Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-κB activity and TNF expression: Relevance to alcoholic liver disease

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 4, 2006, Pages

  Gobejishvili, Leila ^a   Barve, Shirish ^a   Joshi Barve, Swati ^a   Uriarte, Silvia ^a   Song, Zhenyuan ^a   McClain, Craig ^a,b  

^a University of Louisville School of Medicine   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcohol; Dibutyryl cAMP; Kupffer cells

Indexed keywords

ALCOHOL; BUCLADESINE; CELL PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CELL PROLIFERATION; CELL VIABILITY; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; ENTERIC FEEDING; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; IN VITRO STUDY; KUPFFER CELL; MACROPHAGE; MALE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; CYCLIC AMP; ETHANOL; GENE EXPRESSION REGULATION; HUMANS; LIPOPOLYSACCHARIDES; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MONOCYTES; NF-KAPPA B; PROTEIN BINDING; PROTEIN TRANSPORT; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33749447720     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00098.2006     Document Type: Article

References (44)

1. Barnes PJ and Karin M. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336: 1066-1071, 1997.
2. Bigatello L, Broitman S, Fattori L, DiPaoli M, Pontello M, Bevilacqua G, and Nespoli A. Endotoxemia, encephalopathy, and mortality in cirrhotic patients. Am J Gastroenterol 82: 11-15, 1987.
3. Bird GL, Sheron N, Goka AK, Alexander GJ, and Williams RS. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med 112: 917-920, 1990.
4. Bode C, Kugler V, and Bode JC. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol 4: 8-14, 1987.
5. Bode JC, Parlesak A, and Bode C. Gut derived bacterial toxins (endotoxin) and alcohol liver disease. In: Alcohol in Health and Disease, edited by Agarwal P and Seitz HK. New York: Dekker, 2001, p. 369-386.
6. Diamond I, Wrubel B, Estrin W, and Gordon A. Basal and adenosine receptor-stimulated levels of cAMP are reduced in lymphocytes from alcoholic patients. Proc Natl Acad Sci USA 84: 1413-1416, 1987.
7. Enomoto N, Ikejima K, Yamashina S, Hirose M, Shimizu H, Kitamura T, Takei Y, Sato And N, and Thurman RG. Kupffer cell sensitization by alcohol involves increased permeability to gut-derived endotoxin. Alcohol Clin Exp Res 25: 51-54, 2001.
8. Felver ME, Mezey E, McGuire M, Mitchell MC, Herlong HF, Veech GA, and Veech RL. Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol Clin Exp Res 14: 255-259, 1990.
9. French SW, Morimoto M, Reitz R, Koop D, Klopfenstein B, Estes K, Clot P, Ingelman-Sundberg M, and Albano E. Lipid peroxidation, CYP2E1 and fatty acid metabolism in alcoholic liver disease. J Nutr 127: 907S-911S, 1997.
10. Haas JG, Baeuerle PA, Riethmuller G, and Ziegler-Heitbrock HW. Molecular mechanisms in down-regulation of tumor necrosis factor expression. Proc Natl Acad Sci USA 87: 9563-9567, 1990.
11. Hill DB, Barve S, Joshi-Barve S, and McClain C. Increased monocyte nuclear factor-kappaB activation and tumor necrosis factor production in alcoholic hepatitis. J Lab Clin Med 135: 387-395, 2000.
12. Hill DB, Shedlofsky SI, Schmidt J, Cohen D, and McClain CJ. In vitro tumor necrosis factor cytotoxicity in HepG2 liver cells. In: Proceedings of the 1992 Conference on Alcohol, Drugs of Abuse, and Immunomodulators (AIDS). New York: Pergamon, 1993, p. 245-249.
13. Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, and Yodoi J. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. J Biol Chem 274: 27891-27897, 1999.
14. Iimuro Y, Gallucci RM, Luster MI, Kono H, and Thurman RG. Antibodies to tumor necrosis factor-α attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26: 1530-1537, 1997.
15. Kamimura S and Tsukamoto H. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology 22: 1304-1309, 1995.
16. Khoruts A, Stahnke L, McClain CJ, Logan G, and Allen JI. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 13: 267-276, 1991.
17. Kishore R, McMullen MR, and Nagy LE. Stabilization of tumor necrosis factor α mRNA by chronic ethanol: role of A + U-rich elements and p38 mitogen-activated protein kinase signaling pathway. J Biol Chem 276: 41930-41937, 2001.
18. Lee E, Marsano L, and McClain CJ. Veterans Cooperative Study. Liver cytokines in alcoholic hepatitis as assessed by immunohistochemistry (Abstract). Hepatology 14: A141, 1991.
19. -ΔΔCt method. Methods 25: 402-408, 2001.
