-
1
-
-
0020328955
-
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
-
Parada LF, Tabin CJ, Shih C, Weinberg RA. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 1982;297:474-8.
-
(1982)
Nature
, vol.297
, pp. 474-478
-
-
Parada, L.F.1
Tabin, C.J.2
Shih, C.3
Weinberg, R.A.4
-
2
-
-
0008903932
-
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses
-
der CJ, Krontiris TG, Cooper GM. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A 1982;79:3637-40.
-
(1982)
Proc Natl Acad Sci U S A
, vol.79
, pp. 3637-3640
-
-
Der, C.J.1
Krontiris, T.G.2
Cooper, G.M.3
-
3
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
Goddard, A.D.4
Heldens, S.L.5
Herbst, R.S.6
-
4
-
-
57549098807
-
The catalogue of somatic mutations in cancer (COSMIC)
-
Chapter 10:Unit 10 1
-
Forbes SA, Bhamra G, Bamford S, Dawson E, Kok C, Clements J, et al. The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr Protoc Hum Genet 2008; Chapter 10:Unit 10 1.
-
(2008)
Curr Protoc Hum Genet
-
-
Forbes, S.A.1
Bhamra, G.2
Bamford, S.3
Dawson, E.4
Kok, C.5
Clements, J.6
-
5
-
-
84861147473
-
A comprehensive survey of Ras mutations in cancer
-
Prior IA, Lewis PD, Mattos C. A comprehensive survey of Ras mutations in cancer. Cancer Res 2012;72:2457-67.
-
(2012)
Cancer Res
, vol.72
, pp. 2457-2467
-
-
Prior, I.A.1
Lewis, P.D.2
Mattos, C.3
-
6
-
-
0003964363
-
-
cited October 1, 2014
-
Society AC. Cancer facts & figures 2013. [cited October 1, 2014]. Available from: http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-036845.pdf.
-
(2013)
Cancer Facts & Figures
-
-
Society AC1
-
7
-
-
0021126650
-
Biological properties of human c-Ha-ras1 genes mutated at codon 12
-
Seeburg PH, Colby WW, Capon DJ, Goeddel DV, Levinson AD. Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature 1984;312:71-5.
-
(1984)
Nature
, vol.312
, pp. 71-75
-
-
Seeburg, P.H.1
Colby, W.W.2
Capon, D.J.3
Goeddel, D.V.4
Levinson, A.D.5
-
8
-
-
0022471217
-
Biological and biochemical properties of human rasH genes mutated at codon 61
-
der CJ, Finkel T, Cooper GM. Biological and biochemical properties of human rasH genes mutated at codon 61. Cell 1986;44:167-76.
-
(1986)
Cell
, vol.44
, pp. 167-176
-
-
Der, C.J.1
Finkel, T.2
Cooper, G.M.3
-
9
-
-
84908491115
-
Drugging the undruggable RAS: Mission Possible?
-
Cox AD, Fesik SW, Kimmelman AC, Luo J, der CJ. Drugging the undruggable RAS: mission Possible? Nat Rev Drug Discov 2014;13:828-51.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 828-851
-
-
Cox, A.D.1
Fesik, S.W.2
Kimmelman, A.C.3
Luo, J.4
Der, C.J.5
-
11
-
-
78651330430
-
COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
-
Forbes SA, Bindal N, Bamford S, Cole C, Kok CY, Beare D, et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res 2011;39:D945-50.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D945-D950
-
-
Forbes, S.A.1
Bindal, N.2
Bamford, S.3
Cole, C.4
Kok, C.Y.5
Beare, D.6
-
12
-
-
0021871265
-
Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats
-
Zarbl H, Sukumar S, Arthur AV, Martin-Zanca D, Barbacid M. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 1985;315:382-5.
-
(1985)
Nature
, vol.315
, pp. 382-385
-
-
Zarbl, H.1
Sukumar, S.2
Arthur, A.V.3
Martin-Zanca, D.4
Barbacid, M.5
-
13
-
-
0026730948
-
Mapping of UV photoproducts within ras protooncogenes in UV-irradiated cells: Correlation with mutations in human skin cancer
-
Törmänen V, Pfeifer G. Mapping of UV photoproducts within ras protooncogenes in UV-irradiated cells: correlation with mutations in human skin cancer. Oncogene 1992;7:1729-36.
