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Volumn 94, Issue 5, 2016, Pages 523-534

Biological and pathological activities of interleukin-22

Author keywords

Autoimmune; Cancer; IL 22; IL 22BP; IL 22R; ILC22; Infection; T cell; Th22

Indexed keywords

FEZAKINUMAB; INTERLEUKIN 22; INTERLEUKIN 22 RECEPTOR; INTERLEUKIN RECEPTOR; RECOMBINANT INTERLEUKIN 22; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; INTERLEUKIN-22 RECEPTOR;

EID: 84966588506     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-016-1391-6     Document Type: Review
Times cited : (114)

References (182)
  • 1
    • 84891702406 scopus 로고    scopus 로고
    • Therapeutic opportunities of the IL-22-IL-22R1 system
    • COI: 1:CAS:528:DC%2BC2cXlslam, PID: 24378801
    • Sabat R, Ouyang W, Wolk K (2014) Therapeutic opportunities of the IL-22-IL-22R1 system. Nat Rev Drug Discov 13:21–38
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 21-38
    • Sabat, R.1    Ouyang, W.2    Wolk, K.3
  • 2
    • 0034651583 scopus 로고    scopus 로고
    • Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9
    • COI: 1:CAS:528:DC%2BD3cXhtlymt7s%3D
    • Dumoutier L, Louahed J, Renauld JC (2000) Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol (Baltimore, Md: 1950) 164:1814–1819
    • (2000) J Immunol (Baltimore, Md: 1950) , vol.164 , pp. 1814-1819
    • Dumoutier, L.1    Louahed, J.2    Renauld, J.C.3
  • 3
    • 0034565220 scopus 로고    scopus 로고
    • IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes
    • COI: 1:CAS:528:DC%2BD3MXjsF2hug%3D%3D, PID: 11197690
    • Dumoutier L, Van Roost E, Ameye G, Michaux L, Renauld JC (2000) IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immun 1:488–494
    • (2000) Genes Immun , vol.1 , pp. 488-494
    • Dumoutier, L.1    Van Roost, E.2    Ameye, G.3    Michaux, L.4    Renauld, J.C.5
  • 4
    • 0034730141 scopus 로고    scopus 로고
    • Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor
    • COI: 1:CAS:528:DC%2BD3cXmtlehtrw%3D, PID: 10954742
    • Dumoutier L, Van Roost E, Colau D, Renauld JC (2000) Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc Natl Acad Sci U S A 97:10144–10149
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 10144-10149
    • Dumoutier, L.1    Van Roost, E.2    Colau, D.3    Renauld, J.C.4
  • 5
    • 0034613201 scopus 로고    scopus 로고
    • Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
    • COI: 1:CAS:528:DC%2BD3cXntlCitrs%3D, PID: 10875937
    • Xie MH et al (2000) Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem 275:31335–31339
    • (2000) J Biol Chem , vol.275 , pp. 31335-31339
    • Xie, M.H.1
  • 6
    • 0036053225 scopus 로고    scopus 로고
    • Crystal structure of recombinant human interleukin-22
    • COI: 1:CAS:528:DC%2BD38XmtlKhtbg%3D, PID: 12176383
    • Nagem RA et al (2002) Crystal structure of recombinant human interleukin-22. Structure 10:1051–1062
    • (2002) Structure , vol.10 , pp. 1051-1062
    • Nagem, R.A.1
  • 7
    • 42749087384 scopus 로고    scopus 로고
    • The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29
    • COI: 1:CAS:528:DC%2BD1cXlslKltLY%3D, PID: 18405958
    • Commins S, Steinke JW, Borish L (2008) The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29. J Allergy Clin Immunol 121:1108–1111
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 1108-1111
    • Commins, S.1    Steinke, J.W.2    Borish, L.3
  • 8
    • 41449114478 scopus 로고    scopus 로고
    • Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains
    • PID: 18024507
    • de Oliveira Neto M et al (2008) Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains. Biophys J 94:1754–1765
    • (2008) Biophys J , vol.94 , pp. 1754-1765
    • de Oliveira Neto, M.1
  • 9
    • 49849091678 scopus 로고    scopus 로고
    • Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism
    • COI: 1:CAS:528:DC%2BD1cXhtVensL7J, PID: 18675809
    • Bleicher L et al (2008) Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism. FEBS Lett 582:2985–2992
    • (2008) FEBS Lett , vol.582 , pp. 2985-2992
    • Bleicher, L.1
  • 11
    • 0035877222 scopus 로고    scopus 로고
    • Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22
    • COI: 1:CAS:528:DC%2BD3MXksVOntL0%3D
    • Dumoutier L, Lejeune D, Colau D, Renauld JC (2001) Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol (Baltimore, Md: 1950) 166:7090–7095
    • (2001) J Immunol (Baltimore, Md: 1950) , vol.166 , pp. 7090-7095
    • Dumoutier, L.1    Lejeune, D.2    Colau, D.3    Renauld, J.C.4
  • 12
    • 84948070672 scopus 로고    scopus 로고
    • Interleukin (IL)-22 receptor 1 is over-expressed in primary Sjogren's syndrome and Sjogren-associated non-Hodgkin lymphomas and is regulated by IL-18
    • COI: 1:CAS:528:DC%2BC2MXhtFyls7%2FP, PID: 25880879
    • Ciccia F et al (2015) Interleukin (IL)-22 receptor 1 is over-expressed in primary Sjogren's syndrome and Sjogren-associated non-Hodgkin lymphomas and is regulated by IL-18. Clin Exp Immunol 181:219–229
    • (2015) Clin Exp Immunol , vol.181 , pp. 219-229
    • Ciccia, F.1
  • 13
    • 11144354300 scopus 로고    scopus 로고
    • Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2
    • COI: 1:CAS:528:DC%2BD2cXjs1antbg%3D, PID: 15120653
    • Li J et al (2004) Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2. Int Immunopharmacol 4:693–708
    • (2004) Int Immunopharmacol , vol.4 , pp. 693-708
    • Li, J.1
  • 14
    • 0037072796 scopus 로고    scopus 로고
    • Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10
    • COI: 1:CAS:528:DC%2BD38Xnt1Srsr8%3D, PID: 12087100
    • Lejeune D et al (2002) Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J Biol Chem 277:33676–33682
    • (2002) J Biol Chem , vol.277 , pp. 33676-33682
    • Lejeune, D.1
  • 15
    • 2142717328 scopus 로고    scopus 로고
    • Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells
    • COI: 1:CAS:528:DC%2BD2cXjs1antbs%3D, PID: 15120652
    • Nagalakshmi ML, Rascle A, Zurawski S, Menon S, de Waal Malefyt R (2004) Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells. Int Immunopharmacol 4:679–691
    • (2004) Int Immunopharmacol , vol.4 , pp. 679-691
    • Nagalakshmi, M.L.1    Rascle, A.2    Zurawski, S.3    Menon, S.4    de Waal Malefyt, R.5
  • 17
    • 84867808604 scopus 로고    scopus 로고
    • STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC38XhslWisL3J, PID: 22922995
    • Naher L et al (2012) STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma. Int J Oncol 41:1577–1586
    • (2012) Int J Oncol , vol.41 , pp. 1577-1586
    • Naher, L.1
  • 18
    • 50849128804 scopus 로고    scopus 로고
    • Structure of IL-22 bound to its high-affinity IL-22R1 chain
    • COI: 1:CAS:528:DC%2BD1cXhtVyksrnI
    • Jones BC, Logsdon NJ, Walter MR (2008) Structure of IL-22 bound to its high-affinity IL-22R1 chain. Structure (London, England: 1993) 16:1333–1344
    • (2008) Structure (London, England: 1993) , vol.16 , pp. 1333-1344
    • Jones, B.C.1    Logsdon, N.J.2    Walter, M.R.3
  • 19
    • 0035877120 scopus 로고    scopus 로고
    • Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity
    • COI: 1:CAS:528:DC%2BD3MXksVOntLo%3D
    • Kotenko SV et al (2001) Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J Immunol (Baltimore, Md: 1950) 166:7096–7103
    • (2001) J Immunol (Baltimore, Md : 1950) , vol.166 , pp. 7096-7103
    • Kotenko, S.V.1
  • 20
    • 0242473337 scopus 로고    scopus 로고
    • Cloning and characterization of mouse IL-22 binding protein
    • COI: 1:CAS:528:DC%2BD3sXivFGktLc%3D, PID: 12700595
