Factor VIIa Modified in the 170 Loop Shows Enhanced Catalytic Activity but Does Not Change the Zymogen-like Property

Journal of Biological Chemistry

Volumn 276, Issue 20, 2001, Pages 17229-17235

  Soejima, Kenji ^a   Mizuguchi, Jun ^a   Yuguchi, Masato ^a   Nakagaki, Tomohiro ^a   Higashi, Shouichi ^b   Iwanaga, Sadaaki ^a,c  

^a Chemo Sero Therapeutic Research Institute   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYST ACTIVITY; CHEMICAL BONDS; CHROMOGENICS; CONFORMATIONS; MUTAGENESIS; PROTEINS; TISSUE CULTURE;

AMIDOLYTIC ACTIVITIES;

BIOCHEMISTRY;

BLOOD CLOTTING FACTOR 7A; CHROMOGENIC SUBSTRATE; ENZYME PRECURSOR; ISOLEUCINE; SERINE PROTEINASE; THROMBOPLASTIN; TRYPSIN; CYSTEINE; DISULFIDE; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONFORMATIONAL TRANSITION; DISULFIDE BOND; ENZYME CONFORMATION; ENZYME STRUCTURE; EQUILIBRIUM CONSTANT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MODIFICATION; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DOG; GENE DELETION; HAPLORHINI; KINETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; RABBIT; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CATTLE; CYSTEINE; DISULFIDES; DOGS; ENZYME PRECURSORS; FACTOR VIIA; HAPLORHINI; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RABBITS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; THROMBOPLASTIN;

EID: 0035907354     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009206200     Document Type: Article

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