-
1
-
-
84899979288
-
Interleukin-21: a double-edged sword with therapeutic potential
-
24751819
-
Spolski R Leonard WJ: Interleukin-21: a double-edged sword with therapeutic potential. Nat Rev Drug Discov. 2014;13(5):379-395. 24751819 10.1038/nrd4296
-
(2014)
Nat Rev Drug Discov
, vol.13
, Issue.5
, pp. 379-395
-
-
Spolski, R.1
Leonard, W.J.2
-
2
-
-
67649876115
-
New insights into the regulation of T cells by gamma(c) family cytokines
-
19543225, 2814538
-
Rochman Y Spolski R Leonard WJ: New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol. 2009;9(7):480-490. 19543225 10.1038/nri2580 2814538
-
(2009)
Nat Rev Immunol
, vol.9
, Issue.7
, pp. 480-490
-
-
Rochman, Y.1
Spolski, R.2
Leonard, W.J.3
-
3
-
-
84255197284
-
IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo
-
22039266, 3338166
-
Recher M Berglund LJ Avery DT: IL-21 is the primary common γ chain-binding cytokine required for human B-cell differentiation in vivo. Blood. 2011;118(26):6824-6835. 22039266 10.1182/blood-2011-06-362533 3338166
-
(2011)
Blood
, vol.118
, Issue.26
, pp. 6824-6835
-
-
Recher, M.1
Berglund, L.J.2
Avery, D.T.3
-
4
-
-
0037159687
-
A critical role for IL-21 in regulating immunoglobulin production
-
12446913, F1000 Recommendation
-
Ozaki K Spolski R Feng CG: A critical role for IL-21 in regulating immunoglobulin production. Science. 2002;298(5598):1630-1634. 12446913 10.1126/science.1077002 F1000 Recommendation
-
(2002)
Science
, vol.298
, Issue.5598
, pp. 1630-1634
-
-
Ozaki, K.1
Spolski, R.2
Feng, C.G.3
-
5
-
-
84905972007
-
Complex interactions of transcription factors in mediating cytokine biology in T cells
-
25123282, 4174316
-
Li P Spolski R Liao W: Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev. 2014;261(1):141-156. 25123282 10.1111/imr.12199 4174316
-
(2014)
Immunol Rev
, vol.261
, Issue.1
, pp. 141-156
-
-
Li, P.1
Spolski, R.2
Liao, W.3
-
6
-
-
84877614089
-
Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome
-
23440042, 3600901, F1000 Recommendation
-
Kotlarz D Ziȩtara N Uzel G: Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. J Exp Med. 2013;210(3):433-443. 23440042 10.1084/jem.20111229 3600901 F1000 Recommendation
-
(2013)
J Exp Med
, vol.210
, Issue.3
, pp. 433-443
-
-
Kotlarz, D.1
Ziȩtara, N.2
Uzel, G.3
-
7
-
-
84901778963
-
Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency
-
24746753, F1000 Recommendation, e12.
-
Salzer E Kansu A Sic H: Early-onset inflammatory bowel disease and common variable immunodeficiency-like disease caused by IL-21 deficiency. J Allergy Clin Immunol. 2014;133(6):1651-9.e12. 24746753 10.1016/j.jaci.2014.02.034 F1000 Recommendation
-
(2014)
J Allergy Clin Immunol
, vol.133
, Issue.6
, pp. 1651-1659
-
-
Salzer, E.1
Kansu, A.2
Sic, H.3
-
8
-
-
84925188671
-
Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R
-
25769540, 4450632
-
Erman B Bilic I Hirschmugl T: Combined immunodeficiency with CD4 lymphopenia and sclerosing cholangitis caused by a novel loss-of-function mutation affecting IL21R. Haematologica. 2015;100(6):e216-9. 25769540 10.3324/haematol.2014.120980 4450632
-
(2015)
Haematologica
, vol.100
, Issue.6
, pp. e216-e219
-
-
Erman, B.1
Bilic, I.2
Hirschmugl, T.3
-
9
-
-
84922173235
-
Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency
-
25398835
-
Stepensky P Keller B Abuzaitoun O: Extending the clinical and immunological phenotype of human interleukin-21 receptor deficiency. Haematologica. 2015;100(2):e72-6. 25398835 10.3324/haematol.2014.112508
-
(2015)
Haematologica
, vol.100
, Issue.2
, pp. e72-e76
-
-
Stepensky, P.1
Keller, B.2
Abuzaitoun, O.3
-
10
-
-
34248364008
-
The molecular basis of IL-21-mediated proliferation
-
17234735, 1885510
-
Zeng R Spolski R Casas E: The molecular basis of IL-21-mediated proliferation. Blood. 2007;109(10):4135-4142. 17234735 10.1182/blood-2006-10-054973 1885510
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4135-4142
-
-
Zeng, R.1
Spolski, R.2
Casas, E.3
-
11
-
-
82055163110
-
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory
-
22118528, 3228524, F1000 Recommendation
-
Siegel AM Heimall J Freeman AF: A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory. Immunity. 2011;35(5):806-818. 22118528 10.1016/j.immuni.2011.09.016 3228524 F1000 Recommendation
-
(2011)
Immunity
, vol.35
, Issue.5
, pp. 806-818
-
-
Siegel, A.M.1
Heimall, J.2
Freeman, A.F.3
-
12
-
-
76149139419
-
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
-
20048285, 2812540, F1000 Recommendation
-
Avery DT Deenick EK Ma CS: B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med. 2010;207(1):155-171. 20048285 10.1084/jem.20091706 2812540 F1000 Recommendation
-
(2010)
J Exp Med
, vol.207
, Issue.1
, pp. 155-171
-
-
Avery, D.T.1
Deenick, E.K.2
Ma, C.S.3
-
13
-
-
84859711557
-
Functional STAT3 deficiency compromises the generation of human T follicular helper cells
-
22403255, 3355712
-
Ma CS Avery DT Chan A: Functional STAT3 deficiency compromises the generation of human T follicular helper cells. Blood. 2012;119(17):3997-4008. 22403255 10.1182/blood-2011-11-392985 3355712
-
(2012)
Blood
, vol.119
, Issue.17
, pp. 3997-4008
-
-
Ma, C.S.1
Avery, D.T.2
Chan, A.3
-
14
-
-
84881121485
-
+ T-cell memory formation and function
-
23830147, 3785237, e9.
