메뉴 건너뛰기




Volumn 13, Issue 3, 2016, Pages 316-327

Hepatic macrophages in homeostasis and liver diseases: From pathogenesis to novel therapeutic strategies

Author keywords

chemokine; liver fibrosis; macrophage; microbiome; monocyte

Indexed keywords

CONCANAVALIN A; PARACETAMOL;

EID: 84966297002     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2015.104     Document Type: Review
Times cited : (407)

References (136)
  • 1
    • 84927613295 scopus 로고    scopus 로고
    • Macrophages: Development and tissue specialization
    • Varol C, Mildner A, Jung S. Macrophages: development and tissue specialization. Annu Rev Immunol 2015; 33: 643-675.
    • (2015) Annu Rev Immunol , vol.33 , pp. 643-675
    • Varol, C.1    Mildner, A.2    Jung, S.3
  • 2
    • 84898789996 scopus 로고    scopus 로고
    • Macrophage heterogeneity in liver injury and fibrosis
    • Tacke F, Zimmermann HW. Macrophage heterogeneity in liver injury and fibrosis. J Hepatol 2014; 60: 1090-1096.
    • (2014) J Hepatol , vol.60 , pp. 1090-1096
    • Tacke, F.1    Zimmermann, H.W.2
  • 3
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin Y, Winter D, Blecher-Gonen R, David E, Keren-Shaul H, Merad M et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 2014; 159: 1312-1326.
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1    Winter, D.2    Blecher-Gonen, R.3    David, E.4    Keren-Shaul, H.5    Merad, M.6
  • 4
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 2014; 40: 274-288.
    • (2014) Immunity , vol.40 , pp. 274-288
    • Xue, J.1    Schmidt, S.V.2    Sander, J.3    Draffehn, A.4    Krebs, W.5    Quester, I.6
  • 5
    • 84928254123 scopus 로고    scopus 로고
    • A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR21 monocytes at a site of sterile injury
    • Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B et al. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR21 monocytes at a site of sterile injury. J Exp Med 2015; 212: 447-456.
    • (2015) J Exp Med , vol.212 , pp. 447-456
    • Dal-Secco, D.1    Wang, J.2    Zeng, Z.3    Kolaczkowska, E.4    Wong, C.H.5    Petri, B.6
  • 6
    • 84904401883 scopus 로고    scopus 로고
    • Origin and functions of tissue macrophages
    • Epelman S, Lavine KJ, Randolph GJ. Origin and functions of tissue macrophages. Immunity 2014; 41: 21-35.
    • (2014) Immunity , vol.41 , pp. 21-35
    • Epelman, S.1    Lavine, K.J.2    Randolph, G.J.3
  • 7
    • 67651174837 scopus 로고    scopus 로고
    • Hepatic recruitment of the inflammatory Gr11 monocyte subset upon liver injury promotes hepatic fibrosis
    • Karlmark KR, Weiskirchen R, Zimmermann HW, Gassler N, Ginhoux F, Weber C et al. Hepatic recruitment of the inflammatory Gr11 monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 2009; 50: 261-274.
    • (2009) Hepatology , vol.50 , pp. 261-274
    • Karlmark, K.R.1    Weiskirchen, R.2    Zimmermann, H.W.3    Gassler, N.4    Ginhoux, F.5    Weber, C.6
  • 8
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
    • Gomez PE, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L et al. Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 2015; 518: 547-551.
    • (2015) Nature , vol.518 , pp. 547-551
    • Gomez, P.E.1    Klapproth, K.2    Schulz, C.3    Busch, K.4    Azzoni, E.5    Crozet, L.6
  • 9
    • 84872765982 scopus 로고    scopus 로고
    • Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    • Yona S, Kim KW, Wolf Y, Mildner A, Varol D, Breker M et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 2013; 38: 79-91.
    • (2013) Immunity , vol.38 , pp. 79-91
    • Yona, S.1    Kim, K.W.2    Wolf, Y.3    Mildner, A.4    Varol, D.5    Breker, M.6
  • 12
    • 84864351457 scopus 로고    scopus 로고
    • Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
    • Antoniades CG, Quaglia A, Taams LS, Mitry RR, Hussain M, AbelesR et al. Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans. Hepatology 2012; 56: 735-746.
    • (2012) Hepatology , vol.56 , pp. 735-746
    • Antoniades, C.G.1    Quaglia, A.2    Taams, L.S.3    Mitry, R.R.4    Abeles, H.M.5
  • 14
    • 33747358360 scopus 로고    scopus 로고
    • Migratory fate and differentiation of blood monocyte subsets
    • Tacke F, Randolph GJ. Migratory fate and differentiation of blood monocyte subsets. Immunobiology 2006; 211: 609-618.
    • (2006) Immunobiology , vol.211 , pp. 609-618
    • Tacke, F.1    Randolph, G.J.2
  • 16
    • 84880794108 scopus 로고    scopus 로고
    • Measuring intravascular migration of mouse Ly6C(low) monocytes in vivo using intravital microscopy. Curr Protoc Immunol
    • Carlin LM, Auffray C, Geissmann F. Measuring intravascular migration of mouse Ly6C(low) monocytes in vivo using intravital microscopy. Curr Protoc Immunol 2013; Chapter 14:Unit 14. 33. 1-16.
    • (2013) Chapter 14:Unit , vol.14 , Issue.33 , pp. 1-16
    • Carlin, L.M.1    Auffray, C.2    Geissmann, F.3
  • 17
    • 84876207357 scopus 로고    scopus 로고
    • Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal
    • Carlin LM, Stamatiades EG, Auffray C, Hanna RN, Glover L, Vizcay- Barrena G et al. Nr4a1-dependent Ly6C(low) monocytes monitor endothelial cells and orchestrate their disposal. Cell 2013; 153: 362-375.
    • (2013) Cell , vol.153 , pp. 362-375
    • Carlin, L.M.1    Stamatiades, E.G.2    Auffray, C.3    Hanna, R.N.4    Glover, L.5    Vizcay- Barrena, G.6
  • 18
    • 84937678115 scopus 로고    scopus 로고
    • Heterogeneity in the locomotory behavior of human monocyte subsets over human vascular endothelium in vitro
    • Collison JL, Carlin LM, Eichmann M, Geissmann F, Peakman M. Heterogeneity in the locomotory behavior of human monocyte subsets over human vascular endothelium in vitro. J Immunol 2015; 195: 1162-1170.
    • (2015) J Immunol , vol.195 , pp. 1162-1170
    • Collison, J.L.1    Carlin, L.M.2    Eichmann, M.3    Geissmann, F.4    Peakman, M.5
  • 19
    • 84857444883 scopus 로고    scopus 로고
    • Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice
    • Heymann F, Hammerich L, Storch D, Bartneck M, Huss S, Rüsseler V et al. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. Hepatology 2012; 55: 898-909.
