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Volumn 13, Issue 12, 2012, Pages 859-866

Sex differences in pain and pain inhibition: Multiple explanations of a controversial phenomenon

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; BUTORPHANOL; DIZOCILPINE; DYNORPHIN; ESTRADIOL; ESTROGEN; ESTRONE; KAPPA OPIATE RECEPTOR; MELANOCORTIN 1 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; NALBUPHINE; OPIATE; PENTAZOCINE; PROGESTERONE; TESTOSTERONE; TOLL LIKE RECEPTOR 4;

EID: 84872014582     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn3360     Document Type: Review
Times cited : (712)

References (132)
  • 2
    • 0031404362 scopus 로고    scopus 로고
    • Sex differences in pain
    • Berkley, K. J. Sex differences in pain. Behav. Brain Sci. 20, 371-380 (1997).
    • (1997) Behav. Brain Sci , vol.20 , pp. 371-380
    • Berkley, K.J.1
  • 3
    • 0030152338 scopus 로고    scopus 로고
    • Gender variations in clinical pain experience
    • Unruh, A. M. Gender variations in clinical pain experience. Pain 65, 123-167 (1996).
    • (1996) Pain , vol.65 , pp. 123-167
    • Unruh, A.M.1
  • 6
    • 78649903173 scopus 로고    scopus 로고
    • Sex bias in neuroscience and biomedical research
    • Beery, A. K. & Zucker, I. Sex bias in neuroscience and biomedical research. Neurosci. Biobehav. Rev. 35, 565-572 (2010).
    • (2010) Neurosci. Biobehav. Rev , vol.35 , pp. 565-572
    • Beery, A.K.1    Zucker, I.2
  • 7
    • 28844491774 scopus 로고    scopus 로고
    • The case for the inclusion of female subjects in basic science studies of pain
    • Mogil, J. S. & Chanda, M. L. The case for the inclusion of female subjects in basic science studies of pain. Pain 117, 1-5 (2005).
    • (2005) Pain , vol.117 , pp. 1-5
    • Mogil, J.S.1    Chanda, M.L.2
  • 8
    • 72849131622 scopus 로고    scopus 로고
    • Sex differences in molecular neuroscience: From fruit flies to humans
    • Jazin, E. & Cahill, L. Sex differences in molecular neuroscience: from fruit flies to humans. Nature Rev. Neurosci. 11, 9-17 (2010).
    • (2010) Nature Rev. Neurosci , vol.11 , pp. 9-17
    • Jazin, E.1    Cahill, L.2
  • 9
    • 79851508327 scopus 로고    scopus 로고
    • Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies
    • Niesters, M. et al. Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies. Pain 151, 61-68 (2010).
    • (2010) Pain , vol.151 , pp. 61-68
    • Niesters, M.1
  • 10
    • 0023076289 scopus 로고
    • Why do people go to the doctor? Sex differences in the correlates of GP consultation
    • Briscoe, M. E. Why do people go to the doctor? Sex differences in the correlates of GP consultation. Soc. Sci. Med. 25, 507-513 (1987).
    • (1987) Soc. Sci. Med , vol.25 , pp. 507-513
    • Briscoe, M.E.1
  • 11
    • 84862789777 scopus 로고    scopus 로고
    • Sex differences in reported pain across 11,000 patients captured in electronic medical records
    • Ruau, D., Liu, L. Y., Clark, J. D., Angst, M. S. & Butte, A. J. Sex differences in reported pain across 11,000 patients captured in electronic medical records. J. Pain 13, 228-234 (2012).
    • (2012) J. Pain , vol.13 , pp. 228-234
    • Ruau, D.1    Liu, L.Y.2    Clark, J.D.3    Angst, M.S.4    Butte, A.J.5
  • 12
    • 79954414716 scopus 로고    scopus 로고
    • Reference values of mechanical and thermal pain tests in a pain-free population
    • Neziri, A. Y. et al. Reference values of mechanical and thermal pain tests in a pain-free population. Eur. J. Pain 15, 376-383 (2011).
    • (2011) Eur. J. Pain , vol.15 , pp. 376-383
    • Neziri, A.Y.1
  • 14
    • 79960351125 scopus 로고    scopus 로고
    • Individual differences in morphine and butorphanol analgesia: A laboratory pain study
    • Sibille, K. T. et al. Individual differences in morphine and butorphanol analgesia: a laboratory pain study. Pain Med. 12, 1076-1085 (2011).
    • (2011) Pain Med , vol.12 , pp. 1076-1085
    • Sibille, K.T.1
  • 15
    • 84857368950 scopus 로고    scopus 로고
    • A systematic literature review of 10 years of research on sex/gender and experimental pain perception-part 1: Are there really differences between women and men?
    • Racine, M. et al. A systematic literature review of 10 years of research on sex/gender and experimental pain perception-part 1: are there really differences between women and men? Pain 153, 602-618 (2012).
    • (2012) Pain , vol.153 , pp. 602-618
    • Racine, M.1
  • 16
    • 78649344837 scopus 로고    scopus 로고
    • Sex and gender differences in pain and analgesia
    • Mogil, J. S. & Bailey, A. L. Sex and gender differences in pain and analgesia. Prog. Brain Res. 186, 141-157 (2010).
    • (2010) Prog. Brain Res , vol.186 , pp. 141-157
    • Mogil, J.S.1    Bailey, A.L.2
  • 17
    • 62349119256 scopus 로고    scopus 로고
    • Sex-based differences in pain perception and treatment
    • Paller, C. J., Campbell, C. M., Edwards, R. R. & Dobs, A. S. Sex-based differences in pain perception and treatment. Pain Med. 10, 289-299 (2009).
    • (2009) Pain Med , vol.10 , pp. 289-299
    • Paller, C.J.1    Campbell, C.M.2    Edwards, R.R.3    Dobs, A.S.4
  • 18
    • 49849083933 scopus 로고    scopus 로고
    • Sex gender and pain: An overview of a complex field
    • Hurley, R. W. & Adams, M. C. B. Sex, gender and pain: an overview of a complex field. Anesth. Analg. 107, 309-317 (2008).
    • (2008) Anesth. Analg , vol.107 , pp. 309-317
    • Hurley, R.W.1    Adams, M.C.B.2
  • 19
    • 35649018171 scopus 로고    scopus 로고
    • Studying sex and gender differences in pain and analgesia: A consensus report
    • Greenspan, J. D. et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain 132, S26-S45 (2007).
    • (2007) Pain , vol.132
    • Greenspan, J.D.1
  • 20
    • 84857364743 scopus 로고    scopus 로고
    • A systematic literature review of 10 years of research on sex/gender and pain perception-part 2: Do biopsychosocial factors alter pain sensitivity differently in women and men?
    • Racine, M. et al. A systematic literature review of 10 years of research on sex/gender and pain perception-part 2: do biopsychosocial factors alter pain sensitivity differently in women and men? Pain 153, 619-635 (2012).
    • (2012) Pain , vol.153 , pp. 619-635
    • Racine, M.1
  • 21
    • 0033993690 scopus 로고    scopus 로고
    • Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype
    • Mogil, J. S., Chesler, E. J., Wilson, S. G., Juraska, J. M. & Sternberg, W. F. Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype. Neurosci. Biobehav. Rev. 24, 375-389 (2000).
