-
1
-
-
73949150107
-
Effect of bisphosphonates on pain and quality of life in patients with bone metastases
-
Costa L, Major PP: Effect of bisphosphonates on pain and quality of life in patients with bone metastases. Nat. Clin. Pract. Oncol. 6(3), 163-174 (2009).
-
(2009)
Nat. Clin. Pract. Oncol
, vol.6
, Issue.3
, pp. 163-174
-
-
Costa, L.1
Major, P.P.2
-
2
-
-
0037367214
-
Estrogen receptors and distinct patterns of breast cancer relapse
-
Hess KR, Pusztai L, Buzdar AU, Hortobagyi GN: Estrogen receptors and distinct patterns of breast cancer relapse. Breast Cancer Res. Treat. 78(1), 105-118 (2003).
-
(2003)
Breast Cancer Res. Treat
, vol.78
, Issue.1
, pp. 105-118
-
-
Hess, K.R.1
Pusztai, L.2
Buzdar, A.U.3
Hortobagyi, G.N.4
-
3
-
-
0042838307
-
Breast cancer classification and prognosis based on gene expression profiles from a population-based study
-
Sotiriou C, Neo SY, McShane LM et al.: Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc. Natl Acad. Sci. USA 100(18), 10393-10398 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, Issue.18
, pp. 10393-10398
-
-
Sotiriou, C.1
Neo, S.Y.2
McShane, L.M.3
-
4
-
-
0037478605
-
Repeated observation of breast tumor subtypes in independent gene expression data sets
-
Sorlie T, Tibshirani R, Parker J et al.: Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl Acad. Sci. USA 100(14), 8418-8423 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, Issue.14
, pp. 8418-8423
-
-
Sorlie, T.1
Tibshirani, R.2
Parker, J.3
-
5
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sorlie T, Perou CM, Tibshirani R et al.: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl Acad. Sci. USA 98(19), 10869-10874 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, Issue.19
, pp. 10869-10874
-
-
Sorlie, T.1
Perou, C.M.2
Tibshirani, R.3
-
6
-
-
44849114353
-
Subtypes of breast cancer show preferential site of relapse
-
Smid M, Wang Y, Zhang Y et al.: Subtypes of breast cancer show preferential site of relapse. Cancer Res. 68(9), 3108-3114 (2008).
-
(2008)
Cancer Res
, vol.68
, Issue.9
, pp. 3108-3114
-
-
Smid, M.1
Wang, Y.2
Zhang, Y.3
-
7
-
-
58149179539
-
Advancing treatment for metastatic bone cancer: Consensus recommendations from the second Cambridge conference
-
Coleman RE, Guise TA, Lipton A et al.: Advancing treatment for metastatic bone cancer: consensus recommendations from the second Cambridge conference. Clin. Cancer Res. 14(20), 6387-6395 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, Issue.20
, pp. 6387-6395
-
-
Coleman, R.E.1
Guise, T.A.2
Lipton, A.3
-
8
-
-
63049090100
-
Metastasis: From dissemination to organspecific colonization
-
Nguyen DX, Bos PD, Massague J: Metastasis: from dissemination to organspecific colonization. Nat. Rev. Cancer 9(4), 274-284 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.4
, pp. 274-284
-
-
Nguyen, D.X.1
Bos, P.D.2
Massague, J.3
-
9
-
-
33749071868
-
Breast cancer-derived factors facilitate osteolytic bone metastasis
-
Rose AA, Siegel PM: Breast cancer-derived factors facilitate osteolytic bone metastasis. Bull. Cancer 93(9), 931-943 (2006).
-
(2006)
Bull. Cancer
, vol.93
, Issue.9
, pp. 931-943
-
-
Rose, A.A.1
Siegel, P.M.2
-
10
-
-
0036675220
-
Metastasis to bone: Causes, consequences and therapeutic opportunities
-
Mundy GR: Metastasis to bone: causes, consequences and therapeutic opportunities. Nat. Rev. Cancer 2(8), 584-593 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, Issue.8
, pp. 584-593
-
-
Mundy, G.R.1
-
11
-
-
35848966147
-
Bone metastases in breast cancer: Higher prevalence of osteosclerotic lesions
-
Quattrocchi CC, Piciucchi S, Sammarra M et al.: Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions. Radiol. Med. 112(7), 1049-1059 (2007).
-
(2007)
Radiol. Med
, vol.112
, Issue.7
, pp. 1049-1059
-
-
Quattrocchi, C.C.1
Piciucchi, S.2
Sammarra, M.3
-
12
-
-
66449109435
-
Surgical management of prostate cancer metastatic to the spine
-
Williams BJ, Fox BD, Sciubba DM et al.: Surgical management of prostate cancer metastatic to the spine. J. Neurosurg. Spine 10(5), 414-422 (2009).
-
(2009)
J. Neurosurg. Spine
, vol.10
, Issue.5
, pp. 414-422
-
-
Williams, B.J.1
Fox, B.D.2
Sciubba, D.M.3
-
13
-
-
15344340489
-
Management of bone metastases in breast cancer
-
Lipton A: Management of bone metastases in breast cancer. Curr. Treat. Options Oncol. 6(2), 161-171 (2005).
-
(2005)
Curr. Treat. Options Oncol
, vol.6
, Issue.2
, pp. 161-171
-
-
Lipton, A.1
-
14
-
-
5444242637
-
Bisphosphonates: Preclinical review
-
Green JR: Bisphosphonates: preclinical review. Oncologist 9(Suppl. 4), 3-13 (2004).
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL. 4
, pp. 3-13
-
-
Green, J.R.1
-
15
-
-
33750605957
-
Phase II trial evaluating the palliative benefit of second-line zoledronic acid in breast cancer patients with either a skeletal-related event or progressive bone metastases despite first-line bisphosphonate therapy
-
Clemons MJ, Dranitsaris G, Ooi WS et al.: Phase II trial evaluating the palliative benefit of second-line zoledronic acid in breast cancer patients with either a skeletal-related event or progressive bone metastases despite first-line bisphosphonate therapy. J. Clin. Oncol. 24(30), 4895-4900 (2006).
-
(2006)
J. Clin. Oncol
, vol.24
, Issue.30
, pp. 4895-4900
-
-
Clemons, M.J.1
Dranitsaris, G.2
Ooi, W.S.3
-
16
-
-
67349255225
-
Radiological changes following second-line zoledronic acid treatment in breast cancer patients with bone metastases
-
Amir E, Whyne C, Freedman OC et al.: Radiological changes following second-line zoledronic acid treatment in breast cancer patients with bone metastases. Clin. Exp. Metastasis 26(5), 479-484 (2009).
-
(2009)
Clin. Exp. Metastasis
, vol.26
, Issue.5
, pp. 479-484
-
-
Amir, E.1
Whyne, C.2
Freedman, O.C.3
-
17
-
-
0034214362
-
Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
-
Boissier S, Ferreras M, Peyruchaud O et al.: Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res. 60(11), 2949-2954 (2000).
-
(2000)
Cancer Res
, vol.60
, Issue.11
, pp. 2949-2954
-
-
Boissier, S.1
Ferreras, M.2
Peyruchaud, O.3
-
18
-
-
3042729728
-
Zoledronic acid inhibits visceral metastases in the 4t1/luc mouse breast cancer model
-
Hiraga T, Williams PJ, Ueda A, Tamura D, Yoneda T: Zoledronic acid inhibits visceral metastases in the 4t1/luc mouse breast cancer model. Clin. Cancer Res. 10(13), 4559-4567 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.13
, pp. 4559-4567
-
-
Hiraga, T.1
Williams, P.J.2
Ueda, A.3
Tamura, D.4
Yoneda, T.5
-
19
-
-
75149148087
-
Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells
-
Epub ahead of print
-
Rachner TD, Singh SK, Schoppet M et al.: Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells. Cancer Lett. (2009) (Epub ahead of print).
-
(2009)
Cancer Lett
-
-
Rachner, T.D.1
Singh, S.K.2
Schoppet, M.3
-
20
-
-
24044553904
-
Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro
-
Woodward JK, Neville-Webbe HL, Coleman RE, Holen I: Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro. Anticancer Drugs 16(8), 845-854 (2005).
-
(2005)
Anticancer Drugs
, vol.16
, Issue.8
, pp. 845-854
-
-
Woodward, J.K.1
Neville-Webbe, H.L.2
Coleman, R.E.3
Holen, I.4
-
21
-
-
34547653957
-
Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients
-
Santini D, Vincenzi B, Galluzzo S et al.: Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients. Clin. Cancer Res. 13(15 Pt 1), 4482-4486 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, Issue.15 PART 1
, pp. 4482-4486
-
-
Santini, D.1
Vincenzi, B.2
Galluzzo, S.3
-
22
-
-
20144381765
-
Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients
-
Vincenzi B, Santini D, Dicuonzo G et al.: Zoledronic acid-related angiogenesis modifications and survival in advanced breast cancer patients. J. Interferon Cytokine Res. 25(3), 144-151 (2005).
-
(2005)
J. Interferon Cytokine Res
, vol.25
, Issue.3
, pp. 144-151
-
-
Vincenzi, B.1
Santini, D.2
Dicuonzo, G.3
-
23
-
-
66349123652
-
Vascular endothelial growth factor activity after switching of bisphosphonate treatment for metastatic breast cancer
-
Amir E, Trinkaus M, Simmons CE, Dranitsaris G, Clemons MJ: Vascular endothelial growth factor activity after switching of bisphosphonate treatment for metastatic breast cancer. J. Clin. Pathol. 62(5), 474-476 (2009).
