메뉴 건너뛰기




Volumn 6, Issue , 2012, Pages

Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention

Author keywords

Apoptosis; Cancer; Cell cycle arrest; Logical model; Signal transduction; Topoisomerase inhibitors

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53;

EID: 84866150897     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-6-125     Document Type: Article
Times cited : (28)

References (88)
  • 1
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: making it safe to play with knives
    • 10.1016/j.molcel.2010.09.019, 2988877, 20965415
    • Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010, 40:179-204. 10.1016/j.molcel.2010.09.019, 2988877, 20965415.
    • (2010) Mol Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 2
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: signalling, repair and the cancer connection
    • 10.1038/85798, 11242102
    • Khanna KK, Jackson SP. DNA double-strand breaks: signalling, repair and the cancer connection. Nat Genet 2001, 27:247-254. 10.1038/85798, 11242102.
    • (2001) Nat Genet , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 3
    • 2942523593 scopus 로고    scopus 로고
    • Endogenous DNA damage in humans: a review of quantitative data
    • 10.1093/mutage/geh025, 15123782
    • De Bont R, van Larebeke N. Endogenous DNA damage in humans: a review of quantitative data. Mutagenesis 2004, 19:169-185. 10.1093/mutage/geh025, 15123782.
    • (2004) Mutagenesis , vol.19 , pp. 169-185
    • De Bont, R.1    van Larebeke, N.2
  • 4
    • 33751299346 scopus 로고    scopus 로고
    • DNA damage checkpoints and cancer
    • 10.1007/s10735-006-9039-4, 16841236
    • Shimada M, Nakanishi M. DNA damage checkpoints and cancer. J Mol Histol 2006, 37:253-260. 10.1007/s10735-006-9039-4, 16841236.
    • (2006) J Mol Histol , vol.37 , pp. 253-260
    • Shimada, M.1    Nakanishi, M.2
  • 5
    • 38849129888 scopus 로고    scopus 로고
    • Regulation of the cellular DNA double-strand break response
    • 10.1139/O07-135, 18059525
    • Cann KL, Hicks GG. Regulation of the cellular DNA double-strand break response. Biochem Cell Biol 2007, 85:663-674. 10.1139/O07-135, 18059525.
    • (2007) Biochem Cell Biol , vol.85 , pp. 663-674
    • Cann, K.L.1    Hicks, G.G.2
  • 6
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: cellular senescence as a DNA-damage response
    • 10.1038/nrc2440, 18574463
    • D'Adda di Fagagna F. Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer 2008, 8:512. 10.1038/nrc2440, 18574463.
    • (2008) Nat Rev Cancer , vol.8 , pp. 512
    • D'Adda di Fagagna, F.1
  • 7
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the Light: The Growing Complexity of p53
    • 10.1016/j.cell.2009.04.037, 19410540
    • Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell 2009, 137:413-431. 10.1016/j.cell.2009.04.037, 19410540.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 8
    • 67349091738 scopus 로고    scopus 로고
    • The ups and downs of p53: understanding protein dynamics in single cells
    • 10.1038/nrc2604, 2892289, 19360021
    • Batchelor E, Loewer A, Lahav G. The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer 2009, 9:371-377. 10.1038/nrc2604, 2892289, 19360021.
    • (2009) Nat Rev Cancer , vol.9 , pp. 371-377
    • Batchelor, E.1    Loewer, A.2    Lahav, G.3
  • 9
    • 79959343390 scopus 로고    scopus 로고
    • Two-phase dynamics of p53 in the DNA damage response
    • 10.1073/pnas.1100600108, 3107314, 21576488
    • Zhang XP, Liu F, Wang W. Two-phase dynamics of p53 in the DNA damage response. Proc Natl Acad Sci U S A 2011, 108:8990-8995. 10.1073/pnas.1100600108, 3107314, 21576488.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 8990-8995
    • Zhang, X.P.1    Liu, F.2    Wang, W.3
  • 10
    • 84858722471 scopus 로고    scopus 로고
    • DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out
    • 10.1111/j.1600-065X.2012.01101.x, 22435563
    • McCool KW, Miyamoto S. DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out. Immunol Rev 2012, 246:311-326. 10.1111/j.1600-065X.2012.01101.x, 22435563.