    • Wei CC, Ho TW, Liang WG, Chen GY, Chang MS (2003) Cloning and characterization of mouse IL-22 binding protein. Genes Immun 4:204–211
    • (2003) Genes Immun , vol.4 , pp. 204-211
    • Wei, C.C.1    Ho, T.W.2    Liang, W.G.3    Chen, G.Y.4    Chang, M.S.5
  • 21
    • 51349156105 scopus 로고    scopus 로고
    • IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22
    • COI: 1:CAS:528:DC%2BD1cXhtFWlt7nO, PID: 18675824
    • Wu PW et al (2008) IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22. J Mol Biol 382:1168–1183
    • (2008) J Mol Biol , vol.382 , pp. 1168-1183
    • Wu, P.W.1
  • 22
    • 62849126016 scopus 로고    scopus 로고
    • Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22
    • PID: 19285080
    • de Moura PR et al (2009) Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22. FEBS Lett 583:1072–1077
    • (2009) FEBS Lett , vol.583 , pp. 1072-1077
    • de Moura, P.R.1
  • 23
    • 84890905720 scopus 로고    scopus 로고
    • Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid
    • COI: 1:CAS:528:DC%2BC3sXntF2nur0%3D, PID: 23653115
    • Martin JC et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7:101–113
    • (2014) Mucosal Immunol , vol.7 , pp. 101-113
    • Martin, J.C.1
  • 24
    • 84868615556 scopus 로고    scopus 로고
    • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    • COI: 1:CAS:528:DC%2BC38XhsFant7jO, PID: 23075849
    • Huber S et al (2012) IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491:259–263
    • (2012) Nature , vol.491 , pp. 259-263
    • Huber, S.1
  • 25
    • 0035487081 scopus 로고    scopus 로고
    • A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta
    • COI: 1:CAS:528:DC%2BD3MXnvVGjtr4%3D, PID: 11607789
    • Gruenberg BH et al (2001) A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta. Genes Immun 2:329–334
    • (2001) Genes Immun , vol.2 , pp. 329-334
    • Gruenberg, B.H.1
  • 26
    • 4344584114 scopus 로고    scopus 로고
    • Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart
    • COI: 1:CAS:528:DC%2BD2cXlvValsL0%3D, PID: 15201862
    • Weiss B et al (2004) Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. Genes Immun 5:330–336
    • (2004) Genes Immun , vol.5 , pp. 330-336
    • Weiss, B.1
  • 27
    • 84961859374 scopus 로고    scopus 로고
    • IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis
    • Martin JC et al (2015) IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis. Mucosal Immunol. doi:10.1038/mi.2015.83
    • (2015) Mucosal Immunol
    • Martin, J.C.1
  • 28
    • 84906854811 scopus 로고    scopus 로고
    • Increased urinary interleukin 22 binding protein levels correlate with lupus nephritis activity
    • COI: 1:CAS:528:DC%2BC2cXhvVKmt7fF
    • Yang X et al (2014) Increased urinary interleukin 22 binding protein levels correlate with lupus nephritis activity. Jo Rheumatol 41:1793–1800
    • (2014) Jo Rheumatol , vol.41 , pp. 1793-1800
    • Yang, X.1
  • 29
    • 84908255878 scopus 로고    scopus 로고
    • The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation
    • COI: 1:CAS:528:DC%2BC2cXhtFCkt7jK, PID: 25008863
    • Laaksonen H et al (2014) The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation. Genes Immun 15:457–465
    • (2014) Genes Immun , vol.15 , pp. 457-465
    • Laaksonen, H.1
  • 30
    • 34247556456 scopus 로고    scopus 로고
    • IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease
    • COI: 1:CAS:528:DC%2BD2sXktlWhtr4%3D
    • Wolk K et al (2007) IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J Immunol (Baltimore, Md: 1950) 178:5973–5981
    • (2007) J Immunol (Baltimore, Md: 1950) , vol.178 , pp. 5973-5981
    • Wolk, K.1
  • 31
    • 79952516169 scopus 로고    scopus 로고
    • Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription
    • COI: 1:CAS:528:DC%2BC3MXktVKitLk%3D, PID: 21214545
    • Liu Y et al (2011) Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription. Immunology 132:540–548
    • (2011) Immunology , vol.132 , pp. 540-548
    • Liu, Y.1
  • 32
    • 0036604122 scopus 로고    scopus 로고
    • Cutting edge: immune cells as sources and targets of the IL-10 family members?
    • COI: 1:CAS:528:DC%2BD38XktFCrsro%3D
    • Wolk K, Kunz S, Asadullah K, Sabat R (2002) Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol (Baltimore, Md: 1950) 168:5397–5402
    • (2002) J Immunol (Baltimore, Md: 1950) , vol.168 , pp. 5397-5402
    • Wolk, K.1    Kunz, S.2    Asadullah, K.3    Sabat, R.4
  • 33
    • 33751120140 scopus 로고    scopus 로고
    • Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
    • COI: 1:CAS:528:DC%2BD28Xht1Srtb7F, PID: 17088898
    • Chung Y et al (2006) Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res 16:902–907
    • (2006) Cell Res , vol.16 , pp. 902-907
    • Chung, Y.1
  • 34
    • 67649161002 scopus 로고    scopus 로고
    • IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells
    • COI: 1:CAS:528:DC%2BD1MXntVykt7k%3D, PID: 19439349
    • Nograles KE et al (2009) IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells. J Allergy Clin Immunol 123:1244–1252.e1242
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1244
    • Nograles, K.E.1
  • 35
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • COI: 1:CAS:528:DC%2BD28XhtVGls7fF, PID: 16982811
    • Liang SC et al (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271–2279
    • (2006) J Exp Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1
  • 36
    • 84873688049 scopus 로고    scopus 로고
    • IL-22, not simply a Th17 cytokine
    • PID: 23405899
    • Rutz S, Eidenschenk C, Ouyang W (2013) IL-22, not simply a Th17 cytokine. Immunol Rev 252:116–132
    • (2013) Immunol Rev , vol.252 , pp. 116-132
    • Rutz, S.1    Eidenschenk, C.2    Ouyang, W.3
  • 37
    • 67651154105 scopus 로고    scopus 로고
    • Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    • COI: 1:CAS:528:DC%2BD1MXotVClsbw%3D, PID: 19578369
    • Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F (2009) Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol 10:857–863
    • (2009) Nat Immunol , vol.10 , pp. 857-863
    • Duhen, T.1    Geiger, R.2    Jarrossay, D.3    Lanzavecchia, A.4    Sallusto, F.5
  • 38
    • 79954512528 scopus 로고    scopus 로고
    • In vivo dioxin favors interleukin-22 production by human CD4+ T cells in an aryl hydrocarbon receptor (AhR)-dependent manner
    • COI: 1:CAS:528:DC%2BC3MXltV2rtrk%3D, PID: 21525997
    • Brembilla NC et al (2011) In vivo dioxin favors interleukin-22 production by human CD4+ T cells in an aryl hydrocarbon receptor (AhR)-dependent manner. PLoS One 6, e18741. doi:10.1371/journal.pone.0018741
    • (2011) PLoS One , vol.6
    • Brembilla, N.C.1
  • 39
    • 77956469491 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells
    • COI: 1:CAS:528:DC%2BC3cXhtV2gu7%2FL, PID: 20706985
    • Ramirez JM et al (2010) Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur J Immunol 40:2450–2459
    • (2010) Eur J Immunol , vol.40 , pp. 2450-2459
    • Ramirez, J.M.1
  • 40
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • COI: 1:CAS:528:DC%2BD28XksVGns7k%3D, PID: 16648837
    • Mangan PR et al (2006) Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441:231–234
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1
  • 41
    • 67649910766 scopus 로고    scopus 로고
    • TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23
    • COI: 1:CAS:528:DC%2BD1MXltlegtL0%3D, PID: 19350551
    • Aliahmadi E et al (2009) TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol 39:1221–1230
    • (2009) Eur J Immunol , vol.39 , pp. 1221-1230