-
Ives ML Ma CS Palendira U: Signal transducer and activator of transcription 3 ( STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8 + T-cell memory formation and function. J Allergy Clin Immunol. 2013;132(2):400-11.e9. 23830147 10.1016/j.jaci.2013.05.029 3785237
-
(2013)
J Allergy Clin Immunol
, vol.132
, Issue.2
, pp. 400-411
-
-
Ives, M.L.1
Ma, C.S.2
Palendira, U.3
-
15
-
-
84888101388
-
Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells
-
24218138, 3832925
-
Deenick EK Avery DT Chan A: Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells. J Exp Med. 2013;210(12):2739-2753. 24218138 10.1084/jem.20130323 3832925
-
(2013)
J Exp Med
, vol.210
, Issue.12
, pp. 2739-2753
-
-
Deenick, E.K.1
Avery, D.T.2
Chan, A.3
-
16
-
-
58549094107
-
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
-
19088203, 2634912, F1000 Recommendation
-
Huber M Brüstle A Reinhard K: IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A. 2008;105(52):20846-20851. 19088203 10.1073/pnas.0809077106 2634912 F1000 Recommendation
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.52
, pp. 20846-20851
-
-
Huber, M.1
Brüstle, A.2
Reinhard, K.3
-
17
-
-
71749089605
-
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
-
20064451, 3272079
-
Kwon H Thierry-Mieg D Thierry-Mieg J: Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity. 2009;31(6):941-952. 20064451 10.1016/j.immuni.2009.10.008 3272079
-
(2009)
Immunity
, vol.31
, Issue.6
, pp. 941-952
-
-
Kwon, H.1
Thierry-Mieg, D.2
Thierry-Mieg, J.3
-
18
-
-
84867861268
-
BATF-JUN is critical for IRF4-mediated transcription in T cells
-
22992523, 3537508, F1000 Recommendation
-
Li P Spolski R Liao W: BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature. 2012;490(7421):543-546. 22992523 10.1038/nature11530 3537508 F1000 Recommendation
-
(2012)
Nature
, vol.490
, Issue.7421
, pp. 543-546
-
-
Li, P.1
Spolski, R.2
Liao, W.3
-
19
-
-
84867884822
-
Compensatory dendritic cell development mediated by BATF-IRF interactions
-
22992524, 3482832, F1000 Recommendation
-
Tussiwand R Lee WL Murphy TL: Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012;490(7421):502-507. 22992524 10.1038/nature11531 3482832 F1000 Recommendation
-
(2012)
Nature
, vol.490
, Issue.7421
, pp. 502-507
-
-
Tussiwand, R.1
Lee, W.L.2
Murphy, T.L.3
-
20
-
-
84869116884
-
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes
-
22983707, F1000 Recommendation
-
Glasmacher E Agrawal S Chang AB: A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 2012;338(6109):975-980. 22983707 10.1126/science.1228309 F1000 Recommendation
-
(2012)
Science
, vol.338
, Issue.6109
, pp. 975-980
-
-
Glasmacher, E.1
Agrawal, S.2
Chang, A.B.3
-
21
-
-
84900005238
-
+ T cells
-
24796415, 4157605
-
Yeste A Mascanfroni ID Nadeau M: IL-21 induces IL-22 production in CD4 + T cells. Nat Commun. 2014;5: 3753. 24796415 10.1038/ncomms4753 4157605
-
(2014)
Nat Commun
, vol.5
-
-
Yeste, A.1
Mascanfroni, I.D.2
Nadeau, M.3
-
22
-
-
34547188748
-
H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
17581537, F1000 Recommendation
-
Zhou L Ivanov II Spolski R: IL-6 programs T H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8(9):967-974. 17581537 10.1038/ni1488 F1000 Recommendation
-
(2007)
Nat Immunol
, vol.8
, Issue.9
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
-
23
-
-
34247593586
-
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
-
17277312, F1000 Recommendation
-
Yang XO Panopoulos AD Nurieva R: STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007;282(13):9358-9363. 17277312 10.1074/jbc.C600321200 F1000 Recommendation
-
(2007)
J Biol Chem
, vol.282
, Issue.13
, pp. 9358-9363
-
-
Yang, X.O.1
Panopoulos, A.D.2
Nurieva, R.3
-
24
-
-
41449110468
-
H17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
-
18337720, 2864108, F1000 Recommendation
-
Milner JD Brenchley JM Laurence A: Impaired T H17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature. 2008;452(7188):773-776. 18337720 10.1038/nature06764 2864108 F1000 Recommendation
-
(2008)
Nature
, vol.452
, Issue.7188
, pp. 773-776
-
-
Milner, J.D.1
Brenchley, J.M.2
Laurence, A.3
-
25
-
-
6344269331
-
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
-
15494482
-
Ozaki K Spolski R Ettinger R: Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol. 2004;173(9):5361-5371. 15494482 10.4049/jimmunol.173.9.5361
-
(2004)
J Immunol
, vol.173
, Issue.9
, pp. 5361-5371
-
-
Ozaki, K.1
Spolski, R.2
Ettinger, R.3
-
27
-
-
84875981114
-
+ CTL activity via the transcription factor T-bet
-
23479229
-
Sutherland AP Joller N Michaud M: IL-21 promotes CD8 + CTL activity via the transcription factor T-bet. J Immunol. 2013;190(8):3977-3984. 23479229 10.4049/jimmunol.1201730
