-
2
-
-
84891702406
-
Therapeutic opportunities of the IL-22-IL-22R1 system
-
Sabat R, Ouyang W, & Wolk K. Therapeutic opportunities of the IL-22-IL-22R1 system. Nat. Rev. Drug. Discov. 13, 21-38 (2013).
-
(2013)
Nat. Rev. Drug. Discov
, vol.13
, pp. 21-38
-
-
Sabat, R.1
Ouyang, W.2
Wolk, K.3
-
3
-
-
24144477540
-
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
-
Andoh A, et al. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology. 129, 969-984 (2005).
-
(2005)
Gastroenterology
, vol.129
, pp. 969-984
-
-
Andoh, A.1
-
4
-
-
33645829078
-
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
-
Brand S, et al. IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G827-G838 (2006).
-
(2006)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.290
, pp. G827-G838
-
-
Brand, S.1
-
5
-
-
39649121919
-
Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status
-
Schmechel S, et al. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm. Bowel. Dis. 14, 204-212 (2008).
-
(2008)
Inflamm. Bowel. Dis
, vol.14
, pp. 204-212
-
-
Schmechel, S.1
-
6
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto K, et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest. 118, 534-544 (2008).
-
(2008)
J Clin Invest
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
-
7
-
-
79960024210
-
Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease
-
Pariente B, et al. Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease. Gastroenterology. 141, 217-226 (2011).
-
(2011)
Gastroenterology
, vol.141
, pp. 217-226
-
-
Pariente, B.1
-
8
-
-
79958277385
-
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
-
Geremia A, et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J. Exp. Med. 208, 1127-1133 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 1127-1133
-
-
Geremia, A.1
-
9
-
-
57449090428
-
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
-
Zenewicz L.A, et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity. 29, 947-957 (2008).
-
(2008)
Immunity
, vol.29
, pp. 947-957
-
-
Zenewicz, L.A.1
-
10
-
-
67650474246
-
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
-
Pickert G, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206, 1465-1472 (2009).
-
(2009)
J. Exp. Med
, vol.206
, pp. 1465-1472
-
-
Pickert, G.1
-
11
-
-
79959918506
-
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract
-
Monteleone I, et al. Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterology. 141, 237-248 (2011).
-
(2011)
Gastroenterology
, vol.141
, pp. 237-248
-
-
Monteleone, I.1
-
12
-
-
84881110953
-
IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
-
Zindl C.L, et al. IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc. Natl Acad. Sci. USA. 110, 12768-12773 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 12768-12773
-
-
Zindl, C.L.1
-
13
-
-
84881530486
-
Retinoic acid expression associates with enhanced IL-22 production by gd T cells and innate lymphoid cells and attenuation of intestinal inflammation
-
Mielke L.A, et al. Retinoic acid expression associates with enhanced IL-22 production by gd T cells and innate lymphoid cells and attenuation of intestinal inflammation. J. Exp. Med. 210, 1117-1124 (2013).
-
(2013)
J. Exp. Med
, vol.210
, pp. 1117-1124
-
-
Mielke, L.A.1
-
14
-
-
0035859898
-
A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist
-
Xu W, et al. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc. Natl Acad. Sci. USA. 98, 9511-9516 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 9511-9516
-
-
Xu, W.1
-
15
-
-
0036930167
-
Comparison of interleukin-22 and interleukin-10 soluble receptor complexes
-
Logsdon N.J, Jones B.C, Josephson K, Cook J, & Walter M.R. Comparison of interleukin-22 and interleukin-10 soluble receptor complexes. J. Interferon Cytokine Res. 22, 1099-1112 (2002).
-
(2002)
J. Interferon Cytokine Res
, vol.22
, pp. 1099-1112
-
-
Logsdon, N.J.1
Jones, B.C.2
Josephson, K.3
Cook, J.4
Walter, M.R.5
-
16
-
-
84868615556
-
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
-
Huber S, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 491, 259-263 (2012).
-
(2012)
Nature
, vol.491
, pp. 259-263
-
-
Huber, S.1
-
17
-
-
84890905720
-
Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid
-
Martin J.C.J, et al. Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol. 7, 101-113 (2014).
-
(2014)
Mucosal Immunol
, vol.7
, pp. 101-113
-
-
Martin, J.C.J.1
-
18
-
-
84890987173
-
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice
-
Watchmaker P.B, et al. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat. Immunol. 15, 98-108 (2014).
-
(2014)
Nat. Immunol
, vol.15
, pp. 98-108
-
-
Watchmaker, P.B.1
-
19
-
-
84906086946
-
Roles and regulation of gastrointestinal eosinophils in immunity and disease
-
Jung Y, & Rothenberg M.E. Roles and regulation of gastrointestinal eosinophils in immunity and disease. J. Immunol. 193, 999-1005 (2014).
