Release mechanisms of acetaminophen from polyethylene oxide/polyethylene glycol matrix tablets utilizing magnetic resonance imaging

International Journal of Pharmaceutics

Volumn 395, Issue 1-2, 2010, Pages 147-153

  Tajiri, Tomokazu ^a,b   Morita, Shigeaki ^c   Sakamoto, Ryosaku ^a   Suzuki, Masazumi ^a   Yamanashi, Shigeyuki ^a   Ozaki, Yukihiro ^b   Kitamura, Satoshi ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b KWANSEI GAKUIN UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Controlled release tablets; Flow through cell dissolution apparatus; Hydrogel polymer matrix tablets; Magnetic resonance imaging (MRI); Polyethylene oxide (PEO) polyethylene glycol (PEG); Size exclusion chromatography (SEC)

Indexed keywords

MACROGOL; MACROGOL 6000; PARACETAMOL; POLYOX N60K; POLYOX WSR 303; UNCLASSIFIED DRUG; ANALGESIC AGENT; DELAYED RELEASE FORMULATION; DRUG CARRIER; HYDROGEL; MACROGOL DERIVATIVE; TABLET;

ARTICLE; CORRELATION ANALYSIS; DRUG RELEASE; DRUG SOLUBILITY; GEL PERMEATION CHROMATOGRAPHY; HYDROGEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SUSTAINED RELEASE FORMULATION; TABLET; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG FORMULATION; GEL CHROMATOGRAPHY; INFRARED SPECTROSCOPY; KINETICS; MEDICINAL CHEMISTRY; PHARMACEUTICS; PROCEDURES; SOLUBILITY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GEL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; HYDROGELS; KINETICS; MAGNETIC RESONANCE IMAGING; POLYETHYLENE GLYCOLS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 77954309104     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.05.021     Document Type: Article

References (38)

