Y.X.3    Kaye, J.4
  • 119
    • 84863393290 scopus 로고    scopus 로고
    • CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
    • Fourcade, J., Sun, Z., Pagliano, O., Guillaume, P., Luescher, I. F., Sander, C., Kirkwood, J. M. et al., CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 2012. 72: 887-896.
    • (2012) Cancer Res. , vol.72 , pp. 887-896
    • Fourcade, J.1    Sun, Z.2    Pagliano, O.3    Guillaume, P.4    Luescher, I.F.5    Sander, C.6    Kirkwood, J.M.7
  • 120
    • 0031852722 scopus 로고    scopus 로고
    • gp100/pmel 17 is a murine tumor rejection antigen: induction of self-reactive, tumoricidal T cells using high-affinity, altered peptide ligand
    • Overwijk, W. W., Tsung, A., Irvine, K. R., Parkhurst, M. R., Goletz, T. J., Tsung, K., Carroll, M. W. et al., gp100/pmel 17 is a murine tumor rejection antigen: induction of self-reactive, tumoricidal T cells using high-affinity, altered peptide ligand. J. Exp. Med. 1998. 188: 277-286.
    • (1998) J. Exp. Med. , vol.188 , pp. 277-286
    • Overwijk, W.W.1    Tsung, A.2    Irvine, K.R.3    Parkhurst, M.R.4    Goletz, T.J.5    Tsung, K.6    Carroll, M.W.7
  • 121
    • 84862841841 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation
    • Hobo, W., Norde, W. J., Schaap, N., Fredrix, H., Maas, F., Schellens, K., Falkenburg, J. H. et al., B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation. J. Immunol. 2012. 189: 39-49.
    • (2012) J. Immunol. , vol.189 , pp. 39-49
    • Hobo, W.1    Norde, W.J.2    Schaap, N.3    Fredrix, H.4    Maas, F.5    Schellens, K.6    Falkenburg, J.H.7
  • 122
    • 38349149016 scopus 로고    scopus 로고
    • CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
    • Cai, G., Anumanthan, A., Brown, J. A., Greenfield, E. A., Zhu, B. and Freeman, G. J., CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Nat. Immunol. 2008. 9: 176-185.
    • (2008) Nat. Immunol. , vol.9 , pp. 176-185
    • Cai, G.1    Anumanthan, A.2    Brown, J.A.3    Greenfield, E.A.4    Zhu, B.5    Freeman, G.J.6
  • 124
    • 80052414652 scopus 로고    scopus 로고
    • Active immunotherapy combined with blockade of a coinhibitory pathway achieves regression of large tumor masses in cancer-prone mice
    • Lasaro, M. O., Sazanovich, M., Giles-Davis, W., Mrass, P., Bunte, R. M., Sewell, D. A., Hussain, S. F. et al., Active immunotherapy combined with blockade of a coinhibitory pathway achieves regression of large tumor masses in cancer-prone mice. Mol. Ther. 2011. 19: 1727-1736.
    • (2011) Mol. Ther. , vol.19 , pp. 1727-1736
    • Lasaro, M.O.1    Sazanovich, M.2    Giles-Davis, W.3    Mrass, P.4    Bunte, R.M.5    Sewell, D.A.6    Hussain, S.F.7
  • 125
    • 84873534154 scopus 로고    scopus 로고
    • The role of B7 family molecules in hematologic malignancy
    • Greaves, P. and Gribben, J. G., The role of B7 family molecules in hematologic malignancy. Blood 2013. 121: 734-744.
    • (2013) Blood , vol.121 , pp. 734-744
    • Greaves, P.1    Gribben, J.G.2
  • 126
    • 48749093493 scopus 로고    scopus 로고
    • Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses
    • Hashiguchi, M., Kobori, H., Ritprajak, P., Kamimura, Y., Kozono, H. and Azuma, M., Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc. Natl. Acad. Sci. USA 2008. 105: 10495-10500.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 10495-10500
    • Hashiguchi, M.1    Kobori, H.2    Ritprajak, P.3    Kamimura, Y.4    Kozono, H.5    Azuma, M.6
  • 127
    • 84898001946 scopus 로고    scopus 로고
    • B7-H3-mediated tumor immunology: friend or foe?