-
(2014)
J. Immunol
, vol.193
, pp. 999-1005
-
-
Jung, Y.1
Rothenberg, M.E.2
-
20
-
-
0035877222
-
Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22
-
Dumoutier L, Lejeune D, Colau D, & Renauld J.C. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J. Immunol. 166, 7090-7095 (2001).
-
(2001)
J. Immunol
, vol.166
, pp. 7090-7095
-
-
Dumoutier, L.1
Lejeune, D.2
Colau, D.3
Renauld, J.C.4
-
22
-
-
0032798911
-
Dextran sulfate sodium (DSS) colitis in rats: Clinical, structural, and ultrastructural aspects
-
Gaudio E, et al. Dextran sulfate sodium (DSS) colitis in rats: clinical, structural, and ultrastructural aspects. Dig. Dis Sci. 44, 1458-1475 (1999).
-
(1999)
Dig. Dis Sci
, vol.44
, pp. 1458-1475
-
-
Gaudio, E.1
-
23
-
-
84877839153
-
IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic
-
Zenewicz L.A, et al. IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic. J. Immunol. 190, 2306-2312 (2013).
-
(2013)
J. Immunol
, vol.190
, pp. 2306-2312
-
-
Zenewicz, L.A.1
-
24
-
-
84861989207
-
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
-
Sonnenberg G.F, et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 336, 1321-1325 (2012).
-
(2012)
Science
, vol.336
, pp. 1321-1325
-
-
Sonnenberg, G.F.1
-
25
-
-
63449133361
-
Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
-
Kleinschek M.A, et al. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J. Exp. Med. 206, 525-534 (2009).
-
(2009)
J. Exp. Med
, vol.206
, pp. 525-534
-
-
Kleinschek, M.A.1
-
26
-
-
84892536761
-
Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
-
Ramesh R, et al. Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J. Exp. Med. 211, 89-104 (2014).
-
(2014)
J. Exp. Med
, vol.211
, pp. 89-104
-
-
Ramesh, R.1
-
27
-
-
84905118660
-
CX3CR1+ mononuclear phagocytes support colitisassociated innate lymphoid cell production of IL-22
-
Longman R.S, et al. CX3CR1+ mononuclear phagocytes support colitisassociated innate lymphoid cell production of IL-22. J. Exp. Med. 211, 1571-1583 (2014).
-
(2014)
J. Exp. Med
, vol.211
, pp. 1571-1583
-
-
Longman, R.S.1
-
28
-
-
45749107055
-
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
-
Kamada N, et al. Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J. Clin. Invest. 118, 2269-2280 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 2269-2280
-
-
Kamada, N.1
-
29
-
-
79961023788
-
Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease
-
Begue B, et al. Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease. Am. J. Gastroenterol. 106, 1544-1555 (2011).
-
(2011)
Am. J. Gastroenterol
, vol.106
, pp. 1544-1555
-
-
Begue, B.1
-
30
-
-
0035883075
-
Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probe arrays: Abundant expression of major basic protein in mast cells
-
Nakajima T, et al. Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probe arrays: abundant expression of major basic protein in mast cells. Blood. 98, 1127-1134 (2001).
-
(2001)
Blood
, vol.98
, pp. 1127-1134
-
-
Nakajima, T.1
-
31
-
-
84928881439
-
Standardised animal models of host microbial mutualism
-
Macpherson A.J, & McCoy K.D. Standardised animal models of host microbial mutualism. Mucosal Immunol. 8, 476-486 (2014).
-
(2014)
Mucosal Immunol
, vol.8
, pp. 476-486
-
-
Macpherson, A.J.1
McCoy, K.D.2
-
32
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov I.I, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 139, 485-498 (2009).
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov, I.I.1
-
33
-
-
70349742524
-
The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
-
Gaboriau-Routhiau V, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity. 31, 677-689 (2009).
-
(2009)
Immunity
, vol.31
, pp. 677-689
-
-
Gaboriau-Routhiau, V.1
-
34
-
-
84892928571
-
Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity
-
Spencer S.P, et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science. 343, 432-437 (2014).
-
(2014)
Science
, vol.343
, pp. 432-437
-
-
Spencer, S.P.1
-
35
-
-
84880301406
-
Retinoic acids up-regulate functional eosinophil-driving receptor CCR3
-
Ueki S, et al. Retinoic acids up-regulate functional eosinophil-driving receptor CCR3. Allergy. 68, 953-956 (2013).
