Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region

Journal of Biological Chemistry

Volumn 290, Issue 15, 2015, Pages 9465-9477

  Jang, Hyunbum ^a,b   Abraham, Sherwin J ^c,d   Chavan, Tanmay S ^c,e   Hitchinson, Ben ^d   Khavrutskii, Lyuba ^a,b   Tarasova, Nadya I ^b   Nussinov, Ruth ^a,b,f   Gaponenko, Vadim ^d,e  

^a FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c STANFORD UNIVERSITY   (United States)

^d Department of Biochemistry and Molecular Genetics ^*  (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^f TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; MOLECULAR DYNAMICS; PHOSPHOLIPIDS; SURFACE PLASMON RESONANCE;

ANIONIC PHOSPHOLIPIDS; MEMBRANE ASSOCIATION; MEMBRANE FLUIDITY; MEMBRANE INSERTION; MEMBRANE ORIENTATION; MOLECULAR DYNAMICS SIMULATIONS; POSITIVELY CHARGED; STRUCTURAL MECHANISMS;

MEMBRANES;

GUANOSINE TRIPHOSPHATASE; K RAS4B PROTEIN; PHOSPHOLIPID; POLYLYSINE; UNCLASSIFIED DRUG; K-RAS4B PROTEIN, HUMAN; LIPID BILAYER; PEPTIDE; PROTEIN BINDING; PROTEIN P21; SERINE;

ANIMAL CELL; ARTICLE; CAVEOLA; CELL MEMBRANE; CELL MEMBRANE FLUIDITY; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FARNESYLATION; HYPERVARIABLE REGION; LIPID BILAYER; LIPID RAFT; MEMBRANE BINDING; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL MODEL; CHEMISTRY; GENETICS; HUMAN; MEMBRANE FLUIDITY; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN PRENYLATION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; GTP PHOSPHOHYDROLASES; HUMANS; LIPID BILAYERS; MEMBRANE FLUIDITY; MEMBRANE MICRODOMAINS; MICROSCOPY, CONFOCAL; MODELS, CHEMICAL; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHOLIPIDS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN PRENYLATION; PROTO-ONCOGENE PROTEINS P21(RAS); SERINE; SURFACE PLASMON RESONANCE;

EID: 84927144988     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.620724     Document Type: Article

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