    • Wang, L., Kang, F. B. and Shan, B. E., B7-H3-mediated tumor immunology: friend or foe? Int. J. Cancer 2014. 134: 2764-2771.
    • (2014) Int. J. Cancer , vol.134 , pp. 2764-2771
    • Wang, L.1    Kang, F.B.2    Shan, B.E.3
  • 128
    • 84904129269 scopus 로고    scopus 로고
    • Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells
    • Kraan, J., van den Broek, P., Verhoef, C., Grunhagen, D. J., Taal, W., Gratama, J. W. and Sleijfer, S., Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. Br. J. Cancer 2014. 111: 149-156.
    • (2014) Br. J. Cancer , vol.111 , pp. 149-156
    • Kraan, J.1    van den Broek, P.2    Verhoef, C.3    Grunhagen, D.J.4    Taal, W.5    Gratama, J.W.6    Sleijfer, S.7
  • 129
    • 84884491704 scopus 로고    scopus 로고
    • Clinical significance of the induction of macrophage differentiation by the costimulatory molecule B7-H3 in human non-small cell lung cancer
    • Sun, J., Mao, Y., Zhang, Y. Q., Guo, Y. D., Mu, C. Y., Fu, F. Q. and Zhang, X. G., Clinical significance of the induction of macrophage differentiation by the costimulatory molecule B7-H3 in human non-small cell lung cancer. Oncol. Lett. 2013. 6: 1253-1260.
    • (2013) Oncol. Lett. , vol.6 , pp. 1253-1260
    • Sun, J.1    Mao, Y.2    Zhang, Y.Q.3    Guo, Y.D.4    Mu, C.Y.5    Fu, F.Q.6    Zhang, X.G.7
  • 131
    • 84863928141 scopus 로고    scopus 로고
    • Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity
    • Loo, D., Alderson, R. F., Chen, F. Z., Huang, L., Zhang, W., Gorlatov, S., Burke, S. et al., Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity. Clin. Cancer Res. 2012. 18: 3834-3845.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3834-3845
    • Loo, D.1    Alderson, R.F.2    Chen, F.Z.3    Huang, L.4    Zhang, W.5    Gorlatov, S.6    Burke, S.7
  • 132
    • 0038094524 scopus 로고    scopus 로고
    • B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
    • Sica, G. L., Choi, I. H., Zhu, G., Tamada, K., Wang, S. D., Tamura, H., Chapoval, A. I. et al., B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003. 18: 849-861.
    • (2003) Immunity , vol.18 , pp. 849-861
    • Sica, G.L.1    Choi, I.H.2    Zhu, G.3    Tamada, K.4    Wang, S.D.5    Tamura, H.6    Chapoval, A.I.7
  • 133
    • 33645853780 scopus 로고    scopus 로고
    • B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    • Kryczek, I., Zou, L., Rodriguez, P., Zhu, G., Wei, S., Mottram, P., Brumlik, M. et al., B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J. Exp. Med. 2006. 203: 871-881.
    • (2006) J. Exp. Med. , vol.203 , pp. 871-881
    • Kryczek, I.1    Zou, L.2    Rodriguez, P.3    Zhu, G.4    Wei, S.5    Mottram, P.6    Brumlik, M.7
  • 134
    • 84855166172 scopus 로고    scopus 로고
    • The inhibitory role of b7-h4 in antitumor immunity: association with cancer progression and survival
    • He, C., Qiao, H., Jiang, H. and Sun, X., The inhibitory role of b7-h4 in antitumor immunity: association with cancer progression and survival. Clin. Dev. Immunol. 2011. 2011: 695834.
    • (2011) Clin. Dev. Immunol. , vol.2011 , pp. 695834
    • He, C.1    Qiao, H.2    Jiang, H.3    Sun, X.4
  • 135
    • 77958067744 scopus 로고    scopus 로고
    • Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
    • Jiang, J., Zhu, Y., Wu, C., Shen, Y., Wei, W., Chen, L., Zheng, X. et al., Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol. Immunother. 2010. 59: 1707-1714.
