TNFα-Mediated Liver Destruction by Kupffer Cells and Ly6Chi Monocytes during Entamoeba histolytica Infection

PLoS Pathogens

Volumn 9, Issue 1, 2013, Pages

  Helk, Elena ^a   Bernin, Hannah ^a   Ernst, Thomas ^b   Ittrich, Harald ^b   Jacobs, Thomas ^a   Heeren, Joerg ^b   Tacke, Frank ^c   Tannich, Egbert ^a   Lotter, Hannelore ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD68 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CLODRONIC ACID; INTERLEUKIN 1BETA; LIPOSOME; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DESTRUCTION; CELL DIFFERENTIATION; CELL INFILTRATION; CELL SUSPENSION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENTAMOEBA HISTOLYTICA; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; KUPFFER CELL; LIVER AMEBIASIS; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENICITY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TISSUE INJURY;

ANIMALS; ANTIGENS, LY; ENTAMOEBA HISTOLYTICA; ENTAMOEBIASIS; IMMUNITY, INNATE; INFLAMMATION; KUPFFER CELLS; LIVER; LIVER ABSCESS, AMEBIC; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; NEUTROPHILS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OMEGA-N-METHYLARGININE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875062997     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003096     Document Type: Article

References (53)

1. WHO (1997) Amoebiasis. Wkly Epidemiol Rec 72: 97-99.
2. Petri WA Jr, Mann BJ, (1993) Molecular mechanisms of invasion by Entamoeba histolytica. Semin Cell Biol 4: 305-313.
3. Leippe M, (1997) Amoebapores. Parasitol Today 13: 178-183.
4. Bruchhaus I, Loftus BJ, Hall N, Tannich E, (2003) The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation. Eukaryotic cell 2: 501-509.
5. Davis PH, Chen M, Zhang X, Clark CG, Townsend RR, et al. (2009) Proteomic comparison of Entamoeba histolytica and Entamoeba dispar and the role of E. histolytica alcohol dehydrogenase 3 in virulence. PLoS Negl Trop Dis 3: e415.
6. Blessmann J, Ali IK, Nu PA, Dinh BT, Viet TQ, et al. (2003) Longitudinal study of intestinal Entamoeba histolytica infections in asymptomatic adult carriers. J Clin Microbiol 41: 4745-4750.
7. Tsutsumi V, Mena-Lopez R, Anaya-Velazquez F, Martinez-Palomo A, (1984) Cellular bases of experimental amebic liver abscess formation. Am J Pathol 117: 81-91.
8. Ventura-Juárez J, Jarillo-Luna RA, Fuentes-Aguilar E, Pineda-Vázquez A, Munoz-Fernández L, et al. (2003) Human amoebic hepatic abscess: in situ interactions between trophozoites, macrophages, neutrophils and Tcells. Parasite Immunology 25: 503-511.
9. Lotter H, Jacobs T, Gaworski I, Tannich E, (2006) Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease. Infect Immun 74: 118-124.
10. Nathan C, (2006) Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 6: 173-182.
11. Laskin DL, Sunil VR, Gardner CR, Laskin JD, (2011) Macrophages and tissue injury: agents of defense or destruction? Annual review of pharmacology and toxicology 51: 267-288.
12. Fleming TJ, Fleming ML, Malek TR, (1993) Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. Journal of immunology 151: 2399-2408.
13. Segal AW, (2005) How neutrophils kill microbes. Annual review of immunology 23: 197-223.
14. Kolios G, Valatas V, Kouroumalis E, (2006) Role of Kupffer cells in the pathogenesis of liver disease. World J Gastroenterol 12: 7413-7420.
15. Kinoshita M, Uchida T, Sato A, Nakashima M, Nakashima H, et al. (2010) Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice. Journal of hepatology 53: 903-910.
16. Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, et al. (2005) The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. The Journal of experimental medicine 201: 1615-1625.
17. Sanchez-Madrid F, Simon P, Thompson S, Springer TA, (1983) Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. The Journal of experimental medicine 158: 586-602.
18. Smith MJ, Koch GL, (1987) Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes. Journal of cell science 87 (Pt 1):: 113-119.
19. Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, et al. (2007) Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicological sciences: an official journal of the Society of Toxicology 96: 2-15.
20. Nakashima H, Kinoshita M, Nakashima M, Habu Y, Shono S, et al. (2008) Superoxide produced by Kupffer cells is an essential effector in concanavalin A-induced hepatitis in mice. Hepatology 48: 1979-1988.
21. Serbina NV, Jia T, Hohl TM, Pamer EG, (2008) Monocyte-mediated defense against microbial pathogens. Annual review of immunology 26: 421-452.
22. Shi C, Pamer EG, (2011) Monocyte recruitment during infection and inflammation. Nature reviews Immunology 11: 762-774.
23. Bosschaerts T, Guilliams M, Stijlemans B, Morias Y, Engel D, et al. (2010) Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling. PLoS pathogens 6: e1001045.
