메뉴 건너뛰기




Volumn 8, Issue 3, 2012, Pages

SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN; RAPTOR PROTEIN; REGULATOR PROTEIN; SMG 1 PROTEIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 84859233333     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002619     Document Type: Article
Times cited : (72)

References (72)
  • 1
    • 79955544013 scopus 로고    scopus 로고
    • Planarian stem cells: a simple paradigm for regeneration
    • Aboobaker AA, (2011) Planarian stem cells: a simple paradigm for regeneration. Trends Cell Biol 21: 304-311.
    • (2011) Trends Cell Biol , vol.21 , pp. 304-311
    • Aboobaker, A.A.1
  • 2
    • 33646373671 scopus 로고    scopus 로고
    • The power of regeneration and the stem-cell kingdom: freshwater planarians (Platyhelminthes)
    • Saló E, (2006) The power of regeneration and the stem-cell kingdom: freshwater planarians (Platyhelminthes). Bioessays 28: 546-559.
    • (2006) Bioessays , vol.28 , pp. 546-559
    • Saló, E.1
  • 3
    • 0024437224 scopus 로고
    • Regeneration and pattern formation in planarians III. Evidence that neoblasts are totipotent stem cells and the source of blastema cells
    • Baguñà J, Saló E, Auladell C, (1989) Regeneration and pattern formation in planarians III. Evidence that neoblasts are totipotent stem cells and the source of blastema cells. Development 107: 77-86.
    • (1989) Development , vol.107 , pp. 77-86
    • Baguñà, J.1    Saló, E.2    Auladell, C.3
  • 4
    • 79955985703 scopus 로고    scopus 로고
    • Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration
    • Wagner DE, Wang IE, Reddien PW, (2011) Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science 332: 811-816.
    • (2011) Science , vol.332 , pp. 811-816
    • Wagner, D.E.1    Wang, I.E.2    Reddien, P.W.3
  • 5
    • 78650873849 scopus 로고    scopus 로고
    • The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration
    • Gentile L, Cebria F, Bartscherer K, (2011) The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration. Dis Model Mech 4: 12-19.
    • (2011) Dis Model Mech , vol.4 , pp. 12-19
    • Gentile, L.1    Cebria, F.2    Bartscherer, K.3
  • 6
    • 54949153140 scopus 로고    scopus 로고
    • Comparative aspects of animal regeneration
    • Brockes JP, Kumar A, (2008) Comparative aspects of animal regeneration. Annu Rev Cell Dev Biol 24: 525-549.
    • (2008) Annu Rev Cell Dev Biol , vol.24 , pp. 525-549
    • Brockes, J.P.1    Kumar, A.2
  • 7
    • 39149100320 scopus 로고    scopus 로고
    • Slicing across kingdoms: Regeneration in plants and animals
    • Birnbaum KD, Sanchez Alvarado A, (2008) Slicing across kingdoms: regeneration in plants and animals. Cell 132: 697-710.
    • (2008) Cell , vol.132 , pp. 697-710
    • Birnbaum, K.D.1    Sanchez, A.A.2
  • 8
    • 77955274843 scopus 로고    scopus 로고
    • Planarian regeneration involves distinct stem cell responses to wounds and tissue absence
    • Wenemoser D, Reddien PW, (2010) Planarian regeneration involves distinct stem cell responses to wounds and tissue absence. Dev Biol 344: 979-991.
    • (2010) Dev Biol , vol.344 , pp. 979-991
    • Wenemoser, D.1    Reddien, P.W.2
  • 9
    • 84986435987 scopus 로고
    • Mitosis in the intact and regenerating planarian Dugesia mediterranea n. sp. II. Mitotic studies during regeneration and a possible mechanism of blastema formation
    • Baguñà J, (1976) Mitosis in the intact and regenerating planarian Dugesia mediterranea n. sp. II. Mitotic studies during regeneration and a possible mechanism of blastema formation. J Exp Zool 195: 65-80.