-
(2009)
J. Clin. Pathol
, vol.62
, Issue.5
, pp. 474-476
-
-
Amir, E.1
Trinkaus, M.2
Simmons, C.E.3
Dranitsaris, G.4
Clemons, M.J.5
-
24
-
-
34248219009
-
Chemotherapy and zoledronate sensitize solid tumour cells to vγ9vδ2 t cell cytotoxicity
-
Mattarollo SR, Kenna T, Nieda M, Nicol AJ: Chemotherapy and zoledronate sensitize solid tumour cells to vγ9vδ2 t cell cytotoxicity. Cancer Immunol. Immunother. 56(8), 1285-1297 (2007).
-
(2007)
Cancer Immunol. Immunother
, vol.56
, Issue.8
, pp. 1285-1297
-
-
Mattarollo, S.R.1
Kenna, T.2
Nieda, M.3
Nicol, A.J.4
-
25
-
-
34547638252
-
Targeting human {γδ} T cells with zoledronate and interleukin2 for immunotherapy of hormonerefractory prostate cancer
-
Dieli F, Vermijlen D, Fulfaro F et al.: Targeting human {γδ} T cells with zoledronate and interleukin2 for immunotherapy of hormonerefractory prostate cancer. Cancer Res. 67(15), 7450-7457 (2007).
-
(2007)
Cancer Res
, vol.67
, Issue.15
, pp. 7450-7457
-
-
Dieli, F.1
Vermijlen, D.2
Fulfaro, F.3
-
26
-
-
57949103408
-
Zoledronate facilitates largescale ex vivo expansion of functional γδ T cells from cancer patients for use in adoptive immunotherapy
-
Kondo M, Sakuta K, Noguchi A et al.: Zoledronate facilitates largescale ex vivo expansion of functional γδ T cells from cancer patients for use in adoptive immunotherapy. Cytotherapy 10(8), 842-856 (2008).
-
(2008)
Cytotherapy
, vol.10
, Issue.8
, pp. 842-856
-
-
Kondo, M.1
Sakuta, K.2
Noguchi, A.3
-
27
-
-
60549097419
-
Endocrine therapy plus zoledronic acid in premenopausal breast cancer
-
Gnant M, Mlineritsch B, Schippinger W et al.: Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N. Engl. J. Med. 360(7), 679-691 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, Issue.7
, pp. 679-691
-
-
Gnant, M.1
Mlineritsch, B.2
Schippinger, W.3
-
28
-
-
63749110469
-
The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts
-
Hirbe AC, Roelofs AJ, Floyd DH et al.: The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. Bone 44(5), 908-916 (2009).
-
(2009)
Bone
, vol.44
, Issue.5
, pp. 908-916
-
-
Hirbe, A.C.1
Roelofs, A.J.2
Floyd, D.H.3
-
29
-
-
18644373689
-
Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases
-
Chen T, Berenson J, Vescio R et al.: Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases. J. Clin. Pharmacol. 42(11), 1228-1236 (2002).
-
(2002)
J. Clin. Pharmacol
, vol.42
, Issue.11
, pp. 1228-1236
-
-
Chen, T.1
Berenson, J.2
Vescio, R.3
-
30
-
-
0029886359
-
Bisphosphonates: A review of their pharmacokinetic properties
-
Lin JH: Bisphosphonates: a review of their pharmacokinetic properties. Bone 18(2), 75-85 (1996).
-
(1996)
Bone
, vol.18
, Issue.2
, pp. 75-85
-
-
Lin, J.H.1
-
31
-
-
33846044750
-
Bone marrow cells in the 'pre-metastatic niche': Within bone and beyond
-
Kaplan RN, Psaila B, Lyden D: Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer Metastasis Rev. 25(4), 521-529 (2006).
-
(2006)
Cancer Metastasis Rev
, vol.25
, Issue.4
, pp. 521-529
-
-
Kaplan, R.N.1
Psaila, B.2
Lyden, D.3
-
32
-
-
40349098612
-
Migratory neighbors and distant invaders: Tumor-associated niche cells
-
Wels J, Kaplan RN, Rafii S, Lyden D: Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev. 22(5), 559-574 (2008).
-
(2008)
Genes Dev
, vol.22
, Issue.5
, pp. 559-574
-
-
Wels, J.1
Kaplan, R.N.2
Rafii, S.3
Lyden, D.4
-
33
-
-
34948896045
-
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
-
Karnoub AE, Dash AB, Vo AP et al.: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449(7162), 557-563 (2007).
-
(2007)
Nature
, vol.449
, Issue.7162
, pp. 557-563
-
-
Karnoub, A.E.1
Dash, A.B.2
Vo, A.P.3
-
34
-
-
37349100945
-
+ myeloid cells that promote metastasis
-
+ myeloid cells that promote metastasis. Cancer Cell 13(1), 23-35 (2008).
-
(2008)
Cancer Cell
, vol.13
, Issue.1
, pp. 23-35
-
-
Yang, L.1
Huang, J.2
Ren, X.3
-
35
-
-
28644432204
-
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
-
Kaplan RN, Riba RD, Zacharoulis S et al.: VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438(7069), 820-827 (2005).
-
(2005)
Nature
, vol.438
, Issue.7069
, pp. 820-827
-
-
Kaplan, R.N.1
Riba, R.D.2
Zacharoulis, S.3
-
36
-
-
63049121364
-
The metastatic niche: Adapting the foreign soil
-
Psaila B, Lyden D: The metastatic niche: adapting the foreign soil. Nat. Rev. Cancer 9(4), 285-293 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.4
, pp. 285-293
-
-
Psaila, B.1
Lyden, D.2
-
37
-
-
57149098821
-
Anti-angiogenic property of zoledronic acid by inhibition of endothelial progenitor cell differentiation
-
Yamada J, Tsuno NH, Kitayama J et al.: Anti-angiogenic property of zoledronic acid by inhibition of endothelial progenitor cell differentiation. J. Surg. Res. 151(1), 115-120 (2009).
-
(2009)
J. Surg. Res
, vol.151
, Issue.1
, pp. 115-120
-
-
Yamada, J.1
Tsuno, N.H.2
Kitayama, J.3
-
38
-
-
63449128847
-
Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation
-
Ebert R, Zeck S, Krug R et al.: Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation. Bone 44(5), 858-864 (2009).
-
(2009)
Bone
, vol.44
, Issue.5
, pp. 858-864
-
-
Ebert, R.1
Zeck, S.2
Krug, R.3
-
39
-
-
0036792257
-
Expression of interleukin 8 and not parathyroid hormonerelated protein by human breast cancer cells correlates with bone metastasis in vivo
-
Bendre MS, GaddyKurten D, MonFoote T et al.: Expression of interleukin 8 and not parathyroid hormonerelated protein by human breast cancer cells correlates with bone metastasis in vivo. Cancer Res. 62(19), 5571-5579 (2002).
-
(2002)
Cancer Res
, vol.62
, Issue.19
, pp. 5571-5579
-
-
Bendre, M.S.1
GaddyKurten, D.2
MonFoote, T.3
-
40
-
-
35948930203
-
Osteoactivin promotes breast cancer metastasis to bone
-
Rose AA, Pepin F, Russo C, Abou Khalil JE, Hallett M, Siegel PM: Osteoactivin promotes breast cancer metastasis to bone. Mol. Cancer Res. 5(10), 1001-1014 (2007).
-
(2007)
Mol. Cancer Res
, vol.5
, Issue.10
, pp. 1001-1014
-
-
Rose, A.A.1
Pepin, F.2
Russo, C.3
Abou Khalil, J.E.4
Hallett, M.5
Siegel, P.M.6
-
41
-
-
0038488950
-
A multigenic program mediating breast cancer metastasis to bone
-
Kang Y, Siegel PM, Shu W et al.: A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3(6), 537-549 (2003).
-
(2003)
Cancer Cell
, vol.3
, Issue.6
, pp. 537-549
-
-
Kang, Y.1
Siegel, P.M.2
Shu, W.3
-
42
-
-
33846269625
-
Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells
-
Bellahcene A, Bachelier R, Detry C, Lidereau R, Clezardin P, Castronovo V: Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells. Breast Cancer Res. Treat. 101(2), 135-148 (2007).
-
(2007)
Breast Cancer Res. Treat
, vol.101
, Issue.2
, pp. 135-148
-
-
Bellahcene, A.1
Bachelier, R.2
Detry, C.3
Lidereau, R.4
Clezardin, P.5
Castronovo, V.6
-
43
-
-
67649311599
-
Latent bone metastasis in breast cancer tied to src-dependent survival signals
-
Zhang XH, Wang Q, Gerald W et al.: Latent bone metastasis in breast cancer tied to src-dependent survival signals. Cancer Cell 16(1), 67-78 (2009).
-
(2009)
Cancer Cell
, vol.16
, Issue.1
, pp. 67-78
-
-
Zhang, X.H.1
Wang, Q.2
Gerald, W.3
-
44
-
-
13444268127
-
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors
-
Minn AJ, Kang Y, Serganova I et al.: Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J. Clin. Invest. 115(1), 44-55 (2005).
-
(2005)
J. Clin. Invest
, vol.115
, Issue.1
, pp. 44-55
-
-
Minn, A.J.1
Kang, Y.2
Serganova, I.3
-
45
-
-
67249120052
-
Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants
-
Lu X, Kang Y: Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc. Natl Acad. Sci. USA 106(23), 9385-9390 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.23
, pp. 9385-9390
-
-
Lu, X.1
Kang, Y.2
-
46
-
-
23144461051
-
Genes that mediate breast cancer metastasis to lung
-
Minn AJ, Gupta GP, Siegel PM et al.: Genes that mediate breast cancer metastasis to lung. Nature 436(7050), 518-524 (2005).