    • (2012) Hepatology , vol.55 , pp. 898-909
    • Heymann, F.1    Hammerich, L.2    Storch, D.3    Bartneck, M.4    Huss, S.5    Rüsseler, V.6
  • 20
    • 84869208905 scopus 로고    scopus 로고
    • Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
    • Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A 2012; 109: E3186-E3195.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E3186-E3195
    • Ramachandran, P.1    Pellicoro, A.2    Vernon, M.A.3    Boulter, L.4    Aucott, R.L.5    Ali, A.6
  • 21
    • 84885184737 scopus 로고    scopus 로고
    • Role of hepatic resident and infiltrating macrophages in liver repair after acute injury
    • You Q, Holt M, Yin H, Li G, Hu CJ, Ju C. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol 2013; 86: 836-843.
    • (2013) Biochem Pharmacol , vol.86 , pp. 836-843
    • You, Q.1    Holt, M.2    Yin, H.3    Li, G.4    Hu, C.J.5    Ju, C.6
  • 22
    • 84872159959 scopus 로고    scopus 로고
    • Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics
    • Liaskou E, Zimmermann HW, Li KK, Oo YH, Suresh S, Stamataki Z et al. Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Hepatology 2013; 57: 385-398.
    • (2013) Hepatology , vol.57 , pp. 385-398
    • Liaskou, E.1    Zimmermann, H.W.2    Li, K.K.3    Oo, Y.H.4    Suresh, S.5    Stamataki, Z.6
  • 23
    • 77955096540 scopus 로고    scopus 로고
    • Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis
    • Zimmermann HW, Seidler S, Nattermann J, Nikolaus Gassler, Claus Hellerbrand, Alma Zernecke et al. Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One 2010; 5: e11049.
    • (2010) PLoS One , vol.5 , pp. e11049
    • Zimmermann, H.W.1    Seidler, S.2    Nattermann, J.3    Gassler, N.4    Hellerbrand, C.5    Zernecke, A.6
  • 24
    • 84886646838 scopus 로고    scopus 로고
    • Immune surveillance by the liver
    • Jenne CN, Kubes P. Immune surveillance by the liver. Nat Immunol 2013; 14: 996-1006.
    • (2013) Nat Immunol , vol.14 , pp. 996-1006
    • Jenne, C.N.1    Kubes, P.2
  • 26
    • 51349131121 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induction by murine hepatic Kupffer cells
    • You Q, Cheng L, Kedl RM, Ju C. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology 2008; 48: 978-990.
    • (2008) Hepatology , vol.48 , pp. 978-990
    • You, Q.1    Cheng, L.2    Kedl, R.M.3    Ju, C.4
  • 27
    • 76549127740 scopus 로고    scopus 로고
    • Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2, 3- dioxygenase
    • Yan ML, Wang YD, Tian YF, Lai ZD, Yan LN. Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2, 3- dioxygenase. World J Gastroenterol 2010; 16: 636-640.
    • (2010) World J Gastroenterol , vol.16 , pp. 636-640
    • Yan, M.L.1    Wang, Y.D.2    Tian, Y.F.3    Lai, Z.D.4    Yan, L.N.5
  • 28
    • 84942520769 scopus 로고    scopus 로고
    • Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration
    • Elsegood CL, Chan CW, Degli-Esposti MA, Wikstrom ME, Domenichini A, Lazarus K et al. Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration. Hepatology 2015; 62: 1272-1284.
    • (2015) Hepatology , vol.62 , pp. 1272-1284
    • Elsegood, C.L.1    Chan, C.W.2    Degli-Esposti, M.A.3    Wikstrom, M.E.4    Domenichini, A.5    Lazarus, K.6
  • 30
    • 84941941384 scopus 로고    scopus 로고
    • Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse
    • Melgar-Lesmes P, Edelman ER. Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse. J Hepatol 2015; 63: 917-925.
    • (2015) J Hepatol , vol.63 , pp. 917-925
    • Melgar-Lesmes, P.1    Edelman, E.R.2
  • 31
    • 84894072682 scopus 로고    scopus 로고
    • CCL2- dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis
    • Ehling J, Bartneck M, Wei X, Gremse F, Fech V, Möckel D et al. CCL2- dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis. Gut 2014; 63: 1960-1971.
    • (2014) Gut , vol.63 , pp. 1960-1971
    • Ehling, J.1    Bartneck, M.2    Wei, X.3    Gremse, F.4    Fech, V.5    Möckel, D.6
  • 32
    • 84928563808 scopus 로고    scopus 로고
    • Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct
    • Movita D, van de Garde MD, Biesta P, Kim Kreefft, Bart Haagmans, Elina Zuniga et al. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. J Virol 2015; 89: 4809-4817.
    • (2015) J Virol , vol.89 , pp. 4809-4817
    • Movita, D.1    Van De Garde, M.D.2    Biesta, P.3    Kreefft, K.4    Haagmans, B.5    Zuniga, E.6
  • 33
    • 84903625203 scopus 로고    scopus 로고
    • Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury
    • Zigmond E, Samia-Grinberg S, Pasmanik-Chor M, Brazowski E, Shibolet O, Halpern Z et al. Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury. J Immunol 2014; 193: 344-353.
    • (2014) J Immunol , vol.193 , pp. 344-353
    • Zigmond, E.1    Samia-Grinberg, S.2    Pasmanik-Chor, M.3    Brazowski, E.4    Shibolet, O.5    Halpern, Z.6
  • 34
    • 57149108312 scopus 로고    scopus 로고
    • Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury
    • Holt MP, Cheng L, Ju C. Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol 2008; 84: 1410-1421.
    • (2008) J Leukoc Biol , vol.84 , pp. 1410-1421
    • Holt, M.P.1    Cheng, L.2    Ju, C.3
  • 35
    • 79958715229 scopus 로고    scopus 로고
    • Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
    • Jenkins SJ, Ruckerl D, Cook PC, Jones LH, Finkelman FD, van Rooijen N et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 2011; 332: 1284-1288.
    • (2011) Science , vol.332 , pp. 1284-1288
    • Jenkins, S.J.1    Ruckerl, D.2    Cook, P.C.3    Jones, L.H.4    Finkelman, F.D.5    Van Rooijen, N.6
  • 36
    • 0028948724 scopus 로고
    • Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen
    • Laskin DL, Gardner CR, Price VF, Jollow DJ. Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology 1995; 21: 1045-1050.
    • (1995) Hepatology , vol.21 , pp. 1045-1050
    • Laskin, D.L.1    Gardner, C.R.2    Price, V.F.3    Jollow, D.J.4
  • 37
    • 0033000310 scopus 로고    scopus 로고
    • Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species
    • Michael SL, Pumford NR, Mayeux PR, Niesman MR, Hinson JA. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. Hepatology 1999; 30: 186-195.