    • (2012) Immunol Rev , vol.246 , pp. 311-326
    • McCool, K.W.1    Miyamoto, S.2
  • 11
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • 10.1038/nature08467, 2906700, 19847258
    • Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078. 10.1038/nature08467, 2906700, 19847258.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 12
    • 78650215702 scopus 로고    scopus 로고
    • Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes
    • 10.1038/onc.2010.407, 20818418
    • Al-Ejeh F, Kumar R, Wiegmans A, Lakhani SR, Brown MP, Khanna KK. Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene 2010, 29:6085-6098. 10.1038/onc.2010.407, 20818418.
    • (2010) Oncogene , vol.29 , pp. 6085-6098
    • Al-Ejeh, F.1    Kumar, R.2    Wiegmans, A.3    Lakhani, S.R.4    Brown, M.P.5    Khanna, K.K.6
  • 13
    • 77949450557 scopus 로고    scopus 로고
    • Mechanisms of drug-induced mitotic catastrophe in cancer cells
    • 10.2174/138161210789941801, 20214619
    • Portugal J, Mansilla S, Bataller M. Mechanisms of drug-induced mitotic catastrophe in cancer cells. Curr Pharm Des 2010, 16:69-78. 10.2174/138161210789941801, 20214619.
    • (2010) Curr Pharm Des , vol.16 , pp. 69-78
    • Portugal, J.1    Mansilla, S.2    Bataller, M.3
  • 14
    • 78049441629 scopus 로고    scopus 로고
    • Targeting inflammatory pathways for tumor radiosensitization
    • 10.1016/j.bcp.2010.06.039, 3090731, 20599771
    • Deorukhkar A, Krishnan S. Targeting inflammatory pathways for tumor radiosensitization. Biochem Pharmacol 2010, 80:1904-1914. 10.1016/j.bcp.2010.06.039, 3090731, 20599771.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1904-1914
    • Deorukhkar, A.1    Krishnan, S.2
  • 15
    • 70349912096 scopus 로고    scopus 로고
    • Exploiting synthetic lethal interactions for targeted cancer therapy
    • 10.4161/cc.8.19.9626, 3057180, 19755856
    • Reinhardt HC, Jiang H, Hemann MT, Yaffe MB. Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle 2009, 8:3112-3119. 10.4161/cc.8.19.9626, 3057180, 19755856.
    • (2009) Cell Cycle , vol.8 , pp. 3112-3119
    • Reinhardt, H.C.1    Jiang, H.2    Hemann, M.T.3    Yaffe, M.B.4
  • 17
    • 33646337667 scopus 로고    scopus 로고
    • A methodology for the structural and functional analysis of signaling and regulatory networks
    • Klamt S, Saez-Rodriguez J, Lindquist JA, Simeoni L, Gilles ED. A methodology for the structural and functional analysis of signaling and regulatory networks. BMC Bioinforma 2006, 7:56.
    • (2006) BMC Bioinforma , vol.7 , pp. 56
    • Klamt, S.1    Saez-Rodriguez, J.2    Lindquist, J.A.3    Simeoni, L.4    Gilles, E.D.5
  • 18
    • 71549131604 scopus 로고    scopus 로고
    • Discrete dynamic modeling of cellular signaling networks
    • Albert R, Wang RS. Discrete dynamic modeling of cellular signaling networks. Methods Enzymol 2009, 467:281-306.
    • (2009) Methods Enzymol , vol.467 , pp. 281-306
    • Albert, R.1    Wang, R.S.2
  • 20
    • 40149109180 scopus 로고    scopus 로고
    • Host-pathogen system biology: Logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction
    • 10.1186/1752-0509-2-4, 2254585, 18194572
    • Franke R, Müller M, Wundrack N, Gilles ED, Klamt S, Kähne T, Naumann M. Host-pathogen system biology: Logical modelling of hepatocyte growth factor and Helicobacter pylori induced c-Met signal transduction. BMC Syst Biol 2008, 2:4. 10.1186/1752-0509-2-4, 2254585, 18194572.