-
(2005)
Nature
, vol.436
, Issue.7050
, pp. 518-524
-
-
Minn, A.J.1
Gupta, G.P.2
Siegel, P.M.3
-
47
-
-
33744813556
-
Genes associated with breast cancer metastatic to bone
-
Smid M, Wang Y, Klijn JG et al.: Genes associated with breast cancer metastatic to bone. J. Clin. Oncol. 24(15), 2261-2267 (2006).
-
(2006)
J. Clin. Oncol
, vol.24
, Issue.15
, pp. 2261-2267
-
-
Smid, M.1
Wang, Y.2
Klijn, J.G.3
-
48
-
-
55149097886
-
Discordance between receptor status in primary and metastatic breast cancer: An exploratory study of bone and bone marrow biopsies
-
Amir E, Ooi WS, Simmons C et al.: Discordance between receptor status in primary and metastatic breast cancer: an exploratory study of bone and bone marrow biopsies. Clin. Oncol. (R. Coll. Radiol.) 20(10), 763-768 (2008).
-
(2008)
Clin. Oncol. (R. Coll. Radiol.)
, vol.20
, Issue.10
, pp. 763-768
-
-
Amir, E.1
Ooi, W.S.2
Simmons, C.3
-
49
-
-
67650096888
-
Changes in estrogen receptor, progesterone receptor and HER-2/ neu status with time: Discordance rates between primary and metastatic breast cancer
-
Broom RJ, Tang PA, Simmons C et al.: Changes in estrogen receptor, progesterone receptor and HER-2/ neu status with time: discordance rates between primary and metastatic breast cancer. Anticancer Res. 29(5), 1557-1562 (2009).
-
(2009)
Anticancer Res
, vol.29
, Issue.5
, pp. 1557-1562
-
-
Broom, R.J.1
Tang, P.A.2
Simmons, C.3
-
50
-
-
68449084677
-
The role of Src in solid tumors
-
Wheeler DL, Iida M, Dunn EF: The role of Src in solid tumors. Oncologist 14(7), 667-678 (2009).
-
(2009)
Oncologist
, vol.14
, Issue.7
, pp. 667-678
-
-
Wheeler, D.L.1
Iida, M.2
Dunn, E.F.3
-
51
-
-
0028174305
-
Involvement of pp60c-src with two major signaling pathways in human breast cancer
-
Luttrell DK, Lee A, Lansing TJ et al.: Involvement of pp60c-src with two major signaling pathways in human breast cancer. Proc. Natl Acad. Sci. USA 91(1), 83-87 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, Issue.1
, pp. 83-87
-
-
Luttrell, D.K.1
Lee, A.2
Lansing, T.J.3
-
52
-
-
0029165834
-
Direct and specific interaction of c-Src with neu is involved in signaling by the epidermal growth factor receptor
-
Muthuswamy SK, Muller WJ: Direct and specific interaction of c-Src with neu is involved in signaling by the epidermal growth factor receptor. Oncogene 11(2), 271-279 (1995).
-
(1995)
Oncogene
, vol.11
, Issue.2
, pp. 271-279
-
-
Muthuswamy, S.K.1
Muller, W.J.2
-
53
-
-
38449112970
-
GPCRs signaling directly through Srcfamily kinases
-
2007392, pe35
-
Mcgarrigle D, Huang XY: GPCRs signaling directly through Srcfamily kinases. Sci. STKE 2007(392), pe35 (2007).
-
(2007)
Sci. STKE
-
-
Mcgarrigle, D.1
Huang, X.Y.2
-
54
-
-
0028047315
-
Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity
-
Muthuswamy SK, Siegel PM, Dankort DL, Webster MA, Muller WJ: Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Mol. Cell. Biol. 14(1), 735-743 (1994).
-
(1994)
Mol. Cell. Biol
, vol.14
, Issue.1
, pp. 735-743
-
-
Muthuswamy, S.K.1
Siegel, P.M.2
Dankort, D.L.3
Webster, M.A.4
Muller, W.J.5
-
55
-
-
0027954475
-
-
Guy CT, Muthuswamy SK, Cardiff RD, Soriano P, Muller WJ: Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev. 8(1), 23-32 (1994).
-
Guy CT, Muthuswamy SK, Cardiff RD, Soriano P, Muller WJ: Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev. 8(1), 23-32 (1994).
-
-
-
-
56
-
-
33751028441
-
Activated cSrc in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity
-
Wilson GR, Cramer A, Welman A et al.: Activated cSrc in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity. Br. J. Cancer 95(10), 1410-1414 (2006).
-
(2006)
Br. J. Cancer
, vol.95
, Issue.10
, pp. 1410-1414
-
-
Wilson, G.R.1
Cramer, A.2
Welman, A.3
-
57
-
-
75149144814
-
Increased levels of active cSrc distinguish invasive from in situ lobular lesions
-
Zou D, Yoon HS, Anjomshoaa A et al.: Increased levels of active cSrc distinguish invasive from in situ lobular lesions. Breast Cancer Res. 11(4), R45 (2009).
-
(2009)
Breast Cancer Res
, vol.11
, Issue.4
-
-
Zou, D.1
Yoon, H.S.2
Anjomshoaa, A.3
-
58
-
-
33745257077
-
Inhibition of protein kinase cSrc reduces the incidence of breast cancer metastases and increases survival in mice: Implications for therapy
-
Rucci N, Recchia I, Angelucci A et al.: Inhibition of protein kinase cSrc reduces the incidence of breast cancer metastases and increases survival in mice: Implications for therapy. J. Pharmacol. Exp. Ther. 318(1), 161-172 (2006).
-
(2006)
J. Pharmacol. Exp. Ther
, vol.318
, Issue.1
, pp. 161-172
-
-
Rucci, N.1
Recchia, I.2
Angelucci, A.3
-
59
-
-
0026023289
-
BradleyA: Targeted disruption of the cSrc protooncogene leads to osteopetrosis in mice
-
Soriano P, Montgomery C, Geske R, BradleyA: Targeted disruption of the cSrc protooncogene leads to osteopetrosis in mice. Cell 64(4), 693-702 (1991).
-
(1991)
Cell
, vol.64
, Issue.4
, pp. 693-702
-
-
Soriano, P.1
Montgomery, C.2
Geske, R.3
-
61
-
-
0027318189
-
Osteopetrosis in Srcdeficient mice is due to an autonomous defect of osteoclasts
-
Lowe C, Yoneda T, Boyce BF, Chen H, Mundy GR, Soriano P: Osteopetrosis in Srcdeficient mice is due to an autonomous defect of osteoclasts. Proc. Natl Acad. Sci. USA 90(10), 4485-4489 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, Issue.10
, pp. 4485-4489
-
-
Lowe, C.1
Yoneda, T.2
Boyce, B.F.3
Chen, H.4
Mundy, G.R.5
Soriano, P.6
-
62
-
-
33645988520
-
The role of c-Src kinase in the regulation of osteoclast function
-
Miyazaki T, Tanaka S, Sanjay A, Baron R: The role of c-Src kinase in the regulation of osteoclast function. Mod. Rheumatol. 16(2), 68-74 (2006).
-
(2006)
Mod. Rheumatol
, vol.16
, Issue.2
, pp. 68-74
-
-
Miyazaki, T.1
Tanaka, S.2
Sanjay, A.3
Baron, R.4
-
63
-
-
67650601930
-
Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis
-
Koreckij T, Nguyen H, Brown LG, Yu EY, Vessella RL, Corey E: Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis. Br. J. Cancer 101(2), 263-268 (2009).
-
(2009)
Br. J. Cancer
, vol.101
, Issue.2
, pp. 263-268
-
-
Koreckij, T.1
Nguyen, H.2
Brown, L.G.3
Yu, E.Y.4
Vessella, R.L.5
Corey, E.6
-
64
-
-
58149390625
-
Targeting Src signaling in metastatic bone disease
-
Araujo J, Logothetis C: Targeting Src signaling in metastatic bone disease. Int. J. Cancer 124(1), 1-6 (2009).
-
(2009)
Int. J. Cancer
, vol.124
, Issue.1
, pp. 1-6
-
-
Araujo, J.1
Logothetis, C.2
-
65
-
-
48749118203
-
Targeting Src in breast cancer
-
Finn RS: Targeting Src in breast cancer. Ann. Oncol. 19(8), 1379-1386 (2008).
-
(2008)
Ann. Oncol
, vol.19
, Issue.8
, pp. 1379-1386
-
-
Finn, R.S.1
-
66
-
-
70350103708
-
Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia
-
Giles FJ, O'Dwyer M, Swords R: Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia. Leukemia 23(10), 1698-1707 (2009).
-
(2009)
Leukemia
, vol.23
, Issue.10
, pp. 1698-1707
-
-
Giles, F.J.1
O'Dwyer, M.2
Swords, R.3
-
67
-
-
0032918414
-
TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
-
Yin JJ, Selander K, Chirgwin JM et al.: TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J. Clin. Invest. 103(2), 197-206 (1999).
-
(1999)
J. Clin. Invest
, vol.103
, Issue.2
, pp. 197-206
-
-
Yin, J.J.1
Selander, K.2
Chirgwin, J.M.3
-
68
-
-
25444479744
-
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
-
Kang Y, He W, Tulley S et al.: Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl Acad. Sci. USA 102(39), 13909-13914 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, Issue.39
, pp. 13909-13914
-
-
Kang, Y.1
He, W.2
Tulley, S.3
-
69
-
-
33644534795
-
The tumor suppressor smad4 is required for transforming growth factor β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
-
Deckers M, Van Dinther M, Buijs J et al.: The tumor suppressor smad4 is required for transforming growth factor β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res. 66(4), 2202-2209 (2006).
