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Volumn 522, Issue 7555, 2015, Pages 173-178

Cloning and variation of ground state intestinal stem cells

(23)  Wang, Xia a   Yamamoto, Yusuke a   Wilson, Lane H a,b   Zhang, Ting c   Howitt, Brooke E d   Farrow, Melissa A e   Kern, Florian c   Ning, Gang a   Hong, Yue a   Khor, Chiea Chuen c,f   Chevalier, Benoit a   Bertrand, Denis c   Wu, Lingyan c   Nagarajan, Niranjan c   Sylvester, Francisco A g   Hyams, Jeffrey S h   Devers, Thomas b   Bronson, Roderick i   Lacy, D Borden e   Ho, Khek Yu j   more..


Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; BETA CATENIN; CYTOKERATIN 20; EPIDERMAL GROWTH FACTOR; MUCIN 2; NOTCH RECEPTOR; SOMATOMEDIN; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GATA 6; TRANSFORMING GROWTH FACTOR BETA; VILLIN; WNT PROTEIN; CLOSTRIDIUM DIFFICILE LETHAL TOXIN B;

EID: 84931268960     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14484     Document Type: Article
Times cited : (147)

References (58)
  • 1
    • 84892734390 scopus 로고    scopus 로고
    • Pluripotent stem cells in regenerative medicine: Challenges and recent progress
    • Tabar, V., Studer, L. Pluripotent stem cells in regenerative medicine: challenges and recent progress. Nature Rev. Genet. 15, 82-92 (2014).
    • (2014) Nature Rev. Genet. , vol.15 , pp. 82-92
    • Tabar, V.1    Studer, L.2
  • 2
    • 84898464540 scopus 로고    scopus 로고
    • IPS cell technologies: Significance and applications to CNS regeneration and disease
    • Okano, H., Yamanaka, S. iPS cell technologies: significance and applications to CNS regeneration and disease. Mol. Brain 7, 22 (2014).
    • (2014) Mol. Brain , vol.7 , pp. 22
    • Okano, H.1    Yamanaka, S.2
  • 3
    • 0027270776 scopus 로고
    • ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients
    • Mü ller, A. M., Dzierzak, E. A. ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients. Development 118, 1343-1351 (1993).
    • (1993) Development , vol.118 , pp. 1343-1351
    • Müller, A.M.1
  • 4
    • 0029947439 scopus 로고    scopus 로고
    • Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro
    • Helgason, C. D., Sauvageau, G., Lawrence, H. J., Largman, C., Humphries, R. K. Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro. Blood 87, 2740-2749 (1996).
    • (1996) Blood , vol.87 , pp. 2740-2749
    • Helgason, C.D.1    Sauvageau, G.2    Lawrence, H.J.3    Largman, C.4    Humphries, R.K.5
  • 5
    • 58849126544 scopus 로고    scopus 로고
    • HOXB4but not BMP4 confers self-renewal properties to ES-derived hematopoietic progenitor cells
    • Bonde, S., Dowden, A. M., Chan, K. M., Tabayoyong, W. B. & Zavazava, N. HOXB4but not BMP4 confers self-renewal properties to ES-derived hematopoietic progenitor cells. Transplantation 86, 1803-1809 (2008).
    • (2008) Transplantation , vol.86 , pp. 1803-1809
    • Bonde, S.1    Dowden, A.M.2    Chan, K.M.3    Tabayoyong, W.B.4    Zavazava, N.5
  • 7
    • 84874438241 scopus 로고    scopus 로고
    • In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells
    • Amabile, G. et al. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood 121, 1255-1264 (2013).
    • (2013) Blood , vol.121 , pp. 1255-1264
    • Amabile, G.1
  • 8
    • 84879694584 scopus 로고    scopus 로고
    • Generation of engraftable hematopoietic stemcells from induced pluripotent stem cells by way of teratoma formation
    • Suzuki, N. et al. Generation of engraftable hematopoietic stemcells from induced pluripotent stem cells by way of teratoma formation. Mol. Ther. 21, 1424-1431 (2013).
