Nerve growth factor induces sensitization of nociceptors without evidence for increased intraepidermal nerve fiber density

Pain

Volumn 154, Issue 11, 2013, Pages 2500-2511

  Hirth, Michael ^a   Rukwied, Roman ^a   Gromann, Alois ^a,b   Turnquist, Brian ^c   Weinkauf, Benjamin ^a   Francke, Klaus ^a   Albrecht, Philip ^d,e   Rice, Frank ^d,e   Hägglöf, Björn ^f   Ringkamp, Matthias ^g   Engelhardt, Maren ^a   Schultz, Christian ^a   Schmelz, Martin ^a   Obreja, Otilia ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF APPLIED SCIENCES   (Germany)

^c BETHEL UNIVERSITY   (United States)

^d ALBANY MEDICAL COLLEGE   (United States)

^e Integrated Tissue Dynamics   (United States)

^f ASTRAZENECA R AND D   (Sweden)

^g JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Axon; Hyperalgesia; Nerve growth factor; Sensitization; Sprouting

Indexed keywords

NERVE GROWTH FACTOR; CALCIUM CHANNEL; NERVE PROTEIN; SCN10A PROTEIN, HUMAN; SCN9A PROTEIN, HUMAN; SODIUM CHANNEL NAV1.7; SODIUM CHANNEL NAV1.8; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ACTIVITY DEPENDENT SLOWING; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL PIG; HUMAN; HUMAN EXPERIMENT; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTRAEPIDERMAL NERVE FIBER DENSITY; MALE; NERVE CELL EXCITABILITY; NERVE CONDUCTION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NERVOUS SYSTEM PARAMETERS; NOCICEPTION; NONHUMAN; NORMAL HUMAN; PAIN RECEPTOR; PAIN THRESHOLD; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; COLD; DRUG EFFECTS; ELECTROSTIMULATION; EPIDERMIS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; INNERVATION; MECHANORECEPTOR; METABOLISM; NERVE FIBER; NONMYELINATED NERVE; PHYSIOLOGY; SWINE; YOUNG ADULT;

ADULT; ANIMALS; AXONS; CALCIUM CHANNELS; COLD TEMPERATURE; ELECTRIC STIMULATION; EPIDERMIS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MALE; MECHANORECEPTORS; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; NERVE FIBERS; NERVE FIBERS, UNMYELINATED; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NOCICEPTORS; SWINE; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS; YOUNG ADULT;

EID: 84886259919     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.07.036     Document Type: Article

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