    • (2008) BMC Syst Biol , vol.2 , pp. 4
    • Franke, R.1    Müller, M.2    Wundrack, N.3    Gilles, E.D.4    Klamt, S.5    Kähne, T.6    Naumann, M.7
  • 21
    • 80051573330 scopus 로고    scopus 로고
    • Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategies
    • 3169943, 21918620
    • Poltz R, Franke R, Schweitzer K, Klamt S, Gilles ED, Naumann M. Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategies. Adv Appl Bioinform Chem 2009, 2:125-138. 3169943, 21918620.
    • (2009) Adv Appl Bioinform Chem , vol.2 , pp. 125-138
    • Poltz, R.1    Franke, R.2    Schweitzer, K.3    Klamt, S.4    Gilles, E.D.5    Naumann, M.6
  • 22
    • 81355154050 scopus 로고    scopus 로고
    • Dynamical and Structural Analysis of a T Cell Survival Network Identifies Novel Candidate Therapeutic Targets for Large Granular Lymphocyte Leukemia
    • Saadatpour A, Wang RS, Liao A, Liu X, Loughran TP, Albert I, Albert R. Dynamical and Structural Analysis of a T Cell Survival Network Identifies Novel Candidate Therapeutic Targets for Large Granular Lymphocyte Leukemia. PLoS Comput Biol 2012, 7:11.
    • (2012) PLoS Comput Biol , vol.7 , pp. 11
    • Saadatpour, A.1    Wang, R.S.2    Liao, A.3    Liu, X.4    Loughran, T.P.5    Albert, I.6    Albert, R.7
  • 24
    • 0037085451 scopus 로고    scopus 로고
    • ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A-B55 in response to ionizing radiation
    • 10.1074/jbc.M110092200, 11723136
    • Guo CY, Brautigan DL, Larner JM. ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A-B55 in response to ionizing radiation. J Biol Chem 2002, 277:4839-4844. 10.1074/jbc.M110092200, 11723136.
    • (2002) J Biol Chem , vol.277 , pp. 4839-4844
    • Guo, C.Y.1    Brautigan, D.L.2    Larner, J.M.3
  • 25
    • 10044225999 scopus 로고    scopus 로고
    • Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A
    • 10.1038/sj.emboj.7600455, 526470, 15510216
    • Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, Lees-Miller SP, Khanna KK. Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. EMBO J 2004, 23:4451-4461. 10.1038/sj.emboj.7600455, 526470, 15510216.
    • (2004) EMBO J , vol.23 , pp. 4451-4461
    • Goodarzi, A.A.1    Jonnalagadda, J.C.2    Douglas, P.3    Young, D.4    Ye, R.5    Moorhead, G.B.6    Lees-Miller, S.P.7    Khanna, K.K.8
  • 26
    • 53349118240 scopus 로고    scopus 로고
    • SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation
    • Xu Y, Fang F, St Clair DK, Sompol P, Josson S, St Clair WH. SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol Cancer Ther 2008, 7:236-2376.
    • (2008) Mol Cancer Ther , vol.7 , pp. 236-2376
    • Xu, Y.1    Fang, F.2    St Clair, D.K.3    Sompol, P.4    Josson, S.5    St Clair, W.H.6
  • 27
    • 77956394195 scopus 로고    scopus 로고
    • IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function
    • 10.1038/emboj.2010.171, 2944043, 20657549
    • Kenneth NS, Mudie S, Rocha S. IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function. EMBO J 2010, 29:2966-2978. 10.1038/emboj.2010.171, 2944043, 20657549.
    • (2010) EMBO J , vol.29 , pp. 2966-2978
    • Kenneth, N.S.1    Mudie, S.2    Rocha, S.3
  • 28
    • 28944447430 scopus 로고    scopus 로고
    • PIDD Mediates NF-κB Activation in Response to DNA Damage
    • Janssens S, Tinel A, Lippens S, Tschopp J. PIDD Mediates NF-κB Activation in Response to DNA Damage. n Cell 2005, 123:1079-1092.