-
(1992)
Oncogene
, vol.7
, pp. 1729-1736
-
-
Törmänen, V.1
Pfeifer, G.2
-
14
-
-
0029826228
-
Mutations and expression of the ras family genes in leukemias
-
Gougopoulou DM, Kiaris H, Ergazaki M, Anagnostopoulos NI, Grigoraki V, Spandidos DA. Mutations and expression of the ras family genes in leukemias. Stem Cells 1996;14:725-9.
-
(1996)
Stem Cells
, vol.14
, pp. 725-729
-
-
Gougopoulou, D.M.1
Kiaris, H.2
Ergazaki, M.3
Anagnostopoulos, N.I.4
Grigoraki, V.5
Spandidos, D.A.6
-
15
-
-
0032510267
-
Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers
-
Denissenko MF, Pao A, Pfeifer GP, Tang M-S. Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers. Oncogene 1998;16:1241-7.
-
(1998)
Oncogene
, vol.16
, pp. 1241-1247
-
-
Denissenko, M.F.1
Pao, A.2
Pfeifer, G.P.3
Tang, M.-S.4
-
16
-
-
84872107552
-
Rare codons regulate KRas oncogenesis
-
Lampson BL, Pershing NL, Prinz JA, Lacsina JR, Marzluff WF, Nicchitta CV, et al. Rare codons regulate KRas oncogenesis. Curr Biol 2013;23:70-5.
-
(2013)
Curr Biol
, vol.23
, pp. 70-75
-
-
Lampson, B.L.1
Pershing, N.L.2
Prinz, J.A.3
Lacsina, J.R.4
Marzluff, W.F.5
Nicchitta, C.V.6
-
17
-
-
34247897276
-
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
-
Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, Chodosh LA. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol 2007;9:493-505.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 493-505
-
-
Sarkisian, C.J.1
Keister, B.A.2
Stairs, D.B.3
Boxer, R.B.4
Moody, S.E.5
Chodosh, L.A.6
-
18
-
-
84925536961
-
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer
-
Westcott PM, Halliwill KD, To MD, Rashid M, Rust AG, Keane TM, et al. The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. Nature 2015;517:489-92.
-
(2015)
Nature
, vol.517
, pp. 489-492
-
-
Westcott, P.M.1
Halliwill, K.D.2
To, M.D.3
Rashid, M.4
Rust, A.G.5
Keane, T.M.6
-
19
-
-
84863116014
-
Effect of KRAS oncogene substitutions on protein behavior: Implications for signaling and clinical outcome
-
Ihle NT, Byers LA, Kim ES, Saintigny P, Lee JJ, Blumenschein GR, et al. Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst 2012;104:228-39.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 228-239
-
-
Ihle, N.T.1
Byers, L.A.2
Kim, E.S.3
Saintigny, P.4
Lee, J.J.5
Blumenschein, G.R.6
-
20
-
-
84878545631
-
The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma
-
Villaruz LC, Socinski MA, Cunningham DE, Chiosea SI, Burns TF, Siegfried JM, et al. The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma. Cancer 2013;119:2268-74.
-
(2013)
Cancer
, vol.119
, pp. 2268-2274
-
-
Villaruz, L.C.1
Socinski, M.A.2
Cunningham, D.E.3
Chiosea, S.I.4
Burns, T.F.5
Siegfried, J.M.6
-
21
-
-
84881374148
-
Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy
-
Shepherd FA, Domerg C, Hainaut P, Jänne PA, Pignon J-P, Graziano S, et al. Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy. J Clin Oncol 2013;31:2173-81.
-
(2013)
J Clin Oncol
, vol.31
, pp. 2173-2181
-
-
Shepherd, F.A.1
Domerg, C.2
Hainaut, P.3
Jänne, P.A.4
Pignon, J.-P.5
Graziano, S.6
-
22
-
-
79957857433
-
The BATTLE trial: Personalizing therapy for lung cancer
-
Kim ES, Herbst RS, Wistuba II, Lee JJ, Blumenschein GR Jr, Tsao A, et al. The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov 2011;1:44-53.