    • Aliahmadi, E.1
  • 42
    • 55149090692 scopus 로고    scopus 로고
    • Th17 cytokines and mucosal immunity
    • COI: 1:CAS:528:DC%2BD1MXhsFGls7%2FM, PID: 19161423
    • Dubin PJ, Kolls JK (2008) Th17 cytokines and mucosal immunity. Immunol Rev 226:160–171
    • (2008) Immunol Rev , vol.226 , pp. 160-171
    • Dubin, P.J.1    Kolls, J.K.2
  • 43
    • 77950196277 scopus 로고    scopus 로고
    • T(H)17 cells in tumour immunity and immunotherapy
    • COI: 1:CAS:528:DC%2BC3cXjvVGlt7k%3D, PID: 20336152
    • Zou W, Restifo NP (2010) T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol 10:248–256
    • (2010) Nat Rev Immunol , vol.10 , pp. 248-256
    • Zou, W.1    Restifo, N.P.2
  • 44
    • 67651171182 scopus 로고    scopus 로고
    • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
    • COI: 1:CAS:528:DC%2BD1MXotVClsbc%3D, PID: 19578368
    • Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H (2009) Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol 10:864–871
    • (2009) Nat Immunol , vol.10 , pp. 864-871
    • Trifari, S.1    Kaplan, C.D.2    Tran, E.H.3    Crellin, N.K.4    Spits, H.5
  • 45
    • 84884573774 scopus 로고    scopus 로고
    • Th17 and Th22 cells in psoriatic arthritis and psoriasis
    • PID: 24286492
    • Benham H et al (2013) Th17 and Th22 cells in psoriatic arthritis and psoriasis. Arthritis Res Ther 15:R136
    • (2013) Arthritis Res Ther , vol.15 , pp. 136
    • Benham, H.1
  • 46
    • 79959255489 scopus 로고    scopus 로고
    • Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention
    • COI: 1:CAS:528:DC%2BC3MXmslyjtr0%3D, PID: 21384158
    • Zhang N, Pan HF, Ye DQ (2011) Th22 in inflammatory and autoimmune disease: prospects for therapeutic intervention. Mol Cell Biochem 353:41–46
    • (2011) Mol Cell Biochem , vol.353 , pp. 41-46
    • Zhang, N.1    Pan, H.F.2    Ye, D.Q.3
  • 47
    • 81455141962 scopus 로고    scopus 로고
    • Epidermal CCR6+ gammadelta T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis
    • COI: 1:CAS:528:DC%2BC3MXhsVSitLfI
    • Mabuchi T, Takekoshi T, Hwang ST (2011) Epidermal CCR6+ gammadelta T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis. J Immunol (Baltimore, Md: 1950) 187:5026–5031
    • (2011) J Immunol (Baltimore, Md: 1950) , vol.187 , pp. 5026-5031
    • Mabuchi, T.1    Takekoshi, T.2    Hwang, S.T.3
  • 48
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • COI: 1:CAS:528:DC%2BD1cXls12msL4%3D, PID: 18368049
    • Zhou L et al (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453:236–240
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1
  • 49
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    • COI: 1:CAS:528:DC%2BD1MXhtFOgsL%2FP, PID: 19682929
    • Sutton CE et al (2009) Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31:331–341
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1
  • 50
    • 84881530486 scopus 로고    scopus 로고
    • Retinoic acid expression associates with enhanced IL-22 production by gammadelta T cells and innate lymphoid cells and attenuation of intestinal inflammation
    • COI: 1:CAS:528:DC%2BC3sXpt1Oru74%3D, PID: 23690441
    • Mielke LA et al (2013) Retinoic acid expression associates with enhanced IL-22 production by gammadelta T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med 210:1117–1124
    • (2013) J Exp Med , vol.210 , pp. 1117-1124
    • Mielke, L.A.1
  • 51
    • 77955499820 scopus 로고    scopus 로고
    • TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa
    • Van Maele L et al (2010) TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. J Immunol (Baltimore, Md: 1950) 185:1177–1185
    • (2010) J Immunol (Baltimore, Md: 1950) , vol.185 , pp. 1177-1185
    • Van Maele, L.1
  • 52
    • 84887120998 scopus 로고    scopus 로고
    • Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides
    • COI: 1:CAS:528:DC%2BC3sXhvFOmt7nE, PID: 24126111
    • Tominaga A et al (2013) Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides. Int Immunopharmacol 17:1009–1019
    • (2013) Int Immunopharmacol , vol.17 , pp. 1009-1019
    • Tominaga, A.1
  • 53
    • 84906539304 scopus 로고    scopus 로고
    • Toll-like receptor 4-induced IL-22 accelerates kidney regeneration
    • COI: 1:CAS:528:DC%2BC2cXps1Crtr4%3D, PID: 24459235
    • Kulkarni OP et al (2014) Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J Am Soc Nephrol 25:978–989
    • (2014) J Am Soc Nephrol , vol.25 , pp. 978-989
    • Kulkarni, O.P.1
  • 54
    • 84884349959 scopus 로고    scopus 로고
    • SnapShot: innate lymphoid cells
    • COI: 1:CAS:528:DC%2BC3sXhtl2ktrnE, PID: 24012419
    • Sonnenberg GF, Mjosberg J, Spits H, Artis D (2013) SnapShot: innate lymphoid cells. Immunity 39:622–622.e621
    • (2013) Immunity , vol.39 , pp. 622
    • Sonnenberg, G.F.1    Mjosberg, J.2    Spits, H.3    Artis, D.4
  • 55
    • 84905098795 scopus 로고    scopus 로고
    • Human innate lymphoid cells
    • COI: 1:CAS:528:DC%2BC2cXhtlKms7zN, PID: 24778151
    • Hazenberg MD, Spits H (2014) Human innate lymphoid cells. Blood 124:700–709
    • (2014) Blood , vol.124 , pp. 700-709
    • Hazenberg, M.D.1    Spits, H.2
  • 56
    • 84890892433 scopus 로고    scopus 로고
    • IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism
    • COI: 1:CAS:528:DC%2BC3sXotlCqtrs%3D, PID: 23715173
    • Eken A, Singh AK, Treuting PM, Oukka M (2014) IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism. Mucosal Immunol 7:143–154
    • (2014) Mucosal Immunol , vol.7 , pp. 143-154
    • Eken, A.1    Singh, A.K.2    Treuting, P.M.3    Oukka, M.4
  • 57
    • 84892482473 scopus 로고    scopus 로고
    • Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection
    • COI: 1:CAS:528:DC%2BC2cXnt1yquw%3D%3D, PID: 24412612
    • Guo X et al (2014) Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity 40:25–39
    • (2014) Immunity , vol.40 , pp. 25-39
    • Guo, X.1
  • 58
    • 84879571464 scopus 로고    scopus 로고
    • Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
    • COI: 1:CAS:528:DC%2BC3sXntlKjsr0%3D
    • Kirchberger S et al (2013) Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. Jo Exp Med 210:917–931
    • (2013) Jo Exp Med , vol.210 , pp. 917-931
    • Kirchberger, S.1
  • 59
    • 84877799485 scopus 로고    scopus 로고
    • Intestinal Lin- c-Kit+ NKp46- CD4- population strongly produces IL-22 upon IL-1beta stimulation
    • COI: 1:CAS:528:DC%2BC3sXmvFyqt70%3D
    • Lee Y et al (2013) Intestinal Lin- c-Kit+ NKp46- CD4- population strongly produces IL-22 upon IL-1beta stimulation. J Immunol (Baltimore, Md: 1950) 190:5296–5305
    • (2013) J Immunol (Baltimore, Md: 1950) , vol.190 , pp. 5296-5305
    • Lee, Y.1
  • 60
    • 84905118660 scopus 로고    scopus 로고
    • CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
    • COI: 1:CAS:528:DC%2BC2cXht1KrtrnF, PID: 25024136
    • Longman RS et al (2014) CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med 211:1571–1583
    • (2014) J Exp Med , vol.211 , pp. 1571-1583
    • Longman, R.S.1
  • 61
    • 84924548071 scopus 로고    scopus 로고
    • The 3 major types of innate and adaptive cell-mediated effector immunity
    • COI: 1:CAS:528:DC%2BC2MXktVSlsr8%3D
    • Annunziato F, Romagnani C, Romagnani S (2015) The 3 major types of innate and adaptive cell-mediated effector immunity. Jo Allergy Clin Immunol 135:626–635
    • (2015) Jo Allergy Clin Immunol , vol.135 , pp. 626-635
    • Annunziato, F.1    Romagnani, C.2    Romagnani, S.3
  • 62
    • 84872968300 scopus 로고    scopus 로고
    • Innate lymphoid cells--how did we miss them?