    • (1976) J Exp Zool , vol.195 , pp. 65-80
    • Baguñà, J.1
  • 10
    • 65249137149 scopus 로고    scopus 로고
    • Autophagy meets planarians
    • Gonzalez-Estevez C, (2009) Autophagy meets planarians. Autophagy 5: 290-297.
    • (2009) Autophagy , vol.5 , pp. 290-297
    • Gonzalez-Estevez, C.1
  • 12
  • 13
    • 0035449691 scopus 로고    scopus 로고
    • Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
    • Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S, (2001) Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev 15: 2215-2228.
    • (2001) Genes Dev , vol.15 , pp. 2215-2228
    • Yamashita, A.1    Ohnishi, T.2    Kashima, I.3    Taya, Y.4    Ohno, S.5
  • 14
    • 0035933889 scopus 로고    scopus 로고
    • Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein
    • Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP, (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J Biol Chem 276: 22709-22714.
    • (2001) J Biol Chem , vol.276 , pp. 22709-22714
    • Denning, G.1    Jamieson, L.2    Maquat, L.E.3    Thompson, E.A.4    Fields, A.P.5
  • 15
    • 4344570947 scopus 로고    scopus 로고
    • SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans
    • Grimson A, O'Connor S, Newman CL, Anderson P, (2004) SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans. Mol Cell Biol 24: 7483-7490.
    • (2004) Mol Cell Biol , vol.24 , pp. 7483-7490
    • Grimson, A.1    O'Connor, S.2    Newman, C.L.3    Anderson, P.4
  • 16
    • 53749097353 scopus 로고    scopus 로고
    • A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans
    • doi:10.1371/journal.pone.0003354
    • Masse I, Molin L, Mouchiroud L, Vanhems P, Palladino F, et al. (2008) A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. PLoS ONE 3: e3354 doi:10.1371/journal.pone.0003354.
    • (2008) PLoS ONE , vol.3
    • Masse, I.1    Molin, L.2    Mouchiroud, L.3    Vanhems, P.4    Palladino, F.5
  • 17
    • 2942572923 scopus 로고    scopus 로고
    • The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells
    • Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, et al. (2004) The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. Mol Cell 14: 585-598.
    • (2004) Mol Cell , vol.14 , pp. 585-598
    • Brumbaugh, K.M.1    Otterness, D.M.2    Geisen, C.3    Oliveira, V.4    Brognard, J.5
  • 18
    • 45149089919 scopus 로고    scopus 로고
    • A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis
    • Oliveira V, Romanow WJ, Geisen C, Otterness DM, Mercurio F, et al. (2008) A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis. J Biol Chem 283: 13174-13184.
    • (2008) J Biol Chem , vol.283 , pp. 13174-13184
    • Oliveira, V.1    Romanow, W.J.2    Geisen, C.3    Otterness, D.M.4    Mercurio, F.5
  • 19
    • 46449097470 scopus 로고    scopus 로고
    • hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress
    • Gehen SC, Staversky RJ, Bambara RA, Keng PC, O'Reilly MA, (2008) hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress. Oncogene 27: 4065-4074.
    • (2008) Oncogene , vol.27 , pp. 4065-4074
    • Gehen, S.C.1    Staversky, R.J.2    Bambara, R.A.3    Keng, P.C.4    O'Reilly, M.A.5
  • 20
    • 67650541863 scopus 로고    scopus 로고
    • Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia
    • Chen RQ, Yang QK, Chen YL, Oliveira VA, Dalton WS, et al. (2009) Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia. J Biol Chem 284: 16752-16758.
    • (2009) J Biol Chem , vol.284 , pp. 16752-16758
    • Chen, R.Q.1    Yang, Q.K.2    Chen, Y.L.3    Oliveira, V.A.4    Dalton, W.S.5
  • 21
    • 0030828073 scopus 로고    scopus 로고
    • Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
    • Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, et al. (1997) Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106: 348-360.