1. Abrahmsén-Alami S., Körner A., Nilsson I., Larsson A. New release cell for NMR microimaging of tablets Swelling and erosion of poly(ethylene oxide). Int. J. Pharm. 2007, 342:105-114.
2. Alderman D.A. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int. J. Pharm. 1984, 5:1-9.
3. 1H NMR and MRI methods. Eur. J. Pharm. Biopharm. 2005, 59:299-306.
4. Brubach J.B., Ollivon M., Jannin V., Mahler B., Bourgaux C., Lesieur P., Roy P. Structural and thermal characterization of mono- and diacyl polyoxyethylene glycol by infrared spectroscopy and X-ray diffraction coupled to differential calorimetry. J. Phys. Chem. B 2004, 108:17721-17729.
5. Dorozyński P., Kulinowski P., Jachowicz R., Jasiński A. Development of a system for simultaneous dissolution studies and magnetic resonance imaging of water transport in hydrodynamically balanced systems: a technical note. AAPS PharmSciTech 2007, 8:E1-E4. (art no. 15).
6. European Pharmacopoeia, sixth ed., 2007. European Directorate for the Quality of Medicines, pp. 266-275.
7. Ford J.L., Rubinstein M.H., Hogan J.E. Formulation of sustained release promethazine hydrochloride tablets using hydroxypropylmethylcellulose matrices. Int. J. Pharm. 1985, 24:327-338.
8. Ford J.L., Rubinstein M.H., Hogan J.E. Propranolol hydrochloride and aminophylline release from matrix tablet containing hydroxypropylmethylcellulose. Int. J. Pharm. 1985, 24:339-350.
9. Ford J.L., Rubinstein M.H., McCaul F., Hogan J.E., Edgar P.J. Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets. Int. J. Pharm. 1987, 40:223-234.
10. Ford J.L., Mitchell K., Rowe P., Armstrong D.J., Elliott P.N.C., Rostron C., Hogan J.E. Mathematical modeling of drug release from hydroxypropylmethylcellulose matrices: effect of temperature. Int. J. Pharm. 1991, 71:95-104.
11. Fyfe C.A., Blazek A.I. Investigation of hydrogel formation from hydroxypropylmethylcellulose (HPMC) by NMR spectroscopy and NMR imaging techniques. Macromolecules 1997, 30:6230-6237.
12. Fyfe C.A., Grondey H., Blazek-Welsh A.I., Chopra S.K., Fahie B.J. NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus. J. Control. Release 2000, 68:73-83.
13. Graham N.B., McNeill M.E. Hydrogels for controlled drug delivery. Biomaterials 1984, 5:27-36.
14. Kim C.J. Drug release from compressed hydrophilic Polyox WSR tablets. J. Pharm. Sci. 1995, 84:303-306.
15. Kim C.J. Effects of drug solubility, drug loading and polymer molecular weight on drug release from Polyox tablets. Drug Dev. Ind. Pharm. 1998, 24:645-651.
16. Kojima H., Yoshihara K., Sawada T., Kondo H., Sako K. Extended-release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets. Eur. J. Pharm. Biopharm. 2008, 70:556-562.
17. Kojima M., Nakagami H. Investigation of water mobility and diffusivity in hydrating micronized low-substituted hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and hydroxypropyl cellulose matrix tablets by magnetic resonance imaging (MRI). Chem. Pharma. Bull. 2002, 50:1621-1624.
18. Kuga S. Pore size distribution analysis of gel substances by size exclusion chromatography. J. Chromatgr. 1981, 206:449-461.
19. Kulinowski P., Dorozyński P., Jachowicz R., Weglarz W.P. An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms-A tool for quantitative assessment of hydrogel formation processes. J. Pharm. Biomed. Aanl. 2008, 48:685-693.
20. Laguna M.T.R., Medrano R., Plana M.P., Tarazona M.P. Polymer characterization by size-exclusion chromatography with multiple detection. J. Chromatogr. A 2001, 919:13-19.
21. Maggi L., Bruni R., Conte U. High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled-release dosage forms. Int. J. Pharm. 2000, 195:229-238.
22. Maggi L., Segale L., Torre M.L., Machiste E.O., Conte U. Dissolution behaviour of hydrophilic matrix tablets containing two different polyethylene oxides (PEOs) for the controlled release of a water-soluble drug. Dimensionality study. Biomaterials 2002, 23:1113-1119.
23. Malaterre V., Metz H., Ogorka J., Gurny R., Loggia N., Mäder K. Benchtop-magnetic resonance imaging (BT-NMR) characterization of push-pull osmotic controlled-release systems. J. Control. Release 2009, 133:31-36.
24. Metz H., Mäder K. Benchtop-NMR and MRI-A new analytical tool in drug delivery research. Int. J. Pharm. 2008, 364:170-175.
25. Morita S., Tanaka M., Ozaki Y. Time-resolved in situ ATR-IR observations of the process of sorption of water into a poly(2-methoxyethyl acrylate) film. Langmuir 2007, 23:3750-3761.
26. Nott K.P. Magnetic resonance imaging of tablet dissolution. Eur. J. Pharm. Biopharm. 2010, 74:78-83.
27. Rao K.V.R., Devi K.P., Buri P. Influence of molecular size and water solubility of the solute on its release from swelling and erosion controlled polymeric matrices. J. Control. Release 1990, 12:133-141.
28. Richardson J.C., Bowtell R.W., Mäder K., Melia C.D. Pharmaceutical applications of magnetic resonance imaging (MRI). Adv. Drug Deliv. Rev. 2005, 57:1191-1209.
29. Sako K., Nakashima H., Sawada T., Fukui M. Relationship between gelation rate of controlled-release acetaminophen tablet containing polyethylene oxide and colonic drug release in dogs. Pharm. Res. 1996, 13:594-598.
30. Sako K. Design of novel oral controlled-release system (OCAS) for continuous drug absorption. Pharm. Tech. Jpn. 1998, 14:85-98.
31. Salomen J.L., Doelker E., Buri P. Sustained release of a water soluble drug from hydrophilic compressed dosage forms. Pharm. Ind. 1979, 41:799-802.
32. Strübing S., Metz H., Mäder K. Characterization of poly(vinyl acetate) based floating matrix tablets. J. Control. Release 2008, 126:149-155.
33. Tajarobi F., Abrahmsén-Alami S., Carlsson A.S., Larsson A. Simultaneous probing of swelling, erosion and dissolution by NMR-microimaging-Effect of solubility of additives on HPMC matrix tablets. Eur. J. Pharm. Sci. 2009, 37:89-97.
34. Tanaka M., Mochizuki A. Effect of water structure on blood compatibility- thermal analysis of water in poly(meth)acrylate. J. Biomed. Mater. Res. 2004, 68A:684-695.
35. The Japanese Pharmacopoeia, 15th ed., 2006. Society of Japanese Pharmacopoeia, pp. 116-120.
36. The United States Pharmacopeia, 31-National Formulary 26, 2007. The United States Pharmacopeial Convention, pp. 267-274.
37. Yang L., Venkatesh G., Fassihi R. Characterization of compressibility and compactibility of poly(ethylene oxide) polymers for modified release application by compaction simulator. J. Pharm. Sci. 1996, 85:1085-1090.
38. Wu N., Wang L.S., Tan D.C.W., Moochhala S.M., Yang Y.Y. Mathematical modeling and in vitro study of contolled drug release via a highly swellable and dissoluble polymer matrix: polyethylene oxide with high molecular weights. J. Control. Release 2005, 102:569-581.