    • (1999) Hepatology , vol.30 , pp. 186-195
    • Michael, S.L.1    Pumford, N.R.2    Mayeux, P.R.3    Niesman, M.R.4    Hinson, J.A.5
  • 38
    • 0036154452 scopus 로고    scopus 로고
    • Protection against acetaminophen-induced liver injury and lethality by interleukin 10: Role of inducible nitric oxide synthase
    • Bourdi M, Masubuchi Y, Reilly TP, Amouzadeh HR, Martin JL, George JW et al. Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology 2002; 35: 289-298.
    • (2002) Hepatology , vol.35 , pp. 289-298
    • Bourdi, M.1    Masubuchi, Y.2    Reilly, T.P.3    Amouzadeh, H.R.4    Martin, J.L.5    George, J.W.6
  • 39
    • 84855833450 scopus 로고    scopus 로고
    • Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice
    • Ryan PM, Bourdi M, Korrapati MC, Proctor WR, Vasquez RA, Yee SB et al. Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice. Chem Res Toxicol 2012; 25: 83-93.
    • (2012) Chem Res Toxicol , vol.25 , pp. 83-93
    • Ryan, P.M.1    Bourdi, M.2    Korrapati, M.C.3    Proctor, W.R.4    Vasquez, R.A.5    Yee, S.B.6
  • 40
    • 34250733492 scopus 로고    scopus 로고
    • Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminopheninduced liver disease
    • Yee SB, Bourdi M, Masson MJ, Pohl LR. Hepatoprotective role of endogenous interleukin-13 in a murine model of acetaminopheninduced liver disease. Chem Res Toxicol 2007; 20: 734-744.
    • (2007) Chem Res Toxicol , vol.20 , pp. 734-744
    • Yee, S.B.1    Bourdi, M.2    Masson, M.J.3    Pohl, L.R.4
  • 43
    • 84952928093 scopus 로고    scopus 로고
    • CSF1 Restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure
    • e14
    • Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA et al. CSF1 Restores innate immunity after liver injury in mice and serum levels indicate outcomes of patients with acute liver failure. Gastroenterology 2015; 149: 1896-1909. e14
    • (2015) Gastroenterology , vol.149 , pp. 1896-1909
    • Stutchfield, B.M.1    Antoine, D.J.2    Mackinnon, A.C.3    Gow, D.J.4    Bain, C.C.5    Hawley, C.A.6
  • 44
    • 0142180066 scopus 로고    scopus 로고
    • Activated Kupffer cells play an important role in intra-hepatic Th1- associated necro-inflammation in Concanavalin A-induced hepatic injury in mice
    • Morita A, Itoh Y, Toyama T, Fujii H, Nishioji K, Kirishima T et al. Activated Kupffer cells play an important role in intra-hepatic Th1- associated necro-inflammation in Concanavalin A-induced hepatic injury in mice. Hepatol Res 2003; 27: 143-150.
    • (2003) Hepatol Res , vol.27 , pp. 143-150
    • Morita, A.1    Itoh, Y.2    Toyama, T.3    Fujii, H.4    Nishioji, K.5    Kirishima, T.6
  • 46
    • 79953875412 scopus 로고    scopus 로고
    • Kupffer cells contribute to concanavalin A-induced hepatic injury through a Th1 but not Th17 type response-dependent pathway in mice
    • Chen L, Xie XJ, Ye YF, Zhou L, Xie HY, Xie QF et al. Kupffer cells contribute to concanavalin A-induced hepatic injury through a Th1 but not Th17 type response-dependent pathway in mice. Hepatobiliary Pancreat Dis Int 2011; 10: 171-178.
    • (2011) Hepatobiliary Pancreat Dis Int , vol.10 , pp. 171-178
    • Chen, L.1    Xie, X.J.2    Ye, Y.F.3    Zhou, L.4    Xie, H.Y.5    Xie, Q.F.6
  • 47
    • 33847727077 scopus 로고    scopus 로고
    • IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin Ainduced liver injury in mice
    • Erhardt A, Biburger M, Papadopoulos T, Tiegs G. IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin Ainduced liver injury in mice. Hepatology 2007; 45: 475-485.
    • (2007) Hepatology , vol.45 , pp. 475-485
    • Erhardt, A.1    Biburger, M.2    Papadopoulos, T.3    Tiegs, G.4
  • 48
    • 77952559636 scopus 로고    scopus 로고
    • Tolerance induction in response to liver inflammation
    • Erhardt A, Tiegs G. Tolerance induction in response to liver inflammation. Dig Dis 2010; 28: 86-92.
    • (2010) Dig Dis , vol.28 , pp. 86-92
    • Erhardt, A.1    Tiegs, G.2
  • 51
    • 0026728411 scopus 로고
    • Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation
    • Hardonk MJ, Dijkhuis FW, Hulstaert CE, Koudstaal J. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukoc Biol 1992; 52: 296-302.
    • (1992) J Leukoc Biol , vol.52 , pp. 296-302
    • Hardonk, M.J.1    Dijkhuis, F.W.2    Hulstaert, C.E.3    Koudstaal, J.4
  • 52
    • 0141763458 scopus 로고    scopus 로고
    • Blockade of Kupffer cells by gadolinium chloride reduces lipid peroxidation and protects liver from ischemia/reperfusion injury
    • Giakoustidis DE, Iliadis S, Tsantilas D, Papageorgiou G, Kontos N, Kostopoulou E et al. Blockade of Kupffer cells by gadolinium chloride reduces lipid peroxidation and protects liver from ischemia/reperfusion injury. Hepatogastroenterology 2003; 50: 1587-1592.
    • (2003) Hepatogastroenterology , vol.50 , pp. 1587-1592
    • Giakoustidis, D.E.1    Iliadis, S.2    Tsantilas, D.3    Papageorgiou, G.4    Kontos, N.5    Kostopoulou, E.6
  • 53
    • 56149119546 scopus 로고    scopus 로고
    • Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/ reperfusion injury in rats
    • Tomiyama K, Ikeda A, Ueki S, Nakao A, Stolz DB, Koike Y et al. Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/ reperfusion injury in rats. Hepatology 2008; 48: 1608-1620.
    • (2008) Hepatology , vol.48 , pp. 1608-1620
    • Tomiyama, K.1    Ikeda, A.2    Ueki, S.3    Nakao, A.4    Stolz, D.B.5    Koike, Y.6
  • 54
    • 77954693077 scopus 로고    scopus 로고
    • Murine Kupffer cells are protective in total hepatic ischemia/ reperfusion injury with bowel congestion through IL-10
    • Ellett JD, Atkinson C, Evans ZP, Amani Z, Balish E, Schmidt MG et al. Murine Kupffer cells are protective in total hepatic ischemia/ reperfusion injury with bowel congestion through IL-10. J Immunol 2010; 184: 5849-5858.