    • (1997) Chromosoma , vol.106 , pp. 348-360
    • Hendzel, M.J.1    Wei, Y.2    Mancini, M.A.3    van Hooser, A.4    Ranalli, T.5
  • 22
    • 33646678483 scopus 로고    scopus 로고
    • DjPiwi-1, a member of the PAZ-Piwi gene family, defines a subpopulation of planarian stem cells
    • Rossi L, Salvetti A, Lena A, Batistoni R, Deri P, et al. (2006) DjPiwi-1, a member of the PAZ-Piwi gene family, defines a subpopulation of planarian stem cells. Dev Genes Evol.
    • (2006) Dev Genes Evol
    • Rossi, L.1    Salvetti, A.2    Lena, A.3    Batistoni, R.4    Deri, P.5
  • 23
    • 51049089115 scopus 로고    scopus 로고
    • Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea
    • Eisenhoffer GT, Kang H, Sanchez Alvarado A, (2008) Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea. Cell Stem Cell 3: 327-339.
    • (2008) Cell Stem Cell , vol.3 , pp. 327-339
    • Eisenhoffer, G.T.1    Kang, H.2    Sanchez, A.A.3
  • 24
    • 33746518104 scopus 로고    scopus 로고
    • A Bruno-like gene is required for stem cell maintenance in planarians
    • Guo T, Peters AH, Newmark PA, (2006) A Bruno-like gene is required for stem cell maintenance in planarians. Dev Cell 11: 159-169.
    • (2006) Dev Cell , vol.11 , pp. 159-169
    • Guo, T.1    Peters, A.H.2    Newmark, P.A.3
  • 25
    • 77954904047 scopus 로고    scopus 로고
    • Complete functional segregation of planarian beta-catenin-1 and -2 in mediating Wnt signaling and cell adhesion
    • Chai G, Ma C, Bao K, Zheng L, Wang X, et al. (2010) Complete functional segregation of planarian beta-catenin-1 and-2 in mediating Wnt signaling and cell adhesion. J Biol Chem 285: 24120-24130.
    • (2010) J Biol Chem , vol.285 , pp. 24120-24130
    • Chai, G.1    Ma, C.2    Bao, K.3    Zheng, L.4    Wang, X.5
  • 26
    • 45449083025 scopus 로고    scopus 로고
    • Organization of the nervous system in the model planarian Schmidtea mediterranea: an immunocytochemical study
    • Cebria F, (2008) Organization of the nervous system in the model planarian Schmidtea mediterranea: an immunocytochemical study. Neurosci Res 61: 375-384.
    • (2008) Neurosci Res , vol.61 , pp. 375-384
    • Cebria, F.1
  • 27
    • 0030700298 scopus 로고    scopus 로고
    • Myocite differentiation and body wall muscle regeneration in the planarian Girardia tigrina
    • Cebrià F, Vispo M, Newmark P, Bueno D, Romero R, (1997) Myocite differentiation and body wall muscle regeneration in the planarian Girardia tigrina. Dev Gene Evol 207 (5): 306-316.
    • (1997) Dev Gene Evol , vol.207 , Issue.5 , pp. 306-316
    • Cebrià, F.1    Vispo, M.2    Newmark, P.3    Bueno, D.4    Romero, R.5
  • 28
    • 0034342451 scopus 로고    scopus 로고
    • Organization and regeneration ability of spontaneous supernumerary eyes in planarians -eye regeneration field and pathway selection by optic nerves
    • Sakai F, Agata K, Orii H, Watanabe K, (2000) Organization and regeneration ability of spontaneous supernumerary eyes in planarians-eye regeneration field and pathway selection by optic nerves. Zoolog Sci 17: 375-381.
