Influenza a virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

Nature Communications

Volumn 5, Issue , 2014, Pages

  Yoshizumi, Takuma ^a   Ichinohe, Takeshi ^b   Sasaki, Osamu ^a   Otera, Hidenori ^c   Kawabata, Shun Ichiro ^a   Mihara, Katsuyoshi ^c   Koshiba, Takumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; MITOCHONDRIAL PROTEIN; PB1 F2 PROTEIN; POLYPEPTIDE; PROTEIN VARIANT; TOM40 CHANNEL; UNCLASSIFIED DRUG; VIRUS PROTEIN; CARRIER PROTEIN; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; NLRP3 PROTEIN, HUMAN; PB1-F2 PROTEIN, INFLUENZA A VIRUS; RECOMBINANT PROTEIN; TOM40 PROTEIN HUMAN;

IMMUNITY; INFLUENZA; MITOCHONDRIAL DNA; MOLECULAR ANALYSIS; PROTEIN; SIGNAL; TRANSLOCATION; VIRUS;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; DRP 1 GENE; FRACTIONATION; GENE; GENE SILENCING; HOST CELL; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; INNATE IMMUNITY; INNER MEMBRANE; MEMBRANE CHANNEL; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; MOLECULAR MECHANICS; OMA 1 GENE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INFLUENZA A VIRUS (H1N1); MITOCHONDRIAL MEMBRANE POTENTIAL; MITOPHAGY; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; TRANSGENE; TUMOR CELL LINE; VIROLOGY;

CARRIER PROTEINS; CELL LINE, TUMOR; DEAD-BOX RNA HELICASES; GENE EXPRESSION REGULATION; HEK293 CELLS; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INFLUENZA A VIRUS, H1N1 SUBTYPE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSGENES; VIRAL PROTEINS;

EID: 84907319179     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5713     Document Type: Article

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