-
(2006)
Cancer Res
, vol.66
, Issue.4
, pp. 2202-2209
-
-
Deckers, M.1
Van Dinther, M.2
Buijs, J.3
-
70
-
-
52449084680
-
Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation
-
Guo Y, Tiedemann K, Khalil JA, Russo C, Siegel PM, Komarova SV: Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation. Bone 43(2), 386-393 (2008).
-
(2008)
Bone
, vol.43
, Issue.2
, pp. 386-393
-
-
Guo, Y.1
Tiedemann, K.2
Khalil, J.A.3
Russo, C.4
Siegel, P.M.5
Komarova, S.V.6
-
71
-
-
0142250340
-
Transforming growth factor-β in osteolytic breast cancer bone metastases
-
Guise TA, Chirgwin JM: Transforming growth factor-β in osteolytic breast cancer bone metastases. Clin. Orthop. Relat. Res. (415 Suppl.), S32-S38 (2003).
-
(2003)
Clin. Orthop. Relat. Res
, vol.415
, Issue.SUPPL.
-
-
Guise, T.A.1
Chirgwin, J.M.2
-
72
-
-
60549094946
-
Transforming growth factor-β1 is the predominant isoform required for breast cancer cell outgrowth in bone
-
Mourskaia AA, Dong Z, Ng S et al.: Transforming growth factor-β1 is the predominant isoform required for breast cancer cell outgrowth in bone. Oncogene 28(7), 1005-1015 (2009).
-
(2009)
Oncogene
, vol.28
, Issue.7
, pp. 1005-1015
-
-
Mourskaia, A.A.1
Dong, Z.2
Ng, S.3
-
73
-
-
68349160814
-
Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis
-
Korpal M, Yan J, Lu X, Xu S, Lerit DA, KangY: Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis. Nat. Med. 15(8), 960-966 (2009).
-
(2009)
Nat. Med
, vol.15
, Issue.8
, pp. 960-966
-
-
Korpal, M.1
Yan, J.2
Lu, X.3
Xu, S.4
Lerit, D.A.5
Kang, Y.6
-
74
-
-
0842288323
-
TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
Bhowmick NA, Chytil A, Plieth D et al.: TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303(5659), 848-851 (2004).
-
(2004)
Science
, vol.303
, Issue.5659
, pp. 848-851
-
-
Bhowmick, N.A.1
Chytil, A.2
Plieth, D.3
-
75
-
-
23744452875
-
Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSPand HGFmediated signaling networks
-
Cheng N, Bhowmick NA, Chytil A et al.: Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSPand HGFmediated signaling networks. Oncogene 24(32), 5053-5068 (2005).
-
(2005)
Oncogene
, vol.24
, Issue.32
, pp. 5053-5068
-
-
Cheng, N.1
Bhowmick, N.A.2
Chytil, A.3
-
76
-
-
56449127197
-
Transforming growth factor β: Tumor suppressor or promoter? Are host immune cells the answer?
-
Yang L, Moses HL: Transforming growth factor β: tumor suppressor or promoter? Are host immune cells the answer? Cancer Res. 68(22), 9107-9111 (2008).
-
(2008)
Cancer Res
, vol.68
, Issue.22
, pp. 9107-9111
-
-
Yang, L.1
Moses, H.L.2
-
77
-
-
67651005826
-
Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer
-
Bierie B, Chung CH, Parker JS et al.: Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer. J. Clin. Invest. 119(6), 1571-1582 (2009).
-
(2009)
J. Clin. Invest
, vol.119
, Issue.6
, pp. 1571-1582
-
-
Bierie, B.1
Chung, C.H.2
Parker, J.S.3
-
78
-
-
10444261212
-
Development of TGF-β signalling inhibitors for cancer therapy
-
Yingling JM, Blanchard KL, Sawyer JS: Development of TGF-β signalling inhibitors for cancer therapy. Nat. Rev. Drug Discov. 3(12), 1011-1022 (2004).
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, Issue.12
, pp. 1011-1022
-
-
Yingling, J.M.1
Blanchard, K.L.2
Sawyer, J.S.3
-
79
-
-
33751311939
-
Inhibition of transforming growth factor-β signaling in human cancer: Targeting a tumor suppressor network as a therapeutic strategy
-
ArteagaCL
-
Biswas S, Criswell TL, Wang SE, ArteagaCL: Inhibition of transforming growth factor-β signaling in human cancer: Targeting a tumor suppressor network as a therapeutic strategy. Clin. Cancer Res. 12(14 Pt1), 4142-4146 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.14 PT1
, pp. 4142-4146
-
-
Biswas, S.1
Criswell, T.L.2
Wang, S.E.3
-
80
-
-
35748960275
-
-
Mourskaia AA, Northey JJ, Siegel PM: Targeting aberrant TGF-β signaling in preclinical models of cancer. Anticancer Agents Med. Chem. 7(5), 504-514 (2007).
-
Mourskaia AA, Northey JJ, Siegel PM: Targeting aberrant TGF-β signaling in preclinical models of cancer. Anticancer Agents Med. Chem. 7(5), 504-514 (2007).
-
-
-
-
81
-
-
33746145265
-
Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-β type I receptor kinase inhibitor
-
Bandyopadhyay A, Agyin JK, Wang L et al.: Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-β type I receptor kinase inhibitor. Cancer Res. 66(13), 6714-6721 (2006).
-
(2006)
Cancer Res
, vol.66
, Issue.13
, pp. 6714-6721
-
-
Bandyopadhyay, A.1
Agyin, J.K.2
Wang, L.3
-
82
-
-
33751328068
-
Ki26894, a novel transforming growth factor-b type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line
-
Ehata S, Hanyu A, Fujime M et al.: Ki26894, a novel transforming growth factor-b type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line. Cancer Sci. 98(1), 127-133 (2007).
-
(2007)
Cancer Sci
, vol.98
, Issue.1
, pp. 127-133
-
-
Ehata, S.1
Hanyu, A.2
Fujime, M.3
-
83
-
-
41149157649
-
TGFβ primes breast tumors for lung metastasis seeding through angiopoietinlike 4
-
Padua D, Zhang XH, Wang Q et al.: TGFβ primes breast tumors for lung metastasis seeding through angiopoietinlike 4. Cell 133(1), 66-77 (2008).
-
(2008)
Cell
, vol.133
, Issue.1
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.2
Wang, Q.3
-
84
-
-
39149139338
-
TGF-β signallingrelated markers in cancer patients with bone metastasis
-
Baselga J, Rothenberg ML, Tabernero J et al.: TGF-β signallingrelated markers in cancer patients with bone metastasis. Biomarkers 13(2), 217-236 (2008).
-
(2008)
Biomarkers
, vol.13
, Issue.2
, pp. 217-236
-
-
Baselga, J.1
Rothenberg, M.L.2
Tabernero, J.3
-
85
-
-
0033611467
-
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymphnode organogenesis
-
Kong YY, Yoshida H, Sarosi I et al.: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymphnode organogenesis. Nature 397(6717), 315-323 (1999).
-
(1999)
Nature
, vol.397
, Issue.6717
, pp. 315-323
-
-
Kong, Y.Y.1
Yoshida, H.2
Sarosi, I.3
-
86
-
-
67650462567
-
Mechanism of bone metastasis: The role of osteoprotegerin and of the hosttissue microenvironmentrelated survival factors
-
Fili S, Karalaki M, Schaller B: Mechanism of bone metastasis: the role of osteoprotegerin and of the hosttissue microenvironmentrelated survival factors. Cancer Lett. 283(1), 10-19 (2009).
-
(2009)
Cancer Lett
, vol.283
, Issue.1
, pp. 10-19
-
-
Fili, S.1
Karalaki, M.2
Schaller, B.3
-
87
-
-
10144241022
-
Evidence for a causal role of parathyroid hormonerelated protein in the pathogenesis of human breast cancermediated osteolysis
-
Guise TA, Yin JJ, Taylor SD et al.: Evidence for a causal role of parathyroid hormonerelated protein in the pathogenesis of human breast cancermediated osteolysis. J. Clin. Invest. 98(7), 1544-1549 (1996).
-
(1996)
J. Clin. Invest
, vol.98
, Issue.7
, pp. 1544-1549
-
-
Guise, T.A.1
Yin, J.J.2
Taylor, S.D.3
-
88
-
-
33645453481
-
Regulation of cancer cell migration and bone metastasis by RANKL
-
Jones DH, Nakashima T, Sanchez OH et al.: Regulation of cancer cell migration and bone metastasis by RANKL. Nature 440(7084), 692-696 (2006).
-
(2006)
Nature
, vol.440
, Issue.7084
, pp. 692-696
-
-
Jones, D.H.1
Nakashima, T.2
Sanchez, O.H.3
-
89
-
-
41149094679
-
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis
-
Canon JR, Roudier M, Bryant R et al.: Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clin. Exp. Metastasis 25(2), 119-129 (2008).
-
(2008)
Clin. Exp. Metastasis
, vol.25
, Issue.2
, pp. 119-129
-
-
Canon, J.R.1
Roudier, M.2
Bryant, R.3
-
90
-
-
33846085533
-
Inhibition of bone resorption, rather than direct cytotoxicity, mediates the antitumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis
-
Zheng Y, Zhou H, Brennan K et al.: Inhibition of bone resorption, rather than direct cytotoxicity, mediates the antitumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis. Bone 40(2), 471-478 (2007).