-
(2013)
J Immunol
, vol.190
, Issue.8
, pp. 3977-3984
-
-
Sutherland, A.P.1
Joller, N.2
Michaud, M.3
-
28
-
-
84938099078
-
+ T cells
-
26170288, 4522759
-
Wan CK Andraski AB Spolski R: Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 + T cells. Proc Natl Acad Sci U S A. 2015;112(30):9394-9399. 26170288 10.1073/pnas.1511711112 4522759
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, Issue.30
, pp. 9394-9399
-
-
Wan, C.K.1
Andraski, A.B.2
Spolski, R.3
-
29
-
-
79961154447
-
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
-
21727188, 3149226, F1000 Recommendation
-
Liu L Okada S Kong XF: Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med. 2011;208(8):1635-1648. 21727188 10.1084/jem.20110958 3149226 F1000 Recommendation
-
(2011)
J Exp Med
, vol.208
, Issue.8
, pp. 1635-1648
-
-
Liu, L.1
Okada, S.2
Kong, X.F.3
-
30
-
-
84878592257
-
Gain-of-function STAT1 mutations are associated with PD-L1 overexpression and a defect in B-cell survival
-
23403048, 3672340
-
Romberg N Morbach H Lawrence MG: Gain-of-function STAT1 mutations are associated with PD-L1 overexpression and a defect in B-cell survival. J Allergy Clin Immunol. 2013;131(6):1691-1693. 23403048 10.1016/j.jaci.2013.01.004 3672340
-
(2013)
J Allergy Clin Immunol
, vol.131
, Issue.6
, pp. 1691-1693
-
-
Romberg, N.1
Morbach, H.2
Lawrence, M.G.3
-
31
-
-
84911498513
-
IL-21 as a therapeutic target in inflammatory disorders
-
25162763
-
Di Fusco D Izzo R Figliuzzi MM: IL-21 as a therapeutic target in inflammatory disorders. Expert Opin Ther Targets. 2014;18(11):1329-1338. 25162763 10.1517/14728222.2014.945426
-
(2014)
Expert Opin Ther Targets
, vol.18
, Issue.11
, pp. 1329-1338
-
-
Di Fusco, D.1
Izzo, R.2
Figliuzzi, M.M.3
-
32
-
-
77958003426
-
Infant colitis--it's in the genes
-
20934598
-
Glocker EO Frede N Perro M: Infant colitis--it's in the genes. Lancet. 2010;376(9748):1272. 20934598 10.1016/S0140-6736(10)61008-2
-
(2010)
Lancet
, vol.376
, Issue.9748
, pp. 1272
-
-
Glocker, E.O.1
Frede, N.2
Perro, M.3
-
33
-
-
70949087383
-
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
-
19890111, 2787406, F1000 Recommendation
-
Glocker EO Kotlarz D Boztug K: Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009;361(21):2033-2045. 19890111 10.1056/NEJMoa0907206 2787406 F1000 Recommendation
-
(2009)
N Engl J Med
, vol.361
, Issue.21
, pp. 2033-2045
-
-
Glocker, E.O.1
Kotlarz, D.2
Boztug, K.3
-
34
-
-
64849083153
-
IL-21 mediates suppressive effects via its induction of IL-10
-
19234181, 2756221
-
Spolski R Kim HP Zhu W: IL-21 mediates suppressive effects via its induction of IL-10. J Immunol. 2009;182(5):2859-2867. 19234181 10.4049/jimmunol.0802978 2756221
-
(2009)
J Immunol
, vol.182
, Issue.5
, pp. 2859-2867
-
-
Spolski, R.1
Kim, H.P.2
Zhu, W.3
-
35
-
-
69249083836
-
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
-
19570826, 2768608, F1000 Recommendation
-
Pot C Jin H Awasthi A: Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009;183(2):797-801. 19570826 10.4049/jimmunol.0901233 2768608 F1000 Recommendation
-
(2009)
J Immunol
, vol.183
, Issue.2
, pp. 797-801
-
-
Pot, C.1
Jin, H.2
Awasthi, A.3
-
36
-
-
84876494137
-
In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing Th1 but not Th17 or Th2 cells
-
23097377
-
Doganci A Birkholz J Gehring S: In the presence of IL-21 human cord blood T cells differentiate to IL-10-producing Th1 but not Th17 or Th2 cells. Int Immunol. 2013;25(3):157-169. 23097377 10.1093/intimm/dxs097
-
(2013)
Int Immunol
, vol.25
, Issue.3
, pp. 157-169
-
-
Doganci, A.1
Birkholz, J.2
Gehring, S.3
-
37
-
-
33749531054
-
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
-
17015709
-
Good KL Bryant VL Tangye SG: Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol. 2006;177(8):5236-5247. 17015709 10.4049/jimmunol.177.8.5236
-
(2006)
J Immunol
, vol.177
, Issue.8
, pp. 5236-5247
-
-
Good, K.L.1
Bryant, V.L.2
Tangye, S.G.3
-
38
-
-
84868619716
-
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
-
23064231, 3493692, F1000 Recommendation
-
Yoshizaki A Miyagaki T DiLillo DJ: Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature. 2012;491(7423):264-268. 23064231 10.1038/nature11501 3493692 F1000 Recommendation
-
(2012)
Nature
, vol.491
, Issue.7423
, pp. 264-268
-
-
Yoshizaki, A.1
Miyagaki, T.2
DiLillo, D.J.3
-
39
-
-
84876991334
-
Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells
-
23384943
-
Lindner S Dahlke K Sontheimer K: Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells. Cancer Res. 2013;73(8):2468-2479. 23384943 10.1158/0008-5472.CAN-12-3450
-
(2013)
Cancer Res
, vol.73
, Issue.8
, pp. 2468-2479
-
-
Lindner, S.1
Dahlke, K.2
Sontheimer, K.3
-
40
