메뉴 건너뛰기




Volumn 44, Issue 6, 2016, Pages 2769-2781

Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining

Author keywords

[No Author keywords available]

Indexed keywords

MRE11 PROTEIN; RAD50 PROTEIN; UNCLASSIFIED DRUG; XRS2 PROTEIN; DEOXYRIBONUCLEASE; DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE BETA; EXODEOXYRIBONUCLEASE; FUNGAL DNA; HIGH AFFINITY DNA-BINDING FACTOR, S CEREVISIAE; MRE11 PROTEIN, S CEREVISIAE; PHOSPHODIESTERASE; POL4 PROTEIN, S CEREVISIAE; RAD50 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; TDP1 PROTEIN, S CEREVISIAE; XRS2 PROTEIN, S CEREVISIAE;

EID: 84963983765     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkw013     Document Type: Article
Times cited : (23)

References (65)
  • 2
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna, K.K. and Jackson, S.P. (2001) DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet., 27, 247-254.
    • (2001) Nat. Genet. , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 3
    • 84905493192 scopus 로고    scopus 로고
    • End resection at double-strand breaks: Mechanism and regulation
    • Symington, L.S. (2014) End resection at double-strand breaks: mechanism and regulation. Cold Spring Harb. Perspect. Biol., 6, a016436.
    • (2014) Cold Spring Harb. Perspect. Biol. , vol.6 , pp. a016436
    • Symington, L.S.1
  • 5
    • 84899825410 scopus 로고    scopus 로고
    • Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates
    • Ghodke, H., Wang, H., Hsieh, C.L., Woldemeskel, S., Watkins, S.C., Rapic-Otrin, V. and Van Houten, B. (2014) Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates. Proc. Natl. Acad. Sci. U.S.A., 111, E1862-E1871.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. E1862-E1871
    • Ghodke, H.1    Wang, H.2    Hsieh, C.L.3    Woldemeskel, S.4    Watkins, S.C.5    Rapic-Otrin, V.6    Van Houten, B.7
  • 6
    • 0035968210 scopus 로고    scopus 로고
    • Accurate in vitro end joining of a DNA double strand break with partially cohesive 3′-overhangs and 3′-phosphoglycolate termini: Effect of Ku on repair fidelity
    • Chen, S., Inamdar, K.V., Pfeiffer, P., Feldmann, E., Hannah, M.F., Yu, Y., Lee, J.W., Zhou, T., Lees-Miller, S.P. and Povirk, L.F. (2001) Accurate in vitro end joining of a DNA double strand break with partially cohesive 3′-overhangs and 3′-phosphoglycolate termini: effect of Ku on repair fidelity. J. Biol. Chem., 276, 24323-24330.
    • (2001) J. Biol. Chem. , vol.276 , pp. 24323-24330
    • Chen, S.1    Inamdar, K.V.2    Pfeiffer, P.3    Feldmann, E.4    Hannah, M.F.5    Yu, Y.6    Lee, J.W.7    Zhou, T.8    Lees-Miller, S.P.9    Povirk, L.F.10
  • 8
    • 15444370124 scopus 로고    scopus 로고
    • Processing of DNA for nonhomologous end-joining by cell-free extract
    • Budman, J. and Chu, G. (2005) Processing of DNA for nonhomologous end-joining by cell-free extract. EMBO J., 24, 849-860.
    • (2005) EMBO J. , vol.24 , pp. 849-860
    • Budman, J.1    Chu, G.2
  • 10
    • 23844464546 scopus 로고    scopus 로고
    • DNA joint dependence of pol X family polymerase action in nonhomologous end joining
    • Daley, J.M., Laan, R.L., Suresh, A. and Wilson, T.E. (2005) DNA joint dependence of pol X family polymerase action in nonhomologous end joining. J. Biol. Chem., 280, 29030-29037.
