메뉴 건너뛰기




Volumn , Issue , 2015, Pages 81-100

Solid Dispersion - a Pragmatic Method to Improve the Bioavailability of Poorly Soluble Drugs

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BALL MILLING; DISPERSIONS; DRUG DOSAGE; GLASS; GLASS TRANSITION; MELTING; MILLING (MACHINING); POLYMERS; SOLUBILITY; TARGETED DRUG DELIVERY; TEMPERATURE;

EID: 84964619483     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118573983.ch5     Document Type: Chapter
Times cited : (4)

References (81)
  • 1
    • 84655169195 scopus 로고    scopus 로고
    • Investigation of preparation methods on sur- face/bulk structural relaxation and glass fragility of amorphous solid dispersions.
    • Ke, P., Hasegawa, S., Al-Obaidi, H., Buckton G. Investigation of preparation methods on sur- face/bulk structural relaxation and glass fragility of amorphous solid dispersions. International Journal of Pharmaceutics, 2012. 422(1/2): 170-178.
    • (2012) International Journal of Pharmaceutics , vol.422 , Issue.1-2 , pp. 170-178
    • Ke, P.1    Hasegawa, S.2    Al-Obaidi, H.3    Buckton, G.4
  • 2
    • 85008071016 scopus 로고
    • Studies on absorption of eutectic mixture. 1. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man
    • Sekiguchi, K. and N. Obi, Studies on absorption of eutectic mixture. 1. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chemical and Pharmaceutical Bulletin, 1961. 9(11): 866-872.
    • (1961) Chemical and Pharmaceutical Bulletin , vol.9 , Issue.11 , pp. 866-872
    • Sekiguchi, K.1    Obi, N.2
  • 3
    • 0015124656 scopus 로고
    • Pharmaceutical applications of solid dispersion systems
    • Chiou, W.L. and Riegelman. S., Pharmaceutical applications of solid dispersion systems. Journal of Pharmaceutical Sciences, 1971. 60(9): 1281-1302.
    • (1971) Journal of Pharmaceutical Sciences , vol.60 , Issue.9 , pp. 1281-1302
    • Chiou, W.L.1    Riegelman, S.2
  • 4
    • 33847613587 scopus 로고    scopus 로고
    • Factors affecting the formation of eutectic solid dispersions and their dissolution behavior
    • Vippagunta, S.R., Z. Wang, S. Hornung, et al., Factors affecting the formation of eutectic solid dispersions and their dissolution behavior. Journal of Pharmaceutical Sciences, 2007. 96(2): 294-304.
    • (2007) Journal of Pharmaceutical Sciences , vol.96 , Issue.2 , pp. 294-304
    • Vippagunta, S.R.1    Wang, Z.2    Hornung, S.3
  • 6
    • 36549042006 scopus 로고    scopus 로고
    • Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
    • Vasconcelos, T., B. Sarmento, and P. Costa, Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discovery Today, 2007, 12(23/24): 1068-1075.
    • (2007) Drug Discovery Today , vol.12 , Issue.23-24 , pp. 1068-1075
    • Vasconcelos, T.1    Sarmento, B.2    Costa, P.3
  • 7
    • 0000538772 scopus 로고
    • Properties of fused mannitol in compressed tablets
    • Kanig, J.L., Properties of fused mannitol in compressed tablets. Journal of Pharmaceutical Sciences, 1964. 53: 188-192.
    • (1964) Journal of Pharmaceutical Sciences , vol.53 , pp. 188-192
    • Kanig, J.L.1
  • 8
    • 0014628768 scopus 로고
    • Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin
    • Chiou, W.L. and S. Riegelman, Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin. Journal of Pharmaceutical Sciences, 1969. 58(12): 1505-1510.
    • (1969) Journal of Pharmaceutical Sciences , vol.58 , Issue.12 , pp. 1505-1510
    • Chiou, W.L.1    Riegelman, S.2
  • 9
    • 1942434691 scopus 로고    scopus 로고
    • Development of clinical dosage forms for a poorly water soluble drug I: application of polyethylene glycol-polysorbate 80 solid dispersion carrier system
    • Dannenfelser, R.M., H. He, Y. Joshi, et al., Development of clinical dosage forms for a poorly water soluble drug I: application of polyethylene glycol-polysorbate 80 solid dispersion carrier system. Journal of Pharmaceutical Sciences, 2004. 93(5): 1165-1175.
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.5 , pp. 1165-1175
    • Dannenfelser, R.M.1    He, H.2    Joshi, Y.3
  • 10
    • 84889087023 scopus 로고    scopus 로고
    • Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs
    • Vo, C.L.N., C. Park, and B.J. Lee, Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics, 2013. 85(3, Pt. B): 799-813.
