-
1
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B. et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725 (2000).
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
-
2
-
-
0036604306
-
A receptor for the heterodimeric cytokine il-23 is composed of il-12rbeta1 and a novel cytokine receptor subunit il-23r
-
Parham, C. et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168, 5699-5708 (2002).
-
(2002)
J. Immunol
, vol.168
, pp. 5699-5708
-
-
Parham, C.1
-
3
-
-
68649090645
-
Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells
-
Awasthi, A. et al. Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. J. Immunol. 182, 5904-5908 (2009).
-
(2009)
J. Immunol
, vol.182
, pp. 5904-5908
-
-
Awasthi, A.1
-
4
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou, L. et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8, 967-974 (2007).
-
(2007)
Nat. Immunol
, vol.8
, pp. 967-974
-
-
Zhou, L.1
-
5
-
-
77958584113
-
Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling
-
Ghoreschi, K. et al. Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling. Nature 467, 967-971 (2010).
-
(2010)
Nature
, vol.467
, pp. 967-971
-
-
Ghoreschi, K.1
-
6
-
-
47249128991
-
Th17 cells in human disease
-
Tesmer, L.A., Lundy, S.K., Sarkar, S. & Fox, D.A. Th17 cells in human disease. Immunol. Rev. 223, 87-113 (2008).
-
(2008)
Immunol. Rev
, vol.223
, pp. 87-113
-
-
Tesmer, L.A.1
Lundy, S.K.2
Sarkar, S.3
Fox, D.A.4
-
7
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
8
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett, J.C. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955-962 (2008).
-
(2008)
Nat. Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
-
9
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr, R.H. et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-1463 (2006).
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
-
10
-
-
77951210494
-
Pathway analysis ofGWASprovidesnewinsights into genetic susceptibility to 3 inflammatory diseases
-
Eleftherohorinou,H. et al. Pathway analysis ofGWASprovidesnewinsights into genetic susceptibility to 3 inflammatory diseases. PLoS One 4, e8068 (2009).
-
(2009)
PLoS One
, vol.4
-
-
Eleftherohorinou, H.1
-
11
-
-
79959875101
-
Interleukin-23 and T helper 17-type responses in intestinal inflammation: From cytokines to T-cell plasticity
-
Morrison, P.J., Ballantyne, S.J. &Kullberg, M.C. Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity. Immunology 133, 397-408 (2011).
-
(2011)
Immunology
, vol.133
, pp. 397-408
-
-
Morrison, P.J.1
Ballantyne, S.J.2
Kullberg, M.C.3
-
12
-
-
79960776307
-
Interleukin-23: A key cytokine in inflammatory diseases
-
Duvallet, E., Semerano, L., Assier, E., Falgarone, G. & Boissier, M.C. Interleukin-23: a key cytokine in inflammatory diseases. Ann. Med. 43, 503-511 (2011).
-
(2011)
Ann. Med
, vol.43
, pp. 503-511
-
-
Duvallet, E.1
Semerano, L.2
Assier, E.3
Falgarone, G.4
Boissier, M.C.5
-
13
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen, D. et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J. Clin. Invest. 116, 1310-1316 (2006).
-
(2006)
J. Clin. Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
-
14
-
-
33750505009
-
Interleukin-23 drives innate and T cell-mediated intestinal inflammation
-
Hue, S. et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J. Exp. Med. 203, 2473-2483 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2473-2483
-
-
Hue, S.1
-
15
-
-
33750530394
-
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
-
Kullberg, M.C. et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. Exp. Med. 203, 2485-2494 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2485-2494
-
-
Kullberg, M.C.1
-
16
-
-
33747089041
-
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
-
Uhlig, H.H. et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25, 309-318 (2006).
-
(2006)
Immunity
, vol.25
, pp. 309-318
-
-
Uhlig, H.H.1
-
17
-
-
77955890952
-
Interleukin-23 drives intestinal inflammation through direct activity on T cells
-
Ahern, P.P. et al. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity 33, 279-288 (2010).
-
(2010)
Immunity
, vol.33
, pp. 279-288
-
-
Ahern, P.P.1
-
18
-
-
83655183007
-
Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice
-
Cox, J.H. et al. Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice. Mucosal Immunol. 5, 99-109 (2012).
-
(2012)
Mucosal Immunol
, vol.5
, pp. 99-109
-
-
Cox, J.H.1
-
19
-
-
84859879397
-
RORgammatdependent IL-17A-producing cells in the pathogenesis of intestinal inflammation
-
Kanai, T., Mikami, Y., Sujino, T., Hisamatsu, T. & Hibi, T. RORgammatdependent IL-17A-producing cells in the pathogenesis of intestinal inflammation. Mucosal Immunol. 5, 240-247 (2012).
-
(2012)
Mucosal Immunol
, vol.5
, pp. 240-247
-
-
Kanai, T.1
Mikami, Y.2
Sujino, T.3
Hisamatsu, T.4
Hibi, T.5
-
20
-
-
54449102022
-
Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice
-
Ito, R. et al. Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. Biochem. Biophys. Res. Commun. 377, 12-16 (2008).
