메뉴 건너뛰기




Volumn 15, Issue 7, 2014, Pages

Modelling the onset of senescence at the G1/S cell cycle checkpoint

Author keywords

Cell cycle checkpoint; Cell fate; DNA damage; Logical modelling; Senescence; Signalling network

Indexed keywords

DNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; ATM PROTEIN;

EID: 84964312969     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-S7-S7     Document Type: Article
Times cited : (30)

References (63)
  • 1
    • 0034614334 scopus 로고    scopus 로고
    • A long twentieth century of the cell cycle and beyond
    • Nurse P: A long twentieth century of the cell cycle and beyond. Cell. 2000, 100: 71-78. 10.1016/S0092-8674(00)81684-0.
    • (2000) Cell , vol.100 , pp. 71-78
    • Nurse, P.1
  • 2
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S: Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem. 2004, 73: 39-85. 10.1146/annurev.biochem.73.011303.073723.
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kaçmaz, K.3    Linn, S.4
  • 3
    • 84871969335 scopus 로고    scopus 로고
    • Sowing the seeds of cancer: telomeres and age-associated tumorigenesis
    • Pereira B, Ferreira MG: Sowing the seeds of cancer: telomeres and age-associated tumorigenesis. Curr Opin Oncol. 2013, 25: 93-98.
    • (2013) Curr Opin Oncol , vol.25 , pp. 93-98
    • Pereira, B.1    Ferreira, M.G.2
  • 4
    • 84873638532 scopus 로고    scopus 로고
    • Aging, cellular senescence, and cancer
    • Campisi J: Aging, cellular senescence, and cancer. Annu Rev Physiol. 2013, 75: 685-705. 10.1146/annurev-physiol-030212-183653.
    • (2013) Annu Rev Physiol , vol.75 , pp. 685-705
    • Campisi, J.1
  • 6
    • 80054682555 scopus 로고    scopus 로고
    • Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
    • Coppé J-P, Rodier F, Patil CK, Freund A, Desprez P-Y, Campisi J: Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem. 2011, 286: 36396-36403. 10.1074/jbc.M111.257071.
    • (2011) J Biol Chem , vol.286 , pp. 36396-36403
    • Coppé, J.-P.1    Rodier, F.2    Patil, C.K.3    Freund, A.4    Desprez, P.-Y.5    Campisi, J.6
  • 8
    • 84861526824 scopus 로고    scopus 로고
    • Checkpoint control and cancer
    • Medema RH, Macůrek L: Checkpoint control and cancer. Oncogene. 2012, 31: 2601-2613. 10.1038/onc.2011.451.
    • (2012) Oncogene , vol.31 , pp. 2601-2613
    • Medema, R.H.1    Macůrek, L.2
  • 10
    • 36049044199 scopus 로고    scopus 로고
    • Executable cell biology
    • Fisher J, Henzinger TA: Executable cell biology. Nat Biotechnol. 2007, 25: 1239-1249. 10.1038/nbt1356.
    • (2007) Nat Biotechnol , vol.25 , pp. 1239-1249
    • Fisher, J.1    Henzinger, T.A.2
  • 12
    • 0036207347 scopus 로고    scopus 로고
    • Modeling and simulation of genetic regulatory systems: a literature review
    • De Jong H: Modeling and simulation of genetic regulatory systems: a literature review. J Comput Biol. 2002, 9: 67-103. 10.1089/10665270252833208.
    • (2002) J Comput Biol , vol.9 , pp. 67-103
    • De Jong, H.1
  • 14
    • 79751531809 scopus 로고    scopus 로고
    • Mathematical modeling of cell cycle regulation in response to DNA damage: Exploring mechanisms of cell-fate determination
    • Iwamoto K, Hamada H, Eguchi Y, Okamoto M: Mathematical modeling of cell cycle regulation in response to DNA damage: Exploring mechanisms of cell-fate determination. Biosystems. 2011, 103: 384-391. 10.1016/j.biosystems.2010.11.011.
    • (2011) Biosystems , vol.103 , pp. 384-391
    • Iwamoto, K.1    Hamada, H.2    Eguchi, Y.3    Okamoto, M.4
  • 16
    • 72949096331 scopus 로고    scopus 로고
    • Logical modelling of cell cycle control in eukaryotes: a comparative study
    • Fauré A, Thieffry D: Logical modelling of cell cycle control in eukaryotes: a comparative study. Mol Biosyst. 2009, 5: 1569-1581. 10.1039/b907562n.
    • (2009) Mol Biosyst , vol.5 , pp. 1569-1581
    • Fauré, A.1    Thieffry, D.2
  • 18
    • 84866150897 scopus 로고    scopus 로고