    • (2013) Mol. Ther. , vol.21 , pp. 1424-1431
    • Suzuki, N.1
  • 9
    • 0016729431 scopus 로고
    • Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells
    • Rheinwatd, J. G., Green, H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6, 331-343 (1975).
    • (1975) Cell , vol.6 , pp. 331-343
    • Rheinwatd, J.G.1    Green, H.2
  • 10
    • 77954394144 scopus 로고    scopus 로고
    • Limbal stem-cell therapy and long-term corneal regeneration
    • Rama, P. et al. Limbal stem-cell therapy and long-term corneal regeneration. N. Engl. J. Med. 363, 147-155 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 147-155
    • Rama, P.1
  • 11
    • 34247511981 scopus 로고    scopus 로고
    • P63 is essential for the proliferative potential of stem cells of stratified epithelia
    • Senoo, M., Pinto, F., Crum, C. P., McKeon, F. p63 is essential for the proliferative potential of stem cells of stratified epithelia. Cell 129, 523-536 (2007).
    • (2007) Cell , vol.129 , pp. 523-536
    • Senoo, M.1    Pinto, F.2    Crum, C.P.3    McKeon, F.4
  • 12
    • 80155148257 scopus 로고    scopus 로고
    • Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection
    • Kumar, P. A. et al. Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell 147, 525-538 (2011).
    • (2011) Cell , vol.147 , pp. 525-538
    • Kumar, P.A.1
  • 13
    • 33745004426 scopus 로고    scopus 로고
    • Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells
    • Matsuura, R. et al. Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells. Stem Cells 24, 624-630 (2006).
    • (2006) Stem Cells , vol.24 , pp. 624-630
    • Matsuura, R.1
  • 14
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 15
    • 67349157318 scopus 로고    scopus 로고
    • Sustained in vitro intestinal epithelial culture within a Wntdependent stem cell niche
    • Ootani, A. et al. Sustained in vitro intestinal epithelial culture within a Wntdependent stem cell niche. Nature Med. 15, 701-706 (2009).
    • (2009) Nature Med , vol.15 , pp. 701-706
    • Ootani, A.1
  • 16
    • 78751644734 scopus 로고    scopus 로고
    • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    • Sato, T. et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469, 415-418 (2011).
    • (2011) Nature , vol.469 , pp. 415-418
    • Sato, T.1
  • 17
    • 84890051386 scopus 로고    scopus 로고
    • Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury
    • Fordham, R. P. et al. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell 13, 734-744 (2013).
    • (2013) Cell Stem Cell , vol.13 , pp. 734-744
    • Fordham, R.P.1
  • 18
    • 84899029183 scopus 로고    scopus 로고
    • Adult stem cells in the small intestine are intrinsically programmed with their location-specific function
    • Middendorp, S. et al. Adult stem cells in the small intestine are intrinsically programmed with their location-specific function. Stem Cells 32, 1083-1091 (2014).
    • (2014) Stem Cells , vol.32 , pp. 1083-1091
    • Middendorp, S.1
  • 19
    • 84894623720 scopus 로고    scopus 로고
    • Niche-independent high-purity cultures of Lgr51 intestinal stemcells and their progeny
    • Yin, X. et al. Niche-independent high-purity cultures of Lgr51 intestinal stemcells and their progeny. Nature Methods 11, 106-112 (2014).
    • (2014) Nature Methods , vol.11 , pp. 106-112
    • Yin, X.1
  • 20
    • 23844455584 scopus 로고    scopus 로고
    • Mitogenic influence of human R-spondin1 on the intestinal epithelium
    • Kim, K. A. et al. Mitogenic influence of human R-spondin1 on the intestinal epithelium. Science 309, 1256-1259 (2005).
    • (2005) Science , vol.309 , pp. 1256-1259
    • Kim, K.A.1
  • 21
    • 34748866686 scopus 로고    scopus 로고
    • Signaling pathways in cancer and embryonic stem cells
    • Dreesen, O., Brivanlou, A. H. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev. 3, 7-17 (2007).
