Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 24, 2001, Pages 13583-13588

  Persson, Egon ^a   Kjalke, Marianne ^a   Olsen, Ole H ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD VESSEL INJURY; CHEMICAL MODIFICATION; ENZYME SPECIFICITY; HEMOPHILIA; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; THROMBOGENESIS;

ANTITHROMBINS; FACTOR VIIA; MUTAGENESIS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPLASTIN; VARIATION (GENETICS);

THROMBUS;

EID: 0035923721     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.241339498     Document Type: Article

References (29)