    • (2005) J. Biol. Chem. , vol.280 , pp. 29030-29037
    • Daley, J.M.1    Laan, R.L.2    Suresh, A.3    Wilson, T.E.4
  • 11
    • 36549075614 scopus 로고    scopus 로고
    • Evidence that base stacking potential in annealed 3′ overhangs determines polymerase utilization in yeast nonhomologous end joining
    • Daley, J.M. and Wilson, T.E. (2008) Evidence that base stacking potential in annealed 3′ overhangs determines polymerase utilization in yeast nonhomologous end joining. DNA Repair (Amst), 7, 67-76.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 67-76
    • Daley, J.M.1    Wilson, T.E.2
  • 14
    • 84879264708 scopus 로고    scopus 로고
    • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
    • Gaj, T., Gersbach, C.A. and Barbas, C.F. 3rd (2013) ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol., 31, 397-405.
    • (2013) Trends Biotechnol. , vol.31 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Barbas, C.F.3
  • 15
    • 0032579440 scopus 로고    scopus 로고
    • Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
    • Brachmann, C.B., Davies, A., Cost, G.J., Caputo, E., Li, J., Hieter, P. and Boeke, J.D. (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast, 14, 115-132.
    • (1998) Yeast , vol.14 , pp. 115-132
    • Brachmann, C.B.1    Davies, A.2    Cost, G.J.3    Caputo, E.4    Li, J.5    Hieter, P.6    Boeke, J.D.7
  • 16
    • 0028800213 scopus 로고
    • Mutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a)
    • McCormick, S.P., Ng, J.K., Taylor, S., Flynn, L.M., Hammer, R.E. and Young, S.G. (1995) Mutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a). Proc. Natl. Acad. Sci. U.S.A., 92, 10147-10151.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 10147-10151
    • McCormick, S.P.1    Ng, J.K.2    Taylor, S.3    Flynn, L.M.4    Hammer, R.E.5    Young, S.G.6
  • 17
    • 45149104841 scopus 로고    scopus 로고
    • Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae
    • Wu, D., Topper, L.M. and Wilson, T.E. (2008) Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae. Genetics, 178, 1237-1249.
    • (2008) Genetics , vol.178 , pp. 1237-1249
    • Wu, D.1    Topper, L.M.2    Wilson, T.E.3
  • 18
    • 46949098616 scopus 로고    scopus 로고
    • Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
    • Zierhut, C. and Diffley, J.F. (2008) Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J., 27, 1875-1885.
    • (2008) EMBO J. , vol.27 , pp. 1875-1885
    • Zierhut, C.1    Diffley, J.F.2
  • 19
    • 84878183628 scopus 로고    scopus 로고
    • RPA coordinates DNA end resection and prevents formation of DNA hairpins
    • Chen, H., Lisby, M. and Symington, L.S. (2013) RPA coordinates DNA end resection and prevents formation of DNA hairpins. Mol. Cell, 50, 589-600.
    • (2013) Mol. Cell , vol.50 , pp. 589-600
    • Chen, H.1    Lisby, M.2    Symington, L.S.3
  • 20
    • 28544447826 scopus 로고    scopus 로고
    • Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining
    • Palmbos, P.L., Daley, J.M. and Wilson, T.E. (2005) Mutations of the Yku80 C terminus and Xrs2 FHA domain specifically block yeast nonhomologous end joining. Mol. Cell. Biol., 25, 10782-10790.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10782-10790
    • Palmbos, P.L.1    Daley, J.M.2    Wilson, T.E.3
  • 21
    • 61849109768 scopus 로고    scopus 로고
    • Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain
    • Palmbos, P.L., Wu, D., Daley, J.M. and Wilson, T.E. (2008) Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain. Genetics, 180, 1809-1819.
    • (2008) Genetics , vol.180 , pp. 1809-1819
    • Palmbos, P.L.1    Wu, D.2    Daley, J.M.3    Wilson, T.E.4
  • 22
    • 84877033242 scopus 로고    scopus 로고
    • Nonhomologous end joining-mediated gene replacement in plant cells
    • Weinthal, D.M., Taylor, R.A. and Tzfira, T. (2013) Nonhomologous end joining-mediated gene replacement in plant cells. Plant Physiol., 162, 390-400.
    • (2013) Plant Physiol. , vol.162 , pp. 390-400
    • Weinthal, D.M.1    Taylor, R.A.2    Tzfira, T.3
  • 24
    • 84879650163 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity
    • Chiruvella, K.K., Liang, Z., Birkeland, S.R., Basrur, V. and Wilson, T.E. (2013) Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity. PLoS Genet., 9, e1003599.
