Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking

Pain

Volumn 156, Issue 9, 2015, Pages 1620-1636

  Mickle, Aaron D ^a,b   Shepherd, Andrew J ^a,b   Loo, Lipin ^a,c   Mohapatra, Durga P ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Mechanical hypersensitivity; Nociceptor sensitization; Parathyroid hormone related peptide; Peripheral sensitization; Thermal hypersensitivity; TRPV1; TRPV1 phosphorylation

Indexed keywords

PARATHYROID HORMONE RELATED PROTEIN; PROTEIN KINASE C; VANILLOID RECEPTOR 1; CAPSAICIN; CYCLIC AMP; PARATHYROID HORMONE RECEPTOR 1; PROTEIN KINASE C EPSILON; TRPV1 PROTEIN, MOUSE; VANILLOID RECEPTOR;

ACTION POTENTIAL; ADULT; ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CELL MEMBRANE; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVITY; FEMALE; HYPERSENSITIVITY; KNOCKOUT MOUSE; MALE; MECHANICAL HYPERSENSITIVITY; MOUSE; NONHUMAN; PAIN RECEPTOR; PH; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; SENSORY NERVE CELL; SRC HOMOLOGY DOMAIN; THERMAL HYPERSENSITIVITY; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; HYPERALGESIA; MEMBRANE POTENTIAL; METABOLISM; NERVE CELL; PROTEIN TRANSPORT; SPINAL GANGLION; TRANSGENIC MOUSE;

ANIMALS; CAPSAICIN; CELLS, CULTURED; CYCLIC AMP; FEMALE; GANGLIA, SPINAL; HUMANS; HYPERALGESIA; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; PARATHYROID HORMONE-RELATED PROTEIN; PROTEIN KINASE C-EPSILON; PROTEIN TRANSPORT; RECEPTOR, PARATHYROID HORMONE, TYPE 1; TRPV CATION CHANNELS; UP-REGULATION;

EID: 84964617156     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000000224     Document Type: Article

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