    • (2010) Cancer Immunol. Immunother. , vol.59 , pp. 1707-1714
    • Jiang, J.1    Zhu, Y.2    Wu, C.3    Shen, Y.4    Wei, W.5    Chen, L.6    Zheng, X.7
  • 137
    • 79956027063 scopus 로고    scopus 로고
    • B7-h4 expression in human melanoma: its association with patients' survival and antitumor immune response
    • Quandt, D., Fiedler, E., Boettcher, D., Marsch, W. and Seliger, B., B7-h4 expression in human melanoma: its association with patients' survival and antitumor immune response. Clin. Cancer Res. 2011. 17: 3100-3111.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 3100-3111
    • Quandt, D.1    Fiedler, E.2    Boettcher, D.3    Marsch, W.4    Seliger, B.5
  • 138
    • 84859906658 scopus 로고    scopus 로고
    • Increase of circulating B7-H4-expressing CD68+ macrophage correlated with clinical stage of lung carcinomas
    • Chen, C., Zhu, Y. B., Shen, Y., Zhu, Y. H., Zhang, X. G. and Huang, J. A., Increase of circulating B7-H4-expressing CD68+ macrophage correlated with clinical stage of lung carcinomas. J. Immunother. 2012. 35: 354-358.
    • (2012) J. Immunother. , vol.35 , pp. 354-358
    • Chen, C.1    Zhu, Y.B.2    Shen, Y.3    Zhu, Y.H.4    Zhang, X.G.5    Huang, J.A.6
  • 139
    • 79959708884 scopus 로고    scopus 로고
    • B7-H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma
    • Chen, L. J., Sun, J., Wu, H. Y., Zhou, S. M., Tan, Y., Tan, M., Shan, B. E. et al., B7-H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma. Cancer Immunol. Immunother. 2011. 60: 1047-1055.
    • (2011) Cancer Immunol. Immunother. , vol.60 , pp. 1047-1055
    • Chen, L.J.1    Sun, J.2    Wu, H.Y.3    Zhou, S.M.4    Tan, Y.5    Tan, M.6    Shan, B.E.7
  • 140
    • 84881423899 scopus 로고    scopus 로고
    • Novel recombinant human b7-h4 antibodies overcome tumoral immune escape to potentiate T-cell antitumor responses
    • Dangaj, D., Lanitis, E., Zhao, A., Joshi, S., Cheng, Y., Sandaltzopoulos, R., Ra, H. J. et al., Novel recombinant human b7-h4 antibodies overcome tumoral immune escape to potentiate T-cell antitumor responses. Cancer Res. 2013. 73: 4820-4829.
    • (2013) Cancer Res. , vol.73 , pp. 4820-4829
    • Dangaj, D.1    Lanitis, E.2    Zhao, A.3    Joshi, S.4    Cheng, Y.5    Sandaltzopoulos, R.6    Ra, H.J.7
  • 141
    • 79952717517 scopus 로고    scopus 로고
    • VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses
    • Wang, L., Rubinstein, R., Lines, J. L., Wasiuk, A., Ahonen, C., Guo, Y., Lu, L. F. et al., VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J. Exp. Med. 2011. 208: 577-592.
    • (2011) J. Exp. Med. , vol.208 , pp. 577-592
    • Wang, L.1    Rubinstein, R.2    Lines, J.L.3    Wasiuk, A.4    Ahonen, C.5    Guo, Y.6    Lu, L.F.7
  • 145
    • 84926650425 scopus 로고    scopus 로고
    • Chemokine receptor-specific antibodies in cancer immunotherapy: achievements and challenges
    • Vela, M., Aris, M., Llorente, M., Garcia-Sanz, J. A. and Kremer, L., Chemokine receptor-specific antibodies in cancer immunotherapy: achievements and challenges. Front Immunol. 2015. 6: 12.
    • (2015) Front Immunol. , vol.6 , pp. 12
    • Vela, M.1    Aris, M.2    Llorente, M.3    Garcia-Sanz, J.A.4    Kremer, L.5
  • 147
    • 84880704621 scopus 로고    scopus 로고
    • The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
    • Galon, J., Angell, H. K., Bedognetti, D. and Marincola, F. M., The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity 2013. 39: 11-26.
    • (2013) Immunity , vol.39 , pp. 11-26
    • Galon, J.1    Angell, H.K.2    Bedognetti, D.3    Marincola, F.M.4


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