    • (2010) J Immunol , vol.184 , pp. 5849-5858
    • Ellett, J.D.1    Atkinson, C.2    Evans, Z.P.3    Amani, Z.4    Balish, E.5    Schmidt, M.G.6
  • 56
    • 78650765443 scopus 로고    scopus 로고
    • Heme oxygenase system in hepatic ischemia-reperfusion injury
    • Richards JA, Wigmore SJ, Devey LR. Heme oxygenase system in hepatic ischemia-reperfusion injury. World J Gastroenterol. 2010; 16: 6068-6078.
    • (2010) World J Gastroenterol , vol.16 , pp. 6068-6078
    • Richards, J.A.1    Wigmore, S.J.2    Devey, L.R.3
  • 57
    • 79961032414 scopus 로고    scopus 로고
    • Liver ischemia and reperfusion injury: New insights into mechanisms of innateadaptive immune-mediated tissue inflammation
    • Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Liver ischemia and reperfusion injury: new insights into mechanisms of innateadaptive immune-mediated tissue inflammation. Am J Transplant 2011; 11: 1563-1569.
    • (2011) Am J Transplant , vol.11 , pp. 1563-1569
    • Zhai, Y.1    Busuttil, R.W.2    Kupiec-Weglinski, J.W.3
  • 58
    • 84875062997 scopus 로고    scopus 로고
    • TNFalpha-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection
    • Helk E, Bernin H, Ernst T, Jacobs T, Heeren J, Tacke F et al. TNFalpha-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. PLoS Pathog 2013; 9: e1003096.
    • (2013) PLoS Pathog , vol.9 , pp. e1003096
    • Helk, E.1    Bernin, H.2    Ernst, T.3    Jacobs, T.4    Heeren, J.5    Tacke, F.6
  • 59
    • 84930351433 scopus 로고    scopus 로고
    • Ly6C-Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C1 Monocytes into Macrophages
    • Morias Y, Abels C, Laoui D, Guilliams M, Schouppe E, Tacke F et al. Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C1 Monocytes into Macrophages. PLoS Pathog 2015; 11: e1004873.
    • (2015) PLoS Pathog , vol.11 , pp. e1004873
    • Morias, Y.1    Abels, C.2    Laoui, D.3    Guilliams, M.4    Schouppe, E.5    Tacke, F.6
  • 60
    • 0024594014 scopus 로고
    • Portal tract macrophages are increased in alcoholic liver disease
    • Karakucuk I, Dilly SA, Maxwell JD. Portal tract macrophages are increased in alcoholic liver disease. Histopathology 1989; 14: 245-253.
    • (1989) Histopathology , vol.14 , pp. 245-253
    • Karakucuk, I.1    Dilly, S.A.2    Maxwell, J.D.3
  • 62
    • 84893839302 scopus 로고    scopus 로고
    • The liver is populated by a broad spectrum of markers for macrophages. In alcoholic hepatitis the macrophages are M1 and M2
    • Lee J, French B, Morgan T, French SW. The liver is populated by a broad spectrum of markers for macrophages. In alcoholic hepatitis the macrophages are M1 and M2. Exp Mol Pathol 2014; 96: 118-125.
    • (2014) Exp Mol Pathol , vol.96 , pp. 118-125
    • Lee, J.1    French, B.2    Morgan, T.3    French, S.W.4
  • 63
    • 0030821521 scopus 로고    scopus 로고
    • Increased peripheral mononuclear cells expression of adhesion molecules in alcoholic cirrhosis: Its relation to immune activation
    • Luna-Casado L, Diez-Ruiz A, Gutierrez-Gea F, Santos-Perez JL, Rico-Irles J, Wachter H et al. Increased peripheral mononuclear cells expression of adhesion molecules in alcoholic cirrhosis: its relation to immune activation. J Hepatol 1997; 27: 477-483.
    • (1997) J Hepatol , vol.27 , pp. 477-483
    • Luna-Casado, L.1    Diez-Ruiz, A.2    Gutierrez-Gea, F.3    Santos-Perez, J.L.4    Rico-Irles, J.5    Wachter, H.6
  • 64
    • 0031685777 scopus 로고    scopus 로고
    • Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis
    • Afford SC, Fisher NC, Neil DA, Fear J, Brun P, Hubscher SG et al. Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis. J Pathol 1998; 186: 82-89.
    • (1998) J Pathol , vol.186 , pp. 82-89
    • Afford, S.C.1    Fisher, N.C.2    Neil, D.A.3    Fear, J.4    Brun, P.5    Hubscher, S.G.6
  • 65
    • 0032795476 scopus 로고    scopus 로고
    • Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease
    • Fisher NC, Neil DA, Williams A, Adams DH. Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease. Gut 1999; 45: 416-420.
    • (1999) Gut , vol.45 , pp. 416-420
    • Fisher, N.C.1    Neil, D.A.2    Williams, A.3    Adams, D.H.4
  • 67
    • 33749447720 scopus 로고    scopus 로고
    • Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: Relevance to alcoholic liver disease
    • Gobejishvili L, Barve S, Joshi-Barve S, Uriarte S, Song Z, McClain C. Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 2006; 291: G681-G688.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291 , pp. G681-G688
    • Gobejishvili, L.1    Barve, S.2    Joshi-Barve, S.3    Uriarte, S.4    Song, Z.5    McClain, C.6
  • 68
    • 0035099158 scopus 로고    scopus 로고
    • Prolonged ethanol treatment enhances lipopolysaccharide/phorbol myristate acetate-induced tumor necrosis factor-alpha production in human monocytic cells
    • Zhang Z, Bagby GJ, Stoltz D, Oliver P, Schwarzenberger PO, Kolls JK. Prolonged ethanol treatment enhances lipopolysaccharide/phorbol myristate acetate-induced tumor necrosis factor-alpha production in human monocytic cells. Alcohol Clin Exp Res 2001; 25: 444-449.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 444-449
    • Zhang, Z.1    Bagby, G.J.2    Stoltz, D.3    Oliver, P.4    Schwarzenberger, P.O.5    Kolls, J.K.6
  • 70
    • 84867176929 scopus 로고    scopus 로고
    • IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
    • Petrasek J, Bala S, Csak T, Lippai D, Kodys K, Menashy V et al. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest 2012; 122: 3476-3489.
    • (2012) J Clin Invest , vol.122 , pp. 3476-3489
    • Petrasek, J.1    Bala, S.2    Csak, T.3    Lippai, D.4    Kodys, K.5    Menashy, V.6
  • 71
    • 0030914902 scopus 로고    scopus 로고
    • Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1
    • Koop DR, Klopfenstein B, Iimuro Y, Thurman RG. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol Pharmacol 1997; 51: 944-950.
    • (1997) Mol Pharmacol , vol.51 , pp. 944-950
    • Koop, D.R.1    Klopfenstein, B.2    Iimuro, Y.3    Thurman, R.G.4
  • 72
    • 82455167937 scopus 로고    scopus 로고
    • An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice
    • Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology 2011; 54: 2185-2197.