-
-
2942709751
-
Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
-
15210829
-
Jin H Carrio R Yu A: Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol. 2004;173(1):657-665. 15210829 10.4049/jimmunol.173.1.657
-
(2004)
J Immunol
, vol.173
, Issue.1
, pp. 657-665
-
-
Jin, H.1
Carrio, R.2
Yu, A.3
-
41
-
-
0037446642
-
IL-21 induces the apoptosis of resting and activated primary B cells
-
12682241
-
Mehta DS Wurster AL Whitters MJ: IL-21 induces the apoptosis of resting and activated primary B cells. J Immunol. 2003;170(8):4111-4118. 12682241 10.4049/jimmunol.170.8.4111
-
(2003)
J Immunol
, vol.170
, Issue.8
, pp. 4111-4118
-
-
Mehta, D.S.1
Wurster, A.L.2
Whitters, M.J.3
-
42
-
-
84875505809
-
The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells
-
23453633, 3705920, F1000 Recommendation
-
Wan CK Oh J Li P: The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity. 2013;38(3):514-527. 23453633 10.1016/j.immuni.2013.02.011 3705920 F1000 Recommendation
-
(2013)
Immunity
, vol.38
, Issue.3
, pp. 514-527
-
-
Wan, C.K.1
Oh, J.2
Li, P.3
-
43
-
-
29144519767
-
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells
-
16339522
-
Ettinger R Sims GP Fairhurst AM: IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol. 2005;175(12):7867-7879. 16339522 10.4049/jimmunol.175.12.7867
-
(2005)
J Immunol
, vol.175
, Issue.12
, pp. 7867-7879
-
-
Ettinger, R.1
Sims, G.P.2
Fairhurst, A.M.3
-
44
-
-
52649135446
-
STAT3 is required for IL-21-induced secretion of IgE from human naive B cells
-
18579794
-
Avery DT Ma CS Bryant VL: STAT3 is required for IL-21-induced secretion of IgE from human naive B cells. Blood. 2008;112(5):1784-1793. 18579794 10.1182/blood-2008-02-142745
-
(2008)
Blood
, vol.112
, Issue.5
, pp. 1784-1793
-
-
Avery, D.T.1
Ma, C.S.2
Bryant, V.L.3
-
45
-
-
0026017971
-
Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
-
1944559
-
Lenardo MJ: Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature. 1991;353(6347):858-861. 1944559 10.1038/353858a0
-
(1991)
Nature
, vol.353
, Issue.6347
, pp. 858-861
-
-
Lenardo, M.J.1
-
46
-
-
0345257344
-
Interleukin-21 inhibits dendritic cell activation and maturation
-
12893770
-
Brandt K Bulfone-Paus S Foster DC: Interleukin-21 inhibits dendritic cell activation and maturation. Blood. 2003;102(12):4090-4098. 12893770 10.1182/blood-2003-03-0669
-
(2003)
Blood
, vol.102
, Issue.12
, pp. 4090-4098
-
-
Brandt, K.1
Bulfone-Paus, S.2
Foster, D.C.3
-
47
-
-
0346993779
-
Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo
-
14675186
-
Brandt K Bulfone-Paus S Jenckel A: Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo. J Invest Dermatol. 2003;121(6):1379-1382. 14675186 10.1046/j.1523-1747.2003.12603.x
-
(2003)
J Invest Dermatol
, vol.121
, Issue.6
, pp. 1379-1382
-
-
Brandt, K.1
Bulfone-Paus, S.2
Jenckel, A.3
-
48
-
-
84939145953
-
IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells
-
26269257, 4555999
-
Wan CK Li P Spolski R: IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells. Nat Commun. 2015;6: 7988. 26269257 10.1038/ncomms8988 4555999
-
(2015)
Nat Commun
, vol.6
-
-
Wan, C.K.1
Li, P.2
Spolski, R.3
-
49
-
-
52949091915
-
IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
-
18779574, 2544573, F1000 Recommendation
-
Spolski R Kashyap M Robinson C: IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc Natl Acad Sci U S A. 2008;105(37):14028-14033. 18779574 10.1073/pnas.0804358105 2544573 F1000 Recommendation
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.37
, pp. 14028-14033
-
-
Spolski, R.1
Kashyap, M.2
Robinson, C.3
-
50
-
-
65549165290
-
Interleukin-21 is required for the development of type 1 diabetes in NOD mice
-
19208913, 2671036, F1000 Recommendation
-
Sutherland AP Van Belle T Wurster AL: Interleukin-21 is required for the development of type 1 diabetes in NOD mice. Diabetes. 2009;58(5):1144-1155. 19208913 10.2337/db08-0882 2671036 F1000 Recommendation
-
(2009)
Diabetes
, vol.58
, Issue.5
, pp. 1144-1155
-
-
Sutherland, A.P.1
Van Belle, T.2
Wurster, A.L.3
-
51
-
-
60849107595
-
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
-
19164519, 2635818
-
Bubier JA Sproule TJ Foreman O: A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB- Yaa mice. Proc Natl Acad Sci U S A. 2009;106(5):1518-1523. 19164519 10.1073/pnas.0807309106 2635818
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.5
, pp. 1518-1523
-
-
Bubier, J.A.1
Sproule, T.J.2
Foreman, O.3
-
52
-
-
79959365225
-
Key role for IL-21 in experimental autoimmune uveitis
-
21593413, 3111309
-
Wang L Yu CR Kim HP: Key role for IL-21 in experimental autoimmune uveitis. Proc Natl Acad Sci U S A. 2011;108(23):9542-9547. 21593413 10.1073/pnas.1018182108 3111309
