-
1
-
-
84872083977
-
Control of adult stem cells in vivo by a dynamic physiological environment: Diet-dependent systemic factors in drosophila and beyond
-
Ables, E.T., Laws, K.M., and Drummond-Barbosa, D. (2012) Control of adult stem cells in vivo by a dynamic physiological environment: diet-dependent systemic factors in Drosophila and beyond. Wiley Interdiscip. Rev. Dev. Biol. 1, 657-674
-
(2012)
Wiley Interdiscip. Rev. Dev. Biol.
, vol.1
, pp. 657-674
-
-
Ables, E.T.1
Laws, K.M.2
Drummond-Barbosa, D.3
-
2
-
-
80155123827
-
Altered modes of stemcell division drive adaptive intestinal growth
-
O'Brien, L. E., Soliman, S. S., Li, X., and Bilder, D. (2011) Altered modes of stemcell division drive adaptive intestinal growth. Cell 147, 603-614
-
(2011)
Cell
, vol.147
, pp. 603-614
-
-
O'Brien, L.E.1
Soliman, S.S.2
Li, X.3
Bilder, D.4
-
3
-
-
84916941587
-
Nutrient-induced intestinal adaption and its effect in obesity
-
Dailey, M. J. (2014) Nutrient-induced intestinal adaption and its effect in obesity. Physiol. Behav. 136, 74-78
-
(2014)
Physiol. Behav.
, vol.136
, pp. 74-78
-
-
Dailey, M.J.1
-
4
-
-
84904707313
-
Stem cells marked by the R-spondin receptor LGR5
-
Koo, B. K., and Clevers, H. (2014) Stem cells marked by the R-spondin receptor LGR5. Gastroenterology 147, 289-302
-
(2014)
Gastroenterology
, vol.147
, pp. 289-302
-
-
Koo, B.K.1
Clevers, H.2
-
5
-
-
84893768750
-
Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration
-
Metcalfe, C., Kljavin, N. M., Ybarra, R., and de Sauvage, F. J. (2014) Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell 14, 149-159
-
(2014)
Cell Stem Cell
, vol.14
, pp. 149-159
-
-
Metcalfe, C.1
Kljavin, N.M.2
Ybarra, R.3
De Sauvage, F.J.4
-
6
-
-
0031728841
-
The role of enterocytes in gut dysfunction
-
Kong, S. E., Heel, K., McCauley, R., and Hall, J. (1998) The role of enterocytes in gut dysfunction. Pathol. Res. Pract. 194, 741-751
-
(1998)
Pathol. Res. Pract.
, vol.194
, pp. 741-751
-
-
Kong, S.E.1
Heel, K.2
McCauley, R.3
Hall, J.4
-
7
-
-
84888857589
-
-
5th Edition, Wiley-Blackwell, West Sussex, UK
-
Shepherd, N., Warren, B., Williams, G., Greenson, J., Lauwers, G., and Novelli, M. (2013) Morson and Dawson's Gastrointestinal Pathology, 5th Edition, Wiley-Blackwell, West Sussex, UK
-
(2013)
Morson and Dawson's Gastrointestinal Pathology
-
-
Shepherd, N.1
Warren, B.2
Williams, G.3
Greenson, J.4
Lauwers, G.5
Novelli, M.6
-
8
-
-
0142059930
-
Accelerated fat absorption in intestinal alkaline phosphatase knockout mice
-
Narisawa, S., Huang, L., Iwasaki, A., Hasegawa, H., Alpers, D.H., and Millán, J. L. (2003) Accelerated fat absorption in intestinal alkaline phosphatase knockout mice. Mol. Cell. Biol. 23, 7525-7530
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7525-7530
-
-
Narisawa, S.1
Huang, L.2
Iwasaki, A.3
Hasegawa, H.4
Alpers, D.H.5
Millán, J.L.6
-
9
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante, M., and Sabatini, D.M. (2012) mTOR signaling in growth control and disease. Cell 149, 274-293
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
10
-
-
74049088121
-
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
-
Risson, V., Mazelin, L., Roceri, M., Sanchez, H., Moncollin, V., Corneloup, C., Richard-Bulteau, H., Vignaud, A., Baas, D., Defour, A., Freyssenet, D., Tanti, J. F., Le-Marchand-Brustel, Y., Ferrier, B., Conjard-Duplany, A., Romanino, K., Bauché, S., Hantaï, D., Mueller, M., Kozma, S. C., Thomas, G., Rüegg, M. A., Ferry, A., Pende, M., Bigard, X., Koulmann, N., Schaeffer, L., and Gangloff, Y. G. (2009) Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. J. Cell Biol. 187, 859-874
-
(2009)