    • (2000) Neurosci. Biobehav. Rev , vol.24 , pp. 375-389
    • Mogil, J.S.1    Chesler, E.J.2    Wilson, S.G.3    Juraska, J.M.4    Sternberg, W.F.5
  • 22
    • 0038662987 scopus 로고    scopus 로고
    • Sex Differences in Opioid Analgesia "from mouse to man
    • Craft, R. M. Sex differences in opioid analgesia: "from mouse to man". J. Clin. Pain 19, 175-186 (2003).
    • (2003) J. Clin. Pain , vol.19 , pp. 175-186
    • Craft, R.M.1
  • 23
    • 49849091306 scopus 로고    scopus 로고
    • Sex-specific responses to opiates: Animal and human studies
    • Dahan, A., Kest, B., Waxman, A. R. & Sarton, E. Sex-specific responses to opiates: animal and human studies. Anesth. Analg. 107, 83-95 (2008).
    • (2008) Anesth. Analg , vol.107 , pp. 83-95
    • Dahan, A.1    Kest, B.2    Waxman, A.R.3    Sarton, E.4
  • 24
    • 0032774747 scopus 로고    scopus 로고
    • Opioid antinociception in ovariectomized monkeys: Comparison with antinociception in males and effects of estradiol replacement
    • Negus, S. S. & Mello, N. K. Opioid antinociception in ovariectomized monkeys: comparison with antinociception in males and effects of estradiol replacement. J. Pharmacol. Exp. Ther. 290, 1132-1140 (1999).
    • (1999) J. Pharmacol. Exp. Ther , vol.290 , pp. 1132-1140
    • Negus, S.S.1    Mello, N.K.2
  • 25
    • 33745861647 scopus 로고    scopus 로고
    • Does experimental pain resopnse vary across the menstrual cycle? A methodological review
    • Sherman, J. J. & LaResche, L. Does experimental pain resopnse vary across the menstrual cycle? A methodological review. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291, R245-R256 (2006).
    • (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.291
    • Sherman, J.J.1    Laresche, L.2
  • 26
    • 0032998607 scopus 로고    scopus 로고
    • A meta-analytic review of pain perception across the menstrual cycle
    • Riley, J. L., Robinson, M. E., Wise, E. A. & Price, D. D. A meta-analytic review of pain perception across the menstrual cycle. Pain 81, 225-235 (1999).
    • (1999) Pain , vol.81 , pp. 225-235
    • Riley, J.L.1    Robinson, M.E.2    Wise, E.A.3    Price, D.D.4
  • 27
    • 65249129200 scopus 로고    scopus 로고
    • Ovarian hormones and pain response: A review of clinical and basic science studies
    • Martin, V. T. Ovarian hormones and pain response: a review of clinical and basic science studies. Gend. Med. 6, 168-192 (2009).
    • (2009) Gend. Med , vol.6 , pp. 168-192
    • Martin, V.T.1
  • 28
    • 22144474470 scopus 로고    scopus 로고
    • The role of female gonadal hormones in behavioral sex differences in persistent and chronic pain: Clinical versus preclinical studies
    • Kuba, T. & Quinones-Jenab, V. The role of female gonadal hormones in behavioral sex differences in persistent and chronic pain: clinical versus preclinical studies. Brain Res. Bull. 66, 179-188 (2005).
    • (2005) Brain Res. Bull , vol.66 , pp. 179-188
    • Kuba, T.1    Quinones-Jenab, V.2
  • 29
    • 35648939775 scopus 로고    scopus 로고
    • Modulation of pain by estrogens
    • Craft, R. M. Modulation of pain by estrogens. Pain 132, S3-S12 (2007).
    • (2007) Pain , vol.132
    • Craft, R.M.1
  • 30
    • 0033032192 scopus 로고    scopus 로고
    • Sex differences in supraspinal morphine analgesia are dependent on genotype
    • Kest, B., Wilson, S. G. & Mogil, J. S. Sex differences in supraspinal morphine analgesia are dependent on genotype. J. Pharmacol. Exp. Ther. 289, 1370-1375 (1999).
    • (1999) J. Pharmacol. Exp. Ther , vol.289 , pp. 1370-1375
    • Kest, B.1    Wilson, S.G.2    Mogil, J.S.3
  • 31
    • 0031021536 scopus 로고    scopus 로고
    • Sex and genotype determine the selective activation of neurochemically-distinct mechanisms of swim stress-induced analgesia
    • Mogil, J. S. & Belknap, J. K. Sex and genotype determine the selective activation of neurochemically-distinct mechanisms of swim stress-induced analgesia. Pharmacol. Biochem. Behav. 56, 61-66 (1997).
    • (1997) Pharmacol. Biochem. Behav , vol.56 , pp. 61-66
    • Mogil, J.S.1    Belknap, J.K.2
  • 32
    • 23944462895 scopus 로고    scopus 로고
    • The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex
    • LaCroix-Fralish, M. L., Mogil, J. S., Weinstein, J. N., Rutkowski, M. D. & DeLeo, J. A. The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex. Spine 30, 1821-1827 (2005).
    • (2005) Spine , vol.30 , pp. 1821-1827
    • Lacroix-Fralish, M.L.1    Mogil, J.S.2    Weinstein, J.N.3    Rutkowski, M.D.4    Deleo, J.A.5
  • 33
    • 0034708543 scopus 로고    scopus 로고
    • Gender differences in rat neuropathic pain sensitivity is dependent on strain
    • DeLeo, J. A. & Rutkowski, M. D. Gender differences in rat neuropathic pain sensitivity is dependent on strain. Neurosci. Lett. 282, 197-199 (2000).
    • (2000) Neurosci. Lett , vol.282 , pp. 197-199
    • Deleo, J.A.1    Rutkowski, M.D.2
  • 34
    • 0033926592 scopus 로고    scopus 로고
    • Sex-related differences in the antinociceptive effects of opioids: Importance of rat genotype, nociceptive stimulus intensity, and efficacy at the μ opioid receptor
    • Cook, C. D., Barrett, A. C., Roach, E. L., Bowman, J. R. & Picker, M. J. Sex-related differences in the antinociceptive effects of opioids: importance of rat genotype, nociceptive stimulus intensity, and efficacy at the μ opioid receptor. Psychopharmacology 150, 430-442 (2000).
    • (2000) Psychopharmacology , vol.150 , pp. 430-442
    • Cook, C.D.1    Barrett, A.C.2    Roach, E.L.3    Bowman, J.R.4    Picker, M.J.5
  • 35
    • 9644255673 scopus 로고    scopus 로고
    • Strain and sex differences in the expression of nociceptive behavior and stress-induced analgesia in rats
    • Vendruscolo, L. F., Pamplona, F. A. & Takahashi, R. N. Strain and sex differences in the expression of nociceptive behavior and stress-induced analgesia in rats. Brain Res. 1030, 277-283 (2004).
    • (2004) Brain Res , vol.1030 , pp. 277-283
    • Vendruscolo, L.F.1    Pamplona, F.A.2    Takahashi, R.N.3
  • 36
    • 0345168007 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of sex differences in opioid antinociception in rats
    • Terner, J. M., Lomas, L. M., Smith, E. S., Barrett, A. C. & Picker, M. J. Pharmacogenetic analysis of sex differences in opioid antinociception in rats. Pain 106, 381-391 (2003).