    • (2011) Hepatology , vol.54 , pp. 2185-2197
    • Mandrekar, P.1    Ambade, A.2    Lim, A.3    Szabo, G.4    Catalano, D.5
  • 73
    • 0141625009 scopus 로고    scopus 로고
    • Recent insights into the role of the innate immune system in the development of alcoholic liver disease
    • Nagy LE. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med (Maywood) 2003; 228: 882-890.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 882-890
    • Nagy, L.E.1
  • 74
    • 84907552775 scopus 로고    scopus 로고
    • Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice
    • Wang M, You Q, Lor K, Chen F, Gao B, Ju C. Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice. J Leukoc Biol 2014; 96: 657-665.
    • (2014) J Leukoc Biol , vol.96 , pp. 657-665
    • Wang, M.1    You, Q.2    Lor, K.3    Chen, F.4    Gao, B.5    Ju, C.6
  • 75
    • 2342502025 scopus 로고    scopus 로고
    • A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis
    • Naveau S, Chollet-Martin S, Dharancy S, Mathurin P, Jouet P, Piquet MA et al. A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology 2004; 39: 1390-1397.
    • (2004) Hepatology , vol.39 , pp. 1390-1397
    • Naveau, S.1    Chollet-Martin, S.2    Dharancy, S.3    Mathurin, P.4    Jouet, P.5    Piquet, M.A.6
  • 76
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection-natural history and clinical consequences
    • Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 2004; 350: 1118-1129.
    • (2004) N Engl J Med , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 77
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001; 345: 41-52.
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 78
    • 72549097659 scopus 로고    scopus 로고
    • Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells
    • Tu Z, Pierce RH, Kurtis J, Kuroki Y, Crispe IN, Orloff MS. Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells. Gastroenterology 2010; 138: 305-314.
    • (2010) Gastroenterology , vol.138 , pp. 305-314
    • Tu, Z.1    Pierce, R.H.2    Kurtis, J.3    Kuroki, Y.4    Crispe, I.N.5    Orloff, M.S.6
  • 79
    • 34548418137 scopus 로고    scopus 로고
    • Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
    • Chang S, Dolganiuc A, Szabo G. Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins. J Leukoc Biol 2007; 82: 479-487.
    • (2007) J Leukoc Biol , vol.82 , pp. 479-487
    • Chang, S.1    Dolganiuc, A.2    Szabo, G.3
  • 80
    • 79955579228 scopus 로고    scopus 로고
    • HCV-related proteins activate Kupffer cells isolated from human liver tissues
    • Hosomura N, Kono H, Tsuchiya M, Ishii K, Ogiku M, Matsuda M et al. HCV-related proteins activate Kupffer cells isolated from human liver tissues. Dig Dis Sci 2011; 56: 1057-1064.
    • (2011) Dig Dis Sci , vol.56 , pp. 1057-1064
    • Hosomura, N.1    Kono, H.2    Tsuchiya, M.3    Ishii, K.4    Ogiku, M.5    Matsuda, M.6
  • 81
    • 0031056420 scopus 로고    scopus 로고
    • Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity
    • Khakoo SI, Soni PN, Savage K, Brown D, Dhillon AP, Poulter LW et al. Lymphocyte and macrophage phenotypes in chronic hepatitis C infection. Correlation with disease activity. Am J Pathol 1997; 150: 963-970.
    • (1997) Am J Pathol , vol.150 , pp. 963-970
    • Khakoo, S.I.1    Soni, P.N.2    Savage, K.3    Brown, D.4    Dhillon, A.P.5    Poulter, L.W.6
  • 82
    • 0034121558 scopus 로고    scopus 로고
    • Increases in intrahepatic CD68 positive cells MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection
    • McGuinness PH, Painter D, Davies S, McCaughan GW. Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. Gut 2000; 46: 260-269.
    • (2000) Gut , vol.46 , pp. 260-269
    • McGuinness, P.H.1    Painter, D.2    Davies, S.3    McCaughan, G.W.4
  • 83
    • 0031749458 scopus 로고    scopus 로고
    • Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology
    • Burgio VL, Ballardini G, Artini M, Caratozzolo M, Bianchi FB, Levrero M. Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology. Hepatology 1998; 27: 1600-1606.
    • (1998) Hepatology , vol.27 , pp. 1600-1606
    • Burgio, V.L.1    Ballardini, G.2    Artini, M.3    Caratozzolo, M.4    Bianchi, F.B.5    Levrero, M.6
  • 84
    • 35649007401 scopus 로고    scopus 로고
    • Viral and host factors induce macrophage activation and loss of toll- l ike receptor tolerance in chronic HCV infection
    • Dolganiuc A, Norkina O, Kodys K, Catalano D, Bakis G, Marshall C et al. Viral and host factors induce macrophage activation and loss of toll- l ike receptor tolerance in chronic HCV infection. Gastroenterology 2007; 133: 1627-1636.
    • (2007) Gastroenterology , vol.133 , pp. 1627-1636
    • Dolganiuc, A.1    Norkina, O.2    Kodys, K.3    Catalano, D.4    Bakis, G.5    Marshall, C.6
  • 85
    • 84886248519 scopus 로고    scopus 로고
    • Hepatitis C virus induces interleukin-1beta (IL-1beta)/IL-18 in circulatory and resident liver macrophages
    • Shrivastava S, Mukherjee A, Ray R, Ray RB. Hepatitis C virus induces interleukin-1beta (IL-1beta)/IL-18 in circulatory and resident liver macrophages. J Virol 2013; 87: 12284-12290.
    • (2013) J Virol , vol.87 , pp. 12284-12290
    • Shrivastava, S.1    Mukherjee, A.2    Ray, R.3    Ray, R.B.4
  • 86
    • 84906314467 scopus 로고    scopus 로고
    • The role of Kupffer cells in hepatitis B and hepatitis C virus infections
    • Boltjes A, Movita D, Boonstra A, Woltman AM. The role of Kupffer cells in hepatitis B and hepatitis C virus infections. J Hepatol 2014; 61: 660-671.
    • (2014) J Hepatol , vol.61 , pp. 660-671
    • Boltjes, A.1    Movita, D.2    Boonstra, A.3    Woltman, A.M.4
  • 87
    • 43049183612 scopus 로고    scopus 로고
    • Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication
    • Broering R, Wu J, Meng Z, Hilgard P, Lu M, Trippler M et al. Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication. J Hepatol 2008; 48: 914-922.
    • (2008) J Hepatol , vol.48 , pp. 914-922
    • Broering, R.1    Wu, J.2    Meng, Z.3    Hilgard, P.4    Lu, M.5    Trippler, M.6
  • 88
    • 0037405824 scopus 로고    scopus 로고
    • Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway
    • Zhu H, Liu C. Interleukin-1 inhibits hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway. J Virol 2003; 77: 5493-5498.
