Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding

FASEB Journal

Volumn 29, Issue 9, 2015, Pages 3750-3761

  Ting, Pamela Y ^a   Johnson, Christian W ^b   Fang, Cong ^a   Cao, Xiaoqing ^a   Graeber, Thomas G ^a   Mattos, Carla ^b   Colicelli, John ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

GTPase; RAF1; RIN1; Signal transduction

Indexed keywords

ABELSON KINASE; GUANOSINE TRIPHOSPHATE; PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE 1; RAB INTERACTING PROTEIN 1; RAF PROTEIN; RAS PROTEIN; TYROSINE; UNCLASSIFIED DRUG; PROTEIN P21; RAB PROTEIN; RAB5C PROTEIN, HUMAN; RIN1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ALLOSTERISM; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEOMICS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MISSENSE MUTATION; PHOSPHORYLATION; PHYSIOLOGY; RAT;

AMINO ACID SUBSTITUTION; ANIMALS; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTATION, MISSENSE; ONCOGENE PROTEINS V-ABL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS P21(RAS); RAB5 GTP-BINDING PROTEINS; RAF KINASES; RATS; SIGNAL TRANSDUCTION; TYROSINE;

EID: 84942895072     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-271510     Document Type: Article

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