    • (2003) Pain , vol.106 , pp. 381-391
    • Terner, J.M.1    Lomas, L.M.2    Smith, E.S.3    Barrett, A.C.4    Picker, M.J.5
  • 37
    • 20444397451 scopus 로고    scopus 로고
    • Influence of estrous cycle and gonadal hormone depletion on nociception and opioid antinociception in female rats of four strains
    • Terner, J. M., Lomas, L. M. & Picker, M. J. Influence of estrous cycle and gonadal hormone depletion on nociception and opioid antinociception in female rats of four strains. J. Pain 6, 372-383 (2005).
    • (2005) J. Pain , vol.6 , pp. 372-383
    • Terner, J.M.1    Lomas, L.M.2    Picker, M.J.3
  • 38
    • 24644515246 scopus 로고    scopus 로고
    • Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene
    • Mogil, J. S. et al. Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc. Natl Acad. Sci. USA 102, 12938-12943 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 12938-12943
    • Mogil, J.S.1
  • 39
    • 0344341625 scopus 로고    scopus 로고
    • The melanocortin1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
    • Mogil, J. S. et al. The melanocortin1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc. Natl Acad. Sci. USA 100, 4867-4872 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 4867-4872
    • Mogil, J.S.1
  • 40
    • 34547645194 scopus 로고    scopus 로고
    • Sex-specific variability and a 'cage effect' independently mask a neuropathic pain quantitative trait locus detected in a whole genome scan
    • Devor, M. et al. Sex-specific variability and a 'cage effect' independently mask a neuropathic pain quantitative trait locus detected in a whole genome scan. Eur. J. Neurosci. 26, 681-688 (2007).
    • (2007) Eur. J. Neurosci , vol.26 , pp. 681-688
    • Devor, M.1
  • 41
    • 0034975213 scopus 로고    scopus 로고
    • Quantitative trait loci influencing morphine antinociception in four mapping populations
    • Bergeson, S. E. et al. Quantitative trait loci influencing morphine antinociception in four mapping populations. Mamm. Genome 12, 546-553 (2001).
    • (2001) Mamm. Genome , vol.12 , pp. 546-553
    • Bergeson, S.E.1
  • 42
    • 79952659840 scopus 로고    scopus 로고
    • Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene
    • Lindstedt, F., Lonsdorf, T. B., Schalling, M., Kosek, E. & Ingvar, M. Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. PLoS ONE 6, e17752 (2011).
    • (2011) PLoS ONE , vol.6
    • Lindstedt, F.1    Lonsdorf, T.B.2    Schalling, M.3    Kosek, E.4    Ingvar, M.5
  • 43
    • 82255175654 scopus 로고    scopus 로고
    • Pain sensitivity and vasopressin analgesia are mediated by a gene?sex?environment interaction
    • Mogil, J. S. et al. Pain sensitivity and vasopressin analgesia are mediated by a gene?sex?environment interaction. Nature Neurosci. 14, 1569-1573 (2011).
    • (2011) Nature Neurosci , vol.14 , pp. 1569-1573
    • Mogil, J.S.1
  • 44
    • 77952114437 scopus 로고    scopus 로고
    • Social approach to pain in laboratory mice
    • Langford, D. L. et al. Social approach to pain in laboratory mice. Social Neurosci. 5, 163-170 (2009).
    • (2009) Social Neurosci , vol.5 , pp. 163-170
    • Langford, D.L.1
  • 45
    • 78650704400 scopus 로고    scopus 로고
    • Varying perceived social threat modulates pain behavior in male mice
    • Langford, D. L. et al. Varying perceived social threat modulates pain behavior in male mice. J. Pain 12, 125-132 (2011).
    • (2011) J. Pain , vol.12 , pp. 125-132
    • Langford, D.L.1
  • 46
    • 77950960623 scopus 로고    scopus 로고
    • Prenatal endotoxin exposure alters behavioural pain responses to lipopolysaccharide in adult offspring
    • Hodyl, N. A., Walker, F. R., Krivanek, K. M., Clifton, V. L. & Hodgson, D. M. Prenatal endotoxin exposure alters behavioural pain responses to lipopolysaccharide in adult offspring. Physiol. Behav. 100, 143-147 (2010).
    • (2010) Physiol. Behav , vol.100 , pp. 143-147
    • Hodyl, N.A.1    Walker, F.R.2    Krivanek, K.M.3    Clifton, V.L.4    Hodgson, D.M.5
  • 47
    • 35648929846 scopus 로고    scopus 로고
    • Female rats are more vulnerable to the long-term consequences of neonatal inflammatory injury
    • LaPrairie, J. L. & Murphy, A. Z. Female rats are more vulnerable to the long-term consequences of neonatal inflammatory injury. Pain 132, S124-S133 (2007).
    • (2007) Pain , vol.132
    • Laprairie, J.L.1    Murphy, A.Z.2
  • 48
    • 0037350706 scopus 로고    scopus 로고
    • Effects of gestational stress and neonatal handling on pain, analgesia, and stress behavior of adult mice
    • Sternberg, W. F. & Ridgway, C. G. Effects of gestational stress and neonatal handling on pain, analgesia, and stress behavior of adult mice. Physiol. Behav. 78, 375-383 (2003).
    • (2003) Physiol. Behav , vol.78 , pp. 375-383
    • Sternberg, W.F.1    Ridgway, C.G.2
  • 49
    • 0033430167 scopus 로고    scopus 로고
    • Sex differences in the effects of prenatal stress on stress-induced analgesia
    • Sternberg, W. F. Sex differences in the effects of prenatal stress on stress-induced analgesia. Physiol. Behav. 68, 63-72 (1999).
    • (1999) Physiol. Behav , vol.68 , pp. 63-72
    • Sternberg, W.F.1
  • 50
    • 34548218790 scopus 로고    scopus 로고
    • Sex differences in formalin-induced pain in prenatally stressed infant rats
    • Butkevich, I. P., Barr, G. A. & Vershinina, E. A. Sex differences in formalin-induced pain in prenatally stressed infant rats. Eur. J. Pain 11, 888-894 (2007).
    • (2007) Eur. J. Pain , vol.11 , pp. 888-894
    • Butkevich, I.P.1    Barr, G.A.2    Vershinina, E.A.3
  • 51
    • 0037462297 scopus 로고    scopus 로고
    • Maternal stress differently alters nociceptive behaviors in the formalin test in adult female and male rats
    • Butkevich, I. P. & Vershinina, E. A. Maternal stress differently alters nociceptive behaviors in the formalin test in adult female and male rats. Brain Res. 961, 159-165 (2003).
    • (2003) Brain Res , vol.961 , pp. 159-165
    • Butkevich, I.P.1    Vershinina, E.A.2
  • 53
    • 80054947020 scopus 로고    scopus 로고
    • Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice
    • Sorge, R. E. et al. Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice. J. Neurosci. 31, 15450-15454 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 15450-15454
    • Sorge, R.E.1
  • 54
    • 74049108153 scopus 로고    scopus 로고
    • Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin1 receptor
    • Juni, A. et al. Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin1 receptor. Anesthesiology 112, 181-188 (2010).