-
(2007)
Bone
, vol.40
, Issue.2
, pp. 471-478
-
-
Zheng, Y.1
Zhou, H.2
Brennan, K.3
-
91
-
-
0035360265
-
Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis
-
Morony S, Capparelli C, Sarosi I, Lacey DL, Dunstan CR, Kostenuik PJ: Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. Cancer Res. 61(11), 4432-4436 (2001).
-
(2001)
Cancer Res
, vol.61
, Issue.11
, pp. 4432-4436
-
-
Morony, S.1
Capparelli, C.2
Sarosi, I.3
Lacey, D.L.4
Dunstan, C.R.5
Kostenuik, P.J.6
-
92
-
-
42549118918
-
Systemic osteoprotegerin gene therapy restores tumorinduced bone loss in a therapeutic model of breast cancer bone metastasis
-
Chanda D, Isayeva T, Kumar S et al.: Systemic osteoprotegerin gene therapy restores tumorinduced bone loss in a therapeutic model of breast cancer bone metastasis. Mol. Ther. 16(5), 871-878 (2008).
-
(2008)
Mol. Ther
, vol.16
, Issue.5
, pp. 871-878
-
-
Chanda, D.1
Isayeva, T.2
Kumar, S.3
-
93
-
-
33645737542
-
Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically
-
Fisher JL, ThomasMudge RJ, Elliott J et al.: Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically. Cancer Res. 66(7), 3620-3628 (2006).
-
(2006)
Cancer Res
, vol.66
, Issue.7
, pp. 3620-3628
-
-
Fisher, J.L.1
ThomasMudge, R.J.2
Elliott, J.3
-
94
-
-
38148998563
-
Osteoprotegrin and the bone homing and colonization potential of breast cancer cells
-
Kapoor P, Suva LJ, Welch DR, Donahue HJ: Osteoprotegrin and the bone homing and colonization potential of breast cancer cells. J. Cell Biochem. 103(1), 30-41 (2008).
-
(2008)
J. Cell Biochem
, vol.103
, Issue.1
, pp. 30-41
-
-
Kapoor, P.1
Suva, L.J.2
Welch, D.R.3
Donahue, H.J.4
-
95
-
-
69249087342
-
Osteoprotegerin production by breast cancer cells is suppressed by dexamethasone and confers resistance against trailinduced apoptosis
-
Rachner TD, Benad P, Rauner M et al.: Osteoprotegerin production by breast cancer cells is suppressed by dexamethasone and confers resistance against trailinduced apoptosis. J. Cell Biochem. 108(1), 10616 (2009).
-
(2009)
J. Cell Biochem
, vol.108
, Issue.1
, pp. 10616
-
-
Rachner, T.D.1
Benad, P.2
Rauner, M.3
-
96
-
-
4043138669
-
Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from trailinduced apoptosis
-
NevilleWebbe HL, Cross NA, Eaton CL et al.: Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from trailinduced apoptosis. Breast Cancer Res. Treat. 86(3), 269-279 (2004).
-
(2004)
Breast Cancer Res. Treat
, vol.86
, Issue.3
, pp. 269-279
-
-
NevilleWebbe, H.L.1
Cross, N.A.2
Eaton, C.L.3
-
97
-
-
0346837985
-
A Phase I study of amgn-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
-
Body JJ, Greipp P, Coleman RE et al.: A Phase I study of amgn-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 97(3 Suppl.), 887-892 (2003).
-
(2003)
Cancer
, vol.97
, Issue.3 SUPPL.
, pp. 887-892
-
-
Body, J.J.1
Greipp, P.2
Coleman, R.E.3
-
98
-
-
34548401627
-
Clinical development of antirankl therapy
-
S
-
Schwarz EM, Ritchlin CT: Clinical development of antirankl therapy. Arthritis Res. Ther. 9(Suppl. 1), S7 (2007).
-
(2007)
Arthritis Res. Ther
, vol.9
, Issue.SUPPL. 1
, pp. 7
-
-
Schwarz, E.M.1
Ritchlin, C.T.2
-
99
-
-
58649113384
-
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knockin mice that express chimeric (murine/human) rankl
-
Kostenuik PJ, Nguyen HQ, McCabe J et al.: Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knockin mice that express chimeric (murine/human) rankl. J. Bone Miner. Res. 24(2), 182-195 (2009).
-
(2009)
J. Bone Miner. Res
, vol.24
, Issue.2
, pp. 182-195
-
-
Kostenuik, P.J.1
Nguyen, H.Q.2
McCabe, J.3
-
100
-
-
69049083492
-
Denosumab for prevention of fractures in postmenopausal women with osteoporosis
-
Cummings SR, San Martin J, McClung MR et al.: Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N. Engl. J. Med. 361(8), 756-765 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, Issue.8
, pp. 756-765
-
-
Cummings, S.R.1
San Martin, J.2
McClung, M.R.3
-
101
-
-
69049105440
-
Denosumab in men receiving androgendeprivation therapy for prostate cancer
-
Smith MR, Egerdie B, Hernandez Toriz N et al.: Denosumab in men receiving androgendeprivation therapy for prostate cancer. N. Engl. J. Med. 361(8), 745-755 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, Issue.8
, pp. 745-755
-
-
Smith, M.R.1
Egerdie, B.2
Hernandez Toriz, N.3
-
102
-
-
77953454405
-
Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy
-
Epub ahead of print
-
Kendler DL, Roux C, Benhamou CL et al.: Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J. Bone Miner. Res. (2009) (Epub ahead of print).
-
(2009)
J. Bone Miner. Res
-
-
Kendler, D.L.1
Roux, C.2
Benhamou, C.L.3
-
103
-
-
3342982829
-
A singledose placebocontrolled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
-
Bekker PJ, Holloway DL, Rasmussen AS et al.: A singledose placebocontrolled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J. Bone Miner. Res. 19(7), 1059-1066 (2004).
-
(2004)
J. Bone Miner. Res
, vol.19
, Issue.7
, pp. 1059-1066
-
-
Bekker, P.J.1
Holloway, D.L.2
Rasmussen, A.S.3
-
104
-
-
33644760436
-
A study of the biological receptor activator of nuclear factor-κb ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
-
Body JJ, Facon T, Coleman RE et al.: A study of the biological receptor activator of nuclear factor-κb ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin. Cancer Res. 12(4), 1221-1228 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.4
, pp. 1221-1228
-
-
Body, J.J.1
Facon, T.2
Coleman, R.E.3
-
105
-
-
58149198581
-
Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy
-
Lipton A, Steger GG, Figueroa J et al.: Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy. Clin. Cancer Res. 14(20), 6690-6696 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, Issue.20
, pp. 6690-6696
-
-
Lipton, A.1
Steger, G.G.2
Figueroa, J.3
-
106
-
-
63749094012
-
Randomized Phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates
-
Fizazi K, Lipton A, Mariette X et al.: Randomized Phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J. Clin. Oncol. 27(10), 1564-1571 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.10
, pp. 1564-1571
-
-
Fizazi, K.1
Lipton, A.2
Mariette, X.3
-
107
-
-
75149149084
-
A doubleblind
-
September
-
Henry D, Von Moos R, VadhanRaj S et al.: A doubleblind, randomized study of denosumab versus zoledronic acid for the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. Presented at: ECCO 15 - ESMO 34 European Multidisciplinary Congress. Berlin, Germany, 20-24 September (2009).
-
(2009)
randomized study of denosumab versus zoledronic acid for the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. Presented at: ECCO 15 - ESMO 34 European Multidisciplinary Congress. Berlin, Germany, 20-24
-
-
Henry, D.1
Von Moos, R.2
VadhanRaj, S.3
-
108
-
-
78649676254
-
Denosumab versus zoledronic acid for the treatment of breast cancer patients with bone metastases: Results of a randomized Phase 3 study
-
Presented at:, Berlin, Germany, 20-24 September
-
Stopeck A, Body JJ, Fujiwara Y et al.: Denosumab versus zoledronic acid for the treatment of breast cancer patients with bone metastases: results of a randomized Phase 3 study. Presented at: 2009 ECCO 15 - ESMO 34 European Multidisciplinary Congress. Berlin, Germany, 20-24 September (2009).
-
(2009)
2009 ECCO 15 - ESMO 34 European Multidisciplinary Congress
-
-
Stopeck, A.1
Body, J.J.2
Fujiwara, Y.3
-
109
-
-
68949163761
-
Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand
-
Balkan W, Martinez AF, Fernandez I, Rodriguez MA, Pang M, Troen BR: Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand. Gene 446(2), 90-98 (2009).
-
(2009)
Gene
, vol.446
, Issue.2
, pp. 90-98
-
-
Balkan, W.1
Martinez, A.F.2
Fernandez, I.3
Rodriguez, M.A.4
Pang, M.5
Troen, B.R.6
-
110
-
-
67650503219
-
Regulatory mechanism of NFATC1 in RANKL-induced osteoclast activation
-
Song I, Kim JH, Kim K, Jin HM, Youn BU, Kim N: Regulatory mechanism of NFATC1 in RANKL-induced osteoclast activation. FEBS Lett. 583(14), 2435-2440 (2009).
-
(2009)
FEBS Lett
, vol.583
, Issue.14
, pp. 2435-2440
-
-
Song, I.1
Kim, J.H.2
Kim, K.3
Jin, H.M.4
Youn, B.U.5
Kim, N.6
-
111
-
-
59049085396
-
Cathepsin K activitydependent regulation of osteoclast actin ring formation and bone resorption
-
Wilson SR, Peters C, Saftig P, Bromme D: Cathepsin K activitydependent regulation of osteoclast actin ring formation and bone resorption. J. Biol. Chem. 284(4), 2584-2592 (2009).