    • (2003) J Virol , vol.77 , pp. 5493-5498
    • Zhu, H.1    Liu, C.2
  • 89
    • 5144222035 scopus 로고    scopus 로고
    • STAT3 induces anti-hepatitis C viral activity in liver cells
    • Zhu H, Shang X, Terada N, Liu C. STAT3 induces anti-hepatitis C viral activity in liver cells. Biochem Biophys Res Commun 2004; 324: 518-528.
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 518-528
    • Zhu, H.1    Shang, X.2    Terada, N.3    Liu, C.4
  • 90
    • 0031739327 scopus 로고    scopus 로고
    • Perforin and granzyme B lytic protein expression during chronic viral and autoimmune hepatitis
    • Tordjmann T, Soulie A, Guettier C, Schmidt M, Berthou C, Beaugrand M et al. Perforin and granzyme B lytic protein expression during chronic viral and autoimmune hepatitis. Liver 1998; 18: 391-397.
    • (1998) Liver , vol.18 , pp. 391-397
    • Tordjmann, T.1    Soulie, A.2    Guettier, C.3    Schmidt, M.4    Berthou, C.5    Beaugrand, M.6
  • 91
    • 0038053181 scopus 로고    scopus 로고
    • The role of intrahepatic immune effector cells in inflammatory liver injury and viral control during chronic hepatitis B infection
    • Tang TJ, Kwekkeboom J, Laman JD, Niesters HG, Zondervan PE, de Man RA et al. The role of intrahepatic immune effector cells in inflammatory liver injury and viral control during chronic hepatitis B infection. J Viral Hepat 2003; 10: 159-167.
    • (2003) J Viral Hepat , vol.10 , pp. 159-167
    • Tang, T.J.1    Kwekkeboom, J.2    Laman, J.D.3    Niesters, H.G.4    Zondervan, P.E.5    De Man, R.A.6
  • 92
    • 33845899370 scopus 로고    scopus 로고
    • Role of Kupffer cells in the pathogenesis of liver disease
    • Kolios G, Valatas V, Kouroumalis E. Role of Kupffer cells in the pathogenesis of liver disease. World J Gastroenterol 2006; 12: 7413-7420.
    • (2006) World J Gastroenterol , vol.12 , pp. 7413-7420
    • Kolios, G.1    Valatas, V.2    Kouroumalis, E.3
  • 93
    • 34548418137 scopus 로고    scopus 로고
    • Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
    • Chang S, Dolganiuc A, Szabo G. Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins. J Leukoc Biol 2007; 82: 479-487.
    • (2007) J Leukoc Biol , vol.82 , pp. 479-487
    • Chang, S.1    Dolganiuc, A.2    Szabo, G.3
  • 94
    • 84857652138 scopus 로고    scopus 로고
    • Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-beta1 over pro-inflammatory cytokines
    • Li H, Zheng HW, Chen H, Xing ZZ, You H, Cong M et al. Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-beta1 over pro-inflammatory cytokines. Dig Liver Dis 2012; 44: 328-333.
    • (2012) Dig Liver Dis , vol.44 , pp. 328-333
    • Li, H.1    Zheng, H.W.2    Chen, H.3    Xing, Z.Z.4    You, H.5    Cong, M.6
  • 95
    • 77949793555 scopus 로고    scopus 로고
    • A crucial role for Kupffer cell-derived galectin-in regulation of T cell immunity in hepatitis C infection
    • Mengshol JA, Golden-Mason L, Arikawa T, Smith M, Niki T, McWilliams R et al. A crucial role for Kupffer cell-derived galectin-in regulation of T cell immunity in hepatitis C infection. PLoS One 2010; 5: e9504.
    • (2010) PLoS One , vol.5 , pp. e9504
    • Mengshol, J.A.1    Golden-Mason, L.2    Arikawa, T.3    Smith, M.4    Niki, T.5    McWilliams, R.6
  • 96
    • 80053606297 scopus 로고    scopus 로고
    • Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection
    • Sandler NG, Koh C, Roque A, Smith M, Niki T, McWilliams R et al. Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection. Gastroenterology 2011; 141: 1220-1230.
    • (2011) Gastroenterology , vol.141 , pp. 1220-1230
    • Sandler, N.G.1    Koh, C.2    Roque, A.3    Smith, M.4    Niki, T.5    McWilliams, R.6
  • 97
    • 84868159278 scopus 로고    scopus 로고
    • Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection
    • Nebbia G, Peppa D, Schurich A, Khanna P, Singh HD, Cheng Y et al. Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. PLoS One 2012; 7: e47648.
    • (2012) PLoS One , vol.7 , pp. e47648
    • Nebbia, G.1    Peppa, D.2    Schurich, A.3    Khanna, P.4    Singh, H.D.5    Cheng, Y.6
  • 99
    • 84884984479 scopus 로고    scopus 로고
    • Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
    • Pradere JP, Kluwe J, De MS, Jiao JJ, Gwak GY, Dapito DH et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology 2013; 58: 1461-1473.
    • (2013) Hepatology , vol.58 , pp. 1461-1473
    • Pradere, J.P.1    Kluwe, J.2    De Ms Jiao, J.J.3    Gwak, G.Y.4    Dapito, D.H.5
  • 100
    • 34247149014 scopus 로고    scopus 로고
    • Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    • Fallowfield JA, Mizuno M, Kendall TJ, Constandinou CM, Benyon RC, Duffield JS et al. Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J Immunol 2007; 178: 5288-5295.
    • (2007) J Immunol , vol.178 , pp. 5288-5295
    • Fallowfield, J.A.1    Mizuno, M.2    Kendall, T.J.3    Constandinou, C.M.4    Benyon, R.C.5    Duffield, J.S.6
  • 101
    • 84861576741 scopus 로고    scopus 로고
    • Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis
    • Pellicoro A, Aucott RL, Ramachandran P, Robson AJ, Fallowfield JA, Snowdon VK et al. Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis. Hepatology 2012; 55: 1965-1975.
    • (2012) Hepatology , vol.55 , pp. 1965-1975
    • Pellicoro, A.1    Aucott, R.L.2    Ramachandran, P.3    Robson, A.J.4    Fallowfield, J.A.5    Snowdon, V.K.6
  • 102
  • 103
    • 84857055199 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • Baeck C, Wehr A, Karlmark KR, Heymann F, Vucur M, Gassler N et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 2012; 61: 416-426.
    • (2012) Gut , vol.61 , pp. 416-426
    • Baeck, C.1    Wehr, A.2    Karlmark, K.R.3    Heymann, F.4    Vucur, M.5    Gassler, N.6
  • 104
    • 84874642641 scopus 로고    scopus 로고
    • The inflammatory microenvironment in hepatocellular carcinoma: A pivotal role for tumor-associated macrophages
    • Capece D, Fischietti M, Verzella D, Gaggiano A, Cicciarelli G, Tessitore A et al. The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages. Biomed Res Int 2013; 2013: 187204.