    • (2013) PLoS Genet. , vol.9 , pp. e1003599
    • Chiruvella, K.K.1    Liang, Z.2    Birkeland, S.R.3    Basrur, V.4    Wilson, T.E.5
  • 25
    • 28044432797 scopus 로고    scopus 로고
    • Use of a restriction endonuclease cytotoxicity assay to identify inducible GAL1 promoter variants with reduced basal activity
    • Lewis, L.K., Lobachev, K., Westmoreland, J.W., Karthikeyan, G., Williamson, K.M., Jordan, J.J. and Resnick, M.A. (2005) Use of a restriction endonuclease cytotoxicity assay to identify inducible GAL1 promoter variants with reduced basal activity. Gene, 363, 183-192.
    • (2005) Gene , vol.363 , pp. 183-192
    • Lewis, L.K.1    Lobachev, K.2    Westmoreland, J.W.3    Karthikeyan, G.4    Williamson, K.M.5    Jordan, J.J.6    Resnick, M.A.7
  • 28
    • 0034730134 scopus 로고    scopus 로고
    • Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system
    • Kaplun, L., Ivantsiv, Y., Kornitzer, D. and Raveh, D. (2000) Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system. Proc. Natl. Acad. Sci. U.S.A., 97, 10077-10082.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 10077-10082
    • Kaplun, L.1    Ivantsiv, Y.2    Kornitzer, D.3    Raveh, D.4
  • 30
    • 80052492286 scopus 로고    scopus 로고
    • Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation
    • Chen, X., Niu, H., Chung, W.H., Zhu, Z., Papusha, A., Shim, E.Y., Lee, S.E., Sung, P. and Ira, G. (2011) Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation. Nat. Struct. Mol. Biol., 18, 1015-1019.
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 1015-1019
    • Chen, X.1    Niu, H.2    Chung, W.H.3    Zhu, Z.4    Papusha, A.5    Shim, E.Y.6    Lee, S.E.7    Sung, P.8    Ira, G.9
  • 31
    • 0027429846 scopus 로고
    • Single amino acid substitutions uncouple the DNA binding and strand scission activities of Fok i endonuclease
    • Waugh, D.S. and Sauer, R.T. (1993) Single amino acid substitutions uncouple the DNA binding and strand scission activities of Fok I endonuclease. Proc. Natl. Acad. Sci. U.S.A., 90, 9596-9600.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 9596-9600
    • Waugh, D.S.1    Sauer, R.T.2
  • 32
    • 84896703742 scopus 로고    scopus 로고
    • Quantitation of DNA double-strand break resection intermediates in human cells
    • Zhou, Y., Caron, P., Legube, G. and Paull, T.T. (2014) Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res., 42, e19.
    • (2014) Nucleic Acids Res. , vol.42 , pp. e19
    • Zhou, Y.1    Caron, P.2    Legube, G.3    Paull, T.T.4
  • 33
    • 77957786786 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
    • Shim, E.Y., Chung, W.H., Nicolette, M.L., Zhang, Y., Davis, M., Zhu, Z., Paull, T.T., Ira, G. and Lee, S.E. (2010) Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J., 29, 3370-3380.
