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Volumn 9, Issue 2, 2016, Pages 458-467

IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques

Author keywords

[No Author keywords available]

Indexed keywords

INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 21; PROBIOTIC AGENT; ANTIRETROVIRUS AGENT; EMTRICITABINE; INTERLEUKIN DERIVATIVE; TENOFOVIR;

EID: 84961806957     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2015.75     Document Type: Article
Times cited : (69)

References (46)
  • 2
    • 77954734865 scopus 로고    scopus 로고
    • Antiretroviral therapy and management of HIV infection
    • Volberding P.A, & Deeks S.G. Antiretroviral therapy and management of HIV infection. Lancet. 376, 49-62 (2010).
    • (2010) Lancet , vol.376 , pp. 49-62
    • Volberding, P.A.1    Deeks, S.G.2
  • 3
    • 84872174074 scopus 로고    scopus 로고
    • Microbial translocation in the pathogenesis of HIV infection and AIDS
    • Marchetti G, Tincati C, & Silvestri G. Microbial translocation in the pathogenesis of HIV infection and AIDS. Clin. Microbiol. Rev. 26, 2-18 (2013).
    • (2013) Clin. Microbiol. Rev , vol.26 , pp. 2-18
    • Marchetti, G.1    Tincati, C.2    Silvestri, G.3
  • 4
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley J.M, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12, 1365-1371 (2006).
    • (2006) Nat. Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 5
    • 77958083540 scopus 로고    scopus 로고
    • Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections
    • Estes J.D, et al. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathog. 6, e1001052 (2010).
    • (2010) PLoS Pathog , vol.6 , pp. e1001052
    • Estes, J.D.1
  • 6
    • 61449115882 scopus 로고    scopus 로고
    • Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection
    • Favre D, et al. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 5, e1000295 (2009).
    • (2009) PLoS Pathog , vol.5 , pp. e1000295
    • Favre, D.1
  • 7
    • 53449093632 scopus 로고    scopus 로고
    • Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
    • Brenchley J.M, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood. 112, 2826-2835 (2008).
    • (2008) Blood , vol.112 , pp. 2826-2835
    • Brenchley, J.M.1
  • 8
    • 41849142985 scopus 로고    scopus 로고
    • Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
    • Raffatellu M, et al. Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat. Med. 14, 421-428 (2008).
    • (2008) Nat. Med , vol.14 , pp. 421-428
    • Raffatellu, M.1
  • 9
    • 73449093856 scopus 로고    scopus 로고
    • Precarious balance: Th17 cells in host defense
    • Peck A, & Mellins E.D. Precarious balance: Th17 cells in host defense. Infect. Immun. 78, 32-38 (2010).
    • (2010) Infect. Immun , vol.78 , pp. 32-38
    • Peck, A.1    Mellins, E.D.2
  • 10
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking R.J, Atkins C.J, Locksley R.M, & Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 24, 179-189 (2006).
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 11
    • 84898679249 scopus 로고    scopus 로고
    • Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation
    • Goto Y, et al. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity. 40, 594-607 (2014).
    • (2014) Immunity , vol.40 , pp. 594-607
    • Goto, Y.1
  • 12
    • 84901979873 scopus 로고    scopus 로고
    • Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
    • Yang Y, et al. Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 510, 152-156 (2014).
    • (2014) Nature , vol.510 , pp. 152-156
    • Yang, Y.1
  • 13
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov, II et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 139, 485-498 (2009).
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 14
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov, II et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 4, 337-349 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1
  • 15
    • 80054944901 scopus 로고    scopus 로고
    • Role of the commensal microbiota in normal and pathogenic host immune responses
    • Littman D.R, & Pamer E.G. Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe. 10, 311-323 (2011).
    • (2011) Cell Host Microbe , vol.10 , pp. 311-323
    • Littman, D.R.1    Pamer, E.G.2
  • 16
    • 84880540665 scopus 로고    scopus 로고
    • Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
    • Vujkovic-Cvijin I, et al. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci. Trans. Med. 5, 193ra191 (2013).
    • (2013) Sci. Trans. Med , vol.5 , pp. 193ra191
    • Vujkovic-Cvijin, I.1
  • 17
    • 84929633864 scopus 로고    scopus 로고