-
(2008)
Biochem. Biophys. Res. Commun
, vol.377
, pp. 12-16
-
-
Ito, R.1
-
21
-
-
33646804892
-
Critical role of IL-17 receptor signaling in acute TNBS-induced colitis
-
Zhang, Z., Zheng, M., Bindas, J., Schwarzenberger, P. & Kolls, J.K. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm. Bowel Dis. 12, 382-388 (2006).
-
(2006)
Inflamm. Bowel Dis
, vol.12
, pp. 382-388
-
-
Zhang, Z.1
Zheng, M.2
Bindas, J.3
Schwarzenberger, P.4
Kolls, J.K.5
-
22
-
-
43549110961
-
Regulation of inflammatory responses by IL-17F
-
Yang, X.O. et al. Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205, 1063-1075 (2008).
-
(2008)
J. Exp. Med
, vol.205
, pp. 1063-1075
-
-
Yang, X.O.1
-
23
-
-
59849114998
-
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
-
Leppkes, M. et al. RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 136, 257-267 (2009).
-
(2009)
Gastroenterology
, vol.136
, pp. 257-267
-
-
Leppkes, M.1
-
24
-
-
65749091607
-
A protective function for interleukin 17A in T cellmediated intestinal inflammation
-
O'Connor, W. Jr. et al. A protective function for interleukin 17A in T cellmediated intestinal inflammation. Nat. Immunol. 10, 603-609 (2009).
-
(2009)
Nat. Immunol
, vol.10
, pp. 603-609
-
-
O'Connor Jr., W.1
-
25
-
-
79955030498
-
Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
-
Sonnenberg, G.F., Fouser, L.A. & Artis, D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat. Immunol. 12, 383-390 (2011).
-
(2011)
Nat. Immunol
, vol.12
, pp. 383-390
-
-
Sonnenberg, G.F.1
Fouser, L.A.2
Artis, D.3
-
26
-
-
57449090428
-
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
-
Zenewicz, L.A. et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29, 947-957 (2008).
-
(2008)
Immunity
, vol.29
, pp. 947-957
-
-
Zenewicz, L.A.1
-
27
-
-
79954608756
-
Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
-
Kamanaka, M. et al. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J. Exp. Med. 208, 1027-1040 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 1027-1040
-
-
Kamanaka, M.1
-
28
-
-
70149094177
-
Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells
-
Schmutz, S. et al. Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells. J Immunol 183, 2217-2221 (2009).
-
(2009)
J Immunol
, vol.183
, pp. 2217-2221
-
-
Schmutz, S.1
-
29
-
-
33747755806
-
Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15)
-
Kim, M.Y. et al. Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15). J. Immunol. 177, 3074-3081 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 3074-3081
-
-
Kim, M.Y.1
-
30
-
-
60549102720
-
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
-
Takatori, H. et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206, 35-41 (2009).
-
(2009)
J. Exp. Med
, vol.206
, pp. 35-41
-
-
Takatori, H.1
-
31
-
-
78751706261
-
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut
-
Sonnenberg, G.F., Monticelli, L.A., Elloso, M.M., Fouser, L.A. & Artis, D. CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity 34, 122-134 (2011).
-
(2011)
Immunity
, vol.34
, pp. 122-134
-
-
Sonnenberg, G.F.1
Monticelli, L.A.2
Elloso, M.M.3
Fouser, L.A.4
Artis, D.5
-
32
-
-
77951878587
-
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
-
Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375 (2010).
-
(2010)
Nature
, vol.464
, pp. 1371-1375
-
-
Buonocore, S.1
-
33
-
-
78649360369
-
Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes
-
Vonarbourg, C. et al. Regulated expression of nuclear receptor RORgammat confers distinct functional fates to NK cell receptor-expressing RORgammat(+) innate lymphocytes. Immunity 33, 736-751 (2010).
-
(2010)
Immunity
, vol.33
, pp. 736-751
-
-
Vonarbourg, C.1
-
34
-
-
79958277385
-
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
-
Geremia, A. et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J. Exp. Med. 208, 1127-1133 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 1127-1133
-
-
Geremia, A.1
-
35
-
-
0027517545
-
Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C B-17 scid mice
-
Powrie, F., Leach, M.W., Mauze, S., Caddle, L.B. & Coffman, R.L. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5, 1461-1471 (1993).
-
(1993)
Int. Immunol
, vol.5
, pp. 1461-1471
-
-
Powrie, F.1
Leach, M.W.2
Mauze, S.3
Caddle, L.B.4
Coffman, R.L.5
-
36
-
-
56149091567
-
Identification of functional roles for both IL-17RB and IL- 17RA in mediating IL-25-induced activities
-
Rickel, E.A. et al. Identification of functional roles for both IL-17RB and IL- 17RA in mediating IL-25-induced activities. J. Immunol. 181, 4299-4310 (2008).