    • (2000) Zoolog Sci , vol.17 , pp. 375-381
    • Sakai, F.1    Agata, K.2    Orii, H.3    Watanabe, K.4
  • 29
    • 0002170118 scopus 로고
    • Mitosis in the intact and regenerating planarian Dugesia mediterranea n. sp. I. Mitotic studies during growth, feeding and starvation
    • Baguñà J, (1976) Mitosis in the intact and regenerating planarian Dugesia mediterranea n. sp. I. Mitotic studies during growth, feeding and starvation. J of Exp Zool 195: 53-64.
    • (1976) J of Exp Zool , vol.195 , pp. 53-64
    • Baguñà, J.1
  • 30
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM, (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 31
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN, (2006) TOR signaling in growth and metabolism. Cell 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 32
    • 80051637832 scopus 로고    scopus 로고
    • mTORC1 signaling: what we still don't know
    • Wang X, Proud CG, (2011) mTORC1 signaling: what we still don't know. J Mol Cell Biol.
    • (2011) J Mol Cell Biol
    • Wang, X.1    Proud, C.G.2
  • 33
    • 64249153813 scopus 로고    scopus 로고
    • Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling
    • discussion 141
    • Oviedo NJ, Pearson BJ, Levin M, Sanchez Alvarado A, (2008) Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling. Dis Model Mech 1: 131-143; discussion 141.
    • (2008) Dis Model Mech , vol.1 , pp. 131-143
    • Oviedo, N.J.1    Pearson, B.J.2    Levin, M.3    Sanchez, A.A.4
  • 34
    • 0037178781 scopus 로고    scopus 로고
    • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    • Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, et al. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110: 177-189.
    • (2002) Cell , vol.110 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3    Yoshino, K.4    Oshiro, N.5
  • 35
    • 66049149059 scopus 로고    scopus 로고
    • mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells
    • Zhou J, Su P, Wang L, Chen J, Zimmermann M, et al. (2009) mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A 106: 7840-7845.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 7840-7845
    • Zhou, J.1    Su, P.2    Wang, L.3    Chen, J.4    Zimmermann, M.5
  • 36
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM, (2007) Defining the role of mTOR in cancer. Cancer Cell 12: 9-22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 37
    • 63749097287 scopus 로고    scopus 로고
    • Optimal targeting of the mTORC1 kinase in human cancer
    • Lane HA, Breuleux M, (2009) Optimal targeting of the mTORC1 kinase in human cancer. Curr Opin Cell Biol 21: 219-229.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 219-229
    • Lane, H.A.1    Breuleux, M.2
  • 38
    • 0037015269 scopus 로고    scopus 로고
    • TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
    • Long X, Spycher C, Han ZS, Rose AM, Muller F, et al. (2002) TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol 12: 1448-1461.
    • (2002) Curr Biol , vol.12 , pp. 1448-1461
    • Long, X.1    Spycher, C.2    Han, Z.S.3    Rose, A.M.4    Muller, F.5
  • 39
    • 0034312279 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    • Oldham S, Montagne J, Radimerski T, Thomas G, Hafen E, (2000) Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev 14: 2689-2694.
    • (2000) Genes Dev , vol.14 , pp. 2689-2694
    • Oldham, S.1    Montagne, J.2    Radimerski, T.3    Thomas, G.4    Hafen, E.5
  • 40
    • 6344245674 scopus 로고    scopus 로고
    • Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
    • Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, et al. (2004) Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 24: 9508-9516.
    • (2004) Mol Cell Biol , vol.24 , pp. 9508-9516
    • Gangloff, Y.G.1    Mueller, M.2    Dann, S.G.3    Svoboda, P.4    Sticker, M.5
  • 41
    • 3242721268 scopus 로고    scopus 로고
    • mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
    • Murakami M, Ichisaka T, Maeda M, Oshiro N, Hara K, et al. (2004) mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol 24: 6710-6718.