    • Dynamics of p53 and NF-ΚB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention
    • Poltz R, Naumann M: Dynamics of p53 and NF-ΚB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention. BMC Syst Biol. 2012, 6: 125-10.1186/1752-0509-6-125.
    • (2012) BMC Syst Biol , vol.6 , pp. 125
    • Poltz, R.1    Naumann, M.2
  • 21
    • 79959854185 scopus 로고    scopus 로고
    • Transcriptional regulation of cellular senescence
    • Lanigan F, Geraghty JG, Bracken AP: Transcriptional regulation of cellular senescence. Oncogene. 2011, 30: 2901-2911. 10.1038/onc.2011.34.
    • (2011) Oncogene , vol.30 , pp. 2901-2911
    • Lanigan, F.1    Geraghty, J.G.2    Bracken, A.P.3
  • 22
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham RT: Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes & Development. 2001, 15: 2177-2196. 10.1101/gad.914401.
    • (2001) Genes & Development , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 23
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: cellular senescence as a DNA-damage response
    • D' Adda di Fagagna F: Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer. 2008, 8: 512-522. 10.1038/nrc2440.
    • (2008) Nat Rev Cancer , vol.8 , pp. 512-522
    • D' Adda, F.F.1
  • 25
    • 63749131243 scopus 로고    scopus 로고
    • Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
    • Reinhardt HC, Yaffe MB: Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol. 2009, 21: 245-255. 10.1016/j.ceb.2009.01.018.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 245-255
    • Reinhardt, H.C.1    Yaffe, M.B.2
  • 26
    • 84874948475 scopus 로고    scopus 로고
    • A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis
    • Kracikova M, Akiri G, George A, Sachidanandam R, Aaronson SA: A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis. Cell Death Differ. 2013, 20: 576-588. 10.1038/cdd.2012.155.
    • (2013) Cell Death Differ , vol.20 , pp. 576-588
    • Kracikova, M.1    Akiri, G.2    George, A.3    Sachidanandam, R.4    Aaronson, S.A.5
  • 27
    • 0032169516 scopus 로고    scopus 로고
    • The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
    • Stott FJ: The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2. The EMBO Journal. 1998, 17: 5001-5014. 10.1093/emboj/17.17.5001.
    • (1998) The EMBO Journal , vol.17 , pp. 5001-5014
    • Stott, F.J.1
  • 28
    • 1842483852 scopus 로고    scopus 로고
    • Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19Arf pathway
    • Bulavin DV, Phillips C, Nannenga B, Timofeev O, Donehower LA, Anderson CW, Appella E, Fornace AJ: Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19Arf pathway. Nature Genetics. 2004, 36: 343-350. 10.1038/ng1317.
    • (2004) Nature Genetics , vol.36 , pp. 343-350
    • Bulavin, D.V.1    Phillips, C.2    Nannenga, B.3    Timofeev, O.4    Donehower, L.A.5    Anderson, C.W.6    Appella, E.7    Fornace, A.J.8
  • 30
    • 60149093582 scopus 로고    scopus 로고
    • Non-Classical P38 Map Kinase Functions
    • International Journal of Biological Sciences
    • Thornton TM: Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. International Journal of Biological Sciences. 2009, 44-52.
    • (2009) Cell Cycle Checkpoints and Survival , pp. 44-52
    • Thornton, T.M.1
  • 34
    • 0012966157 scopus 로고    scopus 로고
    • Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
    • Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou B-B, Bartek J, Lukas J: Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell. 2003, 3: 247-258. 10.1016/S1535-6108(03)00048-5.
    • (2003) Cancer Cell , vol.3 , pp. 247-258
    • Sørensen, C.S.1    Syljuåsen, R.G.2    Falck, J.3    Schroeder, T.4    Rönnstrand, L.5    Khanna, K.K.6    Zhou, B.-B.7    Bartek, J.8    Lukas, J.9
  • 36
    • 0036242247 scopus 로고    scopus 로고
    • Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