    • (2007) Stem Cell Rev , vol.3 , pp. 7-17
    • Dreesen, O.1    Brivanlou, A.H.2
  • 22
    • 59049087696 scopus 로고    scopus 로고
    • Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    • Zhu, L. et al. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457, 603-607 (2009).
    • (2009) Nature , vol.457 , pp. 603-607
    • Zhu, L.1
  • 23
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007 (2007).
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 24
    • 84859196824 scopus 로고    scopus 로고
    • The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor
    • Powell, A. E. et al. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell 149, 146-158 (2012).
    • (2012) Cell , vol.149 , pp. 146-158
    • Powell, A.E.1
  • 25
    • 4344629704 scopus 로고    scopus 로고
    • Synergy between LRH-1 and beta-catenin induces G1 cyclinmediated cell proliferation
    • Botrugno, O. A. et al. Synergy between LRH-1 and beta-catenin induces G1 cyclinmediated cell proliferation. Mol. Cell 15, 499-509 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 499-509
    • Botrugno, O.A.1
  • 26
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard, J., Sauvageau, G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423, 255-260 (2003).
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 27
    • 46249128798 scopus 로고    scopus 로고
    • Bmi1 is expressed in vivo in intestinal stem cells
    • Sangiorgi, E., Capecchi, M. R. Bmi1 is expressed in vivo in intestinal stem cells. Nature Genet. 40, 915-920 (2008).
    • (2008) Nature Genet , vol.40 , pp. 915-920
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 28
    • 80054041585 scopus 로고    scopus 로고
    • A reserve stemcell population insmall intestine renders Lgr5-positive cells dispensable
    • Tian, H. et al. A reserve stemcell population insmall intestine renders Lgr5-positive cells dispensable. Nature 478, 255-259 (2011).
    • (2011) Nature , vol.478 , pp. 255-259
    • Tian, H.1
  • 29
    • 84893768750 scopus 로고    scopus 로고
    • Lgr51 stem cells are indispensable for radiation-induced intestinal regeneration
    • Metcalfe, C., Kljavin, N. M., Ybarra, R., de Sauvage, F. J. Lgr51 stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell 14, 149-159 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 149-159
    • Metcalfe, C.1    Kljavin, N.M.2    Ybarra, R.3    De Sauvage, F.J.4
  • 30
    • 55249123809 scopus 로고    scopus 로고
    • GATA4 is essential for jejunal function in mice
    • Battle, M. A. et al. GATA4 is essential for jejunal function in mice. Gastroenterology 135, 1676-1686 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 1676-1686
    • Battle, M.A.1
  • 31
    • 84904397909 scopus 로고    scopus 로고
    • GATA4 andGATA6 regulate intestinal epithelial cytodifferentiation duringdevelopment
    • Walker, E. M., Thompson, C. A. & Battle, M. A. GATA4 andGATA6 regulate intestinal epithelial cytodifferentiation duringdevelopment. Dev. Biol. 392, 283-294(2014).
    • (2014) Dev. Biol. , vol.392 , pp. 283-294
    • Walker, E.M.1    Thompson, C.A.2    Battle, M.A.3
  • 32
    • 77953176551 scopus 로고    scopus 로고
    • Onecut-2 knockout mice fail to thrive during early postnatal period and have altered patterns of gene expression in small intestine
    • Dusing, M. R., Maier, E. A., Aronow, B. J., Wiginton, D. A. Onecut-2 knockout mice fail to thrive during early postnatal period and have altered patterns of gene expression in small intestine. Physiol. Genomics 42, 115-125 (2010).
    • (2010) Physiol. Genomics , vol.42 , pp. 115-125
    • Dusing, M.R.1    Maier, E.A.2    Aronow, B.J.3    Wiginton, D.A.4
  • 33
    • 83255189758 scopus 로고    scopus 로고
    • Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage
    • International Stem Cell Initiative
    • International Stem Cell Initiative. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nature Biotechnol. 29, 1132-1144 (2011).