-
(2011)
Cancer Discov
, vol.1
, pp. 44-53
-
-
Kim, E.S.1
Herbst, R.S.2
Wistuba, I.I.3
Lee, J.J.4
Blumenschein, G.R.5
Tsao, A.6
-
23
-
-
84879919632
-
KRAS mutations in lung cancer
-
Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, et al. KRAS mutations in lung cancer. Clin Lung Cancer 2013;14:205-14.
-
(2013)
Clin Lung Cancer
, vol.14
, pp. 205-214
-
-
Karachaliou, N.1
Mayo, C.2
Costa, C.3
Magrí, I.4
Gimenez-Capitan, A.5
Molina-Vila, M.A.6
-
24
-
-
78650372656
-
Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer
-
Garassino MC, Marabese M, Rusconi P, Rulli E, Martelli O, Farina G, et al. Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer. Ann Oncol 2011;22:235-7.
-
(2011)
Ann Oncol
, vol.22
, pp. 235-237
-
-
Garassino, M.C.1
Marabese, M.2
Rusconi, P.3
Rulli, E.4
Martelli, O.5
Farina, G.6
-
25
-
-
0036739336
-
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype
-
Bazan V, Migliavacca M, Zanna I, Tubiolo C, Grassi N, Latteri MA, et al. Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol 2002;13:1438-46.
-
(2002)
Ann Oncol
, vol.13
, pp. 1438-1446
-
-
Bazan, V.1
Migliavacca, M.2
Zanna, I.3
Tubiolo, C.4
Grassi, N.5
Latteri, M.A.6
-
26
-
-
78049341541
-
Association of KRAS p. G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
-
De Roock W, Jonker DJ, Di Nicolantonio F, Sartore-Bianchi A, Tu D, Siena S, et al. Association of KRAS p. G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA 2010;304:1812-20.
-
(2010)
JAMA
, vol.304
, pp. 1812-1820
-
-
De Roock, W.1
Jonker, D.J.2
Di Nicolantonio, F.3
Sartore-Bianchi, A.4
Tu, D.5
Siena, S.6
-
30
-
-
0033635157
-
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma
-
Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, et al. Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell 2000;103:931-43.
-
(2000)
Cell
, vol.103
, pp. 931-943
-
-
Pacold, M.E.1
Suire, S.2
Perisic, O.3
Lara-Gonzalez, S.4
Davis, C.T.5
Walker, E.H.6
-
31
-
-
77954758621
-
What makes Ras an efficient molecular switch: A computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf
-
Filchtinski D, Sharabi O, Ruppel A, Vetter IR, Herrmann C, Shifman JM. What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf. J Mol Biol 2010;399:422-35.
-
(2010)
J Mol Biol
, vol.399
, pp. 422-435
-
-
Filchtinski, D.1
Sharabi, O.2
Ruppel, A.3
Vetter, I.R.4
Herrmann, C.5
Shifman, J.M.6
-
32
-
-
3042796979
-
GAP control: Regulating the regulators of small GTPases
-
Bernards A, Settleman J. GAP control: regulating the regulators of small GTPases. Trends Cell Biol 2004;14:377-85.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 377-385
-
-
Bernards, A.1
Settleman, J.2
-
33
-
-
84942344148
-
-
cited January 13, 2015
-
McCormick F. RAS Pathway v2.0. [cited January 13, 2015]. Available from: http://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/ras-pathway-v2.
-
RAS Pathway v2.0
-
-
McCormick, F.1
-
34
-
-
84902603270
-
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
-
Hunter JC, Gurbani D, Ficarro SB, Carrasco MA, Lim SM, Choi HG, et al. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc Natl Acad Sci U S A 2014;111:8895-900.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 8895-8900
-
-
Hunter, J.C.1
Gurbani, D.2
Ficarro, S.B.3
Carrasco, M.A.4
Lim, S.M.5
Choi, H.G.6
-
35
-
-
84890947640
-
Therapeutic targeting of oncogenic k-ras by a covalent catalytic site inhibitor
-
Lim SM, Westover KD, Ficarro SB, Harrison RA, Choi HG, Pacold ME, et al. Therapeutic targeting of oncogenic k-ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl 2014;53:199-204.