20. Mandrekar P, Dolganiuc A, Bellerose G, Kodys K, Romics L, Nizamani R, and Szabo G. Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation? Alcohol Clin Exp Res 26: 1609-1614, 2002.
21. McClain CJ, Barve S, Deaciuc I, Kugelmas M, and Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis 19: 205-219, 1999.
22. McClain CJ and Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 9: 349-351, 1989.
23. McClain CJ, Hill DB, Marsano L, Cohen D, and Shedlofsky S. A role for cytokines in alcoholic hepatitis. In: Proceedings of the 1992 Conference on Alcohol, Drugs of Abuse, and Immunomodulators (AIDS). New York: Pergamon, 1993, p. 133-141.
24. McClain CJ, Hill DB, Schmidt J, and Diehl AM. Cytokines and alcoholic liver disease. Semin Liver Dis 13: 170-182, 1993.
25. 2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 12: 2005-2015, 1993.
26. Muller JM, Ziegler-Heitbrock HW, and Baeuerle PA. Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology 187: 233-256, 1993.
27. Nagy LE, Diamond I, and Gordon A. Cultured lymphocytes from alcoholic subjects have altered cAMP signal transduction. Proc Natl Acad Sci USA 85: 6973-6976, 1988.
28. Newman WH, Zhang LM, Lee DH, Dalton ML, Warejcka DJ, Castresana MR, and Leeper-Woodford SK. Release of tumor necrosis factor-alpha from coronary smooth muscle: activation of NF-kappaB and inhibition by elevated cyclic AMP. J Surg Res 80: 129-135, 1998.
29. O'Donnell PM and Taffet SM. The proximal promoter region is essential for lipopolysaccharide induction and cyclic AMP inhibition of mouse tumor necrosis factor-alpha. J Interferon Cytokine Res 22: 539-548, 2002.
30. Ohlinger W, Dinges HP, Zatloukal K, Mair S, Gollowitsch F, and Denk H. Immunohistochemical detection of tumor necrosis factor-alpha, other cytokines and adhesion molecules in human livers with alcoholic hepatitis. Virchows Arch A Pathol Anat Histopathol 423: 169-176, 1993.
31. Ollivier V, Parry GCN, Cobb RR, Prost DD, and Mackman N. Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells. J Biol Chem 271: 20828-20835, 1996.
32. Parlesak A, Schafer C, Schutz T, Bode JC, and Bode C. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol 32: 742-747, 2000.
33. Shames BD, McIntyre RC, Bensard DD, Pulido EJ, Selzman CH, Reznikov LL, Harken AH, and Meng X. Suppression of tumor necrosis factor α production by cAMP in human monocytes: dissociation with mRNA level and independent of interleukin-10. J Surg Res 99: 187-193, 2001.
34. Szabo G, Mandrekar P, Girouard L, and Catalano D. Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production. Alcohol Clin Exp Res 20: 900-907, 1996.
35. Tsukamoto H, Towner SJ, Ciofalo LM, and French SW. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology 6: 814-822, 1986.
36. Vincenti MP, Burrell TA, and Taffet SM. Regulation of NF-kappa B activity in murine macrophages: effect of bacterial lipopolysaccharide and phorbol ester. J Cell Physiol 150: 204-213, 1992.
37. Werch CE, Bakema D, Ball M, Lee D, Munodawafa D, and Raub M. Cataloguing blood alcohol level and alcohol consumption data in field settings: feasibility and findings. J Stud Alcohol 49: 561-566, 1988.
38. Woo MS, Jang PG, Park JS, Kim WK, Joh TH, and Kim HS. Selective modulation of lipopolysaccharide-stimulated cytokine expression and mitogen-activated protein kinase pathways by dibutyryl-cAMP in BV2 microglial cells. Brain Res Mol Brain Res 113: 86-96, 2003.
39. Xiong S, She H, Sung CK, and Tsukamoto H. Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol 30: 107-113, 2003.
40. Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luser MI, and Thurman RG. Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice. Gastroenterology 117: 942-952, 1999.
41. Zhang Z, Bagby GJ, Stoltz D, Oliver P, Schwarzenberger PO, and Kolls JK. Prolonged ethanol treatment enhances lipopolysaccharide/phorbol myristate acetate-induced tumor necrosis factor-alpha production in human monocytic cells. Alcohol Clin Exp Res 25: 444-449, 2001.
42. Zhao XJ, Marrero L, Song K, Oliver P, Chin SY, Simon H, Schurr JR, Zhang Z, Thoppil D, Lee S, Nelson S, and Kolls JK. Acute alcohol inhibits TNF-alpha processing in human monocytes by inhibiting TNF/TNF-alpha-converting enzyme interactions in the cell membrane. J Immunol 170: 2923-2931, 2003.
43. Zhao XJ, Oliver P, Song K, Schurr J, Zhang Z, and Kolls JK. Chronic ethanol enhances ectodomain shedding in T cells and monocytes. Alcohol Clin Exp Res 28: 1399-1407, 2004.
44. Zidek Z. Adenosine-cyclic AMP pathways and cytokine expression. Eur Cytokine Netw 10: 319-328, 1999.