J. Cell Biol.
, vol.187
, pp. 859-874
-
-
Risson, V.1
Mazelin, L.2
Roceri, M.3
Sanchez, H.4
Moncollin, V.5
Corneloup, C.6
Richard-Bulteau, H.7
Vignaud, A.8
Baas, D.9
Defour, A.10
Freyssenet, D.11
Tanti, J.F.12
Le-Marchand-Brustel, Y.13
Ferrier, B.14
Conjard-Duplany, A.15
Romanino, K.16
Bauché, S.17
Hantaï, D.18
Mueller, M.19
Kozma, S.C.20
Thomas, G.21
Rüegg, M.A.22
Ferry, A.23
Pende, M.24
Bigard, X.25
Koulmann, N.26
Schaeffer, L.27
Gangloff, Y.G.28
more..
-
11
-
-
77953299671
-
Specific roles of target of rapamycin in the control of stem cells and their progeny in the drosophila ovary
-
LaFever, L., Feoktistov, A., Hsu, H. J., and Drummond-Barbosa, D. (2010) Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development 137, 2117-2126
-
(2010)
Development
, vol.137
, pp. 2117-2126
-
-
LaFever, L.1
Feoktistov, A.2
Hsu, H.J.3
Drummond-Barbosa, D.4
-
12
-
-
54849426651
-
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
-
Bentzinger, C. F., Romanino, K., Cloëtta, D., Lin, S., Mascarenhas, J.B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., Zorzato, F., Hall, M. N., and Rüegg, M. A. (2008) Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 8, 411-424
-
(2008)
Cell Metab.
, vol.8
, pp. 411-424
-
-
Bentzinger, C.F.1
Romanino, K.2
Cloëtta, D.3
Lin, S.4
Mascarenhas, J.B.5
Oliveri, F.6
Xia, J.7
Casanova, E.8
Costa, C.F.9
Brink, M.10
Zorzato, F.11
Hall, M.N.12
Rüegg, M.A.13
-
13
-
-
84883639503
-
Mouse gene targeting reveals an essential role of mTOR in hematopoietic stemcell engraftment and hematopoiesis
-
Guo, F., Zhang, S., Grogg, M., Cancelas, J. A., Varney, M. E., Starczynowski, D.T., Du, W., Yang, J.Q., Liu, W., Thomas, G., Kozma, S., Pang, Q., and Zheng, Y. (2013) Mouse gene targeting reveals an essential role of mTOR in hematopoietic stemcell engraftment and hematopoiesis. Haematologica 98, 1353-1358
-
(2013)
Haematologica
, vol.98
, pp. 1353-1358
-
-
Guo, F.1
Zhang, S.2
Grogg, M.3
Cancelas, J.A.4
Varney, M.E.5
Starczynowski, D.T.6
Du, W.7
Yang, J.Q.8
Liu, W.9
Thomas, G.10
Kozma, S.11
Pang, Q.12
Zheng, Y.13
-
14
-
-
84866082606
-
MTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis
-
Kalaitzidis, D., Sykes, S. M., Wang, Z., Punt, N., Tang, Y., Ragu, C., Sinha, A. U., Lane, S. W., Souza, A. L., Clish, C. B., Anastasiou, D., Gilliland, D. G., Scadden, D. T., Guertin, D. A., and Armstrong, S. A. (2012) mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell 11, 429-439
-
(2012)
Cell Stem Cell
, vol.11
, pp. 429-439
-
-
Kalaitzidis, D.1
Sykes, S.M.2
Wang, Z.3
Punt, N.4
Tang, Y.5
Ragu, C.6
Sinha, A.U.7
Lane, S.W.8
Souza, A.L.9
Clish, C.B.10
Anastasiou, D.11
Gilliland, D.G.12
Scadden, D.T.13
Guertin, D.A.14
Armstrong, S.A.15
-
15
-
-
79960761944
-
An emerging role for TOR signaling in mammalian tissue and stem cell physiology
-
Russell, R. C., Fang, C., and Guan, K. L. (2011) An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development 138, 3343-3356
-
(2011)
Development
, vol.138
, pp. 3343-3356
-
-
Russell, R.C.1
Fang, C.2
Guan, K.L.3
-
16
-
-
84862994618
-
MTORC1 in the paneth cell niche couples intestinal stem-cell function to calorie intake
-
Yilmaz, O. H., Katajisto, P., Lamming, D. W., Gültekin, Y., Bauer-Rowe, K. E., Sengupta, S., Birsoy, K., Dursun, A., Yilmaz, V. O., Selig, M., Nielsen, G. P., Mino-Kenudson, M., Zukerberg, L. R., Bhan, A. K., Deshpande, V., and Sabatini, D.M. (2012) mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature 486, 490-495