    • (2004) Mol Cell Biol , vol.24 , pp. 6710-6718
    • Murakami, M.1    Ichisaka, T.2    Maeda, M.3    Oshiro, N.4    Hara, K.5
  • 42
    • 0035578226 scopus 로고    scopus 로고
    • Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway
    • Martin PM, Sutherland AE, (2001) Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway. Dev Biol 240: 182-193.
    • (2001) Dev Biol , vol.240 , pp. 182-193
    • Martin, P.M.1    Sutherland, A.E.2
  • 43
    • 79551573170 scopus 로고    scopus 로고
    • A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis
    • Morton JP, Myant KB, Sansom OJ, (2011) A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis. Cell Cycle 10: 173-175.
    • (2011) Cell Cycle , vol.10 , pp. 173-175
    • Morton, J.P.1    Myant, K.B.2    Sansom, O.J.3
  • 44
    • 78649874959 scopus 로고    scopus 로고
    • Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    • Gan B, Hu J, Jiang S, Liu Y, Sahin E, et al. (2010) Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468: 701-704.
    • (2010) Nature , vol.468 , pp. 701-704
    • Gan, B.1    Hu, J.2    Jiang, S.3    Liu, Y.4    Sahin, E.5
  • 45
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada D, Saunders TL, Morrison SJ, (2010) Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468: 653-658.
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 46
    • 3242886117 scopus 로고    scopus 로고
    • The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways
    • Abraham RT, (2004) The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst) 3: 919-925.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 919-925
    • Abraham, R.T.1
  • 47
    • 33846015866 scopus 로고    scopus 로고
    • Functions of the nonsense-mediated mRNA decay pathway in Drosophila development
    • doi:10.1371/journal.pgen.0020180
    • Metzstein MM, Krasnow MA, (2006) Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. PLoS Genet 2: e180 doi:10.1371/journal.pgen.0020180.
    • (2006) PLoS Genet , vol.2
    • Metzstein, M.M.1    Krasnow, M.A.2
  • 48
    • 77955448359 scopus 로고    scopus 로고
    • Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay
    • McIlwain DR, Pan Q, Reilly PT, Elia AJ, McCracken S, et al. (2010) Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay. Proc Natl Acad Sci U S A 107: 12186-12191.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12186-12191
    • McIlwain, D.R.1    Pan, Q.2    Reilly, P.T.3    Elia, A.J.4    McCracken, S.5
  • 49
    • 73649143160 scopus 로고    scopus 로고
    • A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages
    • Pearson BJ, Sanchez Alvarado A, (2010) A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development 137: 213-221.
    • (2010) Development , vol.137 , pp. 213-221
    • Pearson, B.J.1    Sanchez, A.A.2
  • 50
    • 61349141302 scopus 로고    scopus 로고
    • Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
    • doi:10.1371/journal.pbio.1000038
    • Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, et al. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7: e38 doi:10.1371/journal.pbio.1000038.
    • (2009) PLoS Biol , vol.7
    • Feldman, M.E.1    Apsel, B.2    Uotila, A.3    Loewith, R.4    Knight, Z.A.5
  • 51
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, et al. (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284: 8023-8032.
    • (2009) J Biol Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3    Liu, Q.4    Zhang, J.5
  • 52
    • 67650228579 scopus 로고    scopus 로고
    • Rapamycin inhibits mTORC1, but not completely
    • Thoreen CC, Sabatini DM, (2009) Rapamycin inhibits mTORC1, but not completely. Autophagy 5: 725-726.
    • (2009) Autophagy , vol.5 , pp. 725-726
    • Thoreen, C.C.1    Sabatini, D.M.2
  • 53
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J, (2008) Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A 105: 17414-17419.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5
  • 54
    • 77952308587 scopus 로고    scopus 로고
    • Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance
    • Rouhana L, Shibata N, Nishimura O, Agata K, (2010) Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance. Dev Biol 341: 429-443.