    • (2005) n Cell , vol.123 , pp. 1079-1092
    • Janssens, S.1    Tinel, A.2    Lippens, S.3    Tschopp, J.4
  • 30
    • 0030925222 scopus 로고    scopus 로고
    • Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
    • 10.1073/pnas.94.12.6048, 20998, 9177166
    • Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A 1997, 94:6048-6053. 10.1073/pnas.94.12.6048, 20998, 9177166.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6048-6053
    • Fiscella, M.1    Zhang, H.2    Fan, S.3    Sakaguchi, K.4    Shen, S.5    Mercer, W.E.6    Vande Woude, G.F.7    O'Connor, P.M.8    Appella, E.9
  • 31
    • 1542725073 scopus 로고    scopus 로고
    • Targeting the checkpoint kinases: chemosensitization versus chemoprotection
    • 10.1038/nrc1296, 14993903
    • Zhou BB, Bartek J. Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat Rev Cancer 2004, 4:216-225. 10.1038/nrc1296, 14993903.
    • (2004) Nat Rev Cancer , vol.4 , pp. 216-225
    • Zhou, B.B.1    Bartek, J.2
  • 32
    • 67650667501 scopus 로고    scopus 로고
    • Molecular targets for tumor radiosensitization
    • 10.1021/cr800504x, 3407885, 19338375
    • Tofilon PJ, Camphausen K. Molecular targets for tumor radiosensitization. Chem Rev 2009, 109:2974-2988. 10.1021/cr800504x, 3407885, 19338375.
    • (2009) Chem Rev , vol.109 , pp. 2974-2988
    • Tofilon, P.J.1    Camphausen, K.2
  • 33
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    • Erratum in: Nat Rev Mol Cell Biol 2008, 10.1038/nrm2514, 18813293
    • Lavin MF. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol 2008, 9:759-769. Erratum in: Nat Rev Mol Cell Biol 2008, 10.1038/nrm2514, 18813293.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 34
    • 70350222210 scopus 로고    scopus 로고
    • Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair
    • 10.1158/1078-0432.CCR-09-0096, 19808869
    • Bolderson E, Richard DJ, Zhou BB, Khanna KK. Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. Clin Cancer Res 2009, 15:6314-6320. 10.1158/1078-0432.CCR-09-0096, 19808869.
    • (2009) Clin Cancer Res , vol.15 , pp. 6314-6320
    • Bolderson, E.1    Richard, D.J.2    Zhou, B.B.3    Khanna, K.K.4
  • 35
    • 77954938500 scopus 로고    scopus 로고
    • Prospects for the use of ATR inhibitors to treat cancer
    • Wagner JM, Kaufmann SH. Prospects for the use of ATR inhibitors to treat cancer. Pharmaceuticals 2010, 3:1311-1334.
    • (2010) Pharmaceuticals , vol.3 , pp. 1311-1334
    • Wagner, J.M.1    Kaufmann, S.H.2
  • 36
    • 17144377827 scopus 로고    scopus 로고
    • The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons
    • 10.1074/jbc.M411890200, 15699047
    • Flatten K, Dai NT, Vroman BT, Loegering D, Erlichman C, Karnitz LM, Kaufmann SH. The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons. J Biol Chem 2005, 280:14349-14355. 10.1074/jbc.M411890200, 15699047.
    • (2005) J Biol Chem , vol.280 , pp. 14349-14355
    • Flatten, K.1    Dai, N.T.2    Vroman, B.T.3    Loegering, D.4    Erlichman, C.5    Karnitz, L.M.6    Kaufmann, S.H.7
  • 37
    • 79651470785 scopus 로고    scopus 로고
    • Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
    • 10.1016/j.molmed.2010.10.009, 21087899
    • Ma CX, Janetka JW, Piwnica-Worms H. Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med 2011, 17:88-96. 10.1016/j.molmed.2010.10.009, 21087899.
    • (2011) Trends Mol Med , vol.17 , pp. 88-96
    • Ma, C.X.1    Janetka, J.W.2    Piwnica-Worms, H.3
  • 39
    • 79955720082 scopus 로고    scopus 로고
    • Anticancer therapy with checkpoint inhibitors: what, where and when?