-
(2009)
J. Biol. Chem
, vol.284
, Issue.4
, pp. 2584-2592
-
-
Wilson, S.R.1
Peters, C.2
Saftig, P.3
Bromme, D.4
-
113
-
-
0032826846
-
Breast cancer cells express Cathepsins B and L but not Cathepsins K or H
-
Ishibashi O, Mori Y, Kurokawa T, KumegawaM: Breast cancer cells express Cathepsins B and L but not Cathepsins K or H. Cancer Biochem. Biophys. 17(1-2), 69-78 (1999).
-
(1999)
Cancer Biochem. Biophys
, vol.17
, Issue.1-2
, pp. 69-78
-
-
Ishibashi, O.1
Mori, Y.2
Kurokawa, T.3
Kumegawa, M.4
-
114
-
-
15144356711
-
The osteoclastassociated protease Cathepsin K is expressed in human breast carcinoma
-
Littlewood-Evans AJ, Bilbe G, Bowler WB et al.: The osteoclastassociated protease Cathepsin K is expressed in human breast carcinoma. Cancer Res. 57(23), 5386-5390 (1997).
-
(1997)
Cancer Res
, vol.57
, Issue.23
, pp. 5386-5390
-
-
Littlewood-Evans, A.J.1
Bilbe, G.2
Bowler, W.B.3
-
115
-
-
53049084066
-
Epithelial and stromal Cathepsin K and CXCL14 expression in breast tumor progression
-
Kleer CG, Bloushtain-Qimron N, Chen YH et al.: Epithelial and stromal Cathepsin K and CXCL14 expression in breast tumor progression. Clin. Cancer Res. 14(17), 5357-5367 (2008).
-
(2008)
Clin. Cancer Res
, vol.14
, Issue.17
, pp. 5357-5367
-
-
Kleer, C.G.1
Bloushtain-Qimron, N.2
Chen, Y.H.3
-
116
-
-
35448959223
-
A Cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden
-
Le Gall C, Bellahcene A, Bonnelye E et al.: A Cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden. Cancer Res. 67(20), 9894-9902 (2007).
-
(2007)
Cancer Res
, vol.67
, Issue.20
, pp. 9894-9902
-
-
Le Gall, C.1
Bellahcene, A.2
Bonnelye, E.3
-
117
-
-
58049204438
-
Potential new drug targets for osteoporosis
-
Deal C: Potential new drug targets for osteoporosis. Nat. Clin. Pract. Rheumatol. 5(1), 20-27 (2009).
-
(2009)
Nat. Clin. Pract. Rheumatol
, vol.5
, Issue.1
, pp. 20-27
-
-
Deal, C.1
-
118
-
-
67651180563
-
Effect of the Cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: Two doubleblind, randomized, placebocontrolled Phase I studies
-
Stoch SA, Zajic S, Stone J et al.: Effect of the Cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two doubleblind, randomized, placebocontrolled Phase I studies. Clin. Pharmacol. Ther. 86(2), 175-182 (2009).
-
(2009)
Clin. Pharmacol. Ther
, vol.86
, Issue.2
, pp. 175-182
-
-
Stoch, S.A.1
Zajic, S.2
Stone, J.3
-
119
-
-
75149193891
-
Effect of Cathepsin K inhibition on suppression of bone resorption in women with breast cancer and established bone metastases in a 4week, doubleblind, randomized controlled trial
-
Presented at:, Washington DC, USA, 5-7 September
-
Jensen AB, Olmeo N, Wynne C et al.: Effect of Cathepsin K inhibition on suppression of bone resorption in women with breast cancer and established bone metastases in a 4week, doubleblind, randomized controlled trial. Presented at: 2008 ASCO Breast Cancer Symposium. Washington DC, USA, 5-7 September (2008).
-
(2008)
2008 ASCO Breast Cancer Symposium
-
-
Jensen, A.B.1
Olmeo, N.2
Wynne, C.3
-
120
-
-
0346158384
-
Bone resorption predicts for skeletal complications in metastatic bone disease
-
Brown JE, Thomson CS, Ellis SP, Gutcher SA, Purohit OP, Coleman RE: Bone resorption predicts for skeletal complications in metastatic bone disease. Br. J. Cancer 89(11), 2031-2037 (2003).
-
(2003)
Br. J. Cancer
, vol.89
, Issue.11
, pp. 2031-2037
-
-
Brown, J.E.1
Thomson, C.S.2
Ellis, S.P.3
Gutcher, S.A.4
Purohit, O.P.5
Coleman, R.E.6
-
121
-
-
19944432878
-
Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors
-
Brown JE, Cook RJ, Major P et al.: Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors. J. Natl Cancer Inst. 97(1), 59-69 (2005).
-
(2005)
J. Natl Cancer Inst
, vol.97
, Issue.1
, pp. 59-69
-
-
Brown, J.E.1
Cook, R.J.2
Major, P.3
-
122
-
-
24644479228
-
Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
-
Coleman RE, Major P, Lipton A et al.: Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. J. Clin. Oncol. 23(22), 4925-4935 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, Issue.22
, pp. 4925-4935
-
-
Coleman, R.E.1
Major, P.2
Lipton, A.3
-
123
-
-
65549165761
-
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
-
Christopher MJ, Liu F, Hilton MJ, Long F, Link DC: Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood 114(7), 1331-1339 (2009).
-
(2009)
Blood
, vol.114
, Issue.7
, pp. 1331-1339
-
-
Christopher, M.J.1
Liu, F.2
Hilton, M.J.3
Long, F.4
Link, D.C.5
-
124
-
-
38149066102
-
Mobilization of hematopoietic stem cells: State of the art
-
Levesque JP, Winkler IG: Mobilization of hematopoietic stem cells: state of the art. Curr. Opin. Organ Transplant. 13(1), 53-58 (2008).
-
(2008)
Curr. Opin. Organ Transplant
, vol.13
, Issue.1
, pp. 53-58
-
-
Levesque, J.P.1
Winkler, I.G.2
-
125
-
-
0035282432
-
Involvement of chemokine receptors in breast cancer metastasis
-
Muller A, Homey B, Soto H et al.: Involvement of chemokine receptors in breast cancer metastasis. Nature 410(6824), 50-56 (2001).
-
(2001)
Nature
, vol.410
, Issue.6824
, pp. 50-56
-
-
Muller, A.1
Homey, B.2
Soto, H.3
-
126
-
-
66149145860
-
Chemokine receptors in advanced breast cancer: Differential expression in metastatic disease sites with diagnostic and therapeutic implications
-
Cabioglu N, Sahin AA, Morandi P et al.: Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications. Ann. Oncol. 20(6), 1013-1019 (2009).
-
(2009)
Ann. Oncol
, vol.20
, Issue.6
, pp. 1013-1019
-
-
Cabioglu, N.1
Sahin, A.A.2
Morandi, P.3
-
127
-
-
7944223780
-
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
-
Li YM, Pan Y, Wei Y et al.: Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 6(5), 459-469 (2004).
-
(2004)
Cancer Cell
, vol.6
, Issue.5
, pp. 459-469
-
-
Li, Y.M.1
Pan, Y.2
Wei, Y.3
-
128
-
-
67649950329
-
The influence of tumor-host interactions in the stromal cell-derived factor-1/CXCR4 ligand/receptor axis in determining metastatic risk in breast cancer
-
Hassan S, Ferrario C, Saragovi U et al.: The influence of tumor-host interactions in the stromal cell-derived factor-1/CXCR4 ligand/receptor axis in determining metastatic risk in breast cancer. Am. J. Pathol. 175(1), 66-73 (2009).
-
(2009)
Am. J. Pathol
, vol.175
, Issue.1
, pp. 66-73
-
-
Hassan, S.1
Ferrario, C.2
Saragovi, U.3
-
129
-
-
33745334601
-
The role of CXCR4 receptor expression in breast cancer: A large tissue microarray study
-
Salvucci O, Bouchard A, Baccarelli A et al.: The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study. Breast Cancer Res. Treat. 97(3), 275-283 (2006).
-
(2006)
Breast Cancer Res. Treat
, vol.97
, Issue.3
, pp. 275-283
-
-
Salvucci, O.1
Bouchard, A.2
Baccarelli, A.3
-
130
-
-
21444433840
-
Genetic manipulation of stromal cell-derived factor-1 attests the pivotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells
-
Kang H, Mansel RE, Jiang WG: Genetic manipulation of stromal cell-derived factor-1 attests the pivotal role of the autocrine SDF-1-CXCR4 pathway in the aggressiveness of breast cancer cells. Int. J. Oncol. 26(5), 1429-1434 (2005).
-
(2005)
Int. J. Oncol
, vol.26
, Issue.5
, pp. 1429-1434
-
-
Kang, H.1
Mansel, R.E.2
Jiang, W.G.3
-
131
-
-
23044472971
-
CXCL-12/stromal cell-derived factor1a transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation
-
Cabioglu N, Summy J, Miller C et al.: CXCL-12/stromal cell-derived factor1a transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Res. 65(15), 6493-6497 (2005).
-
(2005)
Cancer Res
, vol.65
, Issue.15
, pp. 6493-6497
-
-
Cabioglu, N.1
Summy, J.2
Miller, C.3
-
132
-
-
13444265875
-
Silencing of CXCR4 blocks breast cancer metastasis
-
Liang Z, Yoon Y, Votaw J, Goodman MM, Williams L, Shim H: Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res. 65(3), 967-971 (2005).
-
(2005)
Cancer Res
, vol.65
, Issue.3
, pp. 967-971
-
-
Liang, Z.1
Yoon, Y.2
Votaw, J.3
Goodman, M.M.4
Williams, L.5
Shim, H.6
-
133
-
-
9244234390
-
CXCR4 regulates growth of both primary and metastatic breast cancer
-
Smith MC, Luker KE, Garbow JR et al.: CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res. 64(23), 8604-8612 (2004).