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.23
, pp. 9542-9547
-
-
Wang, L.1
Yu, C.R.2
Kim, H.P.3
-
53
-
-
84875768393
-
Interleukin-21 is increased in active systemic lupus erythematosus patients and contributes to the generation of plasma B cells
-
23137515
-
Nakou M Papadimitraki ED Fanouriakis A: Interleukin-21 is increased in active systemic lupus erythematosus patients and contributes to the generation of plasma B cells. Clin Exp Rheumatol. 2013;31(2):172-179. 23137515
-
(2013)
Clin Exp Rheumatol
, vol.31
, Issue.2
, pp. 172-179
-
-
Nakou, M.1
Papadimitraki, E.D.2
Fanouriakis, A.3
-
54
-
-
77957879962
-
Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis
-
20682664
-
Rasmussen TK Andersen T Hvid M: Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J Rheumatol. 2010;37(10):2014-2020. 20682664 10.3899/jrheum.100259
-
(2010)
J Rheumatol
, vol.37
, Issue.10
, pp. 2014-2020
-
-
Rasmussen, T.K.1
Andersen, T.2
Hvid, M.3
-
55
-
-
84886049045
-
IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice
-
24078696, 3807747
-
McPhee CG Bubier JA Sproule TJ: IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB. Yaa mice. J Immunol. 2013;191(9):4581-4588. 24078696 10.4049/jimmunol.1300439 3807747
-
(2013)
J Immunol
, vol.191
, Issue.9
, pp. 4581-4588
-
-
McPhee, C.G.1
Bubier, J.A.2
Sproule, T.J.3
-
56
-
-
84928964205
-
IL-21: a pleiotropic cytokine with potential applications in oncology
-
25961061, 4413888
-
Croce M Rigo V Ferrini S: IL-21: a pleiotropic cytokine with potential applications in oncology. J Immunol Res. 2015;2015: 696578. 25961061 10.1155/2015/696578 4413888
-
(2015)
J Immunol Res
, vol.2015
-
-
Croce, M.1
Rigo, V.2
Ferrini, S.3
-
57
-
-
18344394955
-
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
-
11970879, F1000 Recommendation
-
Kasaian MT Whitters MJ Carter LL: IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity. 2002;16(4):559-569. 11970879 10.1016/S1074-7613(02)00295-9 F1000 Recommendation
-
(2002)
Immunity
, vol.16
, Issue.4
, pp. 559-569
-
-
Kasaian, M.T.1
Whitters, M.J.2
Carter, L.L.3
-
58
-
-
0842278642
-
IL-21 induces the functional maturation of murine NK cells
-
14764669
-
Brady J Hayakawa Y Smyth MJ: IL-21 induces the functional maturation of murine NK cells. J Immunol. 2004;172(4):2048-2058. 14764669 10.4049/jimmunol.172.4.2048
-
(2004)
J Immunol
, vol.172
, Issue.4
, pp. 2048-2058
-
-
Brady, J.1
Hayakawa, Y.2
Smyth, M.J.3
-
59
-
-
0347320749
-
In vivo antitumor activity of interleukin 21 mediated by natural killer cells
-
14695220
-
Wang G Tschoi M Spolski R: In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res. 2003;63(24):9016-9022. 14695220
-
(2003)
Cancer Res
, vol.63
, Issue.24
, pp. 9016-9022
-
-
Wang, G.1
Tschoi, M.2
Spolski, R.3
-
60
-
-
19944434230
-
+ T cell expansion and function
-
15630141, 2212766, F1000 Recommendation
-
Zeng R Spolski R Finkelstein SE: Synergy of IL-21 and IL-15 in regulating CD8 + T cell expansion and function. J Exp Med. 2005;201(1):139-148. 15630141 10.1084/jem.20041057 2212766 F1000 Recommendation
-
(2005)
J Exp Med
, vol.201
, Issue.1
, pp. 139-148
-
-
Zeng, R.1
Spolski, R.2
Finkelstein, S.E.3
-
61
-
-
1642444178
-
IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice
-
14734732
-
Di Carlo E Comes A Orengo AM: IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice. J Immunol. 2004;172(3):1540-1547. 14734732 10.4049/jimmunol.172.3.1540
-
(2004)
J Immunol
, vol.172
, Issue.3
, pp. 1540-1547
-
-
Di Carlo, E.1
Comes, A.2
Orengo, A.M.3
-
62
-
-
0038784488
-
IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma
-
12847225, F1000 Recommendation
-
Ma HL Whitters MJ Konz RF: IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J Immunol. 2003;171(2):608-615. 12847225 10.4049/jimmunol.171.2.608 F1000 Recommendation
-
(2003)
J Immunol
, vol.171
, Issue.2
, pp. 608-615
-
-
Ma, H.L.1
Whitters, M.J.2
Konz, R.F.3
-
63
-
-
0037347311
-
Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts
-
12637939
-
Ugai S Shimozato O Kawamura K: Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts. Cancer Gene Ther. 2003;10(3):187-192. 12637939 10.1038/sj.cgt.7700552
-
(2003)
Cancer Gene Ther
, vol.10
, Issue.3
, pp. 187-192
-
-
Ugai, S.1
Shimozato, O.2
Kawamura, K.3
-
64
-
-
34548422381
-
Interleukin-21 activates cytotoxic T lymphocytes and natural killer cells to generate antitumor response in mouse renal cell carcinoma
-
17707061
-
Kumano M Hara I Furukawa J: Interleukin-21 activates cytotoxic T lymphocytes and natural killer cells to generate antitumor response in mouse renal cell carcinoma. J Urol. 2007;178(4 Pt 1):1504-1509. 17707061 10.1016/j.juro.2007.05.115
-
(2007)
J Urol
, vol.178
, Issue.4