    • 10.1016/j.tips.2011.02.014, 21458083
    • Garrett MD, Collins I. Anticancer therapy with checkpoint inhibitors: what, where and when?. Trends Pharmacol Sci 2011, 32:308-316. 10.1016/j.tips.2011.02.014, 21458083.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 308-316
    • Garrett, M.D.1    Collins, I.2
  • 41
    • 80052825075 scopus 로고    scopus 로고
    • RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors
    • 10.2174/156800911797264734, 3401936, 21834757
    • Martin SE, Wu ZH, Gehlhaus K, Jones TL, Zhang YW, Guha R, Miyamoto S, Pommier Y, Caplen NJ. RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. Curr Cancer Drug Targets 2011, 11:976-986. 10.2174/156800911797264734, 3401936, 21834757.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 976-986
    • Martin, S.E.1    Wu, Z.H.2    Gehlhaus, K.3    Jones, T.L.4    Zhang, Y.W.5    Guha, R.6    Miyamoto, S.7    Pommier, Y.8    Caplen, N.J.9
  • 43
    • 0034306332 scopus 로고    scopus 로고
    • Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
    • 10.1038/35036406, 11025670
    • Melchionna R, Chen XB, Blasiani A, McGowan CH. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. Nat Cell Biol 2000, 2:762-765. 10.1038/35036406, 11025670.
    • (2000) Nat Cell Biol , vol.2 , pp. 762-765
    • Melchionna, R.1    Chen, X.B.2    Blasiani, A.3    McGowan, C.H.4
  • 44
    • 3843066731 scopus 로고    scopus 로고
    • BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage
    • 10.1074/jbc.M405372200, 15159397
    • Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK. BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem 2004, 279:31251-31258. 10.1074/jbc.M405372200, 15159397.
    • (2004) J Biol Chem , vol.279 , pp. 31251-31258
    • Fabbro, M.1    Savage, K.2    Hobson, K.3    Deans, A.J.4    Powell, S.N.5    McArthur, G.A.6    Khanna, K.K.7
  • 45
    • 33646889064 scopus 로고    scopus 로고
    • Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities
    • 10.1038/sj.onc.1209334, 16501611
    • Li DW, Liu JP, Schmid PC, Schlosser R, Feng H, Liu WB, Yan Q, Gong L, Sun SM, Deng M, Liu Y. Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene 2006, 25:3006-3022. 10.1038/sj.onc.1209334, 16501611.
    • (2006) Oncogene , vol.25 , pp. 3006-3022
    • Li, D.W.1    Liu, J.P.2    Schmid, P.C.3    Schlosser, R.4    Feng, H.5    Liu, W.B.6    Yan, Q.7    Gong, L.8    Sun, S.M.9    Deng, M.10    Liu, Y.11
  • 47
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: theory and experimental approaches
    • 10.1038/nrg2102, 17510665
    • Alon U. Network motifs: theory and experimental approaches. Nat Rev Genet 2007, 8:450-461. 10.1038/nrg2102, 17510665.
    • (2007) Nat Rev Genet , vol.8 , pp. 450-461
    • Alon, U.1
  • 48
    • 0142027814 scopus 로고    scopus 로고
    • Structure and function of the feed-forward loop network motif
    • 10.1073/pnas.2133841100, 218699, 14530388
    • Mangan S, Alon U. Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci U S A 2003, 100:11980-11985. 10.1073/pnas.2133841100, 218699, 14530388.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11980-11985
    • Mangan, S.1    Alon, U.2
  • 49
    • 77954312224 scopus 로고    scopus 로고
    • Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells
    • 10.1016/j.cell.2010.05.031, 3003696, 20598361
    • Loewer A, Batchelor E, Gaglia G, Lahav G. Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell 2010, 142:89-100. 10.1016/j.cell.2010.05.031, 3003696, 20598361.
    • (2010) Cell , vol.142 , pp. 89-100
    • Loewer, A.1    Batchelor, E.2    Gaglia, G.3    Lahav, G.4
  • 50
    • 34548327206 scopus 로고    scopus 로고
    • Dynamical roles of biological regulatory circuits
    • 10.1093/bib/bbm028, 17626067
    • Thieffry D. Dynamical roles of biological regulatory circuits. Brief Bioinform 2007, 8:220-225. 10.1093/bib/bbm028, 17626067.