    • (2013) European Journal of Pharmaceutics and Biopharmaceutics , vol.85 , pp. 799-813
    • Vo, C.L.N.1    Park, C.2    Lee, B.J.3
  • 11
    • 0032885450 scopus 로고    scopus 로고
    • Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs
    • Serajuddin, A.T.M., Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. Journal of Pharmaceutical Sciences, 1999. 88(10): 1058-1066.
    • (1999) Journal of Pharmaceutical Sciences , vol.88 , Issue.10 , pp. 1058-1066
    • Serajuddin, A.T.M.1
  • 12
    • 34047252848 scopus 로고    scopus 로고
    • Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling
    • Patterson, J.E., M. B. James, A. H. Forster, et al., Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling. International Journal of Pharmaceutics, 2007. 336(1): 22-34.
    • (2007) International Journal of Pharmaceutics , vol.336 , Issue.1 , pp. 22-34
    • Patterson, J.E.1    James, M.B.2    Forster, A.H.3
  • 13
    • 33750430305 scopus 로고    scopus 로고
    • Industrially feasible alternative approaches in the manufacture of solid dispersions: a technical report
    • Karanth, H., V.S. Shenoy, and R.R. Murthy, Industrially feasible alternative approaches in the manufacture of solid dispersions: a technical report. AAPS PharmSciTech, 2006. 7(4): 8.
    • (2006) AAPS PharmSciTech , vol.7 , Issue.4 , pp. 8
    • Karanth, H.1    Shenoy, V.S.2    Murthy, R.R.3
  • 17
    • 23944480400 scopus 로고    scopus 로고
    • Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process
    • Won, D.H., Kim M.S., Lee S., et al., Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process. International Journal of Pharmaceutics, 2005. 301(1/2): 199-208.
    • (2005) International Journal of Pharmaceutics , vol.301 , Issue.1-2 , pp. 199-208
    • Won, D.H.1    Kim, M.S.2    Lee, S.3
  • 18
    • 64649086799 scopus 로고    scopus 로고
    • Solid state amorphization of pharmaceuticals
    • Willart, J.F. and M. Descamps, Solid state amorphization of pharmaceuticals. Molecular Pharmaceutics, 2008. 5(6): 905-920.
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.6 , pp. 905-920
    • Willart, J.F.1    Descamps, M.2
  • 19
    • 0037369754 scopus 로고    scopus 로고
    • Formation of physically stable amorphous drugs by milling with neusilin
    • Gupta, M.K., A. Vanwert, and R.H. Bogner, Formation of physically stable amorphous drugs by milling with neusilin. Journal of Pharmaceutical Sciences, 2003. 92(3): 536-551.
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.3 , pp. 536-551
    • Gupta, M.K.1    Vanwert, A.2    Bogner, R.H.3
  • 20
    • 84903955078 scopus 로고    scopus 로고
    • Thermodynamic phase behavior of API/polymer solid dispersions
    • Prudic, A., Y. Ji, and G. Sadowski, Thermodynamic phase behavior of API/polymer solid dispersions. Molecular Pharmaceutics, 2014. 11(7): 2294-2304.
    • (2014) Molecular Pharmaceutics , vol.11 , Issue.7 , pp. 2294-2304
    • Prudic, A.1    Ji, Y.2    Sadowski, G.3
  • 22
    • 84869090387 scopus 로고    scopus 로고
    • Investigating the molecular structures of solid dispersions by the simulated annealing method
    • Ouyang, D., Investigating the molecular structures of solid dispersions by the simulated annealing method. Chemical Physics Letters, 2012. 554: 177-184.
    • (2012) Chemical Physics Letters , vol.554 , pp. 177-184
    • Ouyang, D.1
  • 24
    • 0037452415 scopus 로고    scopus 로고
    • Investigations on the predictability of the formation of glassy solid solutions of drugs in sugar alcohols
    • Langer, M., Holtje M., Urbanetz N.A., et al., Investigations on the predictability of the formation of glassy solid solutions of drugs in sugar alcohols. International Journal of Pharmaceutics, 2003. 252(1/2): 167-179.
    • (2003) International Journal of Pharmaceutics , vol.252 , Issue.1-2 , pp. 167-179
    • Langer, M.1    Holtje, M.2    Urbanetz, N.A.3
  • 25
    • 0346492937 scopus 로고    scopus 로고
    • Molecular dynamics simulation studies of binary blend miscibility of poly(3-hydroxybutyrate) and poly(ethylene oxide)
    • Yang, H., L. Ze-Sheng, H. Qian, et al., Molecular dynamics simulation studies of binary blend miscibility of poly(3-hydroxybutyrate) and poly(ethylene oxide). Polymer, 2004. 45(2): 453-457.