    • (2010) Anesthesiology , vol.112 , pp. 181-188
    • Juni, A.1
  • 55
    • 14944361565 scopus 로고    scopus 로고
    • The A118G single nucleotide polymorphism of the μopioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans
    • Fillingim, R. B. et al. The A118G single nucleotide polymorphism of the μopioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J. Pain 6, 159-167 (2005).
    • (2005) J. Pain , vol.6 , pp. 159-167
    • Fillingim, R.B.1
  • 56
    • 2442503913 scopus 로고    scopus 로고
    • Modulation of morphine analgesia by site-specific Nmethyl-Daspartate receptor antagonists: Dependence on sex, site of antagonism, morphine dose, and time
    • Nemmani, K. V. S., Grisel, J. E., Stowe, J. R., Smith-Carliss, R. & Mogil, J. S. Modulation of morphine analgesia by site-specific Nmethyl-Daspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. Pain 109, 274-283 (2004).
    • (2004) Pain , vol.109 , pp. 274-283
    • Nemmani, K.V.S.1    Grisel, J.E.2    Stowe, J.R.3    Smith-Carliss, R.4    Mogil, J.S.5
  • 57
    • 0027173007 scopus 로고
    • Sex differences in the antagonism of swim stress-induced analgesia: Effects of gonadectomy and estrogen replacement
    • Mogil, J. S., Sternberg, W. F., Kest, B., Marek, P. & Liebeskind, J. C. Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement. Pain 53, 17-25 (1993).
    • (1993) Pain , vol.53 , pp. 17-25
    • Mogil, J.S.1    Sternberg, W.F.2    Kest, B.3    Marek, P.4    Liebeskind, J.C.5
  • 58
    • 0033966263 scopus 로고    scopus 로고
    • Brainstem pain modulating circuitry is sexually dimorphic with respect to μ and κ opioid receptor function
    • Tershner, S. A., Mitchell, J. M. & Fields, H. L. Brainstem pain modulating circuitry is sexually dimorphic with respect to μ and κ opioid receptor function. Pain 85, 153-159 (2000).
    • (2000) Pain , vol.85 , pp. 153-159
    • Tershner, S.A.1    Mitchell, J.M.2    Fields, H.L.3
  • 59
    • 78650551486 scopus 로고    scopus 로고
    • Formation of μ-/κopioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia
    • Chakrabarti, S., Liu, N.J. & Gintzler, A. R. Formation of μ-/κopioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Proc. Natl Acad. Sci. USA 107, 20115-20119 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20115-20119
    • Chakrabarti, S.1    Liu, N.J.2    Gintzler, A.R.3
  • 60
    • 34547138142 scopus 로고    scopus 로고
    • Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine
    • Liu, N.J., von Gizycki, H. & Gintzler, A. R. Sexually dimorphic recruitment of spinal opioid analgesic pathways by the spinal application of morphine. J. Pharmacol. Exp. Ther. 322, 654-660 (2007).
    • (2007) J. Pharmacol. Exp. Ther , vol.322 , pp. 654-660
    • Liu, N.J.1    Von Gizycki, H.2    Gintzler, A.R.3
  • 61
    • 0033952151 scopus 로고    scopus 로고
    • Prolonged ovarian sex steroid treatment of male rats produces antinociception: Identification of sex-based divergent analgesic mechanisms
    • Liu, N.J. & Gintzler, A. R. Prolonged ovarian sex steroid treatment of male rats produces antinociception: identification of sex-based divergent analgesic mechanisms. Pain 85, 273-281 (2000).
    • (2000) Pain , vol.85 , pp. 273-281
    • Liu, N.J.1    Gintzler, A.R.2
  • 62
    • 0037422558 scopus 로고    scopus 로고
    • Contribution of GIRKmediated postsynaptic signaling to opiate and α2-adrenergic analgesia and analgesic sex differences
    • Mitrovic, I. et al. Contribution of GIRKmediated postsynaptic signaling to opiate and α2-adrenergic analgesia and analgesic sex differences. Proc. Natl Acad. Sci. USA 100, 271-276 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 271-276
    • Mitrovic, I.1
  • 63
    • 0043135244 scopus 로고    scopus 로고
    • Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat
    • Joseph, E. K. & Levine, J. D. Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat. Neuroscience 120, 907-913 (2003).
    • (2003) Neuroscience , vol.120 , pp. 907-913
    • Joseph, E.K.1    Levine, J.D.2
  • 64
    • 0029961190 scopus 로고    scopus 로고
    • Kappa-opioids produce significantly greater analgesia in women than in men
    • Gear, R. W. et al. Kappa-opioids produce significantly greater analgesia in women than in men. Nature Med. 2, 1248-1250 (1996).
    • (1996) Nature Med , vol.2 , pp. 1248-1250
    • Gear, R.W.1
  • 66
    • 0036151732 scopus 로고    scopus 로고
    • Role of steroids in sex differences in morphine-induced analgesia: Activational and organizational effects
    • Cicero, T. J., Nock, B., O'Connor, L. & Meyer, E. R. Role of steroids in sex differences in morphine-induced analgesia: activational and organizational effects. J. Pharmacol. Exp. Ther. 300, 695-701 (2002).
    • (2002) J. Pharmacol. Exp. Ther , vol.300 , pp. 695-701
    • Cicero, T.J.1    Nock, B.2    O'Connor, L.3    Meyer, E.R.4
  • 67
    • 33751006971 scopus 로고    scopus 로고
    • Organizational and activation effects of testosterone on carrageenan-induced inflammatory pain and morphine analgesia
    • Borzan, J. & Fuchs, P. N. Organizational and activation effects of testosterone on carrageenan-induced inflammatory pain and morphine analgesia. Neuroscience 143, 885-893 (2006).
    • (2006) Neuroscience , vol.143 , pp. 885-893
    • Borzan, J.1    Fuchs, P.N.2
  • 68
    • 0036498282 scopus 로고    scopus 로고
    • Reversal of sex differences in morphine analgesia elicited from the ventrolateral periaqueductal gray in rats by neonatal hormone manipulations
    • Krzanowska, E. K., Ogawa, S., Pfaff, D. W. & Bodnar, R. J. Reversal of sex differences in morphine analgesia elicited from the ventrolateral periaqueductal gray in rats by neonatal hormone manipulations. Brain Res. 929, 1-9 (2002).
    • (2002) Brain Res , vol.929 , pp. 1-9
    • Krzanowska, E.K.1    Ogawa, S.2    Pfaff, D.W.3    Bodnar, R.J.4
  • 69
    • 26844546393 scopus 로고    scopus 로고
    • Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats: Effects of adult ovariectomy and estradiol replacement
    • Cataldo, G. et al. Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats: effects of adult ovariectomy and estradiol replacement. Brain Res. 1059, 13-19 (2005).
    • (2005) Brain Res , vol.1059 , pp. 13-19
    • Cataldo, G.1
  • 70
    • 0028820681 scopus 로고    scopus 로고
    • Neonatal testosterone exposure influences neurochemistry of swim stress-induced analgesia in adult mice
    • Sternberg, W. F. et al. Neonatal testosterone exposure influences neurochemistry of swim stress-induced analgesia in adult mice. Pain 63, 321-326 (1996).