    • COI: 1:CAS:528:DC%2BC3sXjslGjsQ%3D%3D, PID: 23292121
    • Walker JA, Barlow JL, McKenzie AN (2013) Innate lymphoid cells--how did we miss them? Nat Rev Immunol 13:75–87
    • (2013) Nat Rev Immunol , vol.13 , pp. 75-87
    • Walker, J.A.1    Barlow, J.L.2    McKenzie, A.N.3
  • 63
    • 84900867028 scopus 로고    scopus 로고
    • Recognition strategies of group 3 innate lymphoid cells
    • PID: 24744763
    • Killig M, Glatzer T, Romagnani C (2014) Recognition strategies of group 3 innate lymphoid cells. Front Immunol 5:142
    • (2014) Front Immunol , vol.5 , pp. 142
    • Killig, M.1    Glatzer, T.2    Romagnani, C.3
  • 64
    • 57449118239 scopus 로고    scopus 로고
    • Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    • COI: 1:CAS:528:DC%2BD1MXhtlymug%3D%3D, PID: 19084435
    • Satoh-Takayama N et al (2008) Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 29:958–970
    • (2008) Immunity , vol.29 , pp. 958-970
    • Satoh-Takayama, N.1
  • 65
    • 57849117363 scopus 로고    scopus 로고
    • RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    • COI: 1:CAS:528:DC%2BD1cXhsVWhu7bO, PID: 19029903
    • Sanos SL et al (2009) RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol 10:83–91
    • (2009) Nat Immunol , vol.10 , pp. 83-91
    • Sanos, S.L.1
  • 66
    • 78650310810 scopus 로고    scopus 로고
    • The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
    • COI: 1:CAS:528:DC%2BC3cXhsVOrsLjN, PID: 21113163
    • Spits H, Di Santo JP (2011) The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol 12:21–27
    • (2011) Nat Immunol , vol.12 , pp. 21-27
    • Spits, H.1    Di Santo, J.P.2
  • 67
    • 84925943039 scopus 로고    scopus 로고
    • NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors
    • COI: 1:CAS:528:DC%2BC2MXltVWktrg%3D, PID: 25801035
    • Xu W et al (2015) NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Rep 10:2043–2054
    • (2015) Cell Rep , vol.10 , pp. 2043-2054
    • Xu, W.1
  • 68
    • 85017120517 scopus 로고    scopus 로고
    • The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. eLife 3
    • Yu, X et al (2014) The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. eLife 3, doi:10.7554/eLife.04406
    • (2014) doi:10.7554/eLife.04406
    • Yu, X.1
  • 69
    • 84906534108 scopus 로고    scopus 로고
    • Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens
    • COI: 1:CAS:528:DC%2BC2cXhsVKgt7rM, PID: 25113970
    • Geiger TL et al (2014) Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. J Exp Med 211:1723–1731
    • (2014) J Exp Med , vol.211 , pp. 1723-1731
    • Geiger, T.L.1
  • 70
    • 84906568567 scopus 로고    scopus 로고
    • Nfil3 is required for the development of all innate lymphoid cell subsets
    • COI: 1:CAS:528:DC%2BC2cXhsVKgt7rN, PID: 25092873
    • Seillet C et al (2014) Nfil3 is required for the development of all innate lymphoid cell subsets. J Exp Med 211:1733–1740
    • (2014) J Exp Med , vol.211 , pp. 1733-1740
    • Seillet, C.1
  • 71
    • 84928248316 scopus 로고    scopus 로고
    • PLZF expression maps the early stages of ILC1 lineage development
    • COI: 1:CAS:528:DC%2BC2MXlslemurw%3D, PID: 25838284
    • Constantinides MG et al (2015) PLZF expression maps the early stages of ILC1 lineage development. Proc Natl Acad Sci U S A 112:5123–5128
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 5123-5128
    • Constantinides, M.G.1
  • 72
    • 84859384082 scopus 로고    scopus 로고
    • Innate lymphoid cells: emerging insights in development, lineage relationships, and function
    • COI: 1:CAS:528:DC%2BC38XmsVKmurY%3D, PID: 22224763
    • Spits H, Cupedo T (2012) Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol 30:647–675
    • (2012) Annu Rev Immunol , vol.30 , pp. 647-675
    • Spits, H.1    Cupedo, T.2
  • 73
    • 57849131584 scopus 로고    scopus 로고
    • Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
    • COI: 1:CAS:528:DC%2BD1cXhsVWhu7jO, PID: 19029905
    • Cupedo T et al (2009) Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol 10:66–74
    • (2009) Nat Immunol , vol.10 , pp. 66-74
    • Cupedo, T.1
  • 74
    • 0034733039 scopus 로고    scopus 로고
    • Requirement for RORgamma in thymocyte survival and lymphoid organ development
    • Sun, Z et al (2000) Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science 288, 2369–2373, doi:8641
    • (2000) Science , vol.288 , pp. 2369-2373
    • Sun, Z.1
  • 75
    • 0030710079 scopus 로고    scopus 로고
    • Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    • Mebius RE, Rennert P, Weissman IL (1997) Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 7, 493–504, doi:S1074-7613(00)80371-4
    • (1997) Immunity , vol.7 , pp. 493-504
    • Mebius, R.E.1    Rennert, P.2    Weissman, I.L.3
  • 76
    • 60549102720 scopus 로고    scopus 로고
    • Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    • COI: 1:CAS:528:DC%2BD1MXhtVOhtb0%3D, PID: 19114665
    • Takatori H et al (2009) Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med 206:35–41
    • (2009) J Exp Med , vol.206 , pp. 35-41
    • Takatori, H.1
  • 77
    • 57849145994 scopus 로고    scopus 로고
    • Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    • COI: 1:CAS:528:DC%2BD1cXhsVWhu7%2FK, PID: 19029904
    • Luci C et al (2009) Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol 10:75–82
    • (2009) Nat Immunol , vol.10 , pp. 75-82
    • Luci, C.1
  • 78
    • 59649099774 scopus 로고    scopus 로고
    • A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    • COI: 1:CAS:528:DC%2BD1MXht1eiu7c%3D, PID: 18978771
    • Cella M et al (2009) A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 457:722–725
    • (2009) Nature , vol.457 , pp. 722-725
    • Cella, M.1
  • 79
    • 17244381180 scopus 로고    scopus 로고
    • Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine
    • COI: 1:CAS:528:DC%2BD2MXktFCksbc%3D, PID: 15818686
    • Ikeuchi H et al (2005) Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum 52:1037–1046
    • (2005) Arthritis Rheum , vol.52 , pp. 1037-1046
    • Ikeuchi, H.1
  • 80
    • 84937020799 scopus 로고    scopus 로고
    • Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis
    • COI: 1:CAS:528:DC%2BC2MXksFWlsbs%3D, PID: 25792465
    • Mashiko S et al (2015) Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis. J Allergy Clin Immunol 136:351–359.e351
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 351-359
    • Mashiko, S.1
  • 81
    • 84878217205 scopus 로고    scopus 로고
    • Interleukin-22 produced by alveolar macrophages during activation of the innate immune response
    • COI: 1:CAS:528:DC%2BC3sXnsFGiurw%3D
    • Hansson M, Silverpil E, Linden A, Glader P et al (2013) Interleukin-22 produced by alveolar macrophages during activation of the innate immune response. Inflamm Res Off J Eur Histamine Res Soc 62:561–569
    • (2013) Inflamm Res Off J Eur Histamine Res Soc , vol.62 , pp. 561-569
    • Hansson, M.1    Silverpil, E.2    Linden, A.3    Glader, P.4
  • 82
    • 84881110953 scopus 로고    scopus 로고
    • IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
    • COI: 1:CAS:528:DC%2BC3sXht12htLnE, PID: 23781104
    • Zindl CL et al (2013) IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc Natl Acad Sci U S A 110:12768–12773
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 12768-12773
    • Zindl, C.L.1
  • 84
    • 85005980401 scopus 로고    scopus 로고
    • The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes. Cell Regen (London
    • Hill T et al (2013) The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes. Cell Regen (London, England) 2, 2, doi:10.1186/2045-9769-2-2
    • (2013) England) , vol.2 , pp. 2
    • Hill, T.1
  • 85
    • 84859497086 scopus 로고    scopus 로고
    • Interleukin-22 drives endogenous thymic regeneration in mice
    • COI: 1:CAS:528:DC%2BC38XkvV2rs74%3D
    • Dudakov JA et al (2012) Interleukin-22 drives endogenous thymic regeneration in mice. Science (New York, NY) 336:91–95
    • (2012) Science (New York, NY) , vol.336 , pp. 91-95
    • Dudakov, J.A.1
  • 86
    • 84865409069 scopus 로고    scopus 로고
    • IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade
    • COI: 1:CAS:528:DC%2BC38XhtV2ntbfE, PID: 22840496
    • Mitra A, Raychaudhuri SK, Raychaudhuri SP (2012) IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade. Cytokine 60:38–42
    • (2012) Cytokine , vol.60 , pp. 38-42
    • Mitra, A.1    Raychaudhuri, S.K.2    Raychaudhuri, S.P.3
  • 87
    • 84865635247 scopus 로고    scopus 로고
    • Participation of Gab1 and Gab2 in IL-22-mediated keratinocyte proliferation, migration, and differentiation
    • COI: 1:CAS:528:DC%2BC38Xht1GrsbvF, PID: 22851227
    • Zhu X et al (2012) Participation of Gab1 and Gab2 in IL-22-mediated keratinocyte proliferation, migration, and differentiation. Mol Cell Biochem 369:255–266
    • (2012) Mol Cell Biochem , vol.369 , pp. 255-266