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, pp. 199-204
-
-
Lim, S.M.1
Westover, K.D.2
Ficarro, S.B.3
Harrison, R.A.4
Choi, H.G.5
Pacold, M.E.6
-
36
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Minor ZOa W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 1997;276:307-26.
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Minor, Z.Oa.W.1
-
37
-
-
76449098262
-
PHENIX: A comprehensive Python-based system for macromolecular structure solution
-
Adams PD, Afonine PV, Bunkoczi G, Chen VB, Davis IW, Echols N, et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr 2010;66:213-21.
-
(2010)
Acta Crystallogr D Biol Crystallogr
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
Afonine, P.V.2
Bunkoczi, G.3
Chen, V.B.4
Davis, I.W.5
Echols, N.6
-
39
-
-
34547559704
-
PDB2PQR: Expanding and upgrading automated preparation of biomolecular structures for molecular simulations
-
Dolinsky TJ, Czodrowski P, Li H, Nielsen JE, Jensen JH, Klebe G, et al. PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations. Nucleic Acids Res 2007;35:W522-5.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. W522-W525
-
-
Dolinsky, T.J.1
Czodrowski, P.2
Li, H.3
Nielsen, J.E.4
Jensen, J.H.5
Klebe, G.6
-
40
-
-
3242886771
-
PDB2PQR: An automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
-
Dolinsky TJ, Nielsen JE, McCammon JA, Baker NA. PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Res 2004;32:W665-7.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. W665-W667
-
-
Dolinsky, T.J.1
Nielsen, J.E.2
McCammon, J.A.3
Baker, N.A.4
-
41
-
-
0035964342
-
Electrostatics of nanosystems: Application to microtubules and the ribosome
-
Baker NA, Sept D, Joseph S, Holst MJ, McCammon JA. Electrostatics of nanosystems: application to microtubules and the ribosome. Proc Natl Acad Sci U S A 2001;98:10037-41.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10037-10041
-
-
Baker, N.A.1
Sept, D.2
Joseph, S.3
Holst, M.J.4
McCammon, J.A.5
-
42
-
-
84859169877
-
The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012;483:603-7.
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
Venkatesan, K.4
Margolin, A.A.5
Kim, S.6
-
43
-
-
0023664530
-
Preparation and characterization of nucleotide-free and metal ion-free p21 "apoprotein"
-
Feuerstein J, Goody RS, Wittinghofer A. Preparation and characterization of nucleotide-free and metal ion-free p21 "apoprotein. " J Biol Chem 1987;262:8455-8.
-
(1987)
J Biol Chem
, vol.262
, pp. 8455-8458
-
-
Feuerstein, J.1
Goody, R.S.2
Wittinghofer, A.3
-
44
-
-
0023687515
-
Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction
-
John J, Frech M, Wittinghofer A. Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction. J Biol Chem 1988;263:11792-9.
-
(1988)
J Biol Chem
, vol.263
, pp. 11792-11799
-
-
John, J.1
Frech, M.2
Wittinghofer, A.3
-
45
-
-
0025337447
-
Kinetics of interaction of nucleotides with nucleotide-free H-ras p21
-
John J, Sohmen R, Feuerstein J, Linke R, Wittinghofer A, Goody RS. Kinetics of interaction of nucleotides with nucleotide-free H-ras p21. Biochemistry 1990;29:6058-65.
-
(1990)
Biochemistry
, vol.29
, pp. 6058-6065
-
-
John, J.1
Sohmen, R.2
Feuerstein, J.3
Linke, R.4
Wittinghofer, A.5
Goody, R.S.6
-
46
-
-
84888639050
-
K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions
-
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013;503:548-51.
-
(2013)
Nature
, vol.503
, pp. 548-551
-
-
Ostrem, J.M.1
Peters, U.2
Sos, M.L.3
Wells, J.A.4
Shokat, K.M.5
-
47
-
-
0034698068
-
Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine-rich domain interactions
-
Williams JG, Drugan JK, Yi GS, Clark GJ, der CJ, Campbell SL. Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine-rich domain interactions. J Biol Chem 2000;275:22172-9.