    • (2010) Dev Biol , vol.341 , pp. 429-443
    • Rouhana, L.1    Shibata, N.2    Nishimura, O.3    Agata, K.4
  • 55
    • 38549143656 scopus 로고    scopus 로고
    • SmedGD: the Schmidtea mediterranea genome database
    • Robb SM, Ross E, Sanchez Alvarado A, (2008) SmedGD: the Schmidtea mediterranea genome database. Nucleic Acids Res 36: D599-606.
    • (2008) Nucleic Acids Res , vol.36
    • Robb, S.M.1    Ross, E.2    Sanchez, A.A.3
  • 56
    • 78650774202 scopus 로고    scopus 로고
    • A dual platform approach to transcript discovery for the planarian Schmidtea mediterranea to establish RNAseq for stem cell and regeneration biology
    • doi:10.1371/journal.pone.0015617
    • Blythe MJ, Kao D, Malla S, Rowsell J, Wilson R, et al. (2010) A dual platform approach to transcript discovery for the planarian Schmidtea mediterranea to establish RNAseq for stem cell and regeneration biology. PLoS ONE 5: e15617 doi:10.1371/journal.pone.0015617.
    • (2010) PLoS ONE , vol.5
    • Blythe, M.J.1    Kao, D.2    Malla, S.3    Rowsell, J.4    Wilson, R.5
  • 57
    • 0037100671 scopus 로고    scopus 로고
    • MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform
    • Katoh K, Misawa K, Kuma K, Miyata T, (2002) MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res 30: 3059-3066.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3059-3066
    • Katoh, K.1    Misawa, K.2    Kuma, K.3    Miyata, T.4
  • 58
    • 0002051540 scopus 로고    scopus 로고
    • BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT
    • Hall TA, (1999) BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucl Acids Symp Ser 41: 95-98.
    • (1999) Nucl Acids Symp Ser , vol.41 , pp. 95-98
    • Hall, T.A.1
  • 59
    • 0034043778 scopus 로고    scopus 로고
    • Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis
    • Castresana J, (2000) Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. Mol Biol Evol 17: 540-552.
    • (2000) Mol Biol Evol , vol.17 , pp. 540-552
    • Castresana, J.1
  • 60
    • 0041386108 scopus 로고    scopus 로고
    • MrBayes 3: Bayesian phylogenetic inference under mixed models
    • Ronquist F, Huelsenbeck JP, (2003) MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics 19: 1572-1574.
    • (2003) Bioinformatics , vol.19 , pp. 1572-1574
    • Ronquist, F.1    Huelsenbeck, J.P.2
  • 61
    • 33750403801 scopus 로고    scopus 로고
    • RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
    • Stamatakis A, (2006) RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Bioinformatics 22: 2688-2690.
    • (2006) Bioinformatics , vol.22 , pp. 2688-2690
    • Stamatakis, A.1
  • 62
    • 79951769532 scopus 로고    scopus 로고
    • Noggin and noggin-like genes control dorsoventral axis regeneration in planarians
    • Molina MD, Neto A, Maeso I, Gomez-Skarmeta JL, Salo E, et al. (2011) Noggin and noggin-like genes control dorsoventral axis regeneration in planarians. Curr Biol 21: 300-305.
    • (2011) Curr Biol , vol.21 , pp. 300-305
    • Molina, M.D.1    Neto, A.2    Maeso, I.3    Gomez-Skarmeta, J.L.4    Salo, E.5
  • 63
    • 17844395204 scopus 로고    scopus 로고
    • Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria
    • Reddien PW, Bermange AL, Murfitt KJ, Jennings JR, Sanchez Alvarado A, (2005) Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell 8: 635-649.
    • (2005) Dev Cell , vol.8 , pp. 635-649
    • Reddien, P.W.1    Bermange, A.L.2    Murfitt, K.J.3    Jennings, J.R.4    Sanchez, A.A.5
  • 64
    • 59649084941 scopus 로고    scopus 로고
    • Formaldehyde-based whole-mount in situ hybridization method for planarians
    • Pearson BJ, Eisenhoffer GT, Gurley KA, Rink JC, Miller DE, et al. (2009) Formaldehyde-based whole-mount in situ hybridization method for planarians. Dev Dyn 238: 443-450.