    • (2004) Polymer , vol.45 , Issue.2 , pp. 453-457
    • Yang, H.1    Ze-Sheng, L.2    Qian, H.3
  • 26
    • 20044367144 scopus 로고    scopus 로고
    • Interactions of poly(vinylpyrrolidone) with ibuprofen and naproxen: experimental and modeling studies
    • Bogdanova, S., Pajeva, I. Nikolova, P., et al., Interactions of poly(vinylpyrrolidone) with ibuprofen and naproxen: experimental and modeling studies. Pharmaceutical Research, 2005. 22(5): 806-815.
    • (2005) Pharmaceutical Research , vol.22 , Issue.5 , pp. 806-815
    • Bogdanova, S.1    Pajeva Nikolova, P.I.2
  • 27
    • 14644406137 scopus 로고    scopus 로고
    • Molecular interactions in celecoxib-PVP-meglumine amorphous system
    • Gupta, P. and A.K. Bansal, Molecular interactions in celecoxib-PVP-meglumine amorphous system. Journal of Pharmacy and Pharmacology, 2005. 57(3): 303-310.
    • (2005) Journal of Pharmacy and Pharmacology , vol.57 , Issue.3 , pp. 303-310
    • Gupta, P.1    Bansal, A.K.2
  • 28
    • 27144512688 scopus 로고    scopus 로고
    • Role of molecular interaction in stability of celecoxib-PVP amorphous systems
    • Gupta, P., Thilagavathi R., Chakraborti A.K., et al., Role of molecular interaction in stability of celecoxib-PVP amorphous systems. Molecular Pharmaceutics, 2005. 2(5): 384-391.
    • (2005) Molecular Pharmaceutics , vol.2 , Issue.5 , pp. 384-391
    • Gupta, P.1    Thilagavathi, R.2    Chakraborti, A.K.3
  • 29
    • 34249092945 scopus 로고    scopus 로고
    • Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions
    • Karavas, E., Georgarakis E., Sigalas M.P., et al., Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions. European Journal of Pharmaceutics and Biopharmaceutics, 2007. 66(3): 334-347.
    • (2007) European Journal of Pharmaceutics and Biopharmaceutics , vol.66 , Issue.3 , pp. 334-347
    • Karavas, E.1    Georgarakis, E.2    Sigalas, M.P.3
  • 30
    • 70349649718 scopus 로고    scopus 로고
    • Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: a multi-methodological approach
    • Gashi, Z., Censi R., Malaj L., et al., Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: a multi-methodological approach. Journal of Pharmaceutical Sciences, 2009. 98(11): 4216-4228.
    • (2009) Journal of Pharmaceutical Sciences , vol.98 , Issue.11 , pp. 4216-4228
    • Gashi, Z.1    Censi, R.2    Malaj, L.3
  • 31
    • 71349085014 scopus 로고    scopus 로고
    • A theoretical study of red-shifting and blue- shifting hydrogen bonds occurring between imidazolidine derivatives and PEG/PVP polymers
    • Oliveira, B.G., Lima, M.C.A., Pitta, I.R., et al., A theoretical study of red-shifting and blue- shifting hydrogen bonds occurring between imidazolidine derivatives and PEG/PVP polymers. Journal of Molecular Modelling, 2010. 16(1): 119-127.
    • (2010) Journal of Molecular Modelling , vol.16 , Issue.1 , pp. 119-127
    • Oliveira, B.G.1    Lima, M.C.A.2    Pitta, I.R.3
  • 32
    • 79952259745 scopus 로고    scopus 로고
    • Prediction of solubility parameters and miscibility of pharmaceutical compounds by molecular dynamics simulations
    • Gupta, J., Nunes C., Vyas S., et al., Prediction of solubility parameters and miscibility of pharmaceutical compounds by molecular dynamics simulations. Journal of Physical Chemistry B, 2011. 115(9): 2014-2023.
    • (2011) Journal of Physical Chemistry B , vol.115 , Issue.9 , pp. 2014-2023
    • Gupta, J.1    Nunes, C.2    Vyas, S.3
  • 33
    • 10644231005 scopus 로고    scopus 로고
    • Role of blooming in determining the storage stability of lipid- based dosage forms
    • Khan, N. and D.Q.M. Craig, Role of blooming in determining the storage stability of lipid- based dosage forms. Journal of Pharmaceutical Sciences, 2004. 93(12): 2962-2971.
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.12 , pp. 2962-2971
    • Khan, N.1    Craig, D.Q.M.2
  • 34
    • 0023947965 scopus 로고
    • Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)
    • Prentis, R.A., Y. Lis, and S.R. Walker, Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985). British Journal of Clinical Pharmacology, 1988. 25(3): 387-396.
    • (1988) British Journal of Clinical Pharmacology , vol.25 , Issue.3 , pp. 387-396
    • Prentis, R.A.1    Lis, Y.2    Walker, S.R.3
  • 37
    • 84877921505 scopus 로고    scopus 로고
    • Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations
    • Paudel, A., Worku Z.A., Meeus J., et al., Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations. International Journal of Pharmaceutics, 2012. 453(1): 253-284.