    • Zhu, X.1
  • 88
    • 84862915680 scopus 로고    scopus 로고
    • Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway
    • COI: 1:CAS:528:DC%2BC38XhsFWisLk%3D, PID: 22253568
    • Feng D et al (2012) Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway. Int J Biol Sci 8:249–257
    • (2012) Int J Biol Sci , vol.8 , pp. 249-257
    • Feng, D.1
  • 89
    • 35348983341 scopus 로고    scopus 로고
    • Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    • COI: 1:CAS:528:DC%2BD2sXht1ygurzK, PID: 17919941
    • Zenewicz LA et al (2007) Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27:647–659
    • (2007) Immunity , vol.27 , pp. 647-659
    • Zenewicz, L.A.1
  • 90
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • COI: 1:CAS:528:DC%2BD2cXks1Sjtbo%3D
    • Radaeva S, Sun R, Pan HN, Hong F, Gao B (2004) Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology (Baltimore, Md) 39:1332–1342
    • (2004) Hepatology (Baltimore, Md) , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 91
    • 77957946415 scopus 로고    scopus 로고
    • Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3
    • COI: 1:CAS:528:DC%2BC3cXhtlejsrjP
    • Ki SH et al (2010) Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology (Baltimore, Md) 52:1291–1300
    • (2010) Hepatology (Baltimore, Md) , vol.52 , pp. 1291-1300
    • Ki, S.H.1
  • 92
    • 34147139856 scopus 로고    scopus 로고
    • IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro
    • COI: 1:CAS:528:DC%2BD2sXks1Kjsbc%3D, PID: 17204547
    • Brand S et al (2007) IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro. Am J Physiol Gastrointest Liver Physiol 292:G1019–1028
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G1019-G1028
    • Brand, S.1
  • 93
    • 40049098958 scopus 로고    scopus 로고
    • IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    • COI: 1:CAS:528:DC%2BD1cXivFOrtLg%3D, PID: 18264110
    • Aujla SJ et al (2008) IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 14:275–281
    • (2008) Nat Med , vol.14 , pp. 275-281
    • Aujla, S.J.1
  • 94
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    • COI: 1:CAS:528:DC%2BD1cXivFOrtLw%3D, PID: 18264109
    • Zheng Y et al (2008) Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 14:282–289
    • (2008) Nat Med , vol.14 , pp. 282-289
    • Zheng, Y.1
  • 95
    • 84898465181 scopus 로고    scopus 로고
    • Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type 2 diabetes
    • PID: 24465695
    • Zhao R et al (2014) Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type 2 diabetes. PLoS One 9, e85770. doi:10.1371/journal.pone.0085770
    • (2014) PLoS One , vol.9
    • Zhao, R.1
  • 96
    • 84908311821 scopus 로고    scopus 로고
    • Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
    • COI: 1:CAS:528:DC%2BC2cXhslaqs77K, PID: 25119041
    • Wang X et al (2014) Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature 514:237–241
    • (2014) Nature , vol.514 , pp. 237-241
    • Wang, X.1
  • 97
    • 84938652921 scopus 로고    scopus 로고
    • Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival
    • PID: 26155400
    • Di Lullo G et al (2015) Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival. Oncoimmunology 4, e1005460. doi:10.1080/2162402x.2015.1005460
    • (2015) Oncoimmunology , vol.4
    • Di Lullo, G.1
  • 98
    • 84927654352 scopus 로고    scopus 로고
    • Th22 cell accumulation is associated with colorectal cancer development
    • COI: 1:CAS:528:DC%2BC2MXhtVGhs77E, PID: 25892871
    • Huang YH, Cao YF, Jiang ZY, Zhang S, Gao F (2015) Th22 cell accumulation is associated with colorectal cancer development. World J Gastroenterol 21:4216–4224
    • (2015) World J Gastroenterol , vol.21 , pp. 4216-4224
    • Huang, Y.H.1    Cao, Y.F.2    Jiang, Z.Y.3    Zhang, S.4    Gao, F.5
  • 99
    • 84925800448 scopus 로고    scopus 로고
    • IL22/IL-22R pathway induces cell survival in human glioblastoma cells
    • PID: 25793261
    • Akil H et al (2015) IL22/IL-22R pathway induces cell survival in human glioblastoma cells. PLoS One 10, e0119872. doi:10.1371/journal.pone.0119872
    • (2015) PLoS One , vol.10
    • Akil, H.1
  • 100
    • 84924455824 scopus 로고    scopus 로고
    • Interleukin-17 and interleukin-22 promote tumor progression in human nonmelanoma skin cancer
    • COI: 1:CAS:528:DC%2BC2MXovV2rtQ%3D%3D, PID: 25487261
    • Nardinocchi L et al (2015) Interleukin-17 and interleukin-22 promote tumor progression in human nonmelanoma skin cancer. Eur J Immunol 45:922–931
    • (2015) Eur J Immunol , vol.45 , pp. 922-931
    • Nardinocchi, L.1
  • 101
    • 84930885968 scopus 로고    scopus 로고
    • Association of interleukin 22 polymorphisms with gastric cancer risk
    • COI: 1:CAS:528:DC%2BC2cXhvFGgtrrE
    • Qin SY et al (2015) Association of interleukin 22 polymorphisms with gastric cancer risk. Tumour Biol J Int Soc Oncodev Biol Med 36:2033–2039
    • (2015) Tumour Biol J Int Soc Oncodev Biol Med , vol.36 , pp. 2033-2039
    • Qin, S.Y.1
  • 102
    • 84900453541 scopus 로고    scopus 로고
    • IL-22 gets to the stem of colorectal cancer
    • Koltsova EK, Grivennikov SI (2014) IL-22 gets to the stem of colorectal cancer. Immunity 40, 639–641, doi:10.1016/j.cytogfr.2014.04.00510.1016/j.immuni.2014.04.014
    • (2014) Immunity , vol.40 , pp. 639-641
    • Koltsova, E.K.1    Grivennikov, S.I.2
  • 103
    • 84900459331 scopus 로고    scopus 로고
    • IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
    • COI: 1:CAS:528:DC%2BC2cXnslWkt70%3D, PID: 24816405
    • Kryczek I et al (2014) IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity 40:772–784
    • (2014) Immunity , vol.40 , pp. 772-784
    • Kryczek, I.1
  • 104
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
    • COI: 1:CAS:528:DC%2BD28Xlt1ekurY%3D, PID: 16619290
    • Wolk K et al (2006) IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 36:1309–1323
    • (2006) Eur J Immunol , vol.36 , pp. 1309-1323
    • Wolk, K.1
  • 105
    • 73249116548 scopus 로고    scopus 로고
    • The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis
    • COI: 1:CAS:528:DC%2BD1MXhsFaku77K, PID: 19830738
    • Wolk K et al (2009) The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur J Immunol 39:3570–3581
    • (2009) Eur J Immunol , vol.39 , pp. 3570-3581
    • Wolk, K.1
  • 106
    • 67349195975 scopus 로고    scopus 로고
    • IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not
    • COI: 1:CAS:528:DC%2BD1MXkvV2jsbs%3D
    • Wolk K et al (2009) IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. J Mol Med (Berlin, Germany) 87:523–536
    • (2009) J Mol Med (Berlin, Germany) , vol.87 , pp. 523-536
    • Wolk, K.1
  • 107
    • 58649110860 scopus 로고    scopus 로고
    • The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds
    • COI: 1:CAS:528:DC%2BD1cXhsFCjtL%2FE, PID: 18948266
    • Li W et al (2009) The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. J Biol Chem 284:218–228
    • (2009) J Biol Chem , vol.284 , pp. 218-228
    • Li, W.1
  • 108
    • 33645829078 scopus 로고    scopus 로고
    • IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
    • COI: 1:CAS:528:DC%2BD28Xks1Sltbo%3D, PID: 16537974
    • Brand S et al (2006) IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 290:G827–838
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. G827-G838
    • Brand, S.1
  • 109
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD1MXhtlymtQ%3D%3D, PID: 19100701
    • Zenewicz LA et al (2008) Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29:947–957
    • (2008) Immunity , vol.29 , pp. 947-957
    • Zenewicz, L.A.1
  • 110
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • COI: 1:CAS:528:DC%2BD1cXhsFOmsr8%3D, PID: 18172556
    • Sugimoto K et al (2008) IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 118:534–544
    • (2008) J Clin Invest , vol.118 , pp. 534-544
    • Sugimoto, K.1
  • 111
    • 84905439631 scopus 로고    scopus 로고
    • Cross-talk between RORgammat+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease
    • PID: 24991784
    • Mizuno S et al (2014) Cross-talk between RORgammat+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn's disease. Inflamm Bowel Dis 20:1426–1434
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 1426-1434
    • Mizuno, S.1
  • 112
    • 39649121919 scopus 로고    scopus 로고
    • Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status
    • PID: 18022867
    • Schmechel S et al (2008) Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm Bowel Dis 14:204–212
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 204-212
    • Schmechel, S.1
  • 113
    • 84886093242 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor and colitis
    • COI: 1:CAS:528:DC%2BC3sXhs1ehsrnM, PID: 23928874
    • Monteleone I, Pallone F, Monteleone G (2013) Aryl hydrocarbon receptor and colitis. Semin Immunopathol 35:671–675