    • (2010) EMBO J. , vol.29 , pp. 3370-3380
    • Shim, E.Y.1    Chung, W.H.2    Nicolette, M.L.3    Zhang, Y.4    Davis, M.5    Zhu, Z.6    Paull, T.T.7    Ira, G.8    Lee, S.E.9
  • 34
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • Moreau, S., Ferguson, J.R. and Symington, L.S. (1999) The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol., 19, 556-566.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 556-566
    • Moreau, S.1    Ferguson, J.R.2    Symington, L.S.3
  • 36
    • 77749270650 scopus 로고    scopus 로고
    • Yeast Tdp1 regulates the fidelity of nonhomologous end joining
    • Bahmed, K., Nitiss, K.C. and Nitiss, J.L. (2010) Yeast Tdp1 regulates the fidelity of nonhomologous end joining. Proc. Natl. Acad. Sci. U.S.A., 107, 4057-4062.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 4057-4062
    • Bahmed, K.1    Nitiss, K.C.2    Nitiss, J.L.3
  • 38
    • 84903446359 scopus 로고    scopus 로고
    • DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin
    • Ayrapetov, M.K., Gursoy-Yuzugullu, O., Xu, C., Xu, Y. and Price, B.D. (2014) DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proc. Natl. Acad. Sci. U.S.A., 111, 9169-9174.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 9169-9174
    • Ayrapetov, M.K.1    Gursoy-Yuzugullu, O.2    Xu, C.3    Xu, Y.4    Price, B.D.5
  • 39
    • 79952415961 scopus 로고    scopus 로고
    • Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein
    • Hartlerode, A., Odate, S., Shim, I., Brown, J. and Scully, R. (2011) Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein. PLoS One, 6, e16501.
    • (2011) PLoS One , vol.6 , pp. e16501
    • Hartlerode, A.1    Odate, S.2    Shim, I.3    Brown, J.4    Scully, R.5
  • 40
    • 80052403213 scopus 로고    scopus 로고
    • Ligand-switchable substrates for a ubiquitin-proteasome system
    • Egeler, E.L., Urner, L.M., Rakhit, R., Liu, C.W. and Wandless, T.J. (2011) Ligand-switchable substrates for a ubiquitin-proteasome system. J. Biol. Chem., 286, 31328-31336.
    • (2011) J. Biol. Chem. , vol.286 , pp. 31328-31336
    • Egeler, E.L.1    Urner, L.M.2    Rakhit, R.3    Liu, C.W.4    Wandless, T.J.5
  • 41
    • 79951562112 scopus 로고    scopus 로고
    • End-processing during non-homologous end-joining: A role for exonuclease 1
    • Bahmed, K., Seth, A., Nitiss, K.C. and Nitiss, J.L. (2011) End-processing during non-homologous end-joining: a role for exonuclease 1. Nucleic Acids Res., 39, 970-978.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 970-978
    • Bahmed, K.1    Seth, A.2    Nitiss, K.C.3    Nitiss, J.L.4
  • 42
    • 39449129496 scopus 로고    scopus 로고
    • The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends
    • Aniukwu, J., Glickman, M.S. and Shuman, S. (2008) The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes Dev., 22, 512-527.
    • (2008) Genes Dev. , vol.22 , pp. 512-527
    • Aniukwu, J.1    Glickman, M.S.2    Shuman, S.3
  • 43
    • 12844278880 scopus 로고    scopus 로고
    • Rejoining of DNA double-strand breaks as a function of overhang length
    • Daley, J.M. and Wilson, T.E. (2005) Rejoining of DNA double-strand breaks as a function of overhang length. Mol. Cell. Biol., 25, 896-906.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 896-906
    • Daley, J.M.1    Wilson, T.E.2
  • 44
    • 77952582707 scopus 로고    scopus 로고
    • Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae
    • Westmoreland, J.W., Summers, J.A., Holland, C.L., Resnick, M.A. and Lewis, L.K. (2010) Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae. DNA Repair (Amst), 9, 617-626.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 617-626
    • Westmoreland, J.W.1    Summers, J.A.2    Holland, C.L.3    Resnick, M.A.4    Lewis, L.K.5
  • 46
    • 33750041949 scopus 로고    scopus 로고
    • A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis
    • Juarez, R., Ruiz, J.F., Nick McElhinny, S.A., Ramsden, D. and Blanco, L. (2006) A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis. Nucleic Acids Res., 34, 4572-4582.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 4572-4582
    • Juarez, R.1    Ruiz, J.F.2    Nick McElhinny, S.A.3    Ramsden, D.4    Blanco, L.5
  • 48
    • 84982082520 scopus 로고    scopus 로고
    • Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae
    • Galli, A., Chan, C.Y., Parfenova, L., Cervelli, T. and Schiestl, R.H. (2015) Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae. Mutagenesis, 30, 841-849.