-
(2012)
Nature
, vol.486
, pp. 490-495
-
-
Yilmaz, O.H.1
Katajisto, P.2
Lamming, D.W.3
Gültekin, Y.4
Bauer-Rowe, K.E.5
Sengupta, S.6
Birsoy, K.7
Dursun, A.8
Yilmaz, V.O.9
Selig, M.10
Nielsen, G.P.11
Mino-Kenudson, M.12
Zukerberg, L.R.13
Bhan, A.K.14
Deshpande, V.15
Sabatini, D.M.16
-
17
-
-
84893863060
-
MTOR pathway in colorectal cancer: An update
-
Francipane, M. G., and Lagasse, E. (2014) mTOR pathway in colorectal cancer: an update. Oncotarget 5, 49-66
-
(2014)
Oncotarget
, vol.5
, pp. 49-66
-
-
Francipane, M.G.1
Lagasse, E.2
-
18
-
-
6344245674
-
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
-
Gangloff, Y. G., Mueller, M., Dann, S. G., Svoboda, P., Sticker, M., Spetz, J. F., Um, S. H., Brown, E. J., Cereghini, S., Thomas, G., and Kozma, S. C. (2004) Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol. Cell. Biol. 24, 9508-9516
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9508-9516
-
-
Gangloff, Y.G.1
Mueller, M.2
Dann, S.G.3
Svoboda, P.4
Sticker, M.5
Spetz, J.F.6
Um, S.H.7
Brown, E.J.8
Cereghini, S.9
Thomas, G.10
Kozma, S.C.11
-
19
-
-
78650848337
-
MTORC1 controls fasting-induced ketogenesis and its modulation by ageing
-
Sengupta, S., Peterson, T.R., Laplante, M., Oh, S., and Sabatini, D.M. (2010) mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468, 1100-1104
-
(2010)
Nature
, vol.468
, pp. 1100-1104
-
-
Sengupta, S.1
Peterson, T.R.2
Laplante, M.3
Oh, S.4
Sabatini, D.M.5
-
20
-
-
33748950810
-
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
-
Shiota, C., Woo, J. T., Lindner, J., Shelton, K. D., and Magnuson, M. A. (2006) Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11, 583-589
-
(2006)
Dev. Cell
, vol.11
, pp. 583-589
-
-
Shiota, C.1
Woo, J.T.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
21
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene lgr5
-
Barker, N., van Es, J.H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., and Clevers, H. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
Van Es, J.H.2
Kuipers, J.3
Kujala, P.4
Van Den-Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
22
-
-
4043059169
-
Tissue-specific and inducible cre-mediated recombination in the gut epithelium
-
ElMarjou, F., Janssen, K. P., Chang, B. H., Li, M., Hindie, V., Chan, L., Louvard, D., Chambon, P., Metzger, D., and Robine, S. (2004) Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39, 186-193
-
(2004)
Genesis
, vol.39
, pp. 186-193
-
-
ElMarjou, F.1
Janssen, K.P.2
Chang, B.H.3
Li, M.4
Hindie, V.5
Chan, L.6
Louvard, D.7
Chambon, P.8
Metzger, D.9
Robine, S.10
-
23
-
-
84868208004
-
Intestinal crypts reproducibly expand in culture
-
Fuller, M. K., Faulk, D. M., Sundaram, N., Shroyer, N. F., Henning, S. J., and Helmrath, M. A. (2012) Intestinal crypts reproducibly expand in culture. J. Surg. Res. 178, 48-54
-
(2012)
J. Surg. Res.
, vol.178
, pp. 48-54
-
-
Fuller, M.K.1
Faulk, D.M.2
Sundaram, N.3
Shroyer, N.F.4
Henning, S.J.5
Helmrath, M.A.6
-
24
-
-
75949124381
-
In situ hybridization to identify gut stem cells
-
Chapter 2, Unit 2F 1
-
Gregorieff, A., and Clevers, H. (2010) In situ hybridization to identify gut stem cells. Curr. Protoc. Stem Cell Biol. Chapter 2, Unit 2F 1 doi: 10.1002/9780470151808.sc02f01s12
-
(2010)
Curr. Protoc. Stem Cell Biol.