    • (2011) Nature Biotechnol , vol.29 , pp. 1132-1144
  • 34
    • 84888129842 scopus 로고    scopus 로고
    • BCL-XL mediates the strong selective advantage of a 20q11. 21 amplification commonly found in human embryonic stemcell cultures
    • Avery, S. et al. BCL-XL mediates the strong selective advantage of a 20q11. 21 amplification commonly found in human embryonic stemcell cultures. Stem Cell Rep. 1, 379-386 (2013).
    • (2013) Stem Cell Rep. , vol.1 , pp. 379-386
    • Avery, S.1
  • 35
    • 84923825376 scopus 로고    scopus 로고
    • Human cancer growth and therapy in immunodeficient mouse models
    • Shultz, L. D. et al. Human cancer growth and therapy in immunodeficient mouse models. Cold Spring Harb Protoc. http://dx. doi. org/10. 1101/pdb. top073585 (2014).
    • (2014) Cold Spring Harb Protoc
    • Shultz, L.D.1
  • 36
    • 17444366186 scopus 로고    scopus 로고
    • Clostridium difficile toxins: Mechanismof action and role in disease
    • Voth, D. E., Ballard, J. D. Clostridium difficile toxins: mechanismof action and role in disease. Clin. Microbiol. Rev. 18, 247-263 (2005).
    • (2005) Clin. Microbiol. Rev. , vol.18 , pp. 247-263
    • Voth, D.E.1    Ballard, J.D.2
  • 37
    • 84855510455 scopus 로고    scopus 로고
    • The role of toxin A and toxin B in the virulence of Clostridium difficile
    • Carter, G. P., Rood, J. I., Lyras, D. The role of toxin A and toxin B in the virulence of Clostridium difficile. Trends Microbiol. 20, 21-29 (2012).
    • (2012) Trends Microbiol , vol.20 , pp. 21-29
    • Carter, G.P.1    Rood, J.I.2    Lyras, D.3
  • 38
    • 67349114409 scopus 로고    scopus 로고
    • Toxin B is essential for virulence of Clostridium difficile
    • Lyras, D. et al. Toxin B is essential for virulence of Clostridium difficile. Nature 458, 1176-1179 (2009).
    • (2009) Nature , vol.458 , pp. 1176-1179
    • Lyras, D.1
  • 39
    • 84887476533 scopus 로고    scopus 로고
    • Clostridiumdifficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex
    • Farrow, M. A. et al. Clostridiumdifficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc. Natl Acad. Sci. USA 110, 18674-18679 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 18674-18679
    • Farrow, M.A.1
  • 40
    • 34247493760 scopus 로고    scopus 로고
    • Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile
    • Huelsenbeck, J. et al. Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile. Biochemistry 46, 4923-4931 (2007).
    • (2007) Biochemistry , vol.46 , pp. 4923-4931
    • Huelsenbeck, J.1
  • 41
    • 0033924259 scopus 로고    scopus 로고
    • RhoGTPases as targets ofbacterial protein toxins
    • Aktories, K., Schmidt, G. & Just, I. RhoGTPases as targets ofbacterial protein toxins. Biol. Chem. 381, 421-426 (2000).
    • (2000) Biol. Chem. , vol.381 , pp. 421-426
    • Aktories, K.1    Schmidt, G.2    Just, I.3
  • 42
    • 84898714684 scopus 로고    scopus 로고
    • DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid
    • MacFie, T. S. et al. DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid. Inflamm. Bowel Dis. 20, 514-524 (2014).
    • (2014) Inflamm. Bowel Dis. , vol.20 , pp. 514-524
    • MacFie, T.S.1
  • 43
    • 0016325705 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in themouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types
    • Cheng, H., Leblond, C. P. Origin, differentiation and renewal of the four main epithelial cell types in themouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am. J. Anat. 141, 537-561 (1974).