    • (2015) Mutagenesis , vol.30 , pp. 841-849
    • Galli, A.1    Chan, C.Y.2    Parfenova, L.3    Cervelli, T.4    Schiestl, R.H.5
  • 49
    • 84950121586 scopus 로고    scopus 로고
    • DNA polymerases delta and lambda cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae
    • Meyer, D., Fu, B.X. and Heyer, W.D. (2015) DNA polymerases delta and lambda cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 112, E6907-E6916.
    • (2015) Proc. Natl. Acad. Sci. U.S.A. , vol.112 , pp. E6907-E6916
    • Meyer, D.1    Fu, B.X.2    Heyer, W.D.3
  • 52
    • 47249150241 scopus 로고    scopus 로고
    • A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining
    • Pawelczak, K.S. and Turchi, J.J. (2008) A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Res., 36, 4022-4031.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 4022-4031
    • Pawelczak, K.S.1    Turchi, J.J.2
  • 53
    • 84929340149 scopus 로고    scopus 로고
    • Recognition of DNA termini by the C-terminal region of the Ku80 and the DNA-dependent protein kinase catalytic subunit
    • Woods, D.S., Sears, C.R. and Turchi, J.J. (2015) Recognition of DNA termini by the C-terminal region of the Ku80 and the DNA-dependent protein kinase catalytic subunit. PLoS One, 10, e0127321.
    • (2015) PLoS One , vol.10 , pp. e0127321
    • Woods, D.S.1    Sears, C.R.2    Turchi, J.J.3
  • 54
    • 0022827675 scopus 로고
    • Mechanism of interaction between Ku protein and DNA
    • Mimori, T. and Hardin, J.A. (1986) Mechanism of interaction between Ku protein and DNA. J. Biol. Chem., 261, 10375-10379.
    • (1986) J. Biol. Chem. , vol.261 , pp. 10375-10379
    • Mimori, T.1    Hardin, J.A.2
  • 55
    • 0024356877 scopus 로고
    • HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex
    • de Vries, E., van Driel, W., Bergsma, W.G., Arnberg, A.C. and van der Vliet, P.C. (1989) HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J. Mol. Biol., 208, 65-78.
    • (1989) J. Mol. Biol. , vol.208 , pp. 65-78
    • De Vries, E.1    Van Driel, W.2    Bergsma, W.G.3    Arnberg, A.C.4    Van Der Vliet, P.C.5
  • 57
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
    • Paull, T.T. and Gellert, M. (1998) The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell, 1, 969-979.
    • (1998) Mol. Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 58
    • 0037109113 scopus 로고    scopus 로고
    • DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP
    • de Jager, M., Wyman, C., van Gent, D.C. and Kanaar, R. (2002) DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. Nucleic Acids Res., 30, 4425-4431.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 4425-4431
    • De Jager, M.1    Wyman, C.2    Van Gent, D.C.3    Kanaar, R.4
  • 59
    • 84876528858 scopus 로고    scopus 로고
    • Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins
    • Ghodke, I. and Muniyappa, K. (2013) Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins. J. Biol. Chem., 288, 11273-11286.
    • (2013) J. Biol. Chem. , vol.288 , pp. 11273-11286
    • Ghodke, I.1    Muniyappa, K.2
  • 60
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull, T.T. and Gellert, M. (1999) Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev., 13, 1276-1288.
    • (1999) Genes Dev. , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 61
    • 84876896603 scopus 로고    scopus 로고
    • Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection
    • Cannavo, E., Cejka, P. and Kowalczykowski, S.C. (2013) Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection. Proc. Natl. Acad. Sci. U.S.A., 110, E1661-E1668.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. E1661-E1668
    • Cannavo, E.1    Cejka, P.2    Kowalczykowski, S.C.3
  • 63
    • 0033621353 scopus 로고    scopus 로고
    • The RAD2 domain of human exonuclease 1 exhibits 5′ to 3′ exonuclease and flap structure-specific endonuclease activities
    • Lee, B.I. and Wilson, D.M. 3rd (1999) The RAD2 domain of human exonuclease 1 exhibits 5′ to 3′ exonuclease and flap structure-specific endonuclease activities. J. Biol. Chem., 274, 37763-37769.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37763-37769
    • Lee, B.I.1    Wilson, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.