-
-
Gregorieff, A.1
Clevers, H.2
-
25
-
-
0030863618
-
Examining the role of paneth cells in the small intestine by lineage ablation in transgenic mice
-
Garabedian, E. M., Roberts, L. J., McNevin, M. S., and Gordon, J. I. (1997) Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J. Biol. Chem. 272, 23729-23740
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 23729-23740
-
-
Garabedian, E.M.1
Roberts, L.J.2
McNevin, M.S.3
Gordon, J.I.4
-
26
-
-
26944474424
-
Gfi1 functions downstream of math1 to control intestinal secretory cell subtype allocation and differentiation
-
Shroyer, N. F., Wallis, D., Venken, K. J., Bellen, H. J., and Zoghbi, H. Y. (2005) Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 19, 2412-2417
-
(2005)
Genes Dev.
, vol.19
, pp. 2412-2417
-
-
Shroyer, N.F.1
Wallis, D.2
Venken, K.J.3
Bellen, H.J.4
Zoghbi, H.Y.5
-
27
-
-
80455176842
-
Intestinal development and differentiation
-
Noah, T. K., Donahue, B., and Shroyer, N. F. (2011) Intestinal development and differentiation. Exp. Cell Res. 317, 2702-2710
-
(2011)
Exp. Cell Res.
, vol.317
, pp. 2702-2710
-
-
Noah, T.K.1
Donahue, B.2
Shroyer, N.F.3
-
28
-
-
34547549553
-
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium
-
Mori-Akiyama, Y., van den Born, M., van Es, J. H., Hamilton, S. R., Adams, H. P., Zhang, J., Clevers, H., and de Crombrugghe, B. (2007) SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology 133, 539-546
-
(2007)
Gastroenterology
, vol.133
, pp. 539-546
-
-
Mori-Akiyama, Y.1
Van Den-Born, M.2
Van Es, J.H.3
Hamilton, S.R.4
Adams, H.P.5
Zhang, J.6
Clevers, H.7
De Crombrugghe, B.8
-
29
-
-
34249679614
-
MTOR complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
-
Dann, S. G., Selvaraj, A., and Thomas, G. (2007) mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol. Med. 13, 252-259
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 252-259
-
-
Dann, S.G.1
Selvaraj, A.2
Thomas, G.3
-
30
-
-
30544453564
-
Protein kinase B/Akt at a glance
-
Fayard, E., Tintignac, L. A., Baudry, A., and Hemmings, B. A. (2005) Protein kinase B/Akt at a glance. J. Cell Sci. 118, 5675-5678
-
(2005)
J. Cell Sci.
, vol.118
, pp. 5675-5678
-
-
Fayard, E.1
Tintignac, L.A.2
Baudry, A.3
Hemmings, B.A.4
-
31
-
-
78751644734
-
Paneth cells constitute the niche for lgr5 stem cells in intestinal crypts
-
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., and Clevers, H. (2011) Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469, 415-418
-
(2011)
Nature
, vol.469
, pp. 415-418
-
-
Sato, T.1
Van Es, J.H.2
Snippert, H.J.3
Stange, D.E.4
Vries, R.G.5
Van Den-Born, M.6
Barker, N.7
Shroyer, N.F.8
Van De-Wetering, M.9
Clevers, H.10
-
32
-
-
84869864069
-
Redundant sources of wnt regulate intestinal stem cells and promote formation of paneth cells
-
e7
-
Farin, H. F., Van Es, J.H., and Clevers, H. (2012) Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology 143, 1518-1529.e7
-
(2012)
Gastroenterology
, vol.143
, pp. 1518-1529
-
-
Farin, H.F.1
Van Es, J.H.2
Clevers, H.3
-
33
-
-
84868109646
-
Crypt base columnar stem cells in small intestines of mice are radioresistant
-
Hua, G., Thin, T. H., Feldman, R., Haimovitz-Friedman, A., Clevers, H., Fuks, Z., and Kolesnick, R. (2012) Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology143,1266-1276
-
(2012)
Gastroenterology
, vol.143
, pp. 1266-1276
-
-
Hua, G.1
Thin, T.H.2
Feldman, R.3
Haimovitz-Friedman, A.4
Clevers, H.5
Fuks, Z.6
Kolesnick, R.7
-
34
-
-
84862946094
-
The intestinal stem cell markers bmi1 and lgr5 identify two functionally distinct populations