    • Dysbiotic bacteria translocate in progressive SIV infection
    • advance online publication, 14 January 2015
    • Klase Z, et al. Dysbiotic bacteria translocate in progressive SIV infection. Mucosal Immunol. advance online publication, 14 January 2015; doi: 10.1038/mi.2014.128 (2015).
    • Mucosal Immunol
    • Klase, Z.1
  • 18
    • 84873369889 scopus 로고    scopus 로고
    • Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques
    • Klatt N.R, et al. Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. J. Clin. Invest. 123, 903-907 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 903-907
    • Klatt, N.R.1
  • 19
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T, et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 448, 484-487 (2007).
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1
  • 20
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 448, 480-483 (2007).
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1
  • 21
    • 84900005238 scopus 로고    scopus 로고
    • IL-21 induces IL-22 production in CD4+ T cells
    • Yeste A, et al. IL-21 induces IL-22 production in CD4+ T cells. Nat. Commun. 5, 3753 (2014).
    • (2014) Nat. Commun , vol.5 , pp. 3753
    • Yeste, A.1
  • 22
    • 84868609542 scopus 로고    scopus 로고
    • Paucity of IL-21-producing CD4(+) Tcells is associatedwith Th17 cell depletion in SIV infection of rhesusmacaques
    • Micci L, et al. Paucity of IL-21-producing CD4(+) Tcells is associatedwith Th17 cell depletion in SIV infection of rhesusmacaques. Blood. 120, 3925-3935 (2012).
    • (2012) Blood , vol.120 , pp. 3925-3935
    • Micci, L.1
  • 23
    • 84884780138 scopus 로고    scopus 로고
    • Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21
    • Pallikkuth S, et al. Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21. PLoS Pathog. 9, e1003471 (2013).
    • (2013) PLoS Pathog , vol.9 , pp. e1003471
    • Pallikkuth, S.1
  • 24
    • 0038784488 scopus 로고    scopus 로고
    • IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma
    • Ma H.L, et al. IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J. Immunol. 171, 608-615 (2003).
    • (2003) J. Immunol , vol.171 , pp. 608-615
    • Ma, H.L.1
  • 25
    • 82555187124 scopus 로고    scopus 로고
    • Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in Tcells and NKcells and enhances B cell function without increasing immune activation or viral replication
    • Pallikkuth S, et al. Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in Tcells and NKcells and enhances B cell function without increasing immune activation or viral replication. Vaccine. 29, 9229-9238 (2011).
    • (2011) Vaccine , vol.29 , pp. 9229-9238
    • Pallikkuth, S.1
  • 26
    • 84904314814 scopus 로고    scopus 로고
    • The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy
    • Byakwaga H, et al. The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy. J. Infect. Dis. 210, 383-391 (2014).
    • (2014) J. Infect. Dis , vol.210 , pp. 383-391
    • Byakwaga, H.1
  • 27
    • 0023891542 scopus 로고
    • Enterobacter: An emerging nosocomial pathogen
    • Gaston M.A. Enterobacter: an emerging nosocomial pathogen. J. Hosp. Infect. 11, 197-208 (1988).
    • (1988) J. Hosp. Infect , vol.11 , pp. 197-208
    • Gaston, M.A.1
  • 28
    • 0034086710 scopus 로고    scopus 로고
    • Acute renal failure in HIV-infected patients: A brief review of common causes
    • Perazella, M.A. Acute renal failure in HIV-infected patients: a brief review of common causes. Am. J. Med. Sci. 319, 385-391 (2000).
    • (2000) Am. J. Med. Sci , vol.319 , pp. 385-391
    • Perazella, M.A.1
  • 29
    • 68049137678 scopus 로고    scopus 로고
    • Thrombocytopenia is strongly associated with simian AIDS in pigtail macaques
    • Alcantara S, et al. Thrombocytopenia is strongly associated with simian AIDS in pigtail macaques. J. Acquir. Immune Defic. Syndr. 51, 374-379 (2009).
    • (2009) J. Acquir. Immune Defic. Syndr , vol.51 , pp. 374-379
    • Alcantara, S.1
  • 30
    • 84866555781 scopus 로고    scopus 로고
    • Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection
    • Klatt N.R, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 5, 646-657 (2012).
    • (2012) Mucosal Immunol , vol.5 , pp. 646-657
    • Klatt, N.R.1
  • 31
    • 34948906159 scopus 로고    scopus 로고
    • Superior control of HIV-1 replication by CD8+ Tcells is reflected by their avidity, polyfunctionality, and clonal turnover
    • Almeida J.R, et al. Superior control of HIV-1 replication by CD8+ Tcells is reflected by their avidity, polyfunctionality, and clonal turnover. J. Exp. Med. 204, 2473-2485 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 2473-2485