    • (2007) Brief Bioinform , vol.8 , pp. 220-225
    • Thieffry, D.1
  • 51
    • 43249116959 scopus 로고    scopus 로고
    • Understanding NF-kappaB signaling via mathematical modeling
    • 2424295, 18463616
    • Cheong R, Hoffmann A, Levchenko A. Understanding NF-kappaB signaling via mathematical modeling. Mol Syst Biol 2008, 4:192. 2424295, 18463616.
    • (2008) Mol Syst Biol , vol.4 , pp. 192
    • Cheong, R.1    Hoffmann, A.2    Levchenko, A.3
  • 53
    • 68949178676 scopus 로고    scopus 로고
    • Uncovering operational interactions in genetic networks using asynchronous Boolean dynamics
    • 10.1016/j.jtbi.2009.06.006, 19524598
    • Tournier L, Chaves M. Uncovering operational interactions in genetic networks using asynchronous Boolean dynamics. J Theor Biol 2009, 260:196-209. 10.1016/j.jtbi.2009.06.006, 19524598.
    • (2009) J Theor Biol , vol.260 , pp. 196-209
    • Tournier, L.1    Chaves, M.2
  • 54
    • 79953226975 scopus 로고    scopus 로고
    • Dynamically consistent reduction of logical regulatory graphs
    • Naldi A, Remy E, Thieffry D, Chaouiya C. Dynamically consistent reduction of logical regulatory graphs. Theor Comp Sci. 2011, 412:2207-2218.
    • (2011) Theor Comp Sci. , vol.412 , pp. 2207-2218
    • Naldi, A.1    Remy, E.2    Thieffry, D.3    Chaouiya, C.4
  • 55
  • 56
    • 0037219841 scopus 로고    scopus 로고
    • TP53 and ovarian cancer
    • 10.1002/humu.10181, 12619114
    • Schuijer M, Berns EM. TP53 and ovarian cancer. Hum Mutat 2003, 21:285-291. 10.1002/humu.10181, 12619114.
    • (2003) Hum Mutat , vol.21 , pp. 285-291
    • Schuijer, M.1    Berns, E.M.2
  • 57
    • 58249110508 scopus 로고    scopus 로고
    • How cells switch HIPK2 on and off
    • 10.1038/cdd.2008.154, 18974774
    • Sombroek D, Hofmann TG. How cells switch HIPK2 on and off. Cell Death Differ 2009, 16:187-194. 10.1038/cdd.2008.154, 18974774.
    • (2009) Cell Death Differ , vol.16 , pp. 187-194
    • Sombroek, D.1    Hofmann, T.G.2
  • 60
    • 18144428775 scopus 로고    scopus 로고
    • Prospective therapeutic applications of p53 inhibitors
    • Gudkov AV, Komarova EA. Prospective therapeutic applications of p53 inhibitors. Biochem Biophys Res Commun 2005, 33:726-736.
    • (2005) Biochem Biophys Res Commun , vol.33 , pp. 726-736
    • Gudkov, A.V.1    Komarova, E.A.2
  • 61
    • 0029899035 scopus 로고    scopus 로고
    • The ATM gene and the radiobiology of ataxia-telangiectasia
    • 10.1080/095530096145535, 8648240
    • Jorgensen TJ, Shiloh Y. The ATM gene and the radiobiology of ataxia-telangiectasia. Int J Radiat Biol 1996, 69:527-537. 10.1080/095530096145535, 8648240.
    • (1996) Int J Radiat Biol , vol.69 , pp. 527-537
    • Jorgensen, T.J.1    Shiloh, Y.2
  • 62
    • 33847655393 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome and functions of the responsible protein, NBS1
    • Antoccia A, Kobayashi J, Tauchi H, Matsuura S, Komatsu K. Nijmegen breakage syndrome and functions of the responsible protein, NBS1. Genome Dyn 2006, 1:191-205.