-
Yan, K. S., Chia, L.A., Li, X., Ootani, A., Su, J., Lee, J.Y., Su, N., Luo, Y., Heilshorn, S. C., Amieva, M. R., Sangiorgi, E., Capecchi, M. R., and Kuo, C. J. (2012) The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc. Natl. Acad. Sci. USA 109, 466-471
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 466-471
-
-
Yan, K.S.1
Chia, L.A.2
Li, X.3
Ootani, A.4
Su, J.5
Lee, J.Y.6
Su, N.7
Luo, Y.8
Heilshorn, S.C.9
Amieva, M.R.10
Sangiorgi, E.11
Capecchi, M.R.12
Kuo, C.J.13
-
35
-
-
84862617605
-
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
-
Hoffmeyer, K., Raggioli, A., Rudloff, S., Anton, R., Hierholzer, A., Del Valle, I., Hein, K., Vogt, R., and Kemler, R. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336, 1549-1554
-
(2012)
Science
, vol.336
, pp. 1549-1554
-
-
Hoffmeyer, K.1
Raggioli, A.2
Rudloff, S.3
Anton, R.4
Hierholzer, A.5
Del Valle, I.6
Hein, K.7
Vogt, R.8
Kemler, R.9
-
36
-
-
84924910660
-
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts
-
Schuijers, J., Junker, J. P., Mokry, M., Hatzis, P., Koo, B. K., Sasselli, V., van der Flier, L. G., Cuppen, E., van Oudenaarden, A., and Clevers, H. (2015) Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell Stem Cell 16, 158-170
-
(2015)
Cell Stem Cell
, vol.16
, pp. 158-170
-
-
Schuijers, J.1
Junker, J.P.2
Mokry, M.3
Hatzis, P.4
Koo, B.K.5
Sasselli, V.6
Van Der-Flier, L.G.7
Cuppen, E.8
Van Oudenaarden, A.9
Clevers, H.10
-
37
-
-
84859233333
-
SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians
-
González-Estévez, C., Felix, D. A., Smith, M. D., Paps, J., Morley, S. J., James, V., Sharp, T. V., and Aboobaker, A. A. (2012) SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. PLoS Genet. 8, e1002619
-
(2012)
PLoS Genet.
, vol.8
, pp. e1002619
-
-
González-Estévez, C.1
Felix, D.A.2
Smith, M.D.3
Paps, J.4
Morley, S.J.5
James, V.6
Sharp, T.V.7
Aboobaker, A.A.8
-
38
-
-
77955587900
-
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of wnt/c-myc signaling
-
Ashton, G.H., Morton, J. P., Myant, K., Phesse, T. J., Ridgway, R. A., Marsh, V., Wilkins, J.A., Athineos, D., Muncan, V., Kemp, R., Neufeld, K., Clevers, H., Brunton, V., Winton, D. J., Wang, X., Sears, R. C., Clarke, A. R., Frame, M. C., and Sansom, O. J. (2010) Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev. Cell 19, 259-269
-
(2010)
Dev. Cell
, vol.19
, pp. 259-269
-
-
Ashton, G.H.1
Morton, J.P.2
Myant, K.3
Phesse, T.J.4
Ridgway, R.A.5
Marsh, V.6
Wilkins, J.A.7
Athineos, D.8
Muncan, V.9
Kemp, R.10
Neufeld, K.11
Clevers, H.12
Brunton, V.13
Winton, D.J.14
Wang, X.15
Sears, R.C.16
Clarke, A.R.17
Frame, M.C.18
Sansom, O.J.19
-
39
-
-
84925491509
-
MTORC1-mediated translational elongation limits intestinal tumour initiation and growth
-
Faller, W. J., Jackson, T. J., Knight, J. R., Ridgway, R. A., Jamieson, T., Karim, S. A., Jones, C., Radulescu, S., Huels, D. J., Myant, K. B., Dudek, K. M., Casey, H. A., Scopelliti, A., Cordero, J. B., Vidal, M., Pende, M., Ryazanov, A. G., Sonenberg, N., Meyuhas, O., Hall, M. N., Bushell, M., Willis, A. E., and Sansom, O. J. (2015) mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature 517, 497-500
-
(2015)
Nature
, vol.517
, pp. 497-500
-
-
Faller, W.J.1
Jackson, T.J.2
Knight, J.R.3
Ridgway, R.A.4
Jamieson, T.5
Karim, S.A.6
Jones, C.7
Radulescu, S.8
Huels, D.J.9
Myant, K.B.10
Dudek, K.M.11
Casey, H.A.12
Scopelliti, A.13
Cordero, J.B.14
Vidal, M.15
Pende, M.16
Ryazanov, A.G.17
Sonenberg, N.18
Meyuhas, O.19
Hall, M.N.20
Bushell, M.21
Willis, A.E.22
Sansom, O.J.23
more..
