The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer

Cell Reports

Volumn 14, Issue 4, 2016, Pages 920-931

  Audet Walsh, Étienne ^a   Papadopoli, David J ^a,b   Gravel, Simon Pierre ^a   Yee, Tracey ^a,b   Bridon, Gaëlle ^a   Caron, Maxime ^b   Bourque, Guillaume ^b   Giguère, Vincent ^a,b   St Pierre, Julie ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

AMPK; Folate; Metabolic reprogramming; Methotrexate; Nuclear receptor

Indexed keywords

ESTROGEN RELATED RECEPTOR ALPHA; FOLIC ACID ANTAGONIST; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METHOTREXATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; ANTINEOPLASTIC ANTIMETABOLITE; ERRALPHA ESTROGEN-RELATED RECEPTOR; ESTROGEN RECEPTOR; FOLIC ACID; PPARGC1A PROTEIN, HUMAN; PURINE; PURINE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CARBON METABOLISM; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; FOLATE CYCLE GENE; FOLATE METABOLISM; FUNCTIONAL GENOMICS; GENE; GENOME ANALYSIS; HUMAN; HUMAN CELL; METABOLOMICS; MOUSE; MTHFD1 GENE; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROMOTER REGION; PURINE SYNTHESIS; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; BREAST TUMOR; CELL LINE; DRUG RESISTANCE; FEMALE; METABOLISM; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; METHOTREXATE; MICE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PURINES; RECEPTORS, ESTROGEN; TRANSCRIPTION FACTORS;

EID: 84958111745     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.12.086     Document Type: Article

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