Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 15, 2015, Pages E1880-E1887

  Chen, Huan ^a,b   Donnianni, Roberto A ^a   Handa, Naofumi ^c   Deng, Sarah K ^a   Oh, Julyun ^a,b   Timashev, Leonid A ^a   Kowalczykowski, Stephen C ^c   Symington, Lorraine S ^a  

^a NewYork Presbyterian Hospital   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA damage checkpoint; DNA repair; Mre11; Sae2

Indexed keywords

CHECKPOINT KINASE 2; DOUBLE STRANDED DNA; FUNGAL DNA; FUNGAL PROTEIN; MRE11 PROTEIN; RAD50 PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; XRS2 PROTEIN; CELL CYCLE PROTEIN; DEOXYRIBONUCLEASE; DNA BINDING PROTEIN; ENDONUCLEASE; EXODEOXYRIBONUCLEASE; MRE11 PROTEIN, S CEREVISIAE; MULTIPROTEIN COMPLEX; PROTEIN BINDING; RAD50 PROTEIN, S CEREVISIAE; RAD53 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SAE2 PROTEIN, S CEREVISIAE; XRS2 PROTEIN, S CEREVISIAE;

ALLELE; ALU SEQUENCE; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA END JOINING REPAIR; DNA REPLICATION; FLUORESCENCE MICROSCOPY; GENE DOSAGE; HAPLOIDY; IN VITRO STUDY; INVERTED REPEAT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BLOTTING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SOUTHERN BLOTTING; TURNOVER TIME; WESTERN BLOTTING; CELL CYCLE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENETICS; METABOLISM; MUTATION;

SACCHAROMYCES CEREVISIAE;

CELL CYCLE; CELL CYCLE PROTEINS; CHECKPOINT KINASE 2; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; DNA, FUNGAL; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; ENDONUCLEASES; EXODEOXYRIBONUCLEASES; MICROSCOPY, FLUORESCENCE; MULTIPROTEIN COMPLEXES; MUTATION; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

EID: 84927946339     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1503331112     Document Type: Article

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