, pp. 1504-1509
-
-
Kumano, M.1
Hara, I.2
Furukawa, J.3
-
65
-
-
84929103800
-
Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype
-
25876763, F1000 Recommendation
-
Xu M Liu M Du X: Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype. J Immunol. 2015;194(10):4997-5006. 25876763 10.4049/jimmunol.1402603 F1000 Recommendation
-
(2015)
J Immunol
, vol.194
, Issue.10
, pp. 4997-5006
-
-
Xu, M.1
Liu, M.2
Du, X.3
-
66
-
-
84866772544
-
Interleukin-21 has activity in patients with metastatic melanoma: a phase II study
-
22915661, F1000 Recommendation
-
Petrella TM Tozer R Belanger K: Interleukin-21 has activity in patients with metastatic melanoma: a phase II study. J Clin Oncol. 2012;30(27):3396-3401. 22915661 10.1200/JCO.2011.40.0655 F1000 Recommendation
-
(2012)
J Clin Oncol
, vol.30
, Issue.27
, pp. 3396-3401
-
-
Petrella, T.M.1
Tozer, R.2
Belanger, K.3
-
67
-
-
84977111822
-
Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study
-
24829759, 4019894
-
Bhatia S Curti B Ernstoff MS: Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study. J Immunother Cancer. 2014;2:2. 24829759 10.1186/2051-1426-2-2 4019894
-
(2014)
J Immunother Cancer
, vol.2
, pp. 2
-
-
Bhatia, S.1
Curti, B.2
Ernstoff, M.S.3
-
68
-
-
77449155831
-
Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas
-
19965678, 2810990, F1000 Recommendation
-
Sarosiek KA Malumbres R Nechushtan H: Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas. Blood. 2010;115(3):570-580. 19965678 10.1182/blood-2009-08-239996 2810990 F1000 Recommendation
-
(2010)
Blood
, vol.115
, Issue.3
, pp. 570-580
-
-
Sarosiek, K.A.1
Malumbres, R.2
Nechushtan, H.3
-
69
-
-
84942241960
-
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma
-
26194763, 4582332
-
Bhatt S Matthews J Parvin S: Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma. Blood. 2015;126(13):1555-1564. 26194763 10.1182/blood-2015-01-624585 4582332
-
(2015)
Blood
, vol.126
, Issue.13
, pp. 1555-1564
-
-
Bhatt, S.1
Matthews, J.2
Parvin, S.3
-
70
-
-
70350114258
-
Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism
-
19494838
-
Gelebart P Zak Z Anand M: Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism. Leukemia. 2009;23(10):1836-1846. 19494838 10.1038/leu.2009.100
-
(2009)
Leukemia
, vol.23
, Issue.10
, pp. 1836-1846
-
-
Gelebart, P.1
Zak, Z.2
Anand, M.3
-
71
-
-
33646410652
-
Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells
-
16391014
-
de Totero D Meazza R Zupo S: Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells. Blood. 2006;107(9):3708-3715. 16391014 10.1182/blood-2005-09-3535
-
(2006)
Blood
, vol.107
, Issue.9
, pp. 3708-3715
-
-
de Totero, D.1
Meazza, R.2
Zupo, S.3
-
72
-
-
47149117792
-
IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro
-
18182577, 2343602
-
Gowda A Roda J Hussain SR: IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro. Blood. 2008;111(9):4723-4730. 18182577 10.1182/blood-2007-07-099531 2343602
-
(2008)
Blood
, vol.111
, Issue.9
, pp. 4723-4730
-
-
Gowda, A.1
Roda, J.2
Hussain, S.R.3
-
73
-
-
84867524002
-
A phase I dose-finding trial of recombinant interleukin-21 and rituximab in relapsed and refractory low grade B-cell lymphoproliferative disorders
-
22893631
-
Timmerman JM Byrd JC Andorsky DJ: A phase I dose-finding trial of recombinant interleukin-21 and rituximab in relapsed and refractory low grade B-cell lymphoproliferative disorders. Clin Cancer Res. 2012;18(20):5752-5760. 22893631 10.1158/1078-0432.CCR-12-0456
-
(2012)
Clin Cancer Res
, vol.18
, Issue.20
, pp. 5752-5760
-
-
Timmerman, J.M.1
Byrd, J.C.2
Andorsky, D.J.3
-
74
-
-
84875013235
-
Comparison of vascular leak syndrome in mice treated with IL21 or IL2
-
23561933, 3567372
-
Sivakumar PV Garcia R Waggie KS: Comparison of vascular leak syndrome in mice treated with IL21 or IL2. Comp Med. 2013;63(1):13-21. 23561933 3567372
-
(2013)
Comp Med
, vol.63
, Issue.1
, pp. 13-21
-
-
Sivakumar, P.V.1
Garcia, R.2
Waggie, K.S.3
-
75
-
-
84875975917
-
+ T cells can mediate antileukemic activity and persist in post-transplant patients
-
23447018, 3678970, F1000 Recommendation
-
Chapuis AG Ragnarsson GB Nguyen HN: Transferred WT1-reactive CD8 + T cells can mediate antileukemic activity and persist in post-transplant patients. Sci Transl Med. 2013;5(174):174ra27. 23447018 10.1126/scitranslmed.3004916 3678970 F1000 Recommendation
-
(2013)
Sci Transl Med
, vol.5
, Issue.174
, pp. 174-227
-
-
Chapuis, A.G.1
Ragnarsson, G.B.2
Nguyen, H.N.3
-
76
-
-
67649217469
-
IL-21 is required to control chronic viral infection
-
19423777, 2830017, F1000 Recommendation
-
Elsaesser H Sauer K Brooks DG: IL-21 is required to control chronic viral infection. Science. 2009;324(5934):1569-1572. 19423777 10.1126/science.1174182 2830017 F1000 Recommendation
