Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

EMBO Journal

Volumn 29, Issue 20, 2010, Pages 3558-3570

  Niida, Hiroyuki ^a,f   Murata, Kazuhiro ^a   Shimada, Midori ^a   Ogawa, Kumiko ^a   Ohta, Kumiko ^b   Suzuki, Kyoko ^b   Fujigaki, Hidetsugu ^c   Khaw, Aik Kia ^d   Banerjee, Birendranath ^d   Hande, M Prakash ^d   Miyamoto, Tomomi ^e   Miyoshi, Ichiro ^e   Shirai, Tomoyuki ^a   Motoyama, Noboru ^b   Delhase, Mireille ^a   Appella, Ettore ^c   Nakanishi, Makoto ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^f HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

apoptosis; cancer; checkpoint; DNA damage; senescence

Indexed keywords

CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CARCINOGENICITY; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; ENZYME ANALYSIS; FIBROBLAST; GENE DELETION; GENE FREQUENCY; HUMAN; IN VIVO STUDY; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SENESCENCE;

ANIMALS; APOPTOSIS; CELL AGING; CELL CYCLE; CELLS, CULTURED; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA REPAIR; FEMALE; FIBROBLASTS; GENE DELETION; KAPLAN-MEIERS ESTIMATE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES;

MUS;

EID: 77958480403     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2010.218     Document Type: Article

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