    • (1996) Pain , vol.63 , pp. 321-326
    • Sternberg, W.F.1
  • 71
    • 0017718330 scopus 로고
    • Gonadectomy and sensitivity to electric shock in the rat
    • Beatty, W. W. & Fessler, R. G. Gonadectomy and sensitivity to electric shock in the rat. Physiol. Behav. 19, 1-6 (1977).
    • (1977) Physiol. Behav , vol.19 , pp. 1-6
    • Beatty, W.W.1    Fessler, R.G.2
  • 72
    • 14044251363 scopus 로고    scopus 로고
    • The organizational and activational effects of sex hormones on tactile and thermal hypersensitivity following lumbar nerve root injury in male and female rats
    • LaCroix-Fralish, M. L., Tawfik, V. L. & DeLeo, J. A. The organizational and activational effects of sex hormones on tactile and thermal hypersensitivity following lumbar nerve root injury in male and female rats. Pain 114, 71-80 (2005).
    • (2005) Pain , vol.114 , pp. 71-80
    • Lacroix-Fralish, M.L.1    Tawfik, V.L.2    Deleo, J.A.3
  • 73
    • 0037146904 scopus 로고    scopus 로고
    • The role of sex hormones on formalin-induced nociceptive responses
    • Gaumond, I., Arsenault, P. & Marchand, S. The role of sex hormones on formalin-induced nociceptive responses. Brain Res. 958, 139-145 (2002).
    • (2002) Brain Res , vol.958 , pp. 139-145
    • Gaumond, I.1    Arsenault, P.2    Marchand, S.3
  • 74
    • 4744357895 scopus 로고    scopus 로고
    • Acute progesterone can recruit sex-specific neurochemical mechanisms mediating swim stress-induced and κ-opioid analgesia in mice
    • Sternberg, W. F., Chesler, E. J., Wilson, S. G. & Mogil, J. S. Acute progesterone can recruit sex-specific neurochemical mechanisms mediating swim stress-induced and κ-opioid analgesia in mice. Horm. Behav. 46, 467-473 (2004).
    • (2004) Horm. Behav , vol.46 , pp. 467-473
    • Sternberg, W.F.1    Chesler, E.J.2    Wilson, S.G.3    Mogil, J.S.4
  • 75
    • 78149284942 scopus 로고    scopus 로고
    • Progesterone rapidly recruits female-typical opioid-induced hyperalgesic mechanisms
    • Waxman, A. R. et al. Progesterone rapidly recruits female-typical opioid-induced hyperalgesic mechanisms. Physiol. Behav. 101, 759-763 (2010).
    • (2010) Physiol. Behav , vol.101 , pp. 759-763
    • Waxman, A.R.1
  • 76
    • 2342638315 scopus 로고    scopus 로고
    • Testosterone affects formalin-induced responses differently in male and female rats
    • Aloisi, A. M., Ceccarelli, I., Fiorenzani, P., De Padova, A. M. & Massafra, C. Testosterone affects formalin-induced responses differently in male and female rats. Neurosci. Lett. 361, 262-264 (2004).
    • (2004) Neurosci. Lett , vol.361 , pp. 262-264
    • Aloisi, A.M.1    Ceccarelli, I.2    Fiorenzani, P.3    De Padova, A.M.4    Massafra, C.5
  • 77
    • 33846240931 scopus 로고    scopus 로고
    • Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats
    • Hagiwara, H., Funabashi, T., Mitsushima, D. & Kimura, F. Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats. Neurosci. Lett. 412, 264-267 (2007).
    • (2007) Neurosci. Lett , vol.412 , pp. 264-267
    • Hagiwara, H.1    Funabashi, T.2    Mitsushima, D.3    Kimura, F.4
  • 78
    • 58049173922 scopus 로고    scopus 로고
    • What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues?
    • Arnold, A. P. & Chen, X. What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues? Front. Neuroendocrinol. 30, 1-9 (2008).
    • (2008) Front. Neuroendocrinol , vol.30 , pp. 1-9
    • Arnold, A.P.1    Chen, X.2
  • 79
    • 0037109668 scopus 로고    scopus 로고
    • A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits
    • De Vries, G. J. et al. A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J. Neurosci. 22, 9005-9014 (2002).
    • (2002) J. Neurosci , vol.22 , pp. 9005-9014
    • De Vries, G.J.1
  • 80
    • 52149102961 scopus 로고    scopus 로고
    • Sex chromosome complement affects nociception and analgesia in newborn mice
    • Gioiosa, L., Chen, X., Watkins, R., Umeda, E. A. & Arnold, A. P. Sex chromosome complement affects nociception and analgesia in newborn mice. J. Pain 9, 962-969 (2008).
    • (2008) J. Pain , vol.9 , pp. 962-969
    • Gioiosa, L.1    Chen, X.2    Watkins, R.3    Umeda, E.A.4    Arnold, A.P.5
  • 81
    • 37349001257 scopus 로고    scopus 로고
    • Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice
    • Gioiosa, L. et al. Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice. Horm. Behav. 53, 124-130 (2008).
    • (2008) Horm. Behav , vol.53 , pp. 124-130
    • Gioiosa, L.1
  • 82
    • 14644431832 scopus 로고    scopus 로고
    • Individual responder analyses for pain: Does one pain scale fit all?
    • Dionne, R. A., Bartoshuk, L., Mogil, J. S. & Witter, J. Individual responder analyses for pain: does one pain scale fit all? Trends Pharmacol. Sci. 26, 125-130 (2005).
    • (2005) Trends Pharmacol. Sci , vol.26 , pp. 125-130
    • Dionne, R.A.1    Bartoshuk, L.2    Mogil, J.S.3    Witter, J.4
  • 83
    • 0034779649 scopus 로고    scopus 로고
    • Gender role expectations of pain: Relationship to sex differences in pain
    • Robinson, M. E. et al. Gender role expectations of pain: relationship to sex differences in pain. J. Pain 2, 251-257 (2001).
    • (2001) J. Pain , vol.2 , pp. 251-257
    • Robinson, M.E.1
  • 84
    • 0036220456 scopus 로고    scopus 로고
    • Gender role expectations of pain: Relationship to experimental pain perception
    • Wise, E. A., Price, D. D., Myers, C. D., Heft, W. M. & Robinson, M. E. Gender role expectations of pain: relationship to experimental pain perception. Pain 96, 335-342 (2002).
    • (2002) Pain , vol.96 , pp. 335-342
    • Wise, E.A.1    Price, D.D.2    Myers, C.D.3    Heft, W.M.4    Robinson, M.E.5
  • 85
    • 0034253837 scopus 로고    scopus 로고
    • The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: The role of catastrophizing
    • Keefe, F. J. et al. The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: the role of catastrophizing. Pain 87, 325-334 (2000).
    • (2000) Pain , vol.87 , pp. 325-334
    • Keefe, F.J.1
  • 86
    • 4444223555 scopus 로고    scopus 로고
    • Catastrophizing as a mediator of sex differences in pain: Differential effects for daily pain versus laboratory-induced pain
    • Edwards, R. R., Haythornthwaite, J. A., Sullivan, M. J. & Fillingim, R. B. Catastrophizing as a mediator of sex differences in pain: differential effects for daily pain versus laboratory-induced pain. Pain 111, 335-341 (2004).