    • (1974) Am. J. Anat. , vol.141 , pp. 537-561
    • Cheng, H.1    Leblond, C.P.2
  • 44
    • 84862777784 scopus 로고    scopus 로고
    • Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr51 stem cell
    • Yui, S. et al. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr51 stem cell. Nature Med. 18, 618-623 (2012).
    • (2012) Nature Med , vol.18 , pp. 618-623
    • Yui, S.1
  • 45
    • 84880558928 scopus 로고    scopus 로고
    • Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay
    • Wang, F. et al. Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology 145, 383-395 (2013).
    • (2013) Gastroenterology , vol.145 , pp. 383-395
    • Wang, F.1
  • 46
    • 84964313624 scopus 로고    scopus 로고
    • Anin vivomodel ofhumansmall intestine using pluripotent stem cells
    • Watson, C. L. et al. Anin vivomodel ofhumansmall intestine using pluripotent stem cells. Nature Med. 20, 1310-1314 (2014).
    • (2014) Nature Med. , vol.20 , pp. 1310-1314
    • Watson, C.L.1
  • 47
    • 84866091322 scopus 로고    scopus 로고
    • Transcriptional networks in liver and intestinal development
    • Sheaffer, K. L., Kaestner, K. H. Transcriptional networks in liver and intestinal development. Cold Spring Harb. Perspect. Biol. 4, a008284 (2012).
    • (2012) Cold Spring Harb. Perspect. Biol. , vol.4 , pp. a008284
    • Sheaffer, K.L.1    Kaestner, K.H.2
  • 48
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • Nicholson, J. K. et al. Host-gut microbiota metabolic interactions. Science 336, 1262-1267 (2012).
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1
  • 49
    • 84869863647 scopus 로고    scopus 로고
    • Creating diseases to understand what prevents them: Genetic analysis of inflammation in the gastrointestinal tract
    • Brandl, K., Beutler, B. Creating diseases to understand what prevents them: genetic analysis of inflammation in the gastrointestinal tract. Curr. Opin. Immunol. 24, 678-685 (2012).
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 678-685
    • Brandl, K.1    Beutler, B.2
  • 50
    • 80655149205 scopus 로고    scopus 로고
    • New IBD genetics: Common pathways with other diseases
    • Lees, C. W., Barrett, J. C., Parkes, M., Satsangi, J. New IBD genetics: common pathways with other diseases. Gut 60, 1739-1753 (2011).
    • (2011) Gut , vol.60 , pp. 1739-1753
    • Lees, C.W.1    Barrett, J.C.2    Parkes, M.3    Satsangi, J.4
  • 52
    • 84872017421 scopus 로고    scopus 로고
    • Clostridium difficile toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism
    • Chumbler, N. M. et al. Clostridium difficile toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. PLoS Pathog. 8, e1003072 (2012).
    • (2012) PLoS Pathog , vol.8 , pp. e1003072
    • Chumbler, N.M.1
  • 53
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 54
    • 35948984173 scopus 로고    scopus 로고
    • PennCNV: An integrated hidden Markov model designed for highresolution copy number variation detection in whole-genome SNP genotyping data
    • Wang, K. et al. PennCNV: an integrated hidden Markov model designed for highresolution copy number variation detection in whole-genome SNP genotyping data. Genome Res. 17, 1665-1674 (2007).
    • (2007) Genome Res. , vol.17 , pp. 1665-1674
    • Wang, K.1
  • 55
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler Transform
    • Li, H., Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler Transform. Bioinformatics 25, 1754-1760 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 56
    • 77956295988 scopus 로고    scopus 로고
    • The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
    • McKenna, A. et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297-1303 (2010).
    • (2010) Genome Res , vol.20 , pp. 1297-1303
    • McKenna, A.1
  • 57
    • 68549104404 scopus 로고    scopus 로고
    • The Sequence Alignment/Map format and SAMtools
    • Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 58
    • 77956534324 scopus 로고    scopus 로고
    • ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
    • Wang, K., Li, M., Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. e164
    • Wang, K.1    Li, M.2    Hakonarson, H.3


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