-
(2000)
J Biol Chem
, vol.275
, pp. 22172-22179
-
-
Williams, J.G.1
Drugan, J.K.2
Yi, G.S.3
Clark, G.J.4
Der, C.J.5
Campbell, S.L.6
-
48
-
-
84872536378
-
RAC1P29S is a spontaneously activating cancer-associated GTPase
-
Davis MJ, Ha BH, Holman EC, Halaban R, Schlessinger J, Boggon TJ. RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc Natl Acad Sci U S A 2013;110:912-7.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 912-917
-
-
Davis, M.J.1
Ha, B.H.2
Holman, E.C.3
Halaban, R.4
Schlessinger, J.5
Boggon, T.J.6
-
49
-
-
0032534786
-
Purine nucleoside phosphorylase: Its use in a spectroscopic assay for inorganic phosphate and for removing inorganic phosphate with the aid of phosphodeoxyribomutase
-
Nixon AE, Hunter JL, Bonifacio G, Eccleston JF, Webb MR. Purine nucleoside phosphorylase: its use in a spectroscopic assay for inorganic phosphate and for removing inorganic phosphate with the aid of phosphodeoxyribomutase. Anal Biochem 1998;265:299-307.
-
(1998)
Anal Biochem
, vol.265
, pp. 299-307
-
-
Nixon, A.E.1
Hunter, J.L.2
Bonifacio, G.3
Eccleston, J.F.4
Webb, M.R.5
-
50
-
-
84888586550
-
Kinetic mechanisms of mutationdependent Harvey Ras activation and their relevance for the development of Costello syndrome
-
Wey M, Lee J, Jeong SS, Kim J, Heo J. Kinetic mechanisms of mutationdependent Harvey Ras activation and their relevance for the development of Costello syndrome. Biochemistry 2013;52:8465-79.
-
(2013)
Biochemistry
, vol.52
, pp. 8465-8479
-
-
Wey, M.1
Lee, J.2
Jeong, S.S.3
Kim, J.4
Heo, J.5
-
51
-
-
0026670215
-
Interaction of GTPase-activating protein with p21ras, measured using a continuous assay for inorganic phosphate release
-
Webb MR, Hunter JL. Interaction of GTPase-activating protein with p21ras, measured using a continuous assay for inorganic phosphate release. Biochem J 1992;287(Pt 2):555-9.
-
(1992)
Biochem J
, vol.287
, pp. 555-559
-
-
Webb, M.R.1
Hunter, J.L.2
-
52
-
-
0030772378
-
The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek K, Ahmadian MR, Kabsch W, Wiesmuller L, Lautwein A, Schmitz F, et al. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997;277:333-8.
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kabsch, W.3
Wiesmuller, L.4
Lautwein, A.5
Schmitz, F.6
-
53
-
-
0031231083
-
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras
-
Ahmadian MR, Stege P, Scheffzek K, Wittinghofer A. Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nat Struct Biol 1997;4:686-9.
-
(1997)
Nat Struct Biol
, vol.4
, pp. 686-689
-
-
Ahmadian, M.R.1
Stege, P.2
Scheffzek, K.3
Wittinghofer, A.4
-
55
-
-
84862649997
-
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation
-
Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl 2012;51:6140-3.
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, pp. 6140-6143
-
-
Sun, Q.1
Burke, J.P.2
Phan, J.3
Burns, M.C.4
Olejniczak, E.T.5
Waterson, A.G.6
-
56
-
-
0032546533
-
Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm
-
Lenzen C, Cool RH, Prinz H, Kuhlmann J, Wittinghofer A. Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm. Biochemistry 1998;37:7420-30.
-
(1998)
Biochemistry
, vol.37
, pp. 7420-7430
-
-
Lenzen, C.1
Cool, R.H.2
Prinz, H.3
Kuhlmann, J.4
Wittinghofer, A.5
-
57
-
-
84874248179
-
Computational analysis of KRAS mutations: Implications for different effects on the KRAS p. G12D and p. G13D mutations
-
Chen CC, Er TK, Liu YY, Hwang JK, Barrio MJ, Rodrigo M, et al. Computational analysis of KRAS mutations: implications for different effects on the KRAS p. G12D and p. G13D mutations. PLoS ONE 2013;8:e55793.