    • (2006) Genome Dyn , vol.1 , pp. 191-205
    • Antoccia, A.1    Kobayashi, J.2    Tauchi, H.3    Matsuura, S.4    Komatsu, K.5
  • 65
    • 3242881897 scopus 로고    scopus 로고
    • An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
    • O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA. An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst). 2004, 3:1227-1235.
    • (2004) DNA Repair (Amst). , vol.3 , pp. 1227-1235
    • O'Driscoll, M.1    Gennery, A.R.2    Seidel, J.3    Concannon, P.4    Jeggo, P.A.5
  • 66
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • 10.1016/S0092-8674(03)01075-4, 14744434
    • Sherr CJ. Principles of tumor suppression. Cell 2004, 116:235-246. 10.1016/S0092-8674(03)01075-4, 14744434.
    • (2004) Cell , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 68
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • 10.1038/nature04870, 16724054
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006, 441:431-436. 10.1038/nature04870, 16724054.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 69
    • 0037417954 scopus 로고    scopus 로고
    • Multiple mutations and cancer
    • 10.1073/pnas.0334858100, 298677, 12552134
    • Loeb LA, Loeb KR, Anderson JP. Multiple mutations and cancer. Proc Natl Acad Sci U S A 2003, 100:776-781. 10.1073/pnas.0334858100, 298677, 12552134.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 776-781
    • Loeb, L.A.1    Loeb, K.R.2    Anderson, J.P.3
  • 70
    • 0037370476 scopus 로고    scopus 로고
    • The genetics and genomics of cancer
    • Balmain A, Gray J, Ponder B. The genetics and genomics of cancer. Nat Genet 2003, 33(Suppl):238-244.
    • (2003) Nat Genet , vol.33 , Issue.SUPPL , pp. 238-244
    • Balmain, A.1    Gray, J.2    Ponder, B.3
  • 71
    • 0031955368 scopus 로고    scopus 로고
    • Cancer resistance genes in mice: models for the study of tumour modifiers
    • 10.1016/S0168-9525(98)01422-X, 9594661
    • Balmain A, Nagase H. Cancer resistance genes in mice: models for the study of tumour modifiers. Trends Genet 1998, 14:139-144. 10.1016/S0168-9525(98)01422-X, 9594661.
    • (1998) Trends Genet , vol.14 , pp. 139-144
    • Balmain, A.1    Nagase, H.2
  • 75
    • 72949096331 scopus 로고    scopus 로고
    • Logical modelling of cell cycle control in eukaryotes: a comparative study
    • 10.1039/b907562n, 19763341
    • Fauré A, Thieffry D. Logical modelling of cell cycle control in eukaryotes: a comparative study. Mol Biosyst 2009, 5:1569-1581. 10.1039/b907562n, 19763341.
    • (2009) Mol Biosyst , vol.5 , pp. 1569-1581
    • Fauré, A.1    Thieffry, D.2
  • 76
    • 0025948178 scopus 로고
    • Regulatory networks seen as asynchronous automata: A logical description
    • Thomas R. Regulatory networks seen as asynchronous automata: A logical description. J Theor Biol 1991, 1:1-23.
    • (1991) J Theor Biol , vol.1 , pp. 1-23
    • Thomas, R.1
  • 78
    • 67049098922 scopus 로고    scopus 로고
    • Hypergraphs and cellular networks
    • 10.1371/journal.pcbi.1000385, 2673028, 19478865
    • Klamt S, Haus UU, Theis F. Hypergraphs and cellular networks. PLoS Comput Biol 2009, 5:e1000385. 10.1371/journal.pcbi.1000385, 2673028, 19478865.
    • (2009) PLoS Comput Biol , vol.5
    • Klamt, S.1    Haus, U.U.2    Theis, F.3
  • 79
    • 9444266171 scopus 로고    scopus 로고
    • Cell Designer: a process diagram editor for gene-regulatory and biochemical networks
    • Funahashi A, Tanimura N, Morohashi M, Kitano H. Cell Designer: a process diagram editor for gene-regulatory and biochemical networks. Biosilico 2003, 1:159-162.