    • Almeida, J.R.1
  • 32
    • 33646686040 scopus 로고    scopus 로고
    • HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    • Betts M.R, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood. 107, 4781-4789 (2006).
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1
  • 33
    • 46049120719 scopus 로고    scopus 로고
    • High frequencies of polyfunctional HIV-specific Tcells are associated with preservation of mucosal CD4 Tcells in bronchoalveolar lavage
    • Brenchley J.M, et al. High frequencies of polyfunctional HIV-specific Tcells are associated with preservation of mucosal CD4 Tcells in bronchoalveolar lavage. Mucosal Immunol. 1, 49-58 (2008).
    • (2008) Mucosal Immunol , vol.1 , pp. 49-58
    • Brenchley, J.M.1
  • 34
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2, 3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • Favre D, et al. Tryptophan catabolism by indoleamine 2, 3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci. Transl. Med. 2, 32ra36 (2010).
    • (2010) Sci. Transl. Med , vol.2 , pp. 32ra36
    • Favre, D.1
  • 35
    • 76949108202 scopus 로고    scopus 로고
    • Th17 and regulatory T cells: Implications for AIDS pathogenesis
    • Kanwar B, Favre D, & McCune J.M. Th17 and regulatory T cells: implications for AIDS pathogenesis. Curr. Opin. HIV AIDS. 5, 151-157 (2010).
    • (2010) Curr. Opin. HIV AIDS , vol.5 , pp. 151-157
    • Kanwar, B.1    Favre, D.2    McCune, J.M.3
  • 36
    • 84899979288 scopus 로고    scopus 로고
    • Interleukin-21: A double-edged sword with therapeutic potential
    • Spolski R, & Leonard W.J. Interleukin-21: a double-edged sword with therapeutic potential. Nat. Rev. Drug Discov. 13, 379-395 (2014).
    • (2014) Nat. Rev. Drug Discov , vol.13 , pp. 379-395
    • Spolski, R.1    Leonard, W.J.2
  • 37
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 441, 235-238 (2006).
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 38
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • Zhou L, et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 453, 236-240 (2008).
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1
  • 39
    • 42649095378 scopus 로고    scopus 로고
    • Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    • Quintana F.J, et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature. 453, 65-71 (2008).
    • (2008) Nature , vol.453 , pp. 65-71
    • Quintana, F.J.1
  • 40
    • 84902124658 scopus 로고    scopus 로고
    • Earlymicrobial translocation blockade reduces SIV-mediated inflammation and viral replication
    • Kristoff J, et al. Earlymicrobial translocation blockade reduces SIV-mediated inflammation and viral replication. J. Clin. Invest. 124, 2802-2806 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 2802-2806
    • Kristoff, J.1
  • 41
    • 4644249757 scopus 로고    scopus 로고
    • Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells
    • Lichterfeld M, et al. Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J. Exp. Med. 200, 701-712 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 701-712
    • Lichterfeld, M.1
  • 42
    • 0034600786 scopus 로고    scopus 로고
    • HIV-specific CD8(+) Tcells produce antiviral cytokines but are impaired in cytolytic function
    • Appay V, et al. HIV-specific CD8(+) Tcells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 192, 63-75 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 63-75
    • Appay, V.1
  • 43
    • 77953739215 scopus 로고    scopus 로고
    • Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection
    • Klatt N.R, et al. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol. 3, 387-398 (2010).
    • (2010) Mucosal Immunol , vol.3 , pp. 387-398
    • Klatt, N.R.1
  • 44
    • 84888059687 scopus 로고    scopus 로고
    • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
    • Viaud S, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 342, 971-976 (2013).
    • (2013) Science , vol.342 , pp. 971-976
    • Viaud, S.1
  • 45
    • 84888049920 scopus 로고    scopus 로고
    • Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
    • Iida N, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science. 342, 967-970 (2013).
    • (2013) Science , vol.342 , pp. 967-970
    • Iida, N.1
  • 46
    • 84869814713 scopus 로고    scopus 로고
    • Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections
    • Brenchley J.M, et al. Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. Blood. 120, 4172-4181 (2012).
    • (2012) Blood , vol.120 , pp. 4172-4181
    • Brenchley, J.M.1


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