-
40
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser, A., Lee, A.H., Franke, A., Glickman, J. N., Zeissig, S., Tilg, H., Nieuwenhuis, E.E., Higgins, D.E., Schreiber, S., Glimcher, L.H., and Blumberg, R. S. (2008) XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743-756
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.H.2
Franke, A.3
Glickman, J.N.4
Zeissig, S.5
Tilg, H.6
Nieuwenhuis, E.E.7
Higgins, D.E.8
Schreiber, S.9
Glimcher, L.H.10
Blumberg, R.S.11
-
41
-
-
84860468095
-
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
-
Appenzeller-Herzog, C., and Hall, M. N. (2012) Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol. 22, 274-282
-
(2012)
Trends Cell Biol.
, vol.22
, pp. 274-282
-
-
Appenzeller-Herzog, C.1
Hall, M.N.2
-
42
-
-
84878760040
-
Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications
-
Sato, T., and Clevers, H. (2013) Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340, 1190-1194
-
(2013)
Science
, vol.340
, pp. 1190-1194
-
-
Sato, T.1
Clevers, H.2
-
43
-
-
84861871905
-
Functional intestinal stemcells after paneth cell ablation induced by the loss of transcription factor math1 (Atoh1)
-
Durand, A., Donahue, B., Peignon, G., Letourneur, F., Cagnard, N., Slomianny, C., Perret, C., Shroyer, N. F., and Romagnolo, B. (2012) Functional intestinal stemcells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1). Proc. Natl. Acad. Sci. USA 109, 8965-8970
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 8965-8970
-
-
Durand, A.1
Donahue, B.2
Peignon, G.3
Letourneur, F.4
Cagnard, N.5
Slomianny, C.6
Perret, C.7
Shroyer, N.F.8
Romagnolo, B.9
-
44
-
-
84862262750
-
Diet: Friend or foe of enteroendocrine cells-how it interacts with enteroendocrine cells
-
Moran-Ramos, S., Tovar, A. R., and Torres, N. (2012) Diet: friend or foe of enteroendocrine cells-how it interacts with enteroendocrine cells. Adv. Nutr. 3, 8-20
-
(2012)
Adv. Nutr.
, vol.3
, pp. 8-20
-
-
Moran-Ramos, S.1
Tovar, A.R.2
Torres, N.3
-
45
-
-
84896719438
-
The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC davis type 2 diabetes mellitus rat
-
Hansen, C. F., Vassiliadis, E., Vrang, N., Sangild, P. T., Cummings, B. P., Havel, P., and Jelsing, J. (2014) The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat. Regul. Pept. 189, 31-39
-
(2014)
Regul. Pept.
, vol.189
, pp. 31-39
-
-
Hansen, C.F.1
Vassiliadis, E.2
Vrang, N.3
Sangild, P.T.4
Cummings, B.P.5
Havel, P.6
Jelsing, J.7
-
46
-
-
84856511715
-
L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway
-
Rachdi, L., Aïello, V., Duvillié, B., and Scharfmann, R. (2012) L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes 61, 409-417
-
(2012)
Diabetes
, vol.61
, pp. 409-417
-
-
Rachdi, L.1
Aïello, V.2
Duvillié, B.3
Scharfmann, R.4
-
47
-
-
2542446343
-
Minireview: Development and differentiation of gut endocrine cells
-
Schonhoff, S. E., Giel-Moloney, M., and Leiter, A. B. (2004) Minireview: development and differentiation of gut endocrine cells. Endocrinology 145, 2639-2644
-
(2004)
Endocrinology
, vol.145
, pp. 2639-2644
-
-
Schonhoff, S.E.1
Giel-Moloney, M.2
Leiter, A.B.3
-
48
-
-
84888199705
-
Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery
-
Holst, J. J. (2013) Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery. Curr. Opin. Pharmacol. 13, 983-988
-
(2013)
Curr. Opin. Pharmacol.