    • (2012) International Journal of Pharmaceutics , vol.453 , Issue.1 , pp. 253-284
    • Paudel, A.1    Worku, Z.A.2    Meeus, J.3
  • 38
    • 77951652381 scopus 로고    scopus 로고
    • The influence of heterogeneous nucleation on the surface crystallization of guaifenesin from melt extrudates containing EudragitA(r) L10055 or Acryl-EZEA(r)
    • Bruce, C.D., Fegely K.A., Rajabi-Siahboomi A.R., et al., The influence of heterogeneous nucleation on the surface crystallization of guaifenesin from melt extrudates containing EudragitA(r) L10055 or Acryl-EZEA(r). European Journal of Pharmaceutics and Biopharmaceutics, 2010. 75(1): 71-78.
    • (2010) European Journal of Pharmaceutics and Biopharmaceutics , vol.75 , Issue.1 , pp. 71-78
    • Bruce, C.D.1    Fegely, K.A.2    Rajabi-Siahboomi, A.R.3
  • 39
    • 0029056710 scopus 로고
    • Dielectric analysis in the characterization of amorphous pharmaceutical solids. 1. Molecular mobility in poly(vinylpyrrolidone) - Water systems in the glassy state
    • Duddu, S.P. and T.D. Sokoloski, Dielectric analysis in the characterization of amorphous pharmaceutical solids. 1. Molecular mobility in poly(vinylpyrrolidone) - Water systems in the glassy state. Journal of Pharmaceutical Sciences, 1995. 84(6): 773-776.
    • (1995) Journal of Pharmaceutical Sciences , vol.84 , Issue.6 , pp. 773-776
    • Duddu, S.P.1    Sokoloski, T.D.2
  • 40
    • 64649098724 scopus 로고    scopus 로고
    • Thermodynamics, molecular mobility and crystallization kinetics of amorphous griseofulvin
    • Zhou, D., Zhang G.G., Law D., et al., Thermodynamics, molecular mobility and crystallization kinetics of amorphous griseofulvin. Molecular Pharmaceutics, 2008. 5(6): 927-936.
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.6 , pp. 927-936
    • Zhou, D.1    Zhang, G.G.2    Law, D.3
  • 41
    • 68949119479 scopus 로고    scopus 로고
    • Amorphous drug-PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state
    • Tobyn, M., Brown J., Dennis A.B., et al., Amorphous drug-PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in both the crystalline and pure amorphous state. Journal of Pharmaceutical Sciences, 2009. 98(9): 3456-3468.
    • (2009) Journal of Pharmaceutical Sciences , vol.98 , Issue.9 , pp. 3456-3468
    • Tobyn, M.1    Brown, J.2    Dennis, A.B.3
  • 42
    • 0033663452 scopus 로고    scopus 로고
    • Physical stabilisation of amorphous ketocon- azole in solid dispersions with polyvinylpyrrolidone K25
    • Van den Mooter, G., Wuyts M., Blaton N., et al., Physical stabilisation of amorphous ketocon- azole in solid dispersions with polyvinylpyrrolidone K25. European Journal of Pharmaceutical Sciences, 2000. 12(3): 261-269.
    • (2000) European Journal of Pharmaceutical Sciences , vol.12 , Issue.3 , pp. 261-269
    • Van den Mooter, G.1    Wuyts, M.2    Blaton, N.3
  • 43
    • 0033844801 scopus 로고    scopus 로고
    • An evaluation of the use of modulated temperature DSC as a means of assessing the relaxation behaviour of amorphous lactose
    • Craig, D.Q.M., Barsnes M., Royall P.G., et al., An evaluation of the use of modulated temperature DSC as a means of assessing the relaxation behaviour of amorphous lactose. Pharmaceutical Research, 2000. 17(6): 696-700.
    • (2000) Pharmaceutical Research , vol.17 , Issue.6 , pp. 696-700
    • Craig, D.Q.M.1    Barsnes, M.2    Royall, P.G.3
  • 44
    • 0028268210 scopus 로고
    • The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids
    • Hancock, B.C. and G. Zografi, The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids. Pharmaceutical Research, 1994. 11(4): 471-477.
    • (1994) Pharmaceutical Research , vol.11 , Issue.4 , pp. 471-477
    • Hancock, B.C.1    Zografi, G.2
  • 45
    • 0033624390 scopus 로고    scopus 로고
    • Crystallization inhibiton in solid dispersions of MK-0591 and poly(vinylpyrrolidone) polymers
    • Khougaz, K. and S.D. Clas, Crystallization inhibiton in solid dispersions of MK-0591 and poly(vinylpyrrolidone) polymers. Journal of Pharmaceutical Sciences, 2000. 89(10): 1325-1334.