-
(2009)
Science
, vol.324
, Issue.5934
, pp. 1569-1572
-
-
Elsaesser, H.1
Sauer, K.2
Brooks, D.G.3
-
77
-
-
67649203681
-
A vital role for interleukin-21 in the control of a chronic viral infection
-
19443735, 2736049, F1000 Recommendation
-
Yi JS Du M Zajac AJ: A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009;324(5934):1572-1576. 19443735 10.1126/science.1175194 2736049 F1000 Recommendation
-
(2009)
Science
, vol.324
, Issue.5934
, pp. 1572-1576
-
-
Yi, J.S.1
Du, M.2
Zajac, A.J.3
-
78
-
-
67649234772
-
IL-21R on T cells is critical for sustained functionality and control of chronic viral infection
-
19478140, F1000 Recommendation
-
Fröhlich A Kisielow J Schmitz I: IL-21R on T cells is critical for sustained functionality and control of chronic viral infection. Science. 2009;324(5934):1576-1580. 19478140 10.1126/science.1172815 F1000 Recommendation
-
(2009)
Science
, vol.324
, Issue.5934
, pp. 1576-1580
-
-
Fröhlich, A.1
Kisielow, J.2
Schmitz, I.3
-
79
-
-
84878496583
-
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection
-
23696736, 3656089
-
Schmitz I Schneider C Fröhlich A: IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog. 2013;9(5):e1003362. 23696736 10.1371/journal.ppat.1003362 3656089
-
(2013)
PLoS Pathog
, vol.9
, Issue.5
, pp. e1003362
-
-
Schmitz, I.1
Schneider, C.2
Fröhlich, A.3
-
80
-
-
79952753925
-
Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection
-
21257966, 3059504, F1000 Recommendation
-
Novy P Huang X Leonard WJ: Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. J Immunol. 2011;186(5):2729-2738. 21257966 10.4049/jimmunol.1003009 3059504 F1000 Recommendation
-
(2011)
J Immunol
, vol.186
, Issue.5
, pp. 2729-2738
-
-
Novy, P.1
Huang, X.2
Leonard, W.J.3
-
81
-
-
82055208627
-
+ T cells
-
22118527, 3431922, F1000 Recommendation
-
Cui W Liu Y Weinstein JS: An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8 + T cells. Immunity. 2011;35(5):792-805. 22118527 10.1016/j.immuni.2011.09.017 3431922 F1000 Recommendation
-
(2011)
Immunity
, vol.35
, Issue.5
, pp. 792-805
-
-
Cui, W.1
Liu, Y.2
Weinstein, J.S.3
-
82
-
-
84880342643
-
Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells
-
23637417, 3700268
-
Rasheed MA Latner DR Aubert RD: Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. J Virol. 2013;87(13):7737-7746. 23637417 10.1128/JVI.00063-13 3700268
-
(2013)
J Virol
, vol.87
, Issue.13
, pp. 7737-7746
-
-
Rasheed, M.A.1
Latner, D.R.2
Aubert, R.D.3
-
83
-
-
51849116934
-
+ T-cell counts
-
18788946
-
Iannello A Tremblay C Routy JP: Decreased levels of circulating IL-21 in HIV-infected AIDS patients: correlation with CD4 + T-cell counts. Viral Immunol. 2008;21(3):385-388. 18788946 10.1089/vim.2008.0025
-
(2008)
Viral Immunol
, vol.21
, Issue.3
, pp. 385-388
-
-
Iannello, A.1
Tremblay, C.2
Routy, J.P.3
-
84
-
-
73949110184
-
Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study
-
19949086
-
Iannello A Boulassel MR Samarani S: Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study. J Immunol. 2010;184(1):114-126. 19949086 10.4049/jimmunol.0901967
-
(2010)
J Immunol
, vol.184
, Issue.1
, pp. 114-126
-
-
Iannello, A.1
Boulassel, M.R.2
Samarani, S.3
-
85
-
-
78649516786
-
+ T cell function
-
21047960, 3020027
-
Chevalier MF Jülg B Pyo A: HIV-1-specific interleukin-21 + CD4 + T cell responses contribute to durable viral control through the modulation of HIV-specific CD8 + T cell function. J Virol. 2011;85(2):733-741. 21047960 10.1128/JVI.02030-10 3020027
-
(2011)
J Virol
, vol.85
, Issue.2
, pp. 733-741
-
-
Chevalier, M.F.1
Jülg, B.2
Pyo, A.3
-
86
-
-
84911471734
-
Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individuals
-
24942568, 4136345
-
Williams LD Amatya N Bansal A: Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individuals. J Virol. 2014;88(17):10259-10263. 24942568 10.1128/JVI.00764-14 4136345
-
(2014)
J Virol
, vol.88
, Issue.17
, pp. 10259-10263
-
-
Williams, L.D.1
Amatya, N.2
Bansal, A.3
-
87
-
-
79551690940
-
Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
-
21159862, 3067790, F1000 Recommendation
-
Williams LD Bansal A Sabbaj S: Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers. J Virol. 2011;85(5):2316-2324. 21159862 10.1128/JVI.01476-10 3067790 F1000 Recommendation
-
(2011)
J Virol
, vol.85
, Issue.5
, pp. 2316-2324
-
-
Williams, L.D.1
Bansal, A.2
Sabbaj, S.3
-
88
-
-
84874519282
-
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
-
23254284, 3549706, F1000 Recommendation
-
Perreau M Savoye AL De Crignis E: Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. J Exp Med. 2013;210(1):143-156. 23254284 10.1084/jem.20121932 3549706 F1000 Recommendation