, vol.13
, pp. 983-988
-
-
Holst, J.J.1
-
49
-
-
84855419201
-
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
-
Van Dussen, K. L., Carulli, A. J., Keeley, T. M., Patel, S. R., Puthoff, B. J., Magness, S. T., Tran, I.T., Maillard, I., Siebel, C., Kolterud, Å., Grosse, A. S., Gumucio, D. L., Ernst, S. A., Tsai, Y. H., Dempsey, P. J., and Samuelson, L. C. (2012) Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development 139, 488-497
-
(2012)
Development
, vol.139
, pp. 488-497
-
-
Van Dussen, K.L.1
Carulli, A.J.2
Keeley, T.M.3
Patel, S.R.4
Puthoff, B.J.5
Magness, S.T.6
Tran, I.T.7
Maillard, I.8
Siebel, C.9
Kolterud, Å.10
Grosse, A.S.11
Gumucio, D.L.12
Ernst, S.A.13
Tsai, Y.H.14
Dempsey, P.J.15
Samuelson, L.C.16
-
50
-
-
80051926611
-
Lgr5 homologues associate with wnt receptors and mediate R-spondin signalling
-
DeLau, W., Barker, N., Low, T. Y., Koo, B. K., Li, V. S., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P. J., van de Wetering, M., Stange, D. E., van Es, J. E., Guardavaccaro, D., Schasfoort, R. B., Mohri, Y., Nishimori, K., Mohammed, S., Heck, A. J., and Clevers, H. (2011) Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476, 293-297
-
(2011)
Nature
, vol.476
, pp. 293-297
-
-
DeLau, W.1
Barker, N.2
Low, T.Y.3
Koo, B.K.4
Li, V.S.5
Teunissen, H.6
Kujala, P.7
Haegebarth, A.8
Peters, P.J.9
Van De-Wetering, M.10
Stange, D.E.11
Van Es, J.E.12
Guardavaccaro, D.13
Schasfoort, R.B.14
Mohri, Y.15
Nishimori, K.16
Mohammed, S.17
Heck, A.J.18
Clevers, H.19
-
51
-
-
84924219743
-
Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus
-
Schuijers, J., van der Flier, L. G., van Es, J., and Clevers, H. (2014) Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus. Stem Cell Rep. 3, 234-241
-
(2014)
Stem Cell Rep.
, vol.3
, pp. 234-241
-
-
Schuijers, J.1
Van Der-Flier, L.G.2
Van Es, J.3
Clevers, H.4
-
52
-
-
84899618411
-
Specification of regional intestinal stem cell identity during drosophila metamorphosis
-
Driver, I., and Ohlstein, B. (2014) Specification of regional intestinal stem cell identity during Drosophila metamorphosis. Development 141, 1848-1856
-
(2014)
Development
, vol.141
, pp. 1848-1856
-
-
Driver, I.1
Ohlstein, B.2
-
53
-
-
84899029183
-
Adult stem cells in the small intestine are intrinsically programmed with their location-specific function
-
Middendorp, S., Schneeberger, K., Wiegerinck, C. L., Mokry, M., Akkerman, R.D., van Wijngaarden, S., Clevers, H., and Nieuwenhuis, E. E. (2014) Adult stem cells in the small intestine are intrinsically programmed with their location-specific function. Stem Cells 32, 1083-1091
-
(2014)
Stem Cells
, vol.32
, pp. 1083-1091
-
-
Middendorp, S.1
Schneeberger, K.2
Wiegerinck, C.L.3
Mokry, M.4
Akkerman, R.D.5
Van Wijngaarden, S.6
Clevers, H.7
Nieuwenhuis, E.E.8
-
54
-
-
84931268960
-
Cloning and variation of ground state intestinal stem cells
-
Wang, X., Yamamoto, Y., Wilson, L. H., Zhang, T., Howitt, B. E., Farrow, M. A., Kern, F., Ning, G., Hong, Y., Khor, C. C., Chevalier, B., Bertrand, D., Wu, L., Nagarajan, N., Sylvester, F. A., Hyams, J. S., Devers, T., Bronson, R., Lacy, D.B., Ho, K. Y., Crum, C. P., McKeon, F., and Xian, W. (2015) Cloning and variation of ground state intestinal stem cells. Nature 522, 173-178
-
(2015)
Nature
, vol.522
, pp. 173-178
-
-
Wang, X.1
Yamamoto, Y.2
Wilson, L.H.3
Zhang, T.4
Howitt, B.E.5
Farrow, M.A.6
Kern, F.7
Ning, G.8
Hong, Y.9
Khor, C.C.10
Chevalier, B.11
Bertrand, D.12
Wu, L.13
Nagarajan, N.14
Sylvester, F.A.15
Hyams, J.S.16
Devers, T.17
Bronson, R.18
Lacy, D.B.19
Ho, K.Y.20
Crum, C.P.21
McKeon, F.22
Xian, W.23
more..