    • (2004) Pain , vol.111 , pp. 335-341
    • Edwards, R.R.1    Haythornthwaite, J.A.2    Sullivan, M.J.3    Fillingim, R.B.4
  • 87
    • 0036976856 scopus 로고    scopus 로고
    • Gender differences in pain perception: The mediating role of self-efficacy beliefs
    • Jackson, T., Iezzi, T., Gunderson, J., Nagasaka, T. & Fritch, A. Gender differences in pain perception: the mediating role of self-efficacy beliefs. Sex Roles 47, 561-568 (2002).
    • (2002) Sex Roles , vol.47 , pp. 561-568
    • Jackson, T.1    Iezzi, T.2    Gunderson, J.3    Nagasaka, T.4    Fritch, A.5
  • 88
    • 0030816457 scopus 로고    scopus 로고
    • Sex differences in Nmethyl-Daspartate involvement in κ opioid and non-opioid predator-induced analgesia in mice
    • Kavaliers, M. & Choleris, E. Sex differences in Nmethyl-Daspartate involvement in κ opioid and non-opioid predator-induced analgesia in mice. Brain Res. 768, 30-36 (1997).
    • (1997) Brain Res , vol.768 , pp. 30-36
    • Kavaliers, M.1    Choleris, E.2
  • 89
    • 33745815972 scopus 로고    scopus 로고
    • NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice
    • Bryant, C. D., Eitan, S., Sinchak, K., Fanselow, M. S. & Evans, C. J. NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291, R315-R326 (2006).
    • (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.291
    • Bryant, C.D.1    Eitan, S.2    Sinchak, K.3    Fanselow, M.S.4    Evans, C.J.5
  • 90
    • 43949130709 scopus 로고    scopus 로고
    • Sex differences in hyperalgesia during morphine infusion: Effect of gonadectomy and estrogen treatment
    • Juni, A., Klein, G., Kowalczyk, B., Ragnauth, A. & Kest, B. Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment. Neuropharmacology 54, 1264-1270 (2008).
    • (2008) Neuropharmacology , vol.54 , pp. 1264-1270
    • Juni, A.1    Klein, G.2    Kowalczyk, B.3    Ragnauth, A.4    Kest, B.5
  • 91
    • 77958585653 scopus 로고    scopus 로고
    • Involvement of the melanocortin1 receptor in acute pain and pain of inflammatory but not neuropathic origin
    • Delany, A., Keighren, M., Fleetwood-Walker, S. M. & Jackson, I. J. Involvement of the melanocortin1 receptor in acute pain and pain of inflammatory but not neuropathic origin. PLoS ONE 5, e12498 (2010).
    • (2010) PLoS ONE , vol.5
    • Delany, A.1    Keighren, M.2    Fleetwood-Walker, S.M.3    Jackson, I.J.4
  • 92
    • 78049467023 scopus 로고    scopus 로고
    • Sex-specificity and estrogen-dependence of κ opioid receptor-mediated antinociception and antihyperalgesia
    • Lawson, K. P., Nag, S., Thompson, A. D. & Mokha, S. S. Sex-specificity and estrogen-dependence of κ opioid receptor-mediated antinociception and antihyperalgesia. Pain 151, 806-815 (2010).
    • (2010) Pain , vol.151 , pp. 806-815
    • Lawson, K.P.1    Nag, S.2    Thompson, A.D.3    Mokha, S.S.4
  • 93
    • 80051752873 scopus 로고    scopus 로고
    • Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ-and μopioid receptor heterodimerization and female-specific spinal morphine antinociception
    • Liu, N.J., Chakrabarti, S., Schnell, S., Wessendorf, M. & Gintzler, A. R. Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ-and μopioid receptor heterodimerization and female-specific spinal morphine antinociception. J. Neurosci. 31, 11836-11845 (2011).
    • (2011) J. Neurosci , vol.31 , pp. 11836-11845
    • Liu, N.J.1    Chakrabarti, S.2    Schnell, S.3    Wessendorf, M.4    Gintzler, A.R.5
  • 94
    • 0034913072 scopus 로고    scopus 로고
    • Sex hormones regulate the contribution of PKCε and PKA signalling in inflammatory pain in the rat
    • Dina, O. A., Aley, K. O., Isenberg, W. M., Messing, R. O. & Levine, J. D. Sex hormones regulate the contribution of PKCε and PKA signalling in inflammatory pain in the rat. Eur. J. Neurosci. 13, 2227-2233 (2001).
    • (2001) Eur. J. Neurosci , vol.13 , pp. 2227-2233
    • Dina, O.A.1    Aley, K.O.2    Isenberg, W.M.3    Messing, R.O.4    Levine, J.D.5
  • 95
    • 33746254918 scopus 로고    scopus 로고
    • Estrogen controls PKCε-dependent mechanical hyperalgesia through direct action on nociceptive neurons
    • Hucho, T. B., Dina, O. A., Kuhn, J. & Levine, J. D. Estrogen controls PKCε-dependent mechanical hyperalgesia through direct action on nociceptive neurons. Eur. J. Neurosci. 24, 527-534 (2006).
    • (2006) Eur. J. Neurosci , vol.24 , pp. 527-534
    • Hucho, T.B.1    Dina, O.A.2    Kuhn, J.3    Levine, J.D.4
  • 96
    • 33846865572 scopus 로고    scopus 로고
    • Severity of alcohol-induced painful peripheral neuropathy in female rats: Role of estrogen and protein kinase (A and Cε
    • Dina, O. A., Gear, R. W., Messing, R. O. & Levine, J. D. Severity of alcohol-induced painful peripheral neuropathy in female rats: role of estrogen and protein kinase (A and Cε). Neuroscience 145, 350-356 (2007).
    • (2007) Neuroscience , vol.145 , pp. 350-356
    • Dina, O.A.1    Gear, R.W.2    Messing, R.O.3    Levine, J.D.4
  • 97
    • 80053943575 scopus 로고    scopus 로고
    • Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors
    • Benedetti, F., Amanzio, M., Rosato, R. & Blanchard, C. Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nature Med. 17, 1228-1230 (2011).
    • (2011) Nature Med , vol.17 , pp. 1228-1230
    • Benedetti, F.1    Amanzio, M.2    Rosato, R.3    Blanchard, C.4
  • 98
    • 0031005356 scopus 로고    scopus 로고
    • The neurobiology of placebo analgesia: From endogenous opioids to cholecystokinin
    • Benedetti, F. & Amanzio, M. The neurobiology of placebo analgesia: from endogenous opioids to cholecystokinin. Prog. Neurobiol. 52, 109-125 (1997).
    • (1997) Prog. Neurobiol , vol.52 , pp. 109-125
    • Benedetti, F.1    Amanzio, M.2
  • 99
    • 35548937457 scopus 로고    scopus 로고
    • The neuropathic pain triad: Neurons, immune cells, and glia
    • Scholz, J. & Woolf, C. J. The neuropathic pain triad: neurons, immune cells, and glia. Nature Neurosci. 10, 1361-1368 (2007).