    • (2009) Dev Dyn , vol.238 , pp. 443-450
    • Pearson, B.J.1    Eisenhoffer, G.T.2    Gurley, K.A.3    Rink, J.C.4    Miller, D.E.5
  • 65
    • 67650805439 scopus 로고    scopus 로고
    • Diverse miRNA spatial expression patterns suggest important roles in homeostasis and regeneration in planarians
    • Gonzalez-Estevez C, Arseni V, Thambyrajah RS, Felix DA, Aboobaker AA, (2009) Diverse miRNA spatial expression patterns suggest important roles in homeostasis and regeneration in planarians. Int J Dev Biol 53: 493-505.
    • (2009) Int J Dev Biol , vol.53 , pp. 493-505
    • Gonzalez-Estevez, C.1    Arseni, V.2    Thambyrajah, R.S.3    Felix, D.A.4    Aboobaker, A.A.5
  • 66
    • 34347272302 scopus 로고    scopus 로고
    • Regeneration and maintenance of the planarian midline is regulated by a slit orthologue
    • Cebria F, Guo T, Jopek J, Newmark PA, (2007) Regeneration and maintenance of the planarian midline is regulated by a slit orthologue. Dev Biol 307: 394-406.
    • (2007) Dev Biol , vol.307 , pp. 394-406
    • Cebria, F.1    Guo, T.2    Jopek, J.3    Newmark, P.A.4
  • 67
    • 24344437678 scopus 로고    scopus 로고
    • An in situ hybridization protocol for planarian embryos: monitoring myosin heavy chain gene expression
    • Cardona A, Fernandez J, Solana J, Romero R, (2005) An in situ hybridization protocol for planarian embryos: monitoring myosin heavy chain gene expression. Dev Genes Evol 215: 482-488.
    • (2005) Dev Genes Evol , vol.215 , pp. 482-488
    • Cardona, A.1    Fernandez, J.2    Solana, J.3    Romero, R.4
  • 68
    • 0032931102 scopus 로고    scopus 로고
    • Distinct structural domains in the planarian brain defined by the expression of evolutionarily conserved homeobox genes
    • Umesono Y, Watanabe K, Agata K, (1999) Distinct structural domains in the planarian brain defined by the expression of evolutionarily conserved homeobox genes. Dev Genes Evol 209: 31-39.
    • (1999) Dev Genes Evol , vol.209 , pp. 31-39
    • Umesono, Y.1    Watanabe, K.2    Agata, K.3
  • 69
    • 34548072239 scopus 로고    scopus 로고
    • Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation
    • Gonzalez-Estevez C, Felix DA, Aboobaker AA, Salo E, (2007) Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation. Proc Natl Acad Sci U S A 104: 13373-13378.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13373-13378
    • Gonzalez-Estevez, C.1    Felix, D.A.2    Aboobaker, A.A.3    Salo, E.4
  • 70
    • 24944490097 scopus 로고    scopus 로고
    • Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture
    • Cebria F, Newmark PA, (2005) Planarian homologs of netrin and netrin receptor are required for proper regeneration of the central nervous system and the maintenance of nervous system architecture. Development 132: 3691-3703.
    • (2005) Development , vol.132 , pp. 3691-3703
    • Cebria, F.1    Newmark, P.A.2
  • 71
    • 33745816717 scopus 로고    scopus 로고
    • Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting
    • Hayashi T, Asami M, Higuchi S, Shibata N, Agata K, (2006) Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting. Dev Growth Differ 48: 371-380.
    • (2006) Dev Growth Differ , vol.48 , pp. 371-380
    • Hayashi, T.1    Asami, M.2    Higuchi, S.3    Shibata, N.4    Agata, K.5
  • 72


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.