    • (2000) Journal of Pharmaceutical Sciences , vol.89 , Issue.10 , pp. 1325-1334
    • Khougaz, K.1    Clas, S.D.2
  • 47
    • 0031099816 scopus 로고    scopus 로고
    • Frozen state transitions in relation to freeze drying
    • Roos, Y.H., Frozen state transitions in relation to freeze drying. Journal of Thermal Analysis, 1997. 48(3): 535-544.
    • (1997) Journal of Thermal Analysis , vol.48 , Issue.3 , pp. 535-544
    • Roos, Y.H.1
  • 48
    • 0029015405 scopus 로고
    • Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures
    • Hancock, B.C., S.L. Shamblin, and G. Zografi, Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharmaceutical Research, 1995. 12(6): 799-806.
    • (1995) Pharmaceutical Research , vol.12 , Issue.6 , pp. 799-806
    • Hancock, B.C.1    Shamblin, S.L.2    Zografi, G.3
  • 49
    • 0001300435 scopus 로고
    • Effects of annealing and prior history on enthalpy relaxation in glassy polymers. 6. Adam-Gibbs formulation of nonlinearity
    • Hodge, I.M., Effects of annealing and prior history on enthalpy relaxation in glassy polymers. 6. Adam-Gibbs formulation of nonlinearity. Macromolecules, 1987. 20(11): 2897-2908.
    • (1987) Macromolecules , vol.20 , Issue.11 , pp. 2897-2908
    • Hodge, I.M.1
  • 50
    • 0842283231 scopus 로고    scopus 로고
    • Molecular mobility-based estimation of the crystallization rates of amorphous nifedipine and phenobarbital in poly(vinylpyrrolidone) solid dispersions
    • Aso, Y., S. Yoshioka, and S. Kojima, Molecular mobility-based estimation of the crystallization rates of amorphous nifedipine and phenobarbital in poly(vinylpyrrolidone) solid dispersions. Journal of Pharmaceutical Sciences, 2004. 93(2): 384-391.
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.2 , pp. 384-391
    • Aso, Y.1    Yoshioka, S.2    Kojima, S.3
  • 51
    • 0012549316 scopus 로고    scopus 로고
    • Annealing of a glycerol glass: enthalpy, fictive temperature and glass transition temperature change with annealing parameters
    • Claudy, P., S. Jabrane, and J.M. Letoffe, Annealing of a glycerol glass: enthalpy, fictive temperature and glass transition temperature change with annealing parameters. Thermochimica Acta, 1997. 293(1/2): 1-11.
    • (1997) Thermochimica Acta , vol.293 , Issue.1-2 , pp. 1-11
    • Claudy, P.1    Jabrane, S.2    Letoffe, J.M.3
  • 52
    • 34250731349 scopus 로고    scopus 로고
    • The glass transition temperature versus the fictive temperature
    • Badrinarayanan, P., W. Zheng, Q. Li, et al., The glass transition temperature versus the fictive temperature. Journal of Non-Crystalline Solids, 2007. 353(26): 2603-2612.
    • (2007) Journal of Non-Crystalline Solids , vol.353 , Issue.26 , pp. 2603-2612
    • Badrinarayanan, P.1    Zheng, W.2    Li, Q.3
  • 53
    • 0030638567 scopus 로고    scopus 로고
    • Characteristics and significance of the amorphous state in pharmaceutical systems
    • Hancock, B.C. and G. Zografi, Characteristics and significance of the amorphous state in pharmaceutical systems. Journal of Pharmaceutical Sciences, 1997. 86(1): 1-12.
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.1 , pp. 1-12
    • Hancock, B.C.1    Zografi, G.2
  • 54
  • 55
    • 33749439050 scopus 로고    scopus 로고
    • Predictions of onset of crystallization from experimental relaxation times I-correlation of molecular mobility from temperatures above the glass transition to temperatures below the glass transition
    • Bhugra, C.,Shmeis R., Krill S.L., et al., Predictions of onset of crystallization from experimental relaxation times I-correlation of molecular mobility from temperatures above the glass transition to temperatures below the glass transition. Pharmaceutical Research, 2006. 23(10): 2277-2290.
    • (2006) Pharmaceutical Research , vol.23 , Issue.10 , pp. 2277-2290
    • Bhugra, C.1    Shmeis, R.2    Krill, S.L.3
  • 56
    • 67049143086 scopus 로고    scopus 로고
    • Determination of the structural relaxation at the surface of amorphous solid dispersion using inverse gas chromatography
    • Hasegawa, S., P. Ke, and G. Buckton, Determination of the structural relaxation at the surface of amorphous solid dispersion using inverse gas chromatography. Journal of Pharmaceutical Sciences, 2009. 98(6): 2133-2139.