    • (2013) Semin Immunopathol , vol.35 , pp. 671-675
    • Monteleone, I.1    Pallone, F.2    Monteleone, G.3
  • 114
    • 84991981083 scopus 로고    scopus 로고
    • A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing
    • Sun X, Chalmers L, Fu X, Zhao M (2012) A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing. Adv Wound Care 1:231–237
    • (2012) Adv Wound Care , vol.1 , pp. 231-237
    • Sun, X.1    Chalmers, L.2    Fu, X.3    Zhao, M.4
  • 115
    • 84865401664 scopus 로고    scopus 로고
    • Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease
    • COI: 1:CAS:528:DC%2BC38Xht1GksbfO, PID: 22921121
    • Hanash AM et al (2012) Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity 37:339–350
    • (2012) Immunity , vol.37 , pp. 339-350
    • Hanash, A.M.1
  • 116
    • 84869754821 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis
    • COI: 1:CAS:528:DC%2BC38XhslWqtrbE, PID: 23022954
    • Xue J, Nguyen DT, Habtezion A (2012) Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis. Gastroenterology 143:1670–1680
    • (2012) Gastroenterology , vol.143 , pp. 1670-1680
    • Xue, J.1    Nguyen, D.T.2    Habtezion, A.3
  • 117
    • 2342458559 scopus 로고    scopus 로고
    • Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3
    • COI: 1:CAS:528:DC%2BD2cXmvF2rsb0%3D, PID: 16212920
    • Pan H, Hong F, Radaeva S, Gao B (2004) Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol 1:43–49
    • (2004) Cell Mol Immunol , vol.1 , pp. 43-49
    • Pan, H.1    Hong, F.2    Radaeva, S.3    Gao, B.4
  • 118
    • 84894288461 scopus 로고    scopus 로고
    • Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia
    • COI: 1:CAS:528:DC%2BC2cXitFWntLw%3D
    • Xu X et al (2014) Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia. J Immunol (Baltimore, Md: 1950) 192:1778–1786
    • (2014) J Immunol (Baltimore, Md: 1950) , vol.192 , pp. 1778-1786
    • Xu, X.1
  • 120
    • 84904335796 scopus 로고    scopus 로고
    • Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection
    • PID: 24577508
    • Van Maele L et al (2014) Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection. J Infect Dis 210:493–503
    • (2014) J Infect Dis , vol.210 , pp. 493-503
    • Van Maele, L.1
  • 121
    • 84890824171 scopus 로고    scopus 로고
    • Candida albicans airway exposure primes the lung innate immune response against Pseudomonas aeruginosa infection through innate lymphoid cell recruitment and interleukin-22-associated mucosal response
    • PID: 24166952
    • Mear JB et al (2014) Candida albicans airway exposure primes the lung innate immune response against Pseudomonas aeruginosa infection through innate lymphoid cell recruitment and interleukin-22-associated mucosal response. Infect Immun 82:306–315
    • (2014) Infect Immun , vol.82 , pp. 306-315
    • Mear, J.B.1
  • 122
    • 80755128255 scopus 로고    scopus 로고
    • Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis
    • COI: 1:CAS:528:DC%2BC3MXhsVOrur3F
    • Matthews K et al (2011) Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis. Tuberculosis (Edinburgh, Scotland) 91:587–593
    • (2011) Tuberculosis (Edinburgh, Scotland) , vol.91 , pp. 587-593
    • Matthews, K.1
  • 123
    • 84890101939 scopus 로고    scopus 로고
    • Interleukin 22 inhibits intracellular growth of Mycobacterium tuberculosis by enhancing calgranulin A expression
    • COI: 1:CAS:528:DC%2BC2cXhsFaktbY%3D, PID: 24041785
    • Dhiman R et al (2014) Interleukin 22 inhibits intracellular growth of Mycobacterium tuberculosis by enhancing calgranulin A expression. J Infect Dis 209:578–587
    • (2014) J Infect Dis , vol.209 , pp. 578-587
    • Dhiman, R.1
  • 124
    • 77954144916 scopus 로고    scopus 로고
    • IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion
    • COI: 1:CAS:528:DC%2BD1MXhtlKhtr%2FK
    • Dhiman R et al (2009) IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion. J Immunol (Baltimore, Md: 1950) 183:6639–6645
    • (2009) J Immunol (Baltimore, Md: 1950) , vol.183 , pp. 6639-6645
    • Dhiman, R.1
  • 125
    • 84910628469 scopus 로고    scopus 로고
    • Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18
    • COI: 1:CAS:528:DC%2BC2cXhvV2ntL7O
    • Zhang B et al (2014) Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science (New York, NY) 346:861–865
    • (2014) Science (New York, NY) , vol.346 , pp. 861-865
    • Zhang, B.1
  • 126
    • 84879507778 scopus 로고    scopus 로고
    • IL-22 modulates IL-17A production and controls inflammation and tissue damage in experimental dengue infection
    • COI: 1:CAS:528:DC%2BC3sXlvF2itrk%3D, PID: 23505056
    • Guabiraba R et al (2013) IL-22 modulates IL-17A production and controls inflammation and tissue damage in experimental dengue infection. Eur J Immunol 43:1529–1544
    • (2013) Eur J Immunol , vol.43 , pp. 1529-1544
    • Guabiraba, R.1
  • 127
    • 84871313216 scopus 로고    scopus 로고
    • Protective and pathological properties of IL-22 in liver disease: implications for viral hepatitis
    • COI: 1:CAS:528:DC%2BC3sXhslCgu78%3D, PID: 23159948
    • Cobleigh MA, Robek MD (2013) Protective and pathological properties of IL-22 in liver disease: implications for viral hepatitis. Am J Pathol 182:21–28
    • (2013) Am J Pathol , vol.182 , pp. 21-28
    • Cobleigh, M.A.1    Robek, M.D.2
  • 128
    • 84858587977 scopus 로고    scopus 로고
    • Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages
    • COI: 1:CAS:528:DC%2BC38XjvVehtLY%3D, PID: 22294696
    • Paget C et al (2012) Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages. J Biol Chem 287:8816–8829
    • (2012) J Biol Chem , vol.287 , pp. 8816-8829
    • Paget, C.1
  • 129
    • 77954491255 scopus 로고    scopus 로고
    • Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection
    • COI: 1:CAS:528:DC%2BC3cXhtVejt7zN, PID: 20504940
    • Guo H, Topham DJ (2010) Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection. J Virol 84:7750–7759
    • (2010) J Virol , vol.84 , pp. 7750-7759
    • Guo, H.1    Topham, D.J.2
  • 130
    • 33845925316 scopus 로고    scopus 로고
    • IL-22 participates in an innate anti-HIV-1 host-resistance network through acute-phase protein induction
    • COI: 1:CAS:528:DC%2BD2sXnvVan
    • Misse D et al (2007) IL-22 participates in an innate anti-HIV-1 host-resistance network through acute-phase protein induction. J Immunol (Baltimore, Md: 1950) 178:407–415
    • (2007) J Immunol (Baltimore, Md: 1950) , vol.178 , pp. 407-415
    • Misse, D.1
  • 131
    • 84865483236 scopus 로고    scopus 로고
    • IL-22 signaling contributes to West Nile encephalitis pathogenesis
    • COI: 1:CAS:528:DC%2BC38Xht1yktLvN, PID: 22952908
    • Wang P et al (2012) IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS One 7, e44153. doi:10.1371/journal.pone.0044153
    • (2012) PLoS One , vol.7
    • Wang, P.1
  • 132
    • 84875214926 scopus 로고    scopus 로고
    • IL-22 is essential for lung epithelial repair following influenza infection
    • COI: 1:CAS:528:DC%2BC3sXjvVens7g%3D, PID: 23490254
    • Pociask DA et al (2013) IL-22 is essential for lung epithelial repair following influenza infection. Am J Pathol 182:1286–1296
    • (2013) Am J Pathol , vol.182 , pp. 1286-1296
    • Pociask, D.A.1
  • 133
    • 84867658823 scopus 로고    scopus 로고
    • IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection
    • COI: 1:CAS:528:DC%2BC38Xpt1Shtrs%3D, PID: 22739232
    • Kumar P, Thakar MS, Ouyang W, Malarkannan S (2013) IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. Mucosal Immunol 6:69–82
    • (2013) Mucosal Immunol , vol.6 , pp. 69-82
    • Kumar, P.1    Thakar, M.S.2    Ouyang, W.3    Malarkannan, S.4
  • 134
    • 84896489484 scopus 로고    scopus 로고
    • Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment
    • COI: 1:CAS:528:DC%2BC2cXkvVGlsr0%3D
    • Zhao J et al (2014) Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment. Hepatology (Baltimore, Md) 59:1331–1342
    • (2014) Hepatology (Baltimore, Md) , vol.59 , pp. 1331-1342
    • Zhao, J.1
  • 135
    • 84964294829 scopus 로고    scopus 로고
    • Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C
    • COI: 1:CAS:528:DC%2BC2MXksF2ktb4%3D
    • Wu LY et al (2015) Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C. Clin Immunol (Orlando, Fla) 158:77–87
    • (2015) Clin Immunol (Orlando, Fla) , vol.158 , pp. 77-87
    • Wu, L.Y.1
  • 136
    • 84991947070 scopus 로고    scopus 로고
    • Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signalling
    • Sun D et al (2015) Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signalling. Oncoimmunology
    • (2015) Oncoimmunology
    • Sun, D.1
  • 137
    • 84907535553 scopus 로고    scopus 로고
    • Genetic polymorphisms and plasma levels of interleukin-22 contribute to the development of nonsmall cell lung cancer
    • PID: 24956177