    • (2013) Biomed Res Int , vol.2013 , pp. 187204
    • Capece, D.1    Fischietti, M.2    Verzella, D.3    Gaggiano, A.4    Cicciarelli, G.5    Tessitore, A.6
  • 105
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007; 317: 121-124.
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6
  • 106
    • 84865150085 scopus 로고    scopus 로고
    • The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma
    • Wu J, Li J, Salcedo R, Mivechi NF, Trinchieri G, Horuzsko A. The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma. Cancer Res 2012; 72: 3977-3986.
    • (2012) Cancer Res , vol.72 , pp. 3977-3986
    • Wu, J.1    Li, J.2    Salcedo, R.3    Mivechi, N.F.4    Trinchieri, G.5    Horuzsko, A.6
  • 107
    • 84913580379 scopus 로고    scopus 로고
    • Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
    • Wan S, Zhao E, Kryczek I, Mivechi NF, Trinchieri G, Horuzsko A. Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology 2014; 147: 1393-1404.
    • (2014) Gastroenterology , vol.147 , pp. 1393-1404
    • Wan, S.1    Zhao, E.2    Kryczek, I.3    Mivechi, N.F.4    Trinchieri, G.5    Horuzsko, A.6
  • 108
    • 70350234729 scopus 로고    scopus 로고
    • Kupffer cell suppression of CD81 T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    • Wu K, Kryczek I, Chen L, Zou W, Welling TH. Kupffer cell suppression of CD81 T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions. Cancer Res 2009; 69: 8067-8075.
    • (2009) Cancer Res , vol.69 , pp. 8067-8075
    • Wu, K.1    Kryczek, I.2    Chen, L.3    Zou, W.4    Welling, T.H.5
  • 109
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, Wu C et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 2009; 206: 1327-1337.
    • (2009) J Exp Med , vol.206 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3    Xu, J.4    Zhang, J.P.5    Wu, C.6
  • 110
    • 59049106749 scopus 로고    scopus 로고
    • High tumorinfiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection
    • Ding T, Xu J, Wang F, Shi M, Zhang Y, Li S-P et al. High tumorinfiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection. Hum Pathol 2009; 40: 381-389.
    • (2009) Hum Pathol , vol.40 , pp. 381-389
    • Ding, T.1    Xu, J.2    Wang, F.3    Shi, M.4    Zhang, Y.5    Li, S.-P.6
  • 111
    • 84898461741 scopus 로고    scopus 로고
    • Japanese phase i study of GC33, a humanized antibody against glypican-3 for advanced hepatocellular carcinoma
    • Ikeda M, Ohkawa S, Okusaka T, Mitsunaga S, Kobayashi S, Morizane C et al. Japanese phase I study of GC33, a humanized antibody against glypican-3 for advanced hepatocellular carcinoma. Cancer Sci 2014; 105: 455-462.
    • (2014) Cancer Sci , vol.105 , pp. 455-462
    • Ikeda, M.1    Ohkawa, S.2    Okusaka, T.3    Mitsunaga, S.4    Kobayashi, S.5    Morizane, C.6
  • 112
    • 84874040548 scopus 로고    scopus 로고
    • First-in-man phase i study of GC33, a novel recombinant humanized antibody against glypican-3, in patients with advanced hepatocellular carcinoma
    • Zhu AX, Gold PJ, El-Khoueiry AB, Abrams TA, Morikawa H, Ohishi N et al. First-in-man phase I study of GC33, a novel recombinant humanized antibody against glypican-3, in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2013; 19: 920-928.
    • (2013) Clin Cancer Res , vol.19 , pp. 920-928
    • Zhu, A.X.1    Gold, P.J.2    El-Khoueiry, A.B.3    Abrams, T.A.4    Morikawa, H.5    Ohishi, N.6
  • 113
    • 84890108036 scopus 로고    scopus 로고
    • Macrophages as potential targets for zoledronic acid outside the skeleton-evidence from in vitro and in vivo models
    • Rogers TL, Wind N, Hughes R, Nutter F, Brown HK, Vasiliadou I et al. Macrophages as potential targets for zoledronic acid outside the skeleton-evidence from in vitro and in vivo models. Cell Oncol (Dordr. ) 2013; 36: 505-514.
    • (2013) Cell Oncol (Dordr. ) , vol.36 , pp. 505-514
    • Rogers, T.L.1    Wind, N.2    Hughes, R.3    Nutter, F.4    Brown, H.K.5    Vasiliadou, I.6
  • 114
    • 78650051896 scopus 로고    scopus 로고
    • Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway
    • Coscia M, Quaglino E, Iezzi M, Curcio C, Pantaleoni F, Riganti C et al. Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. J Cell Mol Med 2010; 14: 2803-2815.
    • (2010) J Cell Mol Med , vol.14 , pp. 2803-2815
    • Coscia, M.1    Quaglino, E.2    Iezzi, M.3    Curcio, C.4    Pantaleoni, F.5    Riganti, C.6
  • 115
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • Schnabl B, Brenner DA. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 2014; 146: 1513-1524.
    • (2014) Gastroenterology , vol.146 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 116
    • 84907225684 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in liver cirrhosis
    • Qin N, Yang F, Li A, Prifti E, Chen Y, Shao L et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 2014; 513: 59-64.
    • (2014) Nature , vol.513 , pp. 59-64
    • Qin, N.1    Yang, F.2    Li, A.3    Prifti, E.4    Chen, Y.5    Shao, L.6
  • 118
  • 119
    • 84906535982 scopus 로고    scopus 로고
    • Roles for chemokines in liver disease
    • Marra F, Tacke F. Roles for chemokines in liver disease. Gastroenterology 2014; 147: 577-594.
    • (2014) Gastroenterology , vol.147 , pp. 577-594
    • Marra, F.1    Tacke, F.2
  • 120
    • 84896707511 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(1) macrophage infiltration in mice
    • Baeck C, Wei X, Bartneck M, Fech V, Heymann F, Gassler N et al. Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(1) macrophage infiltration in mice. Hepatology 2014; 59: 1060-1072.
    • (2014) Hepatology , vol.59 , pp. 1060-1072
    • Baeck, C.1    Wei, X.2    Bartneck, M.3    Fech, V.4    Heymann, F.5    Gassler, N.6
  • 121
    • 84911904020 scopus 로고    scopus 로고
    • IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells
    • Preisser L, Miot C, Le Guillou-Guillemette H, Beaumont E, Foucher ED, Garo E et al. IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells. Hepatology 2014; 60: 1879-1890.
