The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes

Cell Regeneration

Volumn 2, Issue 1, 2013, Pages 2:2-

  Hill, Thomas ^a   Krougly, Olga ^a   Nikoopour, Enayat ^a   Bellemore, Stacey ^a   Lee Chan, Edwin ^a   Fouser, Lynette A ^b   Hill, David J ^a,c   Singh, Bhagirath ^a,d  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b PFIZER INC   (United States)

^c LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^d ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Adjuvant immunotherapy; Beta cell regeneration; Interleukin 22; Regenerating (Reg) genes; Type 1 diabetes

Indexed keywords

INTERLEUKIN 22; INTERLEUKIN 22 NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL REGENERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; DNA SYNTHESIS; DOWN REGULATION; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE LOCATION; IL22 GENE; IL22 RECEPTOR ALPHA GENE; IL22 RECEPTOR GENE; IN VITRO STUDY; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REG GENE; REG1 GENE; REG2 GENE; REG3 DELTA GENE; SPLEEN; T LYMPHOCYTE; UPREGULATION;

EID: 85005980401     PISSN: None     EISSN: 20459769     Source Type: Journal    
DOI: 10.1186/2045-9769-2-2     Document Type: Article

References (28)

1. Van Belle TL, Coppieters KT, von Herrath MG: Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 2011, 91: 79-118. 10.1152/physrev.00003.2010
2. Mandrup-Poulsen T: Beta cell death and protection. Ann NY Acad Sci 2003, 1005: 32-42. 10.1196/annals.1288.005
3. Levetan C: Distinctions between islet neogenesis and β-cell replication: implications for reversal of type 1 and 2 diabetes. J Diabetes 2010, 2: 76-84. 10.1111/j.1753-0407.2010.00074.x
4. Dor Y, Brown J, Martinez OI, Melton DA: Adult pancreatic β-cells are formed by self duplication rather than stem-cell differentiation. Nature 2004, 429: 41-46. 10.1038/nature02520
5. Huszarik K, Wright B, Keller C, Nikoopour E, Krougly O, Lee-Chan E, Qin HY, Cameron MJ, Gurr WK, Hill DJ, Sherwin RS, Kelvin DJ, Singh B: Adjuvant immunotherapy increases β cell regenerative factor Reg2 in the pancreas of diabetic mice. J Immunol 2010, 185: 5120-5129. 10.4049/jimmunol.1001596
6. Kaneto H, Matsuoka TA, Miyatsuka T, Kawamori D, Katakami N, Yamasaki Y, Matsuhisa M: PDX-1 functions as a master factor in the pancreas. Front Biosci 2008, 13: 6406-6420.
7. Singh B, Nikoopour E, Huszarik K, Elliot JF, Jevnikar AM: Immunomodulation and regeneration of islet beta cells by cytokines in autoimmune type 1 diabetes. J Interferon Cytokine Res 2011, 31: 711-719. 10.1089/jir.2011.0025
8. Taylor-Fishwick DA, Rittman S, Kendall H, Roy L, Shi W, Cao Y, Pittenger GL, Vinik AI: Cloning genomic INGAP: a Reg-related family member with distinct transcriptional regulation sites. Biochem. Biophys. Acta 2003, 1638: 83-89. 10.1016/S0925-4439(03)00042-5
9. Parikh A, Stephan A, Tzanakakis ES: Regenerating proteins and their expression, regulation, and signaling. Biomol Concepts 2012, 3: 57-70.
10. Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK: PDGF signaling controls age-dependent proliferation in pancreatic β-cells. Nature 2011, 478: 349-355. 10.1038/nature10502
11. Sadelain MW, Qin HY, Lauzon J, Singh B: Prevention of type 1 diabetes in NOD mice by adjuvant immunotherapy. Diabetes 1990, 39: 583-589. 10.2337/diabetes.39.5.583
12. Qin HY, Sadelain MW, Hitchon C, Lauzon J, Singh B: Complete freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J Immunol 1993, 150: 2072-2080.
13. Liu L, Cui W, Li B, Lu Y: Possible roles of Reg family proteins in pancreatic islet cell growth. Endocr Metab Immune Disord Drug Targets 2008, 8: 1-10. 10.2174/187153008783928361
14. Unno M, Nata K, Noguchi N, Narushima Y, Akiyama T, Ikeda T, Nakagawa K, Takasawa S, Okamoto H: Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice. Diabetes 2002,51(Suppl 3):S478-S483.
15. Nikoopour E, Schwartz JA, Huszarik K, Sandrock C, Krougly O, Lee-Chan E, Singh B: Th17 polarized cells from nonobese diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes. J Immunol 2010, 184: 4779-4788. 10.4049/jimmunol.0902822
16. Aggarwal S, Xie MH, Maruoka M, Foster J, Gurney AL: Acinar cells of the pancreas are a target of interleukin-22. J Interferon Cytokine Res 2001, 2: 1047-1053.
17. Eyerich S, Eyerich K, Cavani A, Schmidt-Weber C: IL-17 and IL-22: siblings, not twins. Trends Immunol 2010, 31: 354-361. 10.1016/j.it.2010.06.004
18. Wolk K, Witte E, Warszawska K, Sabat R: Biology of interleukin-22. Semin Immunopathol 2010, 3: 17-31.
19. Shioya M, Andoh A, Kakinoki S, Nishida A, Fujiyama Y: Interleukin 22 receptor 1 expression in pancreas islets. Pancreas 2008, 36: 197-199. 10.1097/MPA.0b013e3181594258
20. Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM: Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS One 2012,7(8):e41756. 10.1371/journal.pone.0041756
21. Ma HL, Liang S, Li J, Napierata L, Brown T, Benoit S, Senices M, Gill D, Dunussi-Joannopoulos K, Collins M, Nickerson-Nutter C, Fouser LA, Young DA: IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest 2008, 118: 597-607.
22. Okamoto H, Takasawa S: Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells. Diabetes 2002,51(Suppl 3):S462-S473.
23. Oh YS, Lee YJ, Park EY, Jun HS: Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production. Diabetes Metab Res Rev 2011, 27: 813-819. 10.1002/dmrr.1233
24. Zhang Y, Valdez PA, Danilenko DM, Hu Y, Sa SM, Gong Q, Abbas AR, Modrusan Z, Ghilardi N, de Sauvage FJ, Ouyang W: Interleukin-22 mediates host defense against attacking and effacing bacterial pathogens. Nature Med 2008, 14: 282-289. 10.1038/nm1720
25. Gelebart P, Zak Z, Dien-Bard J, Anand M, Lai R: Interleukin-22 signaling promotes cell growth in mantle cell lymphoma. Transl Oncol 2011, 4: 9-19.
26. Radaeva S, Sun R, Pan H-N, Hong F, Gao B: Interleukin 22 (IL-22) plays a protective role in cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 2004, 39: 1332-1342. 10.1002/hep.20184
27. Takasawa S, Ikeda T, Akiyama T, Nata K, Nakagawa K, Shervani NJ, Noguchi N, Murakami-Kawaguchi S, Yamauchi A, Takahashi I, Tomioka-Kumagai T, Okamoto H: Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration. FEBS Lett 2006, 580: 585-591. 10.1016/j.febslet.2005.12.070
28. Smukler SR, Arntfield ME, Razavi R, Bikopoulos G, Karpowicz P, Seaberg R, Dai F, Lee S, Ahrens R, Fraser PE, Wheeler MB, van der Kooy D: The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell 2011, 8: 281-293. 10.1016/j.stem.2011.01.015