AMP-activated protein kinase α1 protects against diet-induced insulin resistance and obesity

Diabetes

Volumn 61, Issue 12, 2012, Pages 3114-3125

  Zhang, Weiyu ^a   Zhang, Xianling ^a,b   Wang, Huan ^a   Guo, Xin ^c   Li, Honggui ^c   Wang, Ying ^d   Xu, Xin ^a   Tan, Lyhun ^a   Mashek, Mara T ^e   Zhang, Chunxiang ^f   Chen, Yingjie ^a   Mashek, Douglas G ^e   Foretz, Marc ^g,h,i   Zhu, Chuhong ^a,j   Zhou, Huaijun ^d   Liu, Xu ^b   Viollet, Benoit ^g,h,i   Wu, Chaodong ^c   Huo, Yuqing ^a,k  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TEXAS A AND M UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f RUSH MEDICAL COLLEGE   (United States)

^g INSTITUT COCHIN   (France)

^h CNRS   (France)

ⁱ UNIVERSITÉ PARIS DESCARTES   (France)

^j THIRD MILITARY MEDICAL UNIVERSITY   (China)

^k MEDICAL COLLEGE OF GEORGIA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; AMP ACTIVATED PROTEIN KINASE ALPHA1; CCAAT ENHANCER BINDING PROTEIN ALPHA; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE MARROW; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER; MACROPHAGE; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WESTERN BLOTTING; WILD TYPE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DIET, HIGH-FAT; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84870349122     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1373     Document Type: Article

References (44)

1. Hardie DG, Hawley SA. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 2001;23:1112-1119
2. Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005;1:15-25 (Pubitemid 43960587)
3. Minokoshi Y, Alquier T, Furukawa N, et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569-574 (Pubitemid 38480541)
4. Villena JA, Viollet B, Andreelli F, Kahn A, Vaulont S, Sul HS. Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit. Diabetes 2004;53:2242-2249 (Pubitemid 39145577)
5. Viollet B, Andreelli F, Jørgensen SB, et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest 2003;111:91-98 (Pubitemid 36134852)
6. Fujii N, Ho RC, Manabe Y, et al. Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes 2008;57:2958-2966
7. Andreelli F, Foretz M, Knauf C, et al. Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. Endocrinology 2006;147:2432-2441
8. Jelenik T, Rossmeisl M, Kuda O, et al. AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids. Diabetes 2010;59:2737-2746
9. Jørgensen SB, Viollet B, Andreelli F, et al. Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. J Biol Chem 2004;279:1070-1079 (Pubitemid 38082628)
10. Zang M, Zuccollo A, Hou X, et al. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem 2004;279:47898-47905 (Pubitemid 39540941)
11. Nath N, Khan M, Rattan R, et al. Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Biochem Biophys Res Commun 2009;386:16-20
12. Wang S, Dale GL, Song P, Viollet B, Zou MH. AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. J Biol Chem 2010;285:19976-19985
13. Sag D, Carling D, Stout RD, Suttles J. Adenosine 5′-monophosphate- activated protein kinase promotes macrophage polarization to an antiinflammatory functional phenotype. J Immunol 2008;181:8633-8641
14. Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem 2010;285:19051-19059
15. Giri S, Rattan R, Haq E, et al. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab (Lond) 2006;3:31
16. Daval M, Diot-Dupuy F, Bazin R, et al. Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem 2005;280:25250-25257 (Pubitemid 40934619)
17. Huo Y, Zhao L, Hyman MC, et al. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation 2004;110:2024-2031 (Pubitemid 39331917)
18. Huo Y, Guo X, Li H, et al. Disruption of inducible 6-phosphofructo-2- kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response. J Biol Chem 2010;285: 3713-3721
19. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007;117:175-184 (Pubitemid 46048464)
20. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808 (Pubitemid 38063703)
21. Zhang W, Wang J, Wang H, et al. Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol 2010;30:1000-1006
22. Vats D, Mukundan L, Odegaard JI, et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab 2006;4:13-24 (Pubitemid 43942258)
23. Ruderman NB, Keller C, Richard AM, et al. Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes 2006;55 (Suppl. 2):S48-S54 (Pubitemid 44927032)
24. Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 2007;100:328-341
25. Baker RG, Hayden MS, Ghosh S. NF-κB, inflammation, and metabolic disease. Cell Metab 2011;13:11-22
26. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444: 860-867 (Pubitemid 46024993)
27. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006;116:1793-1801 (Pubitemid 44033299)
28. Stapleton D, Mitchelhill KI, Gao G, et al. Mammalian AMP-activated protein kinase subfamily. J Biol Chem 1996;271:611-614 (Pubitemid 26034902)
29. Verhoeven AJ, Woods A, Brennan CH, et al. The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. Eur J Biochem 1995;228:236-243
30. Kim KH. Regulation of mammalian acetyl-coenzyme A carboxylase. Annu Rev Nutr 1997;17:77-99
31. Djouder N, Tuerk RD, Suter M, et al. PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J 2010;29:469-481
32. Um JH, Park SJ, Kang H, et al. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2010;59:554-563
33. Steinberg GR, Kemp BE. AMPK in Health and Disease. Physiol Rev 2009; 89:1025-1078
34. Kaminski DA, Randall TD. Adaptive immunity and adipose tissue biology. Trends Immunol 2010;31:384-390
35. Winer S, Chan Y, Paltser G, et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 2009;15:921-929
36. Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009;15:914-920
37. Winer DA, Winer S, Shen L, et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 2011;17:610-617
38. Ohmura K, Ishimori N, Ohmura Y, et al. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arterioscler Thromb Vasc Biol 2010;30:193-199
39. Kukidome D, Nishikawa T, Sonoda K, et al. Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 2006;55: 120-127 (Pubitemid 43343306)
40. Cacicedo JM, Yagihashi N, Keaney JF Jr, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun 2004;324:1204-1209 (Pubitemid 40292150)
41. Liu C, Liang B, Wang Q, Wu J, Zou MH. Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin. J Biol Chem 2010; 285:15346-15355
42. Song P, Wang S, He C, et al. AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells. Circ Res 2011;109:1230-1239
43. Gauthier MS, O'Brien EL, Bigornia S, et al. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun 2011;404:382-387
44. Xu XJ, Gauthier MS, Hess DT, et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res 2012;53:792-801