-
(2013)
Allergy
, vol.68
, pp. 953-956
-
-
Ueki, S.1
-
36
-
-
84865680225
-
Human versus mouse eosinophils: That which we call an eosinophil, by any other namewould stain as red
-
Lee J.J, et al. Human versus mouse eosinophils: 'that which we call an eosinophil, by any other namewould stain as red'. J. Allergy Clin. Immunol. 130, 572-584 (2012).
-
(2012)
J. Allergy Clin. Immunol
, vol.130
, pp. 572-584
-
-
Lee, J.J.1
-
37
-
-
84898681828
-
Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis
-
Chu V.T, et al. Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis. Immunity. 40, 582-593 (2014).
-
(2014)
Immunity
, vol.40
, pp. 582-593
-
-
Chu, V.T.1
-
38
-
-
84898679249
-
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation
-
Goto Y, et al. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity. 40, 594-607 (2014).
-
(2014)
Immunity
, vol.40
, pp. 594-607
-
-
Goto, Y.1
-
39
-
-
84876913132
-
Role of the gutmicrobiota in immunity and inflammatory disease
-
Kamada N, Seo S.-U, Chen G.Y, & Núñ ez G. Role of the gutmicrobiota in immunity and inflammatory disease. Nat. Rev. Immunol. 13, 321-335 (2013).
-
(2013)
Nat. Rev. Immunol
, vol.13
, pp. 321-335
-
-
Kamada, N.1
Seo, S.-U.2
Chen, G.Y.3
Núñez, G.4
-
40
-
-
84900459331
-
IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
-
Kryczek I, et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity. 40, 772-784 (2014).
-
(2014)
Immunity
, vol.40
, pp. 772-784
-
-
Kryczek, I.1
-
41
-
-
79954608756
-
Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
-
Kamanaka M, et al. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J. Exp. Med. 208, 1027-1040 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 1027-1040
-
-
Kamanaka, M.1
-
42
-
-
84890892433
-
IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism
-
Eken A., Singh A.K, Treuting, P.M. &Oukka M. IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism. Mucosal Immunol. 7, 143-154 (2014).
-
(2014)
Mucosal Immunol
, vol.7
, pp. 143-154
-
-
Eken, A.1
Singh, A.K.2
Treuting, P.M.3
Oukka, M.4
-
43
-
-
78649360369
-
Regulated expression of nuclear receptor RORgt confers distinct functional fates to NK cell receptor-expressing RORgt(+) innate lymphocytes
-
Vonarbourg C, et al. Regulated expression of nuclear receptor RORgt confers distinct functional fates to NK cell receptor-expressing RORgt(+) innate lymphocytes. Immunity. 33, 736-751 (2010).
-
(2010)
Immunity
, vol.33
, pp. 736-751
-
-
Vonarbourg, C.1
-
44
-
-
40049083827
-
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
-
Zheng Y, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14, 282-289 (2008).
-
(2008)
Nat. Med
, vol.14
, pp. 282-289
-
-
Zheng, Y.1
-
45
-
-
84908128377
-
The necroptosis adaptor ripk3 promotes injury-induced cytokine expression and tissue repair
-
Moriwaki K, et al. The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair. Immunity. 41, 567-578 (2014).
-
(2014)
Immunity
, vol.41
, pp. 567-578
-
-
Moriwaki, K.1
-
46
-
-
84882664672
-
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
-
Zelante T, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 39, 372-385 (2013).
-
(2013)
Immunity
, vol.39
, pp. 372-385
-
-
Zelante, T.1
-
47
-
-
67749106611
-
Knockout rats via embryo microinjection of zinc-finger nucleases
-
Geurts A.M, et al. Knockout rats via embryo microinjection of zinc-finger nucleases. Science. 325, 433 (2009).
-
(2009)
Science
, vol.325
, pp. 433
-
-
Geurts, A.M.1
-
48
-
-
75949084489
-
Methods of inducing inflammatory bowel disease in mice
-
Unit 5.58
-
Maxwell J.R, Brown, W.A, Smith C.L, Byrne F.R, & Viney J.L. Methods of inducing inflammatory bowel disease in mice. Curr. Protoc. Pharmacol, Chapter. 5, Unit 5.58 (2009).
-
(2009)
Curr. Protoc. Pharmacol, Chapter
, vol.5
-
-
Maxwell, J.R.1
Brown, W.A.2
Smith, C.L.3
Byrne, F.R.4
Viney, J.L.5
-
49
-
-
40549113336
-
Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants
-
Jarry A, et al. Mucosal IL-10 and TGF-beta play crucial roles in preventing LPS-driven, IFN-gamma-mediated epithelial damage in human colon explants. J. Clin. Invest. 118, 1132-1142 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 1132-1142
-
-
Jarry, A.1
|