The RNA- and TRIM25-binding domains of influenza virus NS1 protein are essential for suppression of NLRP3 inflammasomemediated interleukin-1β secretion

Journal of Virology

Volumn 90, Issue 8, 2016, Pages 4105-4114

  Moriyama, Miyu ^a,d,e   Chen, I Yin ^a   Kawaguchi, Atsushi ^b   Koshiba, Takumi ^c   Nagata, Kyosuke ^b   Takeyama, Haruko ^d   Hasegawa, Hideki ^e   Ichinohe, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d WASEDA UNIVERSITY   (Japan)

^e NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LENTIVIRUS VECTOR; NONSTRUCTURAL PROTEIN 1; RNA; CARRIER PROTEIN; INS1 PROTEIN, INFLUENZA VIRUS; NLRP3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRIM25 PROTEIN, HUMAN; TRIPARTITE MOTIF PROTEIN; UBIQUITIN PROTEIN LIGASE; VIRAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEK293 CELL LINE; IMMUNOPRECIPITATION; INFLUENZA; INFLUENZA VIRUS; J774A.1 CELL LINE; MACROPHAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NS1 GENE; PLASMID; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; RNA BINDING DOMAIN; TRIM25 BINDING DOMAIN; VIRUS RECOMBINANT; VIRUS STRAIN; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; C57BL MOUSE; HELA CELL LINE; HUMAN; IMMUNOLOGY; METABOLISM; MITOCHONDRIAL MEMBRANE;

ANIMALS; BINDING SITES; CARRIER PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICE, INBRED C57BL; MITOCHONDRIAL MEMBRANES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RNA; TRANSCRIPTION FACTORS; TRIPARTITE MOTIF PROTEINS; UBIQUITIN-PROTEIN LIGASES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84963801147     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00120-16     Document Type: Article

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