    • (2007) Nature Neurosci , vol.10 , pp. 1361-1368
    • Scholz, J.1    Woolf, C.J.2
  • 100
    • 33646043440 scopus 로고    scopus 로고
    • The tetrapartite synapse: Path to CNS sensitization and chronic pain
    • DeLeo, J. A., Tawfik, V. L. & LaCroix-Fralish, M. L. The tetrapartite synapse: path to CNS sensitization and chronic pain. Pain 122, 17-21 (2006).
    • (2006) Pain , vol.122 , pp. 17-21
    • Deleo, J.A.1    Tawfik, V.L.2    Lacroix-Fralish, M.L.3
  • 101
    • 77954005130 scopus 로고    scopus 로고
    • Endogenous ligands of TLR2 and TLR4: Agonists or assistants?
    • Erridge, C. Endogenous ligands of TLR2 and TLR4: agonists or assistants? J. Leukoc. Biol. 87, 989-999 (2010).
    • (2010) J. Leukoc. Biol , vol.87 , pp. 989-999
    • Erridge, C.1
  • 102
    • 0037477629 scopus 로고    scopus 로고
    • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4dependent pathway
    • Lehnardt, S. et al. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4dependent pathway. Proc. Natl Acad. Sci. USA 100, 8514-8519 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8514-8519
    • Lehnardt, S.1
  • 103
    • 0035064830 scopus 로고    scopus 로고
    • The sole gateway to endotoxin response: How LPS was identified as TLR4, and its role in innate immunity
    • Beutler, B. & Poltorak, A. The sole gateway to endotoxin response: how LPS was identified as TLR4, and its role in innate immunity. Drug Metab. Dispos. 29, 474-478 (2001).
    • (2001) Drug Metab. Dispos , vol.29 , pp. 474-478
    • Beutler, B.1    Poltorak, A.2
  • 104
    • 17644414137 scopus 로고    scopus 로고
    • The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
    • Tanga, F. Y., Nutile-McMenemy, N. & DeLeo, J. A. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc. Natl Acad. Sci. USA 102, 5856-5861 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 5856-5861
    • Tanga, F.Y.1    Nutile-Mcmenemy, N.2    Deleo, J.A.3
  • 105
    • 51349166320 scopus 로고    scopus 로고
    • Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice
    • Bettoni, I. et al. Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice. Glia 56, 1312-1319 (2008).
    • (2008) Glia , vol.56 , pp. 1312-1319
    • Bettoni, I.1
  • 106
    • 84862777282 scopus 로고    scopus 로고
    • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
    • Sorge, R. E. et al. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nature Med. 18, 595-599 (2012).
    • (2012) Nature Med , vol.18 , pp. 595-599
    • Sorge, R.E.1
  • 107
    • 77953479215 scopus 로고    scopus 로고
    • Estradiol and testosterone differently affect visceral pain-related behavioural responses in male and female rats
    • Aloisi, A. M. et al. Estradiol and testosterone differently affect visceral pain-related behavioural responses in male and female rats. Eur. J. Pain 14, 602-607 (2010).
    • (2010) Eur. J. Pain , vol.14 , pp. 602-607
    • Aloisi, A.M.1
  • 108
    • 80051796365 scopus 로고    scopus 로고
    • Characteristics of response to experimental pain in sexually abused women
    • Granot, M. et al. Characteristics of response to experimental pain in sexually abused women. Clin. J. Pain 27, 616-622 (2011).
    • (2011) Clin. J. Pain , vol.27 , pp. 616-622
    • Granot, M.1
  • 109
    • 0032730828 scopus 로고    scopus 로고
    • The relationship of sex and clinical pain to experimental pain responses
    • Fillingim, R. B., Edwards, R. R. & Powell, T. The relationship of sex and clinical pain to experimental pain responses. Pain 83, 415-425 (1999).
    • (1999) Pain , vol.83 , pp. 415-425
    • Fillingim, R.B.1    Edwards, R.R.2    Powell, T.3
  • 110
    • 0034194487 scopus 로고    scopus 로고
    • Sex-dependent effects of reported familial pain history on recent pain complaints and experimental pain responses
    • Fillingim, R. B., Edwards, R. R. & Powell, T. Sex-dependent effects of reported familial pain history on recent pain complaints and experimental pain responses. Pain 86, 87-94 (2000).
    • (2000) Pain , vol.86 , pp. 87-94
    • Fillingim, R.B.1    Edwards, R.R.2    Powell, T.3
  • 111
    • 0036181983 scopus 로고    scopus 로고
    • Psychosocial mediators of sex differences in pain responsivity
    • Sanford, S. D., Kersh, B. C., Thorn, B. E., Rich, M. A. & Ward, L. R. Psychosocial mediators of sex differences in pain responsivity. J. Pain 3, 58-64 (2002).
    • (2002) J. Pain , vol.3 , pp. 58-64
    • Sanford, S.D.1    Kersh, B.C.2    Thorn, B.E.3    Rich, M.A.4    Ward, L.R.5
  • 112
    • 59249086601 scopus 로고    scopus 로고
    • Pain-related effects of trait anger expression: Neural substrates and the role of endogenous opioid mechanisms
    • Bruehl, S., Burns, J. W., Chung, O. Y. & Chont, M. Pain-related effects of trait anger expression: neural substrates and the role of endogenous opioid mechanisms. Neurosci. Biobehav. Rev. 33, 475-491 (2009).
    • (2009) Neurosci. Biobehav. Rev , vol.33 , pp. 475-491
    • Bruehl, S.1    Burns, J.W.2    Chung, O.Y.3    Chont, M.4
  • 113
    • 0042322486 scopus 로고    scopus 로고
    • Dispositional anxiety and the experience of pain: Gender-specific effects
    • Jones, A., Zachariae, R. & Arendt-Nielsen, L. Dispositional anxiety and the experience of pain: gender-specific effects. Eur. J. Pain 7, 387-395 (2003).
    • (2003) Eur. J. Pain , vol.7 , pp. 387-395
    • Jones, A.1    Zachariae, R.2    Arendt-Nielsen, L.3
  • 114
    • 33745714192 scopus 로고    scopus 로고
    • Sex differences in adolescent chronic pain and pain-related coping
    • Keogh, E. & Eccleston, C. Sex differences in adolescent chronic pain and pain-related coping. Pain 123, 275-284 (2006).
    • (2006) Pain , vol.123 , pp. 275-284
    • Keogh, E.1    Eccleston, C.2
  • 115
    • 0036903265 scopus 로고    scopus 로고
    • Sex differences in perceptual and cardiovascular responses to pain: The influence of a perceived ability manipulation
    • Fillingim, R. B., Browning, A. D., Powell, T. & Wright, R. Sex differences in perceptual and cardiovascular responses to pain: the influence of a perceived ability manipulation. J. Pain 6, 439-445 (2002).
    • (2002) J. Pain , vol.6 , pp. 439-445
    • Fillingim, R.B.1    Browning, A.D.2    Powell, T.3    Wright, R.4
  • 116
    • 0345688972 scopus 로고    scopus 로고
    • Sex-related difference in collateral sprouting of nociceptive axons after peripheral nerve injury in the rat
    • Kovacic, U., Sketelj, J. & Bajrovic, F. F. Sex-related difference in collateral sprouting of nociceptive axons after peripheral nerve injury in the rat. Exp. Neurol. 184, 479-488 (2003).
