Investigations on the predictability of the formation of glassy solid solutions of drugs in sugar alcohols

International Journal of Pharmaceutics

Volumn 252, Issue 1-2, 2003, Pages 167-179

  Langer, M ^a   Holtje M ^b   Urbanetz, N A ^a   Brandt, B ^a   Holtje H D ^a   Lippold, B C ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Electrostatic interactions; Glassy solid solutions; Hydrogen bonding; Interaction parameter; Molecular dynamics; Poorly soluble drugs; Solubility parameters; Sugar alcohols

Indexed keywords

ACICLOVIR; CARBAMAZEPINE; CLOTRIMAZOLE; DICLOFENAC; DRUG CARRIER; HYDROGEN; IBUPROFEN; INDOMETACIN; ISOMALT; KETOCONAZOLE; LACTITOL; MALTISORB; MALTITOL; MANNITOL; METRONIDAZOLE; NICLOSAMIDE; PAPAVERINE; SALICYLAMIDE; SUGAR ALCOHOL; THEOPHYLLINE; TRIMETHOPRIM; WARFARIN;

ARTICLE; DRUG MIXTURE; DRUG SOLUBILITY; DRUG SOLUTION; DRUG STRUCTURE; ELECTRICITY; ENTROPY; GLASS TRANSITION TEMPERATURE; HYDROGEN BOND; INTERMETHOD COMPARISON; LIQUID CRYSTAL; MATHEMATICAL ANALYSIS; MISCIBILITY; MOLECULAR DYNAMICS; PREDICTION; PRIORITY JOURNAL; SOLID; THEORETICAL MODEL;

EID: 0037452415     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00647-6     Document Type: Article

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