    • Liu F et al (2014) Genetic polymorphisms and plasma levels of interleukin-22 contribute to the development of nonsmall cell lung cancer. DNA Cell Biol 33:705–714
    • (2014) DNA Cell Biol , vol.33 , pp. 705-714
    • Liu, F.1
  • 138
    • 84880923452 scopus 로고    scopus 로고
    • Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells
    • COI: 1:CAS:528:DC%2BC3sXhtFeksrbI
    • Kobold S et al (2013) Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells. J Thorac Oncol Off Publ Int Assoc Stud Lung Cancer 8:1032–1042
    • (2013) J Thorac Oncol Off Publ Int Assoc Stud Lung Cancer , vol.8 , pp. 1032-1042
    • Kobold, S.1
  • 139
    • 58149183235 scopus 로고    scopus 로고
    • Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts
    • COI: 1:CAS:528:DC%2BD1cXht1KgtbvL
    • Zhang W et al (2008) Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts. Clin Cancer Res: an Off J Am Assoc Cancer Res 14:6432–6439
    • (2008) Clin Cancer Res: an Off J Am Assoc Cancer Res , vol.14 , pp. 6432-6439
    • Zhang, W.1
  • 140
    • 84891674362 scopus 로고    scopus 로고
    • High expression of interleukin-22 and its receptor predicts poor prognosis in pancreatic ductal adenocarcinoma
    • PID: 24132627
    • Wen Z et al (2014) High expression of interleukin-22 and its receptor predicts poor prognosis in pancreatic ductal adenocarcinoma. Ann Surg Oncol 21:125–132
    • (2014) Ann Surg Oncol , vol.21 , pp. 125-132
    • Wen, Z.1
  • 141
    • 84896848288 scopus 로고    scopus 로고
    • Interleukin-22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC2cXjsVelur0%3D
    • Waidmann O et al (2014) Interleukin-22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma. Hepatology (Baltimore, Md) 59:1207
    • (2014) Hepatology (Baltimore, Md) , vol.59 , pp. 1207
    • Waidmann, O.1
  • 142
    • 80052023399 scopus 로고    scopus 로고
    • Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
    • COI: 1:CAS:528:DC%2BC3MXhtVOktrrM
    • Jiang R et al (2011) Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. Hepatology (Baltimore, Md) 54:900–909
    • (2011) Hepatology (Baltimore, Md) , vol.54 , pp. 900-909
    • Jiang, R.1
  • 143
    • 84873253765 scopus 로고    scopus 로고
    • IL-22 is related to development of human colon cancer by activation of STAT3
    • COI: 1:CAS:528:DC%2BC3sXnvFWqu7o%3D, PID: 23379788
    • Jiang R et al (2013) IL-22 is related to development of human colon cancer by activation of STAT3. BMC Cancer 13:59
    • (2013) BMC Cancer , vol.13 , pp. 59
    • Jiang, R.1
  • 144
    • 84877330590 scopus 로고    scopus 로고
    • Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis
    • COI: 1:CAS:528:DC%2BC3sXptVGlu7o%3D, PID: 23674871
    • Yu LZ et al (2013) Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis. World J Gastroenterol 19:2638–2649
    • (2013) World J Gastroenterol , vol.19 , pp. 2638-2649
    • Yu, L.Z.1
  • 145
    • 84878249123 scopus 로고    scopus 로고
    • Increased circulating Th22 and Th17 cells are associated with tumor progression and patient survival in human gastric cancer
    • PID: 22760549
    • Liu T et al (2012) Increased circulating Th22 and Th17 cells are associated with tumor progression and patient survival in human gastric cancer. J Clin Immunol 32:1332–1339
    • (2012) J Clin Immunol , vol.32 , pp. 1332-1339
    • Liu, T.1
  • 146
    • 84871018340 scopus 로고    scopus 로고
    • Increased intratumoral IL-22-producing CD4(+) T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival
    • COI: 1:CAS:528:DC%2BC38Xhs1GlsbrL, PID: 22527243
    • Zhuang Y et al (2012) Increased intratumoral IL-22-producing CD4(+) T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival. Cancer Immunol Immunother 61:1965–1975
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1965-1975
    • Zhuang, Y.1
  • 147
    • 84906280320 scopus 로고    scopus 로고
    • IL-22 promotes the migration and invasion of gastric cancer cells via IL-22R1/AKT/MMP-9 signaling
    • COI: 1:CAS:528:DC%2BC2cXhslCjsrjK, PID: 25120745
    • Ji Y et al (2014) IL-22 promotes the migration and invasion of gastric cancer cells via IL-22R1/AKT/MMP-9 signaling. Int J Clin Exp Pathol 7:3694–3703
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 3694-3703
    • Ji, Y.1
  • 148
    • 84901388112 scopus 로고    scopus 로고
    • Th22 cells are associated with hepatocellular carcinoma development and progression
    • COI: 1:CAS:528:DC%2BC2cXhtlGqtr7J, PID: 24826053
    • Qin S et al (2014) Th22 cells are associated with hepatocellular carcinoma development and progression. Chin J Cancer Res = Chung-kuo yen cheng yen chiu 26:135–141
    • (2014) Chin J Cancer Res = Chung-kuo yen cheng yen chiu , vol.26 , pp. 135-141
    • Qin, S.1
  • 149
    • 79955776494 scopus 로고    scopus 로고
    • In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression
    • Park O et al (2011) In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression. Hepatology (Baltimore, Md) 54:252–261
    • (2011) Hepatology (Baltimore, Md) , vol.54 , pp. 252-261
    • Park, O.1
  • 150
    • 84924873032 scopus 로고    scopus 로고
    • Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC2cXhvFGlsLbO
    • Zhao D et al (2015) Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma. Int J Cancer J Int du Cancer 136:2556–2565
    • (2015) Int J Cancer J Int du Cancer , vol.136 , pp. 2556-2565
    • Zhao, D.1
  • 151
    • 84922819295 scopus 로고    scopus 로고
    • Addressing the challenges of pancreatic cancer: future directions for improving outcomes
    • Hidalgo M et al (2015) Addressing the challenges of pancreatic cancer: future directions for improving outcomes. Pancreatol Off J Int Assoc Pancreatol (IAP) 15:8–18
    • (2015) Pancreatol Off J Int Assoc Pancreatol (IAP) , vol.15 , pp. 8-18
    • Hidalgo, M.1
  • 152
    • 84896688553 scopus 로고    scopus 로고
    • Increased intratumoral interleukin 22 levels and frequencies of interleukin 22-producing CD4+ T cells correlate with pancreatic cancer progression
    • COI: 1:CAS:528:DC%2BC2cXktlelu7s%3D, PID: 24622082
    • Xu X et al (2014) Increased intratumoral interleukin 22 levels and frequencies of interleukin 22-producing CD4+ T cells correlate with pancreatic cancer progression. Pancreas 43:470–477
    • (2014) Pancreas , vol.43 , pp. 470-477
    • Xu, X.1
  • 153
    • 84859244400 scopus 로고    scopus 로고
    • Pro-tumour activity of interleukin-22 in HPAFII human pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BC38XotVSlsrY%3D, PID: 22471280
    • Curd LM, Favors SE, Gregg RK (2012) Pro-tumour activity of interleukin-22 in HPAFII human pancreatic cancer cells. Clin Exp Immunol 168:192–199
    • (2012) Clin Exp Immunol , vol.168 , pp. 192-199
    • Curd, L.M.1    Favors, S.E.2    Gregg, R.K.3
  • 154
    • 80052723518 scopus 로고    scopus 로고
    • Diagnostic value of interleukin 22 and carcinoembryonic antigen in tuberculous and malignant pleural effusions
    • COI: 1:CAS:528:DC%2BC3MXhtlGrs7nF, PID: 22977645
    • Jin D et al (2011) Diagnostic value of interleukin 22 and carcinoembryonic antigen in tuberculous and malignant pleural effusions. Exp Ther Med 2:1205–1209
    • (2011) Exp Ther Med , vol.2 , pp. 1205-1209
    • Jin, D.1
  • 155
    • 84866171319 scopus 로고    scopus 로고
    • Interleukin 22-producing CD4+ T cells in malignant pleural effusion
    • COI: 1:CAS:528:DC%2BC38XhtlertL%2FN, PID: 22809567
    • Ye ZJ et al (2012) Interleukin 22-producing CD4+ T cells in malignant pleural effusion. Cancer Lett 326:23–32
    • (2012) Cancer Lett , vol.326 , pp. 23-32
    • Ye, Z.J.1
  • 156
    • 80051664219 scopus 로고    scopus 로고
    • B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis
    • COI: 1:CAS:528:DC%2BC3MXhtVWrsLvM, PID: 21741035
    • Zhang M et al (2011) B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis. Cell Immunol 270:217–223
    • (2011) Cell Immunol , vol.270 , pp. 217-223
    • Zhang, M.1
  • 157
    • 84905381855 scopus 로고    scopus 로고
    • Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation
    • COI: 1:CAS:528:DC%2BC2cXpvFGjsLs%3D, PID: 24517997
    • Kim K et al (2014) Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation. Carcinogenesis 35:1352–1361
    • (2014) Carcinogenesis , vol.35 , pp. 1352-1361
    • Kim, K.1
  • 158
    • 33751564062 scopus 로고    scopus 로고
    • IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase
    • COI: 1:CAS:528:DC%2BD28Xht1WrsLbI
    • Weber GF et al (2006) IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase. J Immunol (Baltimore, Md: 1950) 177:8266–8272
    • (2006) J Immunol (Baltimore, Md: 1950) , vol.177 , pp. 8266-8272
    • Weber, G.F.1
  • 159
    • 79956368077 scopus 로고    scopus 로고
    • Interleukin-22 suppresses the growth of A498 renal cell carcinoma cells via regulation of STAT1 pathway
    • COI: 1:CAS:528:DC%2BC3MXmslCqsb4%3D, PID: 21625390