    • (2003) Exp. Neurol , vol.184 , pp. 479-488
    • Kovacic, U.1    Sketelj, J.2    Bajrovic, F.F.3
  • 117
    • 84855952463 scopus 로고    scopus 로고
    • Sex similarities and differences in pain-related periaqueductal gray connectivity
    • Linnman, C., Beucke, J.C., Jensen, K. B., Gollub, R. L. & Kong, J. Sex similarities and differences in pain-related periaqueductal gray connectivity. Pain 153, 444-454 (2012).
    • (2012) Pain , vol.153 , pp. 444-454
    • Linnman, C.1    Beucke, J.C.2    Jensen, K.B.3    Gollub, R.L.4    Kong, J.5
  • 118
    • 77955307411 scopus 로고    scopus 로고
    • Gender differences in pain modulation by diffuse noxious inhibitory controls: A systematic review
    • Popescu, A., LeResche, L., Truelove, E. L. & Drangsholt, M. T. Gender differences in pain modulation by diffuse noxious inhibitory controls: a systematic review. Pain 150, 309-318 (2010).
    • (2010) Pain , vol.150 , pp. 309-318
    • Popescu, A.1    Leresche, L.2    Truelove, E.L.3    Drangsholt, M.T.4
  • 119
    • 33745807946 scopus 로고    scopus 로고
    • Testosterone and estrogen have opposing actions on inflammation-induced plasma extravasation in the rat temporomandibular joint
    • Flake, N. M., Hermanstyne, T. O. & Gold, M. S. Testosterone and estrogen have opposing actions on inflammation-induced plasma extravasation in the rat temporomandibular joint. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291, R343-R348 (2006).
    • (2006) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.291
    • Flake, N.M.1    Hermanstyne, T.O.2    Gold, M.S.3
  • 120
    • 60849095554 scopus 로고    scopus 로고
    • The role of the periaqueductal gray in the modulation of pain in males and females: Are the anatomy and physiology really that different?
    • Loyd, D. R. & Murphy, A. The role of the periaqueductal gray in the modulation of pain in males and females: are the anatomy and physiology really that different? Neural Plast. 2009, 462879 (2009).
    • (2009) Neural Plast , vol.2009 , pp. 462879
    • Loyd, D.R.1    Murphy, A.2
  • 121
    • 0037642241 scopus 로고    scopus 로고
    • Gonadal hormones do not account for sexual dimorphism in vagal modulation of nociception in the rat
    • Khasar, S. G., Green, P. G., Gear, R. W., Isenberg, W. & Levine, J. D. Gonadal hormones do not account for sexual dimorphism in vagal modulation of nociception in the rat. J. Pain 4, 190-196 (2003).
    • (2003) J. Pain , vol.4 , pp. 190-196
    • Khasar, S.G.1    Green, P.G.2    Gear, R.W.3    Isenberg, W.4    Levine, J.D.5
  • 122
    • 79952118971 scopus 로고    scopus 로고
    • Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice
    • Li, L. et al. Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice. Neuroscience 170, 923-928 (2010).
    • (2010) Neuroscience , vol.170 , pp. 923-928
    • Li, L.1
  • 124
    • 72949090802 scopus 로고    scopus 로고
    • The cAMP response element-binding protein in the bed nucleus of the stria terminalis modulates the formalin-induced pain behavior in the female rat
    • Hagiwara, H. et al. The cAMP response element-binding protein in the bed nucleus of the stria terminalis modulates the formalin-induced pain behavior in the female rat. Eur. J. Neurosci. 30, 2379-2386 (2009).
    • (2009) Eur. J. Neurosci , vol.30 , pp. 2379-2386
    • Hagiwara, H.1
  • 125
    • 80655125511 scopus 로고    scopus 로고
    • Sexual dimorphism on cytokines expression in the temporomandibular joint: The role of gonadal steroid hormones
    • Torres-Chavez, K. E. et al. Sexual dimorphism on cytokines expression in the temporomandibular joint: the role of gonadal steroid hormones. Inflammation 34, 487-498 (2011).
    • (2011) Inflammation , vol.34 , pp. 487-498
    • Torres-Chavez, K.E.1
  • 126
    • 79952703048 scopus 로고    scopus 로고
    • Sex-related differences in descending norepinephrine and serotonin controls of spinal withdrawal reflex during intramuscular saline induced muscle nociception in rats
    • Lei, J. et al. Sex-related differences in descending norepinephrine and serotonin controls of spinal withdrawal reflex during intramuscular saline induced muscle nociception in rats. Exp. Neurol. 228, 206-214 (2011).
    • (2011) Exp. Neurol , vol.228 , pp. 206-214
    • Lei, J.1
  • 127
    • 43049153240 scopus 로고    scopus 로고
    • Sex-specific pain modulation: The growth factor, neuregulin1, as a pro-nociceptive cytokine
    • LaCroix-Fralish, M. L. Sex-specific pain modulation: the growth factor, neuregulin1, as a pro-nociceptive cytokine. Neurosci. Lett. 437,184-187 (2008).
    • (2008) Neurosci. Lett , vol.437 , pp. 184-187
    • Lacroix-Fralish, M.L.1
  • 128
    • 3142619945 scopus 로고    scopus 로고
    • Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5αreduced metabolites in the hippocampus
    • Edinger, K. L. & Frye, C. A. Testosterone's analgesic, anxiolytic, and cognitive-enhancing effects may be due in part to actions of its 5αreduced metabolites in the hippocampus. Behav. Neurosci. 118, 1352-1364 (2004).
    • (2004) Behav. Neurosci , vol.118 , pp. 1352-1364
    • Edinger, K.L.1    Frye, C.A.2
  • 129
    • 34247230366 scopus 로고    scopus 로고
    • Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity
    • Dong, X. D. et al. Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity. Neuroscience 146, 822-832 (2007).
    • (2007) Neuroscience , vol.146 , pp. 822-832
    • Dong, X.D.1
  • 130
    • 58149389441 scopus 로고    scopus 로고
    • Sex differences in μopioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia
    • Loyd, D. R., Wang, X. & Murphy, A. Z. Sex differences in μopioid receptor expression in the rat midbrain periaqueductal gray are essential for eliciting sex differences in morphine analgesia. J. Neurosci. 28, 14007-14017 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 14007-14017
    • Loyd, D.R.1    Wang, X.2    Murphy, A.Z.3
  • 131
    • 64749107740 scopus 로고    scopus 로고
    • Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat
    • Claiborne, J. A., Nag, S. & Mokha, S. S. Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat. Neurosci. Lett. 456, 59-63 (2009).
    • (2009) Neurosci. Lett , vol.456 , pp. 59-63
    • Claiborne, J.A.1    Nag, S.2    Mokha, S.S.3
  • 132
    • 79960469764 scopus 로고    scopus 로고
    • Sex differences in neuropeptide content and release from rat dental pulp
    • Bowles, W. R. et al. Sex differences in neuropeptide content and release from rat dental pulp. J. Endod. 37, 1098-1101 (2011).
    • (2011) J. Endod , vol.37 , pp. 1098-1101
    • Bowles, W.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.