-
(2013)
PLoS ONE
, vol.8
, pp. e55793
-
-
Chen, C.C.1
Er, T.K.2
Liu, Y.Y.3
Hwang, J.K.4
Barrio, M.J.5
Rodrigo, M.6
-
58
-
-
84875233112
-
NMR-based functional profiling of RASopathies and oncogenic RAS mutations
-
Smith MJ, Neel BG, Ikura M. NMR-based functional profiling of RASopathies and oncogenic RAS mutations. Proc Natl Acad Sci U S A 2013;110:4574-9.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 4574-4579
-
-
Smith, M.J.1
Neel, B.G.2
Ikura, M.3
-
59
-
-
30644480321
-
Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: Results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study
-
Bazan V, Agnese V, Corsale S, Calo V, Valerio MR, Latteri MA, et al. Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study. Ann Oncol 2005;16(Suppl 4): iv50-5.
-
(2005)
Ann Oncol
, vol.16
, pp. iv50-iv55
-
-
Bazan, V.1
Agnese, V.2
Corsale, S.3
Calo, V.4
Valerio, M.R.5
Latteri, M.A.6
-
60
-
-
0030932131
-
Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy
-
Ahmadian MR, Hoffmann U, Goody RS, Wittinghofer A. Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy. Biochemistry 1997;36:4535-41.
-
(1997)
Biochemistry
, vol.36
, pp. 4535-4541
-
-
Ahmadian, M.R.1
Hoffmann, U.2
Goody, R.S.3
Wittinghofer, A.4
-
61
-
-
79952811451
-
Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase
-
Buhrman G, Kumar VS, Cirit M, Haugh JM, Mattos C. Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase. J Biol Chem 2011;286:3323-31.
-
(2011)
J Biol Chem
, vol.286
, pp. 3323-3331
-
-
Buhrman, G.1
Kumar, V.S.2
Cirit, M.3
Haugh, J.M.4
Mattos, C.5
-
62
-
-
0032898066
-
Structural and biochemical analysis of Ras-effector signaling via RalGDS
-
Vetter I, Linnemann T, Wohlgemuth S, Geyer M, Kalbitzer HR, Herrmann C, et al. Structural and biochemical analysis of Ras-effector signaling via RalGDS. FEBS Lett 1999;451:175-80.
-
(1999)
FEBS Lett
, vol.451
, pp. 175-180
-
-
Vetter, I.1
Linnemann, T.2
Wohlgemuth, S.3
Geyer, M.4
Kalbitzer, H.R.5
Herrmann, C.6
-
63
-
-
0029147166
-
Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets
-
Moodie SA, Paris M, Villafranca E, Kirshmeier P, Willumsen BM, Wolfman A. Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets. Oncogene 1995;11:447-54.
-
(1995)
Oncogene
, vol.11
, pp. 447-454
-
-
Moodie, S.A.1
Paris, M.2
Villafranca, E.3
Kirshmeier, P.4
Willumsen, B.M.5
Wolfman, A.6
-
65
-
-
36749036721
-
Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf
-
Buhrman G, Wink G, Mattos C. Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure 2007;15:1618-29.
-
(2007)
Structure
, vol.15
, pp. 1618-1629
-
-
Buhrman, G.1
Wink, G.2
Mattos, C.3
-
66
-
-
84862908097
-
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
-
Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med 2012;366:207-15.
-
(2012)
N Engl J Med
, vol.366
, pp. 207-215
-
-
Su, F.1
Viros, A.2
Milagre, C.3
Trunzer, K.4
Bollag, G.5
Spleiss, O.6
-
67
-
-
33750474485
-
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12
-
Cespedes MV, Sancho FJ, Guerrero S, Parreno M, Casanova I, Pavon MA, et al. K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12. Carcinogenesis 2006;27:2190-200.
-
(2006)
Carcinogenesis
, vol.27
, pp. 2190-2200
-
-
Cespedes, M.V.1
Sancho, F.J.2
Guerrero, S.3
Parreno, M.4
Casanova, I.5
Pavon, M.A.6
|