Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-β1 over pro-inflammatory cytokines

Digestive and Liver Disease

Volumn 44, Issue 4, 2012, Pages 328-333

  Li, Hai ^a   Zheng, Huan Wei ^a   Chen, Hui ^a   Xing, Zhi Zhi ^a   You, Hong ^a   Cong, Min ^a   Jia, Ji Dong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Hepatitis B virus; Kupffer cells; Liver fibrosis; TGF 1

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; HEPATITIS B; HEPATITIS B VIRUS; KUPFFER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; VIRUS PARTICLE; VIRUS TITRATION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; FIBROSIS; HEPATITIS B VIRUS; INTERLEUKIN-1; INTERLEUKIN-6; KUPFFER CELLS; MALE; RATS; RATS, WISTAR; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84857652138     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2011.11.005     Document Type: Article

References (26)

1. Villa E., Fattovich G., Mauro A., et al. Natural history of chronic HBV infection: special emphasis on the prognostic implications of the inactive carrier state versus chronic hepatitis. Dig Liver Dis 2011, 43(Suppl. 1):S8-S14.
2. Lai C.L., Yuen M.F. The natural history of chronic hepatitis B. J Viral Hepat 2007, 14(Suppl. 1):6-10.
3. Wiegand J., van B.F., Berg T. Management of chronic hepatitis B: status and challenges beyond treatment guidelines. Semin Liver Dis 2010, 30:361-377.
4. Lee Y., Friedman S.L. Fibrosis in the liver: acute protection and chronic disease. Prog Mol Biol Transl Sci 2010, 97:151-200.
5. Friedman S.L. Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol 2010, 7:425-436.
6. Kolios G., Valatas V., Kouroumalis E. Role of Kupffer cells in the pathogenesis of liver disease. World J Gastroenterol 2006, 12:7413-7420.
7. Osawa Y., Seki E., Adachi M., et al. Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology 2010, 51:237-245.
8. Wu J.B., Chuang H.R., Yang L.C., et al. A standardized aqueous extract of Anoectochilus formosanus ameliorated thioacetamide-induced liver fibrosis in mice: the role of Kupffer cells. Biosci Biotechnol Biochem 2010, 74:781-787.
9. Isogawa M., Robek M.D., Furuichi Y., et al. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol 2005, 79:7269-7272.
10. Wu J., Lu M., Meng Z., et al. Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice. Hepatology 2007, 46:1769-1778.
11. Wu J., Meng Z., Jiang M., et al. Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells. Hepatology 2009, 49:1132-1140.
12. Kimura T., Ohno N., Terada N., et al. Hepatitis B virus DNA-negative dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain. J Biol Chem 2005, 280:21713-21719.
13. Ikejima K., Enomoto N., Seabra V., et al. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Am J Physiol 1999, 276:G591-G598.
14. Nieto N. Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells. Hepatology 2006, 44:1487-1501.
15. Wang P., Cong M., Liu T.H., et al. Primary isolated hepatic oval cells maintain progenitor cell phenotypes after two-year prolonged cultivation. J Hepatol 2010, 53:863-871.
16. Kapur N.K. Transforming growth factor-beta: governing the transition from inflammation to fibrosis in heart failure with preserved left ventricular function. Circ Heart Fail 2011, 4:5-7.
17. Lai M., Hyatt B.J., Nasser I., et al. The clinical significance of persistently normal ALT in chronic hepatitis B infection. J Hepatol 2007, 47:760-767.
18. Wang C.C., Lim L.Y., Deubner H., et al. Factors predictive of significant hepatic fibrosis in adults with chronic hepatitis B and normal serum ALT. J Clin Gastroenterol 2008, 42:820-826.
19. Wynn T.A., Barron L. Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis 2010, 30:245-257.
20. Heydtmann M. Macrophages in hepatitis B and hepatitis C virus infections. J Virol 2009, 83:2796-2802.
21. Zhang W., Yue B., Wang G.Q., et al. Serum and ascites levels of macrophage migration inhibitory factor, TNF-alpha and IL-6 in patients with chronic virus hepatitis B and hepatitis cirrhosis. Hepatobiliary Pancreat Dis Int 2002, 1:577-580.
22. Breous E., Somanathan S., Vandenberghe L.H., et al. Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver. Hepatology 2009, 50:612-621.
23. Liu X., Zhu S.T., You H., et al. Hepatitis B virus infects hepatic stellate cells and affects their proliferation and expression of collagen type I. Chin Med J (Engl) 2009, 122:1455-1461.
24. Ogata H., Chinen T., Yoshida T., et al. Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. Oncogene 2006, 25:2520-2530.
25. Liu R.M., Gaston P.K.A. Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med 2010, 48:1-15.
26. Kimura K., Kakimi K., Wieland S., et al. Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice. J Immunol 2002, 169:5188-5195.