Modeling the role of G12V and G13V ras mutations in the ras-GAP-catalyzed hydrolysis reaction of guanosine triphosphate

Biochemistry

Volumn 53, Issue 45, 2014, Pages 7093-7099

  Khrenova, Maria G ^a   Mironov, Vladimir A ^a   Grigorenko, Bella L ^a,b   Nemukhin, Alexander V ^a,b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b EMANUEL INSTITUTE OF BIOCHEMICAL PHYSICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; CHAINS; CONFORMATIONS; HYDROLYSIS; MOLECULAR DYNAMICS; MOLECULAR MODELING; MOLECULES; QUANTUM THEORY; REACTION KINETICS;

COMPUTATIONAL RESULTS; CONFORMATIONAL DYNAMICS; GUANOSINE TRIPHOSPHATE; HYDROLYSIS REACTION; MODEL MOLECULAR SYSTEMS; MOLECULAR DYNAMICS SIMULATIONS; OPTIMIZATION OF GEOMETRIES; QUANTUM MECHANICS/MOLECULAR MECHANICS;

CRYSTAL STRUCTURE;

ARGININE; GLYCINE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; PHOSPHATE; PHOSPHORUS; RAS PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; HYDROLYSIS; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MODEL; POINT MUTATION; PROTEIN CONFORMATION; QUANTUM MECHANICS; REACTION ANALYSIS; SIMULATION; WILD TYPE; AMINO ACID SEQUENCE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY;

AMINO ACID SEQUENCE; CATALYSIS; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; RAS GTPASE-ACTIVATING PROTEINS;

EID: 84910635300     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5011333     Document Type: Article

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