24. Dambach DM, Watson LM, Gray KR, Durham SK, Laskin DL, (2002) Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse. Hepatology 35: 1093-1103.
25. Holt MP, Cheng L, Ju C, (2008) Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol 84: 1410-1421.
26. Baeck C, Wehr A, Karlmark KR, Heymann F, Vucur M, et al. (2012) Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 61: 416-426.
27. Daley JM, Thomay AA, Connolly MD, Reichner JS, Albina JE, (2008) Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. Journal of leukocyte biology 83: 64-70.
28. Karlmark KR, Weiskirchen R, Zimmermann HW, Gassler N, Ginhoux F, et al. (2009) Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 50: 261-274.
29. Van Rooijen N, Sanders A, (1996) Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid. Hepatology 23: 1239-1243.
30. Serbina NV, Pamer EG, (2006) Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nature immunology 7: 311-317.
31. Serbina NV, Salazar-Mather TP, Biron CA, Kuziel WA, Pamer EG, (2003) TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity 19: 59-70.
32. Ravdin JI, (1995) Amebiasis. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 20: 1453-1464 quiz 1465-1456.
33. Rigothier MC, Khun H, Tavares P, Cardona A, Huerre M, et al. (2002) Fate of Entamoeba histolytica during establishment of amoebic liver abscess analyzed by quantitative radioimaging and histology. Infection and immunity 70: 3208-3215.
34. Chadee K, Meerovitch E, (1984) The pathogenesis of experimentally induced amebic liver abscess in the gerbil (Meriones unguiculatus). Am J Pathol 117: 71-80.
35. Lotter H, Zhang T, Seydel KB, Stanley SL Jr, Tannich E, (1997) Identification of an epitope on the Entamoeba histolytica 170-kD lectin conferring antibody-mediated protection against invasive amebiasis. J Exp Med 185: 1793-1801.
36. Guo X, Houpt E, Petri WA Jr, (2007) Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies. Current opinion in immunology 19: 376-384.
37. Chadee K, Moreau F, Meerovitch E, (1987) Entamoeba histolytica: chemoattractant activity for gerbil neutrophils in vivo and in vitro. Experimental parasitology 64: 12-23.
38. Soehnlein O, Lindbom L, (2010) Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol 10: 427-439.
39. Shi C, Hohl TM, Leiner I, Equinda MJ, Fan X, et al. (2011) Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection. Journal of immunology 187: 5293-5298.
40. Seydel KB, Zhang T, Stanley SL Jr, (1997) Neutrophils play a critical role in early resistance to amebic liver abscesses in severe combined immunodeficient mice. Infect Immun 65: 3951-3953.
41. Elnekave K, Siman-Tov R, Ankri S, (2003) Consumption of L-arginine mediated by Entamoeba histolytica L-arginase (EhArg) inhibits amoebicidal activity and nitric oxide production by activated macrophages. Parasite immunology 25: 597-608.
42. Polakos NK, Cornejo JC, Murray DA, Wright KO, Treanor JJ, et al. (2006) Kupffer cell-dependent hepatitis occurs during influenza infection. The American journal of pathology 168: 1169-1178 quiz 1404-1165.
43. Heydtmann M, (2009) Macrophages in hepatitis B and hepatitis C virus infections. Journal of virology 83: 2796-2802.
44. Wu Z, Han M, Chen T, Yan W, Ning Q, (2010) Acute liver failure: mechanisms of immune-mediated liver injury. Liver international: official journal of the International Association for the Study of the Liver 30: 782-794.
45. Guidotti LG, Chisari FV, (2006) Immunobiology and pathogenesis of viral hepatitis. Annual review of pathology 1: 23-61.
46. Karlmark KR, Wasmuth HE, Trautwein C, Tacke F, (2008) Chemokine-directed immune cell infiltration in acute and chronic liver disease. Expert review of gastroenterology & hepatology 2: 233-242.
47. Wang W, Keller K, Chadee K, (1994) Entamoeba histolytica modulates the nitric oxide synthase gene and nitric oxide production by macrophages for cytotoxicity against amoebae and tumour cells. Immunology 83: 601-610.
48. Seydel KB, Smith SJ, Stanley SL Jr, (2000) Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease. Infect Immun 68: 400-402.
49. Lotter H, Gonzalez-Roldan N, Lindner B, Winau F, Isibasi A, et al. (2009) Natural killer T cells activated by a lipopeptidophosphoglycan from Entamoeba histolytica are critically important to control amebic liver abscess. PLoS Pathog 5: e1000434.
50. Biller L, Schmidt H, Krause E, Gelhaus C, Matthiesen J, et al. (2009) Comparison of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties. Proteomics 9: 4107-4120.
51. Diamond LS, Harlow DR, Cunnick CC, (1978) A new medium for the axenic cultivation of Entamoeba histolytica. Trans R Soc Trop Med Hyg 72: 431-432.
52. Biller L, Davis PH, Tillack M, Matthiesen J, Lotter H, et al. (2010) Differences in the transcriptome signatures of two genetically related Entamoeba histolytica cell lines derived from the same isolate with different pathogenic properties. BMC genomics 11: 63.
53. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.