    • (2014) Hepatology , vol.60 , pp. 1879-1890
    • Preisser, L.1    Miot, C.2    Le Guillou-Guillemette, H.3    Beaumont, E.4    Foucher, E.D.5    Garo, E.6
  • 122
    • 84930018853 scopus 로고    scopus 로고
    • Combination of granulocyte colony-stimulating factor and erythropoietin improves outcomes of patients with decompensated cirrhosis
    • Kedarisetty CK, Anand L, Bhardwaj A, Bhadoria AS, Kumar G, Vyas AK et al. Combination of granulocyte colony-stimulating factor and erythropoietin improves outcomes of patients with decompensated cirrhosis. Gastroenterology 2015; 148: 1362-1370.
    • (2015) Gastroenterology , vol.148 , pp. 1362-1370
    • Kedarisetty, C.K.1    Anand, L.2    Bhardwaj, A.3    Bhadoria, A.S.4    Kumar, G.5    Vyas, A.K.6
  • 123
    • 84924227124 scopus 로고    scopus 로고
    • Therapeutic targeting of liver inflammation and fibrosis by nanomedicine
    • Bartneck M, Warzecha KT, Tacke F. Therapeutic targeting of liver inflammation and fibrosis by nanomedicine. Hepatobiliary Surg Nutr 2014; 3: 364-376.
    • (2014) Hepatobiliary Surg Nutr , vol.3 , pp. 364-376
    • Bartneck, M.1    Warzecha, K.T.2    Tacke, F.3
  • 124
    • 84855726392 scopus 로고    scopus 로고
    • Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles
    • Liu T, Li L, Fu C, Liu H, Chen D, Tang F. Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles. Biomaterials 2012; 33: 2399-2407.
    • (2012) Biomaterials , vol.33 , pp. 2399-2407
    • Liu, T.1    Li, L.2    Fu, C.3    Liu, H.4    Chen, D.5    Tang, F.6
  • 125
  • 126
    • 84922323024 scopus 로고    scopus 로고
    • Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases
    • Bartneck M, Scheyda KM, Warzecha KT, Rizzo LY, Hittatiya K, Luedde T et al. Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases. Biomaterials 2015; 37: 367-382.
    • (2015) Biomaterials , vol.37 , pp. 367-382
    • Bartneck, M.1    Scheyda, K.M.2    Warzecha, K.T.3    Rizzo, L.Y.4    Hittatiya, K.5    Luedde, T.6
  • 127
    • 84905250766 scopus 로고    scopus 로고
    • Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of pr imary human macrophages
    • Bartneck M, Peters FM, Warzecha KT, Bienert M, van Bloois L, Trautwein C et al. Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of pr imary human macrophages. Nanomedicine 2014; 10: 1209-1220.
    • (2014) Nanomedicine , vol.10 , pp. 1209-1220
    • Bartneck, M.1    Peters, F.M.2    Warzecha, K.T.3    Bienert, M.4    Van Bloois, L.5    Trautwein, C.6
  • 128
    • 0034802467 scopus 로고    scopus 로고
    • Targeting dexamethasone to Kupffer cells: Effects on liver inflammation and fibrosis in rats
    • Melgert BN, Olinga P, Van Der Laan JM, Weert B, Cho J, Schuppan D et al. Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats. Hepatology 2001; 34: 719-728.
    • (2001) Hepatology , vol.34 , pp. 719-728
    • Melgert, B.N.1    Olinga, P.2    Van Der Laan, J.M.3    Weert, B.4    Cho, J.5    Schuppan, D.6
  • 129
    • 84873095720 scopus 로고    scopus 로고
    • Multifunctional polymeric nanoparticles for oral delivery of TNF-alpha siRNA to macrophages
    • He C, Yin L, Tang C, Yin C. Multifunctional polymeric nanoparticles for oral delivery of TNF-alpha siRNA to macrophages. Biomaterials 2013; 34: 2843-2854.
    • (2013) Biomaterials , vol.34 , pp. 2843-2854
    • He, C.1    Yin, L.2    Tang, C.3    Yin, C.4
  • 130
    • 84922144775 scopus 로고    scopus 로고
    • Interleukins in chronic liver disease: Lessons learned from experimental mouse models
    • Hammerich L, Tacke F. Interleukins in chronic liver disease: lessons learned from experimental mouse models. Clin Exp Gastroenterol 2014; 7: 297-306.
    • (2014) Clin Exp Gastroenterol , vol.7 , pp. 297-306
    • Hammerich, L.1    Tacke, F.2
  • 131
    • 84885155926 scopus 로고    scopus 로고
    • Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease
    • Traber PG, Chou H, Zomer E, Hong F, Klyosov A, Fiel M-I et al. Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS One 2013; 8: e75361.
    • (2013) PLoS One , vol.8 , pp. e75361
    • Traber, P.G.1    Chou, H.2    Zomer, E.3    Hong, F.4    Klyosov, A.5    Fiel, M.-I.6
  • 132
    • 84893191346 scopus 로고    scopus 로고
    • Therapy of experimental NASH and fibrosis with galectin inhibitors
    • Traber PG, Zomer E. Therapy of experimental NASH and fibrosis with galectin inhibitors. PLoS One 2013; 8: e83481.
    • (2013) PLoS One , vol.8 , pp. e83481
    • Traber, P.G.1    Zomer, E.2
  • 133
    • 84898961453 scopus 로고    scopus 로고
    • Identifying molecular factors that contribute to resolution of liver fibrosis
    • Iredale JP, Bataller R. Identifying molecular factors that contribute to resolution of liver fibrosis. Gastroenterology 2014; 146: 1160-1164.
    • (2014) Gastroenterology , vol.146 , pp. 1160-1164
    • Iredale, J.P.1    Bataller, R.2
  • 134
    • 84941944562 scopus 로고    scopus 로고
    • Mechanisms of liver fibrosis resolution
    • Tacke F, Trautwein C. Mechanisms of liver fibrosis resolution. J Hepatol 2015; 63: 1038-1039.
    • (2015) J Hepatol , vol.63 , pp. 1038-1039
    • Tacke, F.1    Trautwein, C.2
  • 135
    • 79957465441 scopus 로고    scopus 로고
    • Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function
    • Thomas JA, Pope C, Wojtacha D, Robson AJ, Gordon-Walker TT, Hartland S et al. Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology 2011; 53: 2003-2015.
    • (2011) Hepatology , vol.53 , pp. 2003-2015
    • Thomas, J.A.1    Pope, C.2    Wojtacha, D.3    Robson, A.J.4    Gordon-Walker, T.T.5    Hartland, S.6
  • 136
    • 84926471980 scopus 로고    scopus 로고
    • REpeated AutoLogous Infusions of STem cells in Cirrhosis (REALISTIC): A multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD1331 bone marrow stem cells in patients with cirrhosis
    • King A, Barton D, Beard HA, Ni Than N, Moore J, Corbett C et al. REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD1331 bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial. BMJ Open 2015; 5: e007700.
    • (2015) A Study Protocol for A Randomised Controlled Trial. BMJ Open , vol.5 , pp. e007700
    • King, A.1    Barton, D.2    Beard, H.A.3    Ni Than, N.4    Moore, J.5    Corbett, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.