    • (2009) Journal of Pharmaceutical Sciences , vol.98 , Issue.6 , pp. 2133-2139
    • Hasegawa, S.1    Ke, P.2    Buckton, G.3
  • 57
    • 77953296607 scopus 로고    scopus 로고
    • Drug-polymer solubility and miscibility: stability consideration and practical challenges in amorphous solid dispersion development
    • Qian, F., J. Huang, and M.A. Hussain, Drug-polymer solubility and miscibility: stability consideration and practical challenges in amorphous solid dispersion development. Journal of Pharmaceutical Sciences, 2010. 99(7): p. 2941-2947.
    • (2010) Journal of Pharmaceutical Sciences , vol.99 , Issue.7 , pp. 2941-2947
    • Qian, F.1    Huang, J.2    Hussain, M.A.3
  • 58
    • 43349097105 scopus 로고    scopus 로고
    • Ability of different polymers to inhibit the crystallization of amorphous felodipine in the presence of moisture
    • Konno, H. and L.S. Taylor, Ability of different polymers to inhibit the crystallization of amorphous felodipine in the presence of moisture. Pharmaceutical Research, 2008. 25(4): 969-978.
    • (2008) Pharmaceutical Research , vol.25 , Issue.4 , pp. 969-978
    • Konno, H.1    Taylor, L.S.2
  • 59
    • 0025102704 scopus 로고
    • The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state
    • Ahlneck, C. and G. Zografi, The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state. International Journal of Pharmaceutics, 1990. 62(2/3): 87-95.
    • (1990) International Journal of Pharmaceutics , vol.62 , Issue.2-3 , pp. 87-95
    • Ahlneck, C.1    Zografi, G.2
  • 60
    • 55749113671 scopus 로고    scopus 로고
    • Miscibility and interactions between 1712- estradiol and EudragitA(r) RS in solid dispersion
    • Wiranidchapong, C., Tucker I.G., Rades T., et al., Miscibility and interactions between 1712- estradiol and EudragitA(r) RS in solid dispersion. Journal of Pharmaceutical Sciences, 2008. 97(11): 4879-4888.
    • (2008) Journal of Pharmaceutical Sciences , vol.97 , Issue.11 , pp. 4879-4888
    • Wiranidchapong, C.1    Tucker, I.G.2    Rades, T.3
  • 61
    • 70350220585 scopus 로고    scopus 로고
    • Evaluation of drug-polymer miscibility in amorphous solid dispersion systems
    • Rumondor, A.C.F., Ivanisevic I., Bates S., et al., Evaluation of drug-polymer miscibility in amorphous solid dispersion systems. Pharmaceutical Research, 2009. 26(11): 2523-2534.
    • (2009) Pharmaceutical Research , vol.26 , Issue.11 , pp. 2523-2534
    • Rumondor, A.C.F.1    Ivanisevic, I.2    Bates, S.3
  • 62
    • 67049162360 scopus 로고    scopus 로고
    • Improved physical stability of amorphous state through acid base interactions
    • Telang, C., S. Mujumdar, and M. Mathew, Improved physical stability of amorphous state through acid base interactions. Journal of Pharmaceutical Sciences, 2009. 98(6): 2149-2159.
    • (2009) Journal of Pharmaceutical Sciences , vol.98 , Issue.6 , pp. 2149-2159
    • Telang, C.1    Mujumdar, S.2    Mathew, M.3
  • 63
    • 0036104692 scopus 로고    scopus 로고
    • A spectroscopic investigation of hydrogen bond patterns in crystalline and amorphous phases in dihydropyridine calcium channel blockers
    • Tang, X.C., M.J. Pikal, and L.S. Taylor, A spectroscopic investigation of hydrogen bond patterns in crystalline and amorphous phases in dihydropyridine calcium channel blockers. Pharmaceutical Research, 2002. 19(4): 477-483.
    • (2002) Pharmaceutical Research , vol.19 , Issue.4 , pp. 477-483
    • Tang, X.C.1    Pikal, M.J.2    Taylor, L.S.3
  • 64
    • 38349182320 scopus 로고    scopus 로고
    • Drug-polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend
    • Huang, J., R.J. Wigent, and J.B. Schwartz, Drug-polymer interaction and its significance on the physical stability of nifedipine amorphous dispersion in microparticles of an ammonio methacrylate copolymer and ethylcellulose binary blend. Journal of Pharmaceutical Sciences, 2008. 97(1): 251-262.
    • (2008) Journal of Pharmaceutical Sciences , vol.97 , Issue.1 , pp. 251-262
    • Huang, J.1    Wigent, R.J.2    Schwartz, J.B.3
  • 65
    • 84879126587 scopus 로고    scopus 로고
    • Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films
    • Ng, Y.C., Yang Z., McAuley W.J., et al., Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films. European Journal of Pharmaceutics and Biopharmaceutics, 2013. 84(3): 555-565.