    • Wang W, Chen JX, Liao R, Deng Q, Zhou JJ, Huang S, Sun P: Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol. 2002, 22: 3389-3403. 10.1128/MCB.22.10.3389-3403.2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 3389-3403
    • Wang, W.1    Chen, J.X.2    Liao, R.3    Deng, Q.4    Zhou, J.J.5    Huang, S.6    Sun, P.7
  • 40
    • 22244486020 scopus 로고    scopus 로고
    • Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer
    • Chen C-R, Wang W, Rogoff HA, Li X, Mang W, Li CJ: Dual induction of apoptosis and senescence in cancer cells by Chk2 activation: checkpoint activation as a strategy against cancer. Cancer Res. 2005, 65: 6017-6021. 10.1158/0008-5472.CAN-05-0677.
    • (2005) Cancer Res , vol.65 , pp. 6017-6021
    • Chen, C.-R.1    Wang, W.2    Rogoff, H.A.3    Li, X.4    Mang, W.5    Li, C.J.6
  • 41
    • 77956517413 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence
    • Zhan H, Suzuki T, Aizawa K, Miyagawa K, Nagai R: Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence. J Biol Chem. 2010, 285: 29662-29670. 10.1074/jbc.M110.125138.
    • (2010) J Biol Chem , vol.285 , pp. 29662-29670
    • Zhan, H.1    Suzuki, T.2    Aizawa, K.3    Miyagawa, K.4    Nagai, R.5
  • 44
    • 77952543499 scopus 로고    scopus 로고
    • The p53 orchestra: Mdm2 and Mdmx set the tone
    • Wade M, Wang YV, Wahl GM: The p53 orchestra: Mdm2 and Mdmx set the tone. Trends in Cell Biology. 2010, 20: 299-309. 10.1016/j.tcb.2010.01.009.
    • (2010) Trends in Cell Biology , vol.20 , pp. 299-309
    • Wade, M.1    Wang, Y.V.2    Wahl, G.M.3
  • 45
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • De Oca Luna RM, Wagner DS, Lozano G: Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 1995, 378: 203-206. 10.1038/378203a0.
    • (1995) Nature , vol.378 , pp. 203-206
    • De Oca Luna, R.M.1    Wagner, D.S.2    Lozano, G.3
  • 47
    • 21244502525 scopus 로고    scopus 로고
    • Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells
    • Hemmati PG, Normand G, Verdoodt B, von Haefen C, Hasenjäger A, Güner D, Wendt J, Dörken B, Daniel PT: Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells. Oncogene. 2005, 24: 4114-4128. 10.1038/sj.onc.1208579.
    • (2005) Oncogene , vol.24 , pp. 4114-4128
    • Hemmati, P.G.1    Normand, G.2    Verdoodt, B.3    von Haefen, C.4    Hasenjäger, A.5    Güner, D.6    Wendt, J.7    Dörken, B.8    Daniel, P.T.9
  • 48
  • 49
    • 40449093139 scopus 로고    scopus 로고
    • CDC25A Phosphatase: a Rate-Limiting Oncogene That Determines Genomic Stability
    • Ray D, Kiyokawa H: CDC25A Phosphatase: a Rate-Limiting Oncogene That Determines Genomic Stability. Cancer Research. 2008, 68: 1251-1253. 10.1158/0008-5472.CAN-07-5983.
    • (2008) Cancer Research , vol.68 , pp. 1251-1253
    • Ray, D.1    Kiyokawa, H.2
  • 50
    • 0033552627 scopus 로고    scopus 로고
    • mdm2: a bridge over the two tumour suppressors, p53 and Rb
    • Yap DB, Hsieh JK, Chan FS, Lu X: mdm2: a bridge over the two tumour suppressors, p53 and Rb. Oncogene. 1999, 18: 7681-7689. 10.1038/sj.onc.1202954.
    • (1999) Oncogene , vol.18 , pp. 7681-7689
    • Yap, D.B.1    Hsieh, J.K.2    Chan, F.S.3    Lu, X.4
  • 51
    • 50149108858 scopus 로고    scopus 로고
    • Conserved functions of the pRB and E2F families
    • Van den Heuvel S, Dyson NJ: Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol. 2008, 9: 713-724. 10.1038/nrm2469.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 713-724
    • Van den Heuvel, S.1    Dyson, N.J.2
  • 52
    • 84855872610 scopus 로고    scopus 로고
    • Logical modelling of gene regulatory networks with GINsim
    • Chaouiya C, Naldi A, Thieffry D: Logical modelling of gene regulatory networks with GINsim. Methods Mol Biol. 2012, 804: 463-479. 10.1007/978-1-61779-361-5_23.
    • (2012) Methods Mol Biol , vol.804 , pp. 463-479
    • Chaouiya, C.1    Naldi, A.2    Thieffry, D.3
  • 54
    • 34548327206 scopus 로고    scopus 로고
    • Dynamical roles of biological regulatory circuits