    • Zhang F, Shang D, Zhang Y, Tian Y (2011) Interleukin-22 suppresses the growth of A498 renal cell carcinoma cells via regulation of STAT1 pathway. PLoS One 6, e20382. doi:10.1371/journal.pone.0020382
    • (2011) PLoS One , vol.6
    • Zhang, F.1    Shang, D.2    Zhang, Y.3    Tian, Y.4
  • 161
    • 84877114418 scopus 로고    scopus 로고
    • Increased Tc22 and Treg/CD8 ratio contribute to aggressive growth of transplant associated squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC3sXnslGjtrw%3D, PID: 23667456
    • Zhang S et al (2013) Increased Tc22 and Treg/CD8 ratio contribute to aggressive growth of transplant associated squamous cell carcinoma. PLoS One 8, e62154. doi:10.1371/journal.pone.0062154
    • (2013) PLoS One , vol.8
    • Zhang, S.1
  • 162
    • 84055222105 scopus 로고    scopus 로고
    • IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma
    • COI: 1:CAS:528:DC%2BC3MXhs1CqtrvF
    • Miyagaki T et al (2011) IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin Cancer Res: an Off J Am Assoc Cancer Res 17:7529–7538
    • (2011) Clin Cancer Res: an Off J Am Assoc Cancer Res , vol.17 , pp. 7529-7538
    • Miyagaki, T.1
  • 163
    • 84862769727 scopus 로고    scopus 로고
    • Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection
    • COI: 1:CAS:528:DC%2BC38XnslSntb4%3D, PID: 22484119
    • Feng D et al (2012) Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection. Gastroenterology 143:188–198.e187
    • (2012) Gastroenterology , vol.143 , pp. 188-198
    • Feng, D.1
  • 164
    • 84876681730 scopus 로고    scopus 로고
    • IL-22 promotes fibroblast-mediated wound repair in the skin
    • COI: 1:CAS:528:DC%2BC38XhslyntbvL, PID: 23223145
    • McGee HM et al (2013) IL-22 promotes fibroblast-mediated wound repair in the skin. J Investig Dermatol 133:1321–1329
    • (2013) J Investig Dermatol , vol.133 , pp. 1321-1329
    • McGee, H.M.1
  • 165
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • COI: 1:CAS:528:DC%2BD1MXos1eis7Y%3D, PID: 19564350
    • Pickert G et al (2009) STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med 206:1465–1472
    • (2009) J Exp Med , vol.206 , pp. 1465-1472
    • Pickert, G.1
  • 166
    • 80051701140 scopus 로고    scopus 로고
    • CCL20, gammadelta T cells, and IL-22 in corneal epithelial healing
    • COI: 1:CAS:528:DC%2BC3MXpvFers7g%3D
    • Li Z, Burns AR, Miller SB, Smith CW (2011) CCL20, gammadelta T cells, and IL-22 in corneal epithelial healing. FASEB J Off Publ Fed Am Soc Exp Biol 25:2659–2668
    • (2011) FASEB J Off Publ Fed Am Soc Exp Biol , vol.25 , pp. 2659-2668
    • Li, Z.1    Burns, A.R.2    Miller, S.B.3    Smith, C.W.4
  • 167
    • 73549109368 scopus 로고    scopus 로고
    • IL-22 is involved in liver regeneration after hepatectomy
    • COI: 1:CAS:528:DC%2BC3cXhsFKmtbc%3D, PID: 19875704
    • Ren X, Hu B, Colletti LM (2010) IL-22 is involved in liver regeneration after hepatectomy. Am J Physiol Gastrointest Liver Physiol 298:G74–80
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , pp. G74-G80
    • Ren, X.1    Hu, B.2    Colletti, L.M.3
  • 168
    • 77957736967 scopus 로고    scopus 로고
    • gammadelta T cells protect against lung fibrosis via IL-22
    • COI: 1:CAS:528:DC%2BC3cXht1Cms73K, PID: 20855496
    • Simonian PL et al (2010) gammadelta T cells protect against lung fibrosis via IL-22. J Exp Med 207:2239–2253
    • (2010) J Exp Med , vol.207 , pp. 2239-2253
    • Simonian, P.L.1
  • 169
    • 84882260764 scopus 로고    scopus 로고
    • Interleukin-22 inhibits bleomycin-induced pulmonary fibrosis
    • Liang M et al (2013) Interleukin-22 inhibits bleomycin-induced pulmonary fibrosis. Mediat Inflamm 2013:209179
    • (2013) Mediat Inflamm , vol.2013 , pp. 209179
    • Liang, M.1
  • 170
    • 84880421357 scopus 로고    scopus 로고
    • Hepatoprotective and anti-fibrotic functions of interleukin-22: therapeutic potential for the treatment of alcoholic liver disease
    • COI: 1:CAS:528:DC%2BC3sXhtFeqt77P, PID: 23855297
    • Kong X, Feng D, Mathews S, Gao B (2013) Hepatoprotective and anti-fibrotic functions of interleukin-22: therapeutic potential for the treatment of alcoholic liver disease. J Gastroenterol Hepatol 28(Suppl 1):56–60
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 56-60
    • Kong, X.1    Feng, D.2    Mathews, S.3    Gao, B.4
  • 171
    • 84922569926 scopus 로고    scopus 로고
    • Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines
    • COI: 1:CAS:528:DC%2BC2MXkt1Sntbo%3D, PID: 25663772
    • Lu DH et al (2015) Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines. World J Gastroenterol 21:1531–1545
    • (2015) World J Gastroenterol , vol.21 , pp. 1531-1545
    • Lu, D.H.1
  • 172
    • 84858002867 scopus 로고    scopus 로고
    • Increased serum human beta-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M
    • COI: 1:CAS:528:DC%2BC38XjsFOnt7g%3D, PID: 22137028
    • Kanda N, Watanabe S (2012) Increased serum human beta-defensin-2 levels in atopic dermatitis: relationship to IL-22 and oncostatin M. Immunobiology 217:436–445
    • (2012) Immunobiology , vol.217 , pp. 436-445
    • Kanda, N.1    Watanabe, S.2
  • 173
    • 4143095716 scopus 로고    scopus 로고
    • IL-22 increases the innate immunity of tissues
    • COI: 1:CAS:528:DC%2BD2cXnsVKlt7k%3D, PID: 15308104
    • Wolk K et al (2004) IL-22 increases the innate immunity of tissues. Immunity 21:241–254
    • (2004) Immunity , vol.21 , pp. 241-254
    • Wolk, K.1
  • 174
    • 84893638135 scopus 로고    scopus 로고
    • Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells
    • COI: 1:CAS:528:DC%2BC2cXlsFyr, PID: 24342613
    • Murano T et al (2014) Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem Biophys Res Commun 443:840–846
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 840-846
    • Murano, T.1
  • 175
    • 84923107393 scopus 로고    scopus 로고
    • Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection
    • COI: 1:CAS:528:DC%2BC2MXisVygt78%3D, PID: 25680273
    • Munoz M et al (2015) Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection. Immunity 42:321–331
    • (2015) Immunity , vol.42 , pp. 321-331
    • Munoz, M.1
  • 176
    • 84857511355 scopus 로고    scopus 로고
    • IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1beta by keratinocytes via the ROS-NLRP3-caspase-1 pathway
    • COI: 1:CAS:528:DC%2BC38XivVelsbs%3D, PID: 22207130
    • Cho KA, Suh JW, Lee KH, Kang JL, Woo SY (2012) IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1beta by keratinocytes via the ROS-NLRP3-caspase-1 pathway. Int Immunol 24:147–158
    • (2012) Int Immunol , vol.24 , pp. 147-158
    • Cho, K.A.1    Suh, J.W.2    Lee, K.H.3    Kang, J.L.4    Woo, S.Y.5
  • 177
    • 84865564349 scopus 로고    scopus 로고
    • Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
    • COI: 1:CAS:528:DC%2BC38Xht1Kit7vO
    • Kong X et al (2012) Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology (Baltimore, Md) 56:1150–1159
    • (2012) Hepatology (Baltimore, Md) , vol.56 , pp. 1150-1159
    • Kong, X.1
  • 178
    • 24144477540 scopus 로고    scopus 로고
    • Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
    • COI: 1:CAS:528:DC%2BD2MXhtV2isrnO, PID: 16143135
    • Andoh A et al (2005) Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 129:969–984
    • (2005) Gastroenterology , vol.129 , pp. 969-984
    • Andoh, A.1
  • 179
    • 78149487314 scopus 로고    scopus 로고
    • IL-22 induces an acute-phase response
    • COI: 1:CAS:528:DC%2BC3cXhtlWhs77E
    • Liang SC et al (2010) IL-22 induces an acute-phase response. J Immunol (Baltimore, Md: 1950) 185:5531–5538
    • (2010) J Immunol (Baltimore, Md: 1950) , vol.185 , pp. 5531-5538
    • Liang, S.C.1
  • 180
    • 80054847781 scopus 로고    scopus 로고
    • A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus
    • COI: 1:CAS:528:DC%2BC3MXhtlOksbvO, PID: 21708106
    • Zhang Y et al (2011) A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus. Gastroenterology 141:1897–1906
    • (2011) Gastroenterology , vol.141 , pp. 1897-1906
    • Zhang, Y.1
  • 181
    • 45549092326 scopus 로고    scopus 로고
    • Interleukin 22 receptor 1 expression in pancreas islets
    • COI: 1:CAS:528:DC%2BD1cXjt1eqsbw%3D, PID: 18376313
    • Shioya M, Andoh A, Kakinoki S, Nishida A, Fujiyama Y (2008) Interleukin 22 receptor 1 expression in pancreas islets. Pancreas 36:197–199
    • (2008) Pancreas , vol.36 , pp. 197-199
    • Shioya, M.1    Andoh, A.2    Kakinoki, S.3    Nishida, A.4    Fujiyama, Y.5
  • 182
    • 0035951795 scopus 로고    scopus 로고
    • Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes
    • COI: 1:CAS:528:DC%2BD3MXhtVGjtrY%3D, PID: 11035029
    • Kotenko SV et al (2001) Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. The J Biol Chem 276:2725–2732
    • (2001) The J Biol Chem , vol.276 , pp. 2725-2732
    • Kotenko, S.V.1


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