Molecular basis of enhanced activity in factor VIIa-trypsin variants conveys insights into tissue factor-mediated allosteric regulation of factor VIIa activity

Journal of Biological Chemistry

Volumn 291, Issue 9, 2016, Pages 4671-4683

  Sorensen, Anders B ^a,b   Madsen, Jesper J ^a,c,d   Svensson, L Anders ^a   Pedersen, Anette A ^a   Østergaard, Henrik ^a   Overgaard, Michael T ^b   Olsen, Ole H ^a   Gandhi, Prafull S ^a  

^a NOVO NORDISK A S   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINS; COAGULATION; CRYSTALLOGRAPHY; MOLECULAR DYNAMICS; QUENCHING; TISSUE;

ALLOSTERIC COMMUNICATION; ALLOSTERIC REGULATION; CATALYTIC PROPERTIES; COAGULATION FACTOR; CONFORMATIONAL CHANGE; FLUORESCENCE QUENCHING; MOLECULAR DYNAMICS SIMULATIONS; TRYPSIN-LIKE SERINE PROTEASE;

X RAY CRYSTALLOGRAPHY;

BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN; TRYPSIN; HYBRID PROTEIN; PEPTIDE FRAGMENT; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MOLECULAR DYNAMICS; MUTAGENESIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYME STABILITY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN UNFOLDING; SOLUBILITY;

ALLOSTERIC REGULATION; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; FACTOR VIIA; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN UNFOLDING; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SOLUBILITY; THROMBOPLASTIN; TRYPSIN;

EID: 84964599249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.698613     Document Type: Article

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