    • (2003) Biosilico , vol.1 , pp. 159-162
    • Funahashi, A.1    Tanimura, N.2    Morohashi, M.3    Kitano, H.4
  • 80
    • 34447551397 scopus 로고    scopus 로고
    • Structural and functional analysis of cellular networks with Cell NetAnalyzer
    • 10.1186/1752-0509-1-2, 1847467, 17408509
    • Klamt S, Saez-Rodriguez J, Gilles ED. Structural and functional analysis of cellular networks with Cell NetAnalyzer. BMC Syst Biol 2007, 1:2. 10.1186/1752-0509-1-2, 1847467, 17408509.
    • (2007) BMC Syst Biol , vol.1 , pp. 2
    • Klamt, S.1    Saez-Rodriguez, J.2    Gilles, E.D.3
  • 81
    • 84855863573 scopus 로고    scopus 로고
    • MAVisto: a tool for biological network motif analysis
    • 10.1007/978-1-61779-361-5_14, 22144158
    • Schwöbbermeyer H, Wünschiers R. MAVisto: a tool for biological network motif analysis. Methods Mol Biol 2012, 804:263-280. 10.1007/978-1-61779-361-5_14, 22144158.
    • (2012) Methods Mol Biol , vol.804 , pp. 263-280
    • Schwöbbermeyer, H.1    Wünschiers, R.2
  • 82
    • 0000915688 scopus 로고
    • On the relation between the logical structure of systems and their ability to generate multiple steady states or sustained oscillations
    • Thomas R. On the relation between the logical structure of systems and their ability to generate multiple steady states or sustained oscillations. Springer Ser Synergetics 1981, 9:180-193.
    • (1981) Springer Ser Synergetics , vol.9 , pp. 180-193
    • Thomas, R.1
  • 83
    • 38049150712 scopus 로고    scopus 로고
    • Decision diagrams for the representation of logical models of regulatory networks
    • Naldi A, Thieffry D, Chaouiya C. Decision diagrams for the representation of logical models of regulatory networks. Lecture Notes Comput Sci 2007, 4695:233-247.
    • (2007) Lecture Notes Comput Sci , vol.4695 , pp. 233-247
    • Naldi, A.1    Thieffry, D.2    Chaouiya, C.3
  • 84
    • 84855872610 scopus 로고    scopus 로고
    • Logical modelling of gene regulatory networks with GINsim
    • 10.1007/978-1-61779-361-5_23, 22144167
    • Chaouiya C, Naldi A, Thieffry D. Logical modelling of gene regulatory networks with GINsim. Methods Mol Biol 2012, 804:463-479. 10.1007/978-1-61779-361-5_23, 22144167.
    • (2012) Methods Mol Biol , vol.804 , pp. 463-479
    • Chaouiya, C.1    Naldi, A.2    Thieffry, D.3
  • 85
    • 77149160061 scopus 로고    scopus 로고
    • Computing combinatorial intervention strategies and failure modes in signaling networks
    • 10.1089/cmb.2009.0121, 20078396
    • Samaga R, Von Kamp A, Klamt S. Computing combinatorial intervention strategies and failure modes in signaling networks. J Comput Biol 2010, 17:39-53. 10.1089/cmb.2009.0121, 20078396.
    • (2010) J Comput Biol , vol.17 , pp. 39-53
    • Samaga, R.1    Von Kamp, A.2    Klamt, S.3
  • 86
    • 70450186871 scopus 로고    scopus 로고
    • A tutorial on analysis and simulation of boolean gene regulatory network models
    • 10.2174/138920209789208237, 2808677, 20436877
    • Xiao Y. A tutorial on analysis and simulation of boolean gene regulatory network models. Curr Genomics 2009, 10:511-525. 10.2174/138920209789208237, 2808677, 20436877.
    • (2009) Curr Genomics , vol.10 , pp. 511-525
    • Xiao, Y.1
  • 88
    • 33747874092 scopus 로고    scopus 로고
    • Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle
    • Fauré A, Naldi A, Chaouiya C, Thieffry D. Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle. Bioinformatics 2006, 14:e124-e131.
    • (2006) Bioinformatics , vol.14
    • Fauré, A.1    Naldi, A.2    Chaouiya, C.3    Thieffry, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.