    • Thieffry D: Dynamical roles of biological regulatory circuits. Briefings in Bioinformatics. 2007, 8: 220-225. 10.1093/bib/bbm028.
    • (2007) Briefings in Bioinformatics , vol.8 , pp. 220-225
    • Thieffry, D.1
  • 55
    • 67349272002 scopus 로고    scopus 로고
    • From structure to dynamics: frequency tuning in the p53-Mdm2 network I. Logical approach
    • Abou-Jaoudé W, Ouattara DA, Kaufman M: From structure to dynamics: frequency tuning in the p53-Mdm2 network I. Logical approach. J Theor Biol. 2009, 258: 561-77. 10.1016/j.jtbi.2009.02.005.
    • (2009) J Theor Biol , vol.258 , pp. 561-577
    • Abou-Jaoudé, W.1    Ouattara, D.A.2    Kaufman, M.3
  • 56
    • 0000915688 scopus 로고    scopus 로고
    • On the Relation Between the Logical Structure of Systems and Their Ability to Generate Multiple Steady States or Sustained Oscillations
    • Edited by: Dora J, Demongeot J, Lacolle B Berlin, Heidelberg. 1981, Springer Berlin Heidelberg
    • Thomas R: On the Relation Between the Logical Structure of Systems and Their Ability to Generate Multiple Steady States or Sustained Oscillations. Numerical Methods in the Study of Critical Phenomena. Edited by: Dora J, Demongeot J, Lacolle B Berlin, Heidelberg. 1981, Springer Berlin Heidelberg, 9: 180-193. 10.1007/978-3-642-81703-8_24.
    • Numerical Methods in the Study of Critical Phenomena , vol.9 , pp. 180-193
    • Thomas, R.1
  • 57
    • 84894902363 scopus 로고
    • D'Ari R: Biological Feedback
    • CRC Press
    • Thomas R, D'Ari R: Biological Feedback. 1990, CRC Press
    • (1990)
    • Thomas, R.1
  • 58
    • 0029267491 scopus 로고
    • Dynamical behaviour of biological regulatory networks-I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state
    • Thomas R, Thieffry D, Kaufman M: Dynamical behaviour of biological regulatory networks-I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state. Bull Math Biol. 1995, 57: 247-76. 10.1007/BF02460618.
    • (1995) Bull Math Biol , vol.57 , pp. 247-276
    • Thomas, R.1    Thieffry, D.2    Kaufman, M.3
  • 59
    • 27544505428 scopus 로고    scopus 로고
    • Qualitative Analysis of Regulatory Graphs: A Computational Tool Based on a Discrete Formal Framework
    • Chaouiya C, Remy É, Mossé B, Thieffry D: Qualitative Analysis of Regulatory Graphs: A Computational Tool Based on a Discrete Formal Framework. Lecture Notes in Control and Information Sciences. 2003, 294: 119-126. [ http://dx.doi.org/10.1007/b79667 ]
    • (2003) Lecture Notes in Control and Information Sciences , vol.294 , pp. 119-126
    • Chaouiya, C.1    Remy, E.2    Mossé, B.3    Thieffry, D.4
  • 60
    • 33747874092 scopus 로고    scopus 로고
    • Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle
    • Fauré A, Naldi A, Chaouiya C, Thieffry D: Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle. Bioinformatics. 2006, 22: e124-31. 10.1093/bioinformatics/btl210.
    • (2006) Bioinformatics , vol.22 , pp. e124-e131
    • Fauré, A.1    Naldi, A.2    Chaouiya, C.3    Thieffry, D.4
  • 62
    • 38049150712 scopus 로고    scopus 로고
    • Decision Diagrams for the Representation and Analysis of Logical Models of Genetic Networks
    • Naldi A, Thieffry D, Chaouiya C: Decision Diagrams for the Representation and Analysis of Logical Models of Genetic Networks. Lecture Notes in Computer Science. 2007, 4695: 233-247. 10.1007/978-3-540-75140-3_16.
    • (2007) Lecture Notes in Computer Science , vol.4695 , pp. 233-247
    • Naldi, A.1    Thieffry, D.2    Chaouiya, C.3
  • 63
    • 49549119997 scopus 로고    scopus 로고
    • From minimal signed circuits to the dynamics of Boolean regulatory networks
    • Remy E, Ruet P: From minimal signed circuits to the dynamics of Boolean regulatory networks. Bioinformatics. 2008, 24: i220-226. 10.1093/bioinformatics/btn287.
    • (2008) Bioinformatics , vol.24 , pp. 220-226
    • Remy, E.1    Ruet, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.