-
(2004)
Cancer Res
, vol.64
, Issue.23
, pp. 8604-8612
-
-
Smith, M.C.1
Luker, K.E.2
Garbow, J.R.3
-
134
-
-
24944553762
-
Stromal cell-derived factor-1a (SDF-1α/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation
-
Porcile C, Bajetto A, Barbieri F et al.: Stromal cell-derived factor-1a (SDF-1α/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation. Exp. Cell Res. 308(2), 241-253 (2005).
-
(2005)
Exp. Cell Res
, vol.308
, Issue.2
, pp. 241-253
-
-
Porcile, C.1
Bajetto, A.2
Barbieri, F.3
-
135
-
-
67650992011
-
A CXCR4 antagonist CTCE9908 inhibits primary tumor growth and metastasis of breast cancer
-
Huang EH, Singh B, Cristofanilli M et al.: A CXCR4 antagonist CTCE9908 inhibits primary tumor growth and metastasis of breast cancer. J. Surg. Res. 155(2), 231-236 (2008).
-
(2008)
J. Surg. Res
, vol.155
, Issue.2
, pp. 231-236
-
-
Huang, E.H.1
Singh, B.2
Cristofanilli, M.3
-
136
-
-
64849102577
-
Inhibition of CXCR4 by CTCE9908 inhibits breast cancer metastasis to lung and bone
-
Richert MM, Vaidya KS, Mills CN et al.: Inhibition of CXCR4 by CTCE9908 inhibits breast cancer metastasis to lung and bone. Oncol. Rep. 21(3), 761-767 (2009).
-
(2009)
Oncol. Rep
, vol.21
, Issue.3
, pp. 761-767
-
-
Richert, M.M.1
Vaidya, K.S.2
Mills, C.N.3
-
137
-
-
71749105089
-
Final results of a Phase I/II study of CTCE9908, a novel anticancer agent that inhibits CXCR4, in patients with advanced solid cancers
-
Presented at:, Geneva, Switzerland, October 21-24
-
Hotte SJ HH, P Moretto et al.: Final results of a Phase I/II study of CTCE9908, a novel anticancer agent that inhibits CXCR4, in patients with advanced solid cancers. Presented at: 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Geneva, Switzerland, October 21-24 (2008).
-
(2008)
20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
-
-
Hotte1
SJ, H.H.2
Moretto, P.3
-
138
-
-
35348884254
-
Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone
-
Hirbe AC, Rubin J, Uluckan O et al.: Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone. Proc. Natl Acad. Sci. USA 104(35), 14062-14067 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, Issue.35
, pp. 14062-14067
-
-
Hirbe, A.C.1
Rubin, J.2
Uluckan, O.3
-
139
-
-
61349193896
-
Hydrolysis of insoluble collagen by deseasin MCP01 from deepsea pseudoalteromonas sp. Sm9913: Collagenolytic characters, collagenbinding ability of c-terminal polycystic kidney disease domain, and implication for its novel role in deepsea sedimentary particulate organic nitrogen degradation
-
Zhao GY, Chen XL, Zhao HL, Xie BB, ZhouBC, Zhang YZ: Hydrolysis of insoluble collagen by deseasin MCP01 from deepsea pseudoalteromonas sp. Sm9913: collagenolytic characters, collagenbinding ability of c-terminal polycystic kidney disease domain, and implication for its novel role in deepsea sedimentary particulate organic nitrogen degradation. J. Biol. Chem. 283(52), 36100-36107 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, Issue.52
, pp. 36100-36107
-
-
Zhao, G.Y.1
Chen, X.L.2
Zhao, H.L.3
Xie, B.B.4
Zhou, B.C.5
Zhang, Y.Z.6
-
140
-
-
14844324979
-
Expression of osteoactivin in rat and human liver and isolated rat liver cells
-
HaralanovaIlieva B, Ramadori G, ArmbrustT: Expression of osteoactivin in rat and human liver and isolated rat liver cells. J. Hepatol. 42(4), 565-572 (2005).
-
(2005)
J. Hepatol
, vol.42
, Issue.4
, pp. 565-572
-
-
HaralanovaIlieva, B.1
Ramadori, G.2
Armbrust, T.3
-
141
-
-
0036720825
-
Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis
-
Ahn JH, Lee Y, Jeon C et al.: Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis. Blood 100(5), 1742-1754 (2002).
-
(2002)
Blood
, vol.100
, Issue.5
, pp. 1742-1754
-
-
Ahn, J.H.1
Lee, Y.2
Jeon, C.3
-
142
-
-
0035896629
-
Molecular cloning of a dendritic cellassociated transmembrane protein, DCHIL, that promotes RGDdependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycans
-
Shikano S, Bonkobara M, Zukas PK, AriizumiK: Molecular cloning of a dendritic cellassociated transmembrane protein, DCHIL, that promotes RGDdependent adhesion of endothelial cells through recognition of heparan sulfate proteoglycans. J. Biol. Chem. 276(11), 8125-8134 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, Issue.11
, pp. 8125-8134
-
-
Shikano, S.1
Bonkobara, M.2
Zukas, P.K.3
Ariizumi, K.4
-
143
-
-
34248226374
-
GPNMB is induced in macrophages by IFN-g and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses
-
Ripoll VM, Irvine KM, Ravasi T, Sweet MJ, Hume DA: GPNMB is induced in macrophages by IFN-g and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J. Immunol. 178(10), 6557-6566 (2007).
-
(2007)
J. Immunol
, vol.178
, Issue.10
, pp. 6557-6566
-
-
Ripoll, V.M.1
Irvine, K.M.2
Ravasi, T.3
Sweet, M.J.4
Hume, D.A.5
-
144
-
-
65449138030
-
The DCHIL/syndecan4 pathway inhibits human allogeneic Tcell responses
-
Chung JS, Bonkobara M, Tomihari M, Cruz PD Jr, Ariizumi K: The DCHIL/syndecan4 pathway inhibits human allogeneic Tcell responses. Eur. J. Immunol. 39(4), 965-974 (2009).
-
(2009)
Eur. J. Immunol
, vol.39
, Issue.4
, pp. 965-974
-
-
Chung, J.S.1
Bonkobara, M.2
Tomihari, M.3
Cruz Jr, P.D.4
Ariizumi, K.5
-
145
-
-
38449094315
-
AriizumiK: Syndecan4 mediates the coinhibitory function of DCHIL on T cell activation
-
Chung JS, Dougherty I, Cruz PD Jr, AriizumiK: Syndecan4 mediates the coinhibitory function of DCHIL on T cell activation. J. Immunol. 179(9), 5778-5784 (2007).
-
(2007)
J. Immunol
, vol.179
, Issue.9
, pp. 5778-5784
-
-
Chung, J.S.1
Dougherty, I.2
Cruz Jr, P.D.3
-
146
-
-
34248368552
-
Jr, Ariizumi K: DCHIL is a negative regulator of T lymphocyte activation
-
Chung JS, Sato K, Dougherty II, Cruz PD Jr, Ariizumi K: DCHIL is a negative regulator of T lymphocyte activation. Blood 109(10), 4320-4327 (2007).
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4320-4327
-
-
Chung, J.S.1
Sato, K.2
Dougherty, I.I.3
Cruz, P.D.4
-
147
-
-
0028927442
-
-
Weterman MA, Ajubi N, Van Dinter IM et al.: NMB, a novel gene, is expressed in lowmetastatic human melanoma cell lines and xenografts. Int. J. Cancer 60(1), 73-81 (1995).
-
Weterman MA, Ajubi N, Van Dinter IM et al.: NMB, a novel gene, is expressed in lowmetastatic human melanoma cell lines and xenografts. Int. J. Cancer 60(1), 73-81 (1995).
-
-
-
-
148
-
-
0038521296
-
Bonerelated genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model
-
Rich JN, Shi Q, Hjelmeland M et al.: Bonerelated genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. J. Biol. Chem. 278(18), 15951-15957 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, Issue.18
, pp. 15951-15957
-
-
Rich, J.N.1
Shi, Q.2
Hjelmeland, M.3
-
149
-
-
33644747384
-
Cr011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma
-
Tse KF, Jeffers M, Pollack VA et al.: Cr011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma. Clin. Cancer Res. 12(4), 1373-1382 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.4
, pp. 1373-1382
-
-
Tse, K.F.1
Jeffers, M.2
Pollack, V.A.3
-
150
-
-
66949112599
-
Jr, Ariizumi K: GPNMB is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGDdependent fashion
-
Tomihari M, Hwang SH, Chung JS, CruzPD Jr, Ariizumi K: GPNMB is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGDdependent fashion. Exp. Dermatol. 18(7), 586-595 (2009).
-
(2009)
Exp. Dermatol
, vol.18
, Issue.7
, pp. 586-595
-
-
Tomihari, M.1
Hwang, S.H.2
Chung, J.S.3
Cruz, P.D.4
-
151
-
-
33646230317
-
Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme
-
Kuan CT, Wakiya K, Dowell JM et al.: Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. Clin. Cancer Res. 12(7 Pt1), 1970-1982 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.7 PT1
, pp. 1970-1982
-
-
Kuan, C.T.1
Wakiya, K.2
Dowell, J.M.3
-
152
-
-
0242690379
-
Osteoactivin expressed during cirrhosis development in rats fed a cholinedeficient, lamino aciddefined diet, accelerates motility of hepatoma cells
-
Onaga M, Ido A, Hasuike S et al.: Osteoactivin expressed during cirrhosis development in rats fed a cholinedeficient, lamino aciddefined diet, accelerates motility of hepatoma cells. J. Hepatol. 39(5), 779-785 (2003).