-
(2008)
J. Immunol
, vol.181
, pp. 4299-4310
-
-
Rickel, E.A.1
-
37
-
-
81255158786
-
IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens
-
Song, X. et al. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat. Immunol. 12, 1151-1158 (2011).
-
(2011)
Nat. Immunol
, vol.12
, pp. 1151-1158
-
-
Song, X.1
-
38
-
-
33748039462
-
Symbiotic bacteria direct expression of an intestinal bactericidal lectin
-
Cash, H.L., Whitham, C.V., Behrendt, C.L. & Hooper, L.V. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313, 1126-1130 (2006).
-
(2006)
Science
, vol.313
, pp. 1126-1130
-
-
Cash, H.L.1
Whitham, C.V.2
Behrendt, C.L.3
Hooper, L.V.4
-
39
-
-
33749318470
-
Interleukin IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
-
Liang, S.C. et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271-2279 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 2271-2279
-
-
Liang, S.C.1
-
40
-
-
27644479966
-
Jak3 negatively regulates dendritic-cell cytokine production and survival
-
Yamaoka, K.,Min, B., Zhou, Y.J., Paul,W.E. & O'Shea J, J. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106, 3227-3233 (2005).
-
(2005)
Blood
, vol.106
, pp. 3227-3233
-
-
Yamaoka, K.1
Min, B.2
Zhou, Y.J.3
Paul, W.E.4
O'Shea, J.J.5
-
41
-
-
77953495368
-
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
-
Sonnenberg, G.F. et al. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J. Exp. Med. 207, 1293-1305 (2010).
-
(2010)
J. Exp. Med
, vol.207
, pp. 1293-1305
-
-
Sonnenberg, G.F.1
-
42
-
-
0033848986
-
Matrix metalloproteinases: Effectors of development and normal physiology
-
Vu, T.H. & Werb, Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev. 14, 2123-2133 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 2123-2133
-
-
Vu, T.H.1
Werb, Z.2
-
43
-
-
0032880168
-
Matrix metalloproteinase levels are elevated in inflammatory bowel disease
-
Baugh, M.D. et al. Matrix metalloproteinase levels are elevated in inflammatory bowel disease. Gastroenterology 117, 814-822 (1999).
-
(1999)
Gastroenterology
, vol.117
, pp. 814-822
-
-
Baugh, M.D.1
-
44
-
-
2342417829
-
Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease
-
Kirkegaard, T., Hansen, A., Bruun, E. & Brynskov, J. Expression and localisation of matrix metalloproteinases and their natural inhibitors in fistulae of patients with Crohn's disease. Gut 53, 701-709 (2004).
-
(2004)
Gut
, vol.53
, pp. 701-709
-
-
Kirkegaard, T.1
Hansen, A.2
Bruun, E.3
Brynskov, J.4
-
45
-
-
33748477283
-
Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: Contrasting role of gelatinases in the pathogenesis of colitis
-
Garg, P. et al. Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis. J. Immunol. 177, 4103-4112 (2006).
-
(2006)
J. Immunol
, vol.177
, pp. 4103-4112
-
-
Garg, P.1
-
46
-
-
57449118239
-
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
-
Satoh-Takayama, N. et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 29, 958-970 (2008).
-
(2008)
Immunity
, vol.29
, pp. 958-970
-
-
Satoh-Takayama, N.1
-
47
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto, K. et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
-
48
-
-
35348983341
-
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
-
Zenewicz, L.A. et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647-659 (2007).
-
(2007)
Immunity
, vol.27
, pp. 647-659
-
-
Zenewicz, L.A.1
-
49
-
-
33846906224
-
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
-
Zheng, Y. et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648-651 (2007).
-
(2007)
Nature
, vol.445
, pp. 648-651
-
-
Zheng, Y.1
-
50
-
-
24144477540
-
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
-
Andoh, A. et al. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 129, 969-984 (2005).
-
(2005)
Gastroenterology
, vol.129
, pp. 969-984
-
-
Andoh, A.1
-
51
-
-
0141539412
-
High-level factor VIII gene expression in vivo achieved by nonviral liver-specific gene therapy vectors
-
Miao, C.H., Ye, X. & Thompson, A.R. High-level factor VIII gene expression in vivo achieved by nonviral liver-specific gene therapy vectors. Hum. Gene Ther. 14, 1297-1305 (2003).
-
(2003)
Hum. Gene Ther
, vol.14
, pp. 1297-1305
-
-
Miao, C.H.1
Ye, X.2
Thompson, A.R.3
-
52
-
-
0034828657
-
Helicobacter-induced inflammatory bowel disease in IL-10- and T-cell-deficient mice
-
Burich, A. et al. Helicobacter-induced inflammatory bowel disease in IL-10- and T-cell-deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol. 281, G764-G778 (2001).
-
(2001)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.281
-
-
Burich, A.1
-
53
-
-
84863180511
-
GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity
-
Lin, J.E. et al. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PLoS One 7, e31686 (2012).
-
(2012)
PLoS One
, vol.7
-
-
Lin, J.E.1
|