-
(2013)
J Exp Med
, vol.210
, Issue.1
, pp. 143-156
-
-
Perreau, M.1
Savoye, A.L.2
De Crignis, E.3
-
89
-
-
84878454838
-
Inadequate T follicular cell help impairs B cell immunity during HIV infection
-
23475201, 3843317, F1000 Recommendation
-
Cubas RA Mudd JC Savoye AL: Inadequate T follicular cell help impairs B cell immunity during HIV infection. Nat Med. 2013;19(4):494-499. 23475201 10.1038/nm.3109 3843317 F1000 Recommendation
-
(2013)
Nat Med
, vol.19
, Issue.4
, pp. 494-499
-
-
Cubas, R.A.1
Mudd, J.C.2
Savoye, A.L.3
-
90
-
-
77952540913
-
IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication
-
20103765
-
Iannello A Boulassel MR Samarani S: IL-21 enhances NK cell functions and survival in healthy and HIV-infected patients with minimal stimulation of viral replication. J Leukoc Biol. 2010;87(5):857-867. 20103765 10.1189/jlb.1009701
-
(2010)
J Leukoc Biol
, vol.87
, Issue.5
, pp. 857-867
-
-
Iannello, A.1
Boulassel, M.R.2
Samarani, S.3
-
91
-
-
52249084769
-
IL-21 augments natural killer effector functions in chronically HIV-infected individuals
-
18670213, 2665999
-
Strbo N de Armas L Liu H: IL-21 augments natural killer effector functions in chronically HIV-infected individuals. AIDS. 2008;22(13):1551-1560. 18670213 10.1097/QAD.0b013e3283089367 2665999
-
(2008)
AIDS
, vol.22
, Issue.13
, pp. 1551-1560
-
-
Strbo, N.1
de Armas, L.2
Liu, H.3
-
92
-
-
82555187124
-
Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication
-
21996099, 3260006, F1000 Recommendation
-
Pallikkuth S Rogers K Villinger F: Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication. Vaccine. 2011;29(49):9229-9238. 21996099 10.1016/j.vaccine.2011.09.118 3260006 F1000 Recommendation
-
(2011)
Vaccine
, vol.29
, Issue.49
, pp. 9229-9238
-
-
Pallikkuth, S.1
Rogers, K.2
Villinger, F.3
-
93
-
-
84884780138
-
Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21
-
23853592, 3701718, F1000 Recommendation
-
Pallikkuth S Micci L Ende ZS: Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21. PLoS Pathog. 2013;9(7):e1003471. 23853592 10.1371/journal.ppat.1003471 3701718 F1000 Recommendation
-
(2013)
PLoS Pathog
, vol.9
, Issue.7
, pp. e1003471
-
-
Pallikkuth, S.1
Micci, L.2
Ende, Z.S.3
-
94
-
-
84961806957
-
IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques
-
26286233
-
Ortiz AM Klase ZA DiNapoli SR: IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal Immunol. 2015. 26286233 10.1038/mi.2015.75
-
(2015)
Mucosal Immunol
-
-
Ortiz, A.M.1
Klase, Z.A.2
DiNapoli, S.R.3
-
95
-
-
84948807352
-
Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques
-
26551680, 4665780
-
Micci L Ryan ES Fromentin R: Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. J Clin Invest. 2015;125(12):4497-4513. 26551680 10.1172/JCI81400 4665780
-
(2015)
J Clin Invest
, vol.125
, Issue.12
, pp. 4497-4513
-
-
Micci, L.1
Ryan, E.S.2
Fromentin, R.3
-
96
-
-
84862909139
-
Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes
-
22077059, 3257019
-
Hippen KL Bucher C Schirm DK: Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes. Blood. 2012;119(2):619-628. 22077059 10.1182/blood-2011-07-368027 3257019
-
(2012)
Blood
, vol.119
, Issue.2
, pp. 619-628
-
-
Hippen, K.L.1
Bucher, C.2
Schirm, D.K.3
-
97
-
-
79960533396
-
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL
-
21596854, 3138694
-
Hanash AM Kappel LW Yim NL: Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood. 2011;118(2):446-455. 21596854 10.1182/blood-2010-07-294785 3138694
-
(2011)
Blood
, vol.118
, Issue.2
, pp. 446-455
-
-
Hanash, A.M.1
Kappel, L.W.2
Yim, N.L.3
-
98
-
-
73949116753
-
IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation
-
19843883, 2796140
-
Bucher C Koch L Vogtenhuber C: IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Blood. 2009;114(26):5375-5384. 19843883 10.1182/blood-2009-05-221135 2796140
-
(2009)
Blood
, vol.114
, Issue.26
, pp. 5375-5384
-
-
Bucher, C.1
Koch, L.2
Vogtenhuber, C.3
-
99
-
-
84856114840
-
Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells
-
21258423, 3401481
-
Meguro A Ozaki K Hatanaka K: Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells. Bone Marrow Transplant. 2011;46(12):1557-1565. 21258423 10.1038/bmt.2010.342 3401481
-
(2011)
Bone Marrow Transplant
, vol.46
, Issue.12
, pp. 1557-1565
-
-
Meguro, A.1
Ozaki, K.2
Hatanaka, K.3
-
100
-
-
77950599836
-
IL-21 is critical for GVHD in a mouse model
-
19718060, 3403836
-
Meguro A Ozaki K Oh I: IL-21 is critical for GVHD in a mouse model. Bone Marrow Transplant. 2010;45(4):723-729. 19718060 10.1038/bmt.2009.223 3403836
-
(2010)
Bone Marrow Transplant
, vol.45
, Issue.4
, pp. 723-729
-
-
Meguro, A.1
Ozaki, K.2
Oh, I.3
|