-
(2003)
J. Hepatol
, vol.39
, Issue.5
, pp. 779-785
-
-
Onaga, M.1
Ido, A.2
Hasuike, S.3
-
153
-
-
23944480317
-
Osteoactivin upregulates expression of MMP3 and MMP9 in fibroblasts infiltrated into denervated skeletal muscle in mice
-
Ogawa T, Nikawa T, Furochi H et al.: Osteoactivin upregulates expression of MMP3 and MMP9 in fibroblasts infiltrated into denervated skeletal muscle in mice. Am. J. Physiol. Cell Physiol. 289(3), C697-707 (2005).
-
(2005)
Am. J. Physiol. Cell Physiol
, vol.289
, Issue.3
-
-
Ogawa, T.1
Nikawa, T.2
Furochi, H.3
-
154
-
-
49449119098
-
Antibodydrug conjugates for cancer therapy
-
Carter PJ, Senter PD: Antibodydrug conjugates for cancer therapy. Cancer J. 14(3), 154-169 (2008).
-
(2008)
Cancer J
, vol.14
, Issue.3
, pp. 154-169
-
-
Carter, P.J.1
Senter, P.D.2
-
155
-
-
34250613133
-
Treatment parameters modulating regression of human melanoma xenografts by an antibody-drug conjugate (CR011-vcMMAE) targeting GPNMB
-
Pollack VA, Alvarez E, Tse KF et al.: Treatment parameters modulating regression of human melanoma xenografts by an antibody-drug conjugate (CR011-vcMMAE) targeting GPNMB. Cancer Chemother. Pharmacol. 60(3), 423-435 (2007).
-
(2007)
Cancer Chemother. Pharmacol
, vol.60
, Issue.3
, pp. 423-435
-
-
Pollack, V.A.1
Alvarez, E.2
Tse, K.F.3
-
156
-
-
43649099521
-
Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011-vcMMAE antibody-drug conjugate
-
Qian X, Mills E, Torgov M, Larochelle WJ, Jeffers M: Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011-vcMMAE antibody-drug conjugate. Mol. Oncol. 2(1), 81-93 (2008).
-
(2008)
Mol. Oncol
, vol.2
, Issue.1
, pp. 81-93
-
-
Qian, X.1
Mills, E.2
Torgov, M.3
Larochelle, W.J.4
Jeffers, M.5
-
157
-
-
77952239035
-
A Phase I/II study of CR011-vcMMAE, an antibodydrug conjugate targeting GPNMB in patients with advanced melanoma
-
Presented at:, Orlando, FL, USA 29 May-2 June
-
Hwu P, Sznol M, Pavlick A et al.: A Phase I/II study of CR011-vcMMAE, an antibodydrug conjugate targeting GPNMB in patients with advanced melanoma. Presented at: 2008 ASCO Annual Meeting. Orlando, FL, USA 29 May-2 June (2009).
-
(2009)
2008 ASCO Annual Meeting
-
-
Hwu, P.1
Sznol, M.2
Pavlick, A.3
-
158
-
-
75149134295
-
A Phase I/II study of CR011-VCMMAE, an antibody-drug conjugate, in patients with locally advanced or metastatic breast cancer
-
Presented at:, Orlando, FL, USA, 29 May-2 June
-
Peacock N, Saleh M, Bendell J et al.: A Phase I/II study of CR011-VCMMAE, an antibody-drug conjugate, in patients with locally advanced or metastatic breast cancer. Presented at: 2009 ASCO Annual Meeting. Orlando, FL, USA, 29 May-2 June (2009).
-
(2009)
2009 ASCO Annual Meeting
-
-
Peacock, N.1
Saleh, M.2
Bendell, J.3
-
159
-
-
0035185649
-
Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts
-
Safadi FF, Xu J, Smock SL, Rico MC, Owen TA, Popoff SN: Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts. J. Cell Biochem. 84(1), 12-26 (2001).
-
(2001)
J. Cell Biochem
, vol.84
, Issue.1
, pp. 12-26
-
-
Safadi, F.F.1
Xu, J.2
Smock, S.L.3
Rico, M.C.4
Owen, T.A.5
Popoff, S.N.6
-
160
-
-
33845417908
-
Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function
-
Abdelmagid SM, Barbe MF, Arango-Hisijara I, Owen TA, Popoff SN, Safadi FF: Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function. J. Cell Physiol. 210(1), 26-37 (2007).
-
(2007)
J. Cell Physiol
, vol.210
, Issue.1
, pp. 26-37
-
-
Abdelmagid, S.M.1
Barbe, M.F.2
Arango-Hisijara, I.3
Owen, T.A.4
Popoff, S.N.5
Safadi, F.F.6
-
161
-
-
0345732695
-
Anti-osteoactivin antibody inhibits osteoblast differentiation and function in vitro
-
Selim AA, Abdelmagid SM, Kanaan RA et al.: Anti-osteoactivin antibody inhibits osteoblast differentiation and function in vitro. Crit. Rev. Eukaryot. Gene Expr. 13(2-4), 265-275 (2003).
-
(2003)
Crit. Rev. Eukaryot. Gene Expr
, vol.13
, Issue.2-4
, pp. 265-275
-
-
Selim, A.A.1
Abdelmagid, S.M.2
Kanaan, R.A.3
-
162
-
-
42049100127
-
Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity
-
Sheng MH, Wergedal JE, Mohan S, Lau KH: Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity. FEBS Lett. 582(10), 1451-1458 (2008).
-
(2008)
FEBS Lett
, vol.582
, Issue.10
, pp. 1451-1458
-
-
Sheng, M.H.1
Wergedal, J.E.2
Mohan, S.3
Lau, K.H.4
-
163
-
-
58449105062
-
GPNMB is a melanoblast-expressed, MITF-dependent gene
-
Loftus SK, Antonellis A, Matera I et al.: GPNMB is a melanoblast-expressed, MITF-dependent gene. Pigment Cell Melanoma Res. 22(1), 99-110 (2009).
-
(2009)
Pigment Cell Melanoma Res
, vol.22
, Issue.1
, pp. 99-110
-
-
Loftus, S.K.1
Antonellis, A.2
Matera, I.3
-
164
-
-
1642263620
-
MITF and TFE3: Members of a B-HLH-zip transcription factor family essential for osteoclast development and function
-
Hershey CL, Fisher DE: MITF and TFE3: Members of a B-HLH-zip transcription factor family essential for osteoclast development and function. Bone 34(4), 689-696 (2004).
-
(2004)
Bone
, vol.34
, Issue.4
, pp. 689-696
-
-
Hershey, C.L.1
Fisher, D.E.2
-
165
-
-
34347222589
-
Roles of epidermal growth factor family in the regulation of postnatal somatic growth
-
Xian CJ: Roles of epidermal growth factor family in the regulation of postnatal somatic growth. Endocr. Rev. 28(3), 284-296 (2007).
-
(2007)
Endocr. Rev
, vol.28
, Issue.3
, pp. 284-296
-
-
Xian, C.J.1
-
166
-
-
34848827653
-
EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: Implications for osteolytic bone metastases
-
Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L: EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J. Biol. Chem. 282(37), 26656-26664 (2007).
-
(2007)
J. Biol. Chem
, vol.282
, Issue.37
, pp. 26656-26664
-
-
Zhu, J.1
Jia, X.2
Xiao, G.3
Kang, Y.4
Partridge, N.C.5
Qin, L.6
-
167
-
-
69249228553
-
Adamts1 and MMP-1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
-
Lu X, Wang Q, Hu G et al.: Adamts1 and MMP-1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev. 23(16), 1882-1894 (2009).
-
(2009)
Genes Dev
, vol.23
, Issue.16
, pp. 1882-1894
-
-
Lu, X.1
Wang, Q.2
Hu, G.3
-
168
-
-
21244450719
-
Gefitinib inhibits the ability of human bone marrow stromal cells to induce osteoclast differentiation: Implications for the pathogenesis and treatment of bone metastasis
-
Normanno N, De Luca A, Aldinucci D et al.: Gefitinib inhibits the ability of human bone marrow stromal cells to induce osteoclast differentiation: implications for the pathogenesis and treatment of bone metastasis. Endocr. Relat. Cancer 12(2), 471-482 (2005).
-
(2005)
Endocr. Relat. Cancer
, vol.12
, Issue.2
, pp. 471-482
-
-
Normanno, N.1
De Luca, A.2
Aldinucci, D.3
-
169
-
-
33645996708
-
Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: Different mechanisms of action for a novel therapeutic application?
-
Normanno N, Gullick WJ: Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application? Endocr. Relat. Cancer 13(1), 3-6 (2006).
-
(2006)
Endocr. Relat. Cancer
, vol.13
, Issue.1
, pp. 3-6
-
-
Normanno, N.1
Gullick, W.J.2
-
170
-
-
2142708757
-
Challenges in the development of anti-epidermal growth factor receptor therapies in breast cancer
-
Arteaga CL, Truica CI: Challenges in the development of anti-epidermal growth factor receptor therapies in breast cancer. Semin. Oncol. 31(1 Suppl. 3), 3-8 (2004).
-
(2004)
Semin. Oncol
, vol.31
, Issue.1 SUPPL. 3
, pp. 3-8
-
-
Arteaga, C.L.1
Truica, C.I.2
-
171
-
-
58149397235
-
14th CTOS annual meeting
-
Jouret J: 14th CTOS annual meeting. Lancet Oncol. 10(1), 17 (2009).
-
(2009)
Lancet Oncol
, vol.10
, Issue.1
, pp. 17
-
-
Jouret, J.1
|