-
55
-
-
33845191713
-
Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine
-
Bosse, T., Piaseckyj, C.M., Burghard, E., Fialkovich, J. J., Rajagopal, S., Pu, W. T., and Krasinski, S. D. (2006) Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol. Cell. Biol. 26, 9060-9070
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 9060-9070
-
-
Bosse, T.1
Piaseckyj, C.M.2
Burghard, E.3
Fialkovich, J.J.4
Rajagopal, S.5
Pu, W.T.6
Krasinski, S.D.7
-
56
-
-
0036234199
-
Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis
-
Bates, M. D., Erwin, C. R., Sanford, L. P., Wiginton, D., Bezerra, J. A., Schatzman, L. C., Jegga, A. G., Ley-Ebert, C., Williams, S. S., Steinbrecher, K. A., Warner, B. W., Cohen, M. B., and Aronow, B. J. (2002) Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis. Gastroenterology 122, 1467-1482
-
(2002)
Gastroenterology
, vol.122
, pp. 1467-1482
-
-
Bates, M.D.1
Erwin, C.R.2
Sanford, L.P.3
Wiginton, D.4
Bezerra, J.A.5
Schatzman, L.C.6
Jegga, A.G.7
Ley-Ebert, C.8
Williams, S.S.9
Steinbrecher, K.A.10
Warner, B.W.11
Cohen, M.B.12
Aronow, B.J.13
-
57
-
-
0031048229
-
Regional expression of intestinal genes for nutrient absorption
-
Shaw-Smith, C. J., and Walters, J. R. (1997) Regional expression of intestinal genes for nutrient absorption. Gut 40, 5-8
-
(1997)
Gut
, vol.40
, pp. 5-8
-
-
Shaw-Smith, C.J.1
Walters, J.R.2
-
58
-
-
84858082548
-
MTOR inhibitors in cancer therapy
-
Zaytseva, Y. Y., Valentino, J. D., Gulhati, P., and Evers, B. M. (2012) mTOR inhibitors in cancer therapy. Cancer Lett. 319, 1-7
-
(2012)
Cancer Lett.
, vol.319
, pp. 1-7
-
-
Zaytseva, Y.Y.1
Valentino, J.D.2
Gulhati, P.3
Evers, B.M.4
-
59
-
-
51649126752
-
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice
-
Fujishita, T., Aoki, K., Lane, H.A., Aoki, M., and Taketo, M.M.(2008) Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc. Natl. Acad. Sci. USA 105, 13544-13549
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 13544-13549
-
-
Fujishita, T.1
Aoki, K.2
Lane, H.A.3
Aoki, M.4
Taketo, M.M.5
-
60
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase balpha
-
Alessi, D.R., James, S.R., Downes, C. P., Holmes, A. B., Gaffney, P.R., Reese, C. B., and Cohen, P. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 7, 261-269
-
(1997)
Curr. Biol.
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
61
-
-
84899977976
-
Calories, carbohydrates, and cancer therapy with radiation: Exploiting the fiveR's through dietary manipulation
-
Klement, R. J., and Champ, C.E. (2014) Calories, carbohydrates, and cancer therapy with radiation: exploiting the fiveR's through dietary manipulation. Cancer Metastasis Rev. 33, 217-229
-
(2014)
Cancer Metastasis Rev.
, vol.33
, pp. 217-229
-
-
Klement, R.J.1
Champ, C.E.2
|