    • (2013) European Journal of Pharmaceutics and Biopharmaceutics , vol.84 , Issue.3 , pp. 555-565
    • Ng, Y.C.1    Yang, Z.2    McAuley, W.J.3
  • 66
    • 33846256269 scopus 로고    scopus 로고
    • Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine
    • Konno, H. and L.S. Taylor, Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine. Journal of Pharmaceutical Sciences, 2006. 95(12): 2692-2705.
    • (2006) Journal of Pharmaceutical Sciences , vol.95 , Issue.12 , pp. 2692-2705
    • Konno, H.1    Taylor, L.S.2
  • 67
    • 77950549481 scopus 로고    scopus 로고
    • Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture
    • Rumondor, A.C.F. and L.S. Taylor, Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture. Molecular Pharmaceutics, 2010. 7(2): 477-490.
    • (2010) Molecular Pharmaceutics , vol.7 , Issue.2 , pp. 477-490
    • Rumondor, A.C.F.1    Taylor, L.S.2
  • 68
    • 84874599515 scopus 로고    scopus 로고
    • Early stage phase separation in pharmaceutical solid dispersion thin films under high humidity: improved spatial understanding using probe-based thermal and spectroscopic nanocharacterization methods
    • Qi, S., J.G. Moffat, and Z. Yang, Early stage phase separation in pharmaceutical solid dispersion thin films under high humidity: improved spatial understanding using probe-based thermal and spectroscopic nanocharacterization methods. Molecular Pharmaceutics, 2013. 10(3): 918-930.
    • (2013) Molecular Pharmaceutics , vol.10 , Issue.3 , pp. 918-930
    • Qi, S.1    Moffat, J.G.2    Yang, Z.3
  • 69
    • 78449288962 scopus 로고    scopus 로고
    • Detection of phase separation in hot melt extruded solid dispersion formulations: global vs. localized characterization
    • Qi, S. and D.Q.M. Craig, Detection of phase separation in hot melt extruded solid dispersion formulations: global vs. localized characterization. American Pharmaceutical Review, 2010. 13(6): 68-74.
    • (2010) American Pharmaceutical Review , vol.13 , Issue.6 , pp. 68-74
    • Qi, S.1    Craig, D.Q.M.2
  • 70
    • 21244448416 scopus 로고    scopus 로고
    • Multivariate data analysis for Raman imaging of a model pharmaceutical tablet
    • Zhang, L., M.J. Henson, and S.S. Sekulic, Multivariate data analysis for Raman imaging of a model pharmaceutical tablet. Analytica Chimica Acta, 2005. 545(2): 262-278.
    • (2005) Analytica Chimica Acta , vol.545 , Issue.2 , pp. 262-278
    • Zhang, L.1    Henson, M.J.2    Sekulic, S.S.3
  • 71
    • 70349327387 scopus 로고    scopus 로고
    • Raman microscopic evaluation of technology dependent structural differences in tablets containing imipramine model drug
    • Vajna, B., Farkas I., Szabo A., et al., Raman microscopic evaluation of technology dependent structural differences in tablets containing imipramine model drug. Journal of Pharmaceutical and Biomedical Analysis, 2010. 51(1): 30-38.
    • (2010) Journal of Pharmaceutical and Biomedical Analysis , vol.51 , Issue.1 , pp. 30-38
    • Vajna, B.1    Farkas, I.2    Szabo, A.3
  • 72
    • 77954309104 scopus 로고    scopus 로고
    • Release mechanisms of acetaminophen from polyethylene oxide/polyethylene glycol matrix tablets utilizing magnetic resonance imaging
    • Tajiri, T., Morita S., Sakamoto R., et al., Release mechanisms of acetaminophen from polyethylene oxide/polyethylene glycol matrix tablets utilizing magnetic resonance imaging. International Journal of Pharmaceutics, 2010. 395(1/2): 147-153.
    • (2010) International Journal of Pharmaceutics , vol.395 , Issue.1-2 , pp. 147-153
    • Tajiri, T.1    Morita, S.2    Sakamoto, R.3
  • 73
    • 78650039081 scopus 로고    scopus 로고
    • Physicochemical properties of the amorphous drug, cast films, and spray dried powders to predict formulation probability of success for solid dispersions: etravirine
    • Weuts, I., Van Dycke F., Voorspoels J., et al., Physicochemical properties of the amorphous drug, cast films, and spray dried powders to predict formulation probability of success for solid dispersions: etravirine. Journal of Pharmaceutical Sciences, 2011. 100(1): 260-274.
    • (2011) Journal of Pharmaceutical Sciences , vol.100 , Issue.1 , pp. 260-274
    • Weuts, I.1    Van Dycke, F.2    Voorspoels, J.3
  • 74
    • 69549116454 scopus 로고    scopus 로고
    • Nanoscale thermal analysis of pharmaceutical solid dispersions
    • Zhang, J., Bunker M., Chen X., et al., Nanoscale thermal analysis of pharmaceutical solid dispersions. International Journal of Pharmaceutics, 2009. 380(1/2): 170-173.
    • (2009) International Journal of Pharmaceutics , vol.380 , Issue.1-2 , pp. 170-173
    • Zhang, J.1    Bunker, M.2    Chen, X.3
  • 75
    • 40849119736 scopus 로고    scopus 로고
    • Characterisation of solid dispersions of paracetamol and EUDRAGITA(r) E prepared by hot-melt extrusion using thermal, microthermal and spectro] scopic analysis
    • Qi, S., Gryczke A., Belton P., et al., Characterisation of solid dispersions of paracetamol and EUDRAGITA(r) E prepared by hot-melt extrusion using thermal, microthermal and spectro] scopic analysis. International Journal of Pharmaceutics, 2008. 354(1/2): 158-167.
    • (2008) International Journal of Pharmaceutics , vol.354 , Issue.1-2 , pp. 158-167
    • Qi, S.1    Gryczke, A.2    Belton, P.3
  • 76
    • 77955471047 scopus 로고    scopus 로고
    • Characterisation and prediction of phase separation in hot-melt extruded solid dispersions: a thermal, microscopic and NMR relaxometry study
    • Qi, S., Belton P., Nollenberger K., et al., Characterisation and prediction of phase separation in hot-melt extruded solid dispersions: a thermal, microscopic and NMR relaxometry study. Pharmaceutical Research, 2010. 27(9): 1869-1883.
    • (2010) Pharmaceutical Research , vol.27 , Issue.9 , pp. 1869-1883
    • Qi, S.1    Belton, P.2    Nollenberger, K.3
  • 77
    • 80054726007 scopus 로고    scopus 로고
    • Compositional analysis of low quantities of phase separation in hot-melt-extruded solid dispersions: a combined atomic force microscopy, photothermal Fourier-transform infrared microspectroscopy, and localised thermal analysis approach
    • Qi, S., Belton P., Nollenberger K., et al., Compositional analysis of low quantities of phase separation in hot-melt-extruded solid dispersions: a combined atomic force microscopy, photothermal Fourier-transform infrared microspectroscopy, and localised thermal analysis approach. Pharmaceutical Research, 2011. 28(9): 2311-2326.
    • (2011) Pharmaceutical Research , vol.28 , Issue.9 , pp. 2311-2326
    • Qi, S.1    Belton, P.2    Nollenberger, K.3
  • 78
    • 40849094363 scopus 로고    scopus 로고
    • The development of microthermal analysis and photothermal microspectroscopy as novel approaches to drug-excipient compatibility studies
    • Harding, L., Qi S., Hill G., et al., The development of microthermal analysis and photothermal microspectroscopy as novel approaches to drug-excipient compatibility studies. International Journal of Pharmaceutics, 2008. 354(1/2): 149-157.
    • (2008) International Journal of Pharmaceutics , vol.354 , Issue.1-2 , pp. 149-157
    • Harding, L.1    Qi, S.2    Hill, G.3
  • 79
    • 68849132236 scopus 로고    scopus 로고
    • Thermal probe based analytical microscopy: thermal analysis and photothermal Fourier-transform infrared microspectroscopy together with thermally assisted nanosampling coupled with capillary electrophoresis
    • Dai, X., Moffat J.G., Mayes A.G., et al., Thermal probe based analytical microscopy: thermal analysis and photothermal Fourier-transform infrared microspectroscopy together with thermally assisted nanosampling coupled with capillary electrophoresis. Analytical Chemistry, 2009. 81(16): 6612-6619.
    • (2009) Analytical Chemistry , vol.81 , Issue.16 , pp. 6612-6619
    • Dai, X.1    Moffat, J.G.2    Mayes, A.G.3
  • 80
    • 84879730846 scopus 로고    scopus 로고
    • Microstructure of an immiscible polymer blend and its stabilization effect on amorphous solid dispersions
    • Yang, Z., Nollenberger, K., Albers, J., Craig, D., Qi, S., Microstructure of an immiscible polymer blend and its stabilization effect on amorphous solid dispersions. Molecular Pharmaceutics, 2013. 10(7): 2767-2780.
    • (2013) Molecular Pharmaceutics , vol.10 , Issue.7 , pp. 2767-2780
    • Yang, Z.1    Nollenberger, K.2    Albers, J.3    Craig, D.4    Qi, S.5
  • 81
    • 70949102033 scopus 로고    scopus 로고
    • Electrospun nanofiber-based drug delivery systems
    • Yu, D.G., Zhu, L.-M., White, K., et al., Electrospun nanofiber-based drug delivery systems. Health, 2009. 1(2): 67-75.
    • (2009) Health , vol.1 , Issue.2 , pp. 67-75
    • Yu, D.G.1    Zhu, L.-M.2    White, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.