메뉴 건너뛰기




Volumn 44, Issue 6, 2015, Pages

Integrated microfluidic approach for quantitative high-throughput measurements of transcription factor binding affinities

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 1; ACTIVATING TRANSCRIPTION FACTOR 3; DNA; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; ATF1 PROTEIN, HUMAN; PROTEIN BINDING; STRESS ACTIVATED PROTEIN KINASE;

EID: 84963795305     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv1327     Document Type: Article
Times cited : (16)

References (69)
  • 1
    • 0036469065 scopus 로고    scopus 로고
    • Signal transduction and the control of gene expression
    • Brivanlou, A.H. and Darnell, J.E. (2002) Signal transduction and the control of gene expression. Science, 295, 813-818.
    • (2002) Science , vol.295 , pp. 813-818
    • Brivanlou, A.H.1    Darnell, J.E.2
  • 2
    • 77958096076 scopus 로고    scopus 로고
    • Determining the specificity of protein-DNA interactions
    • Stormo, G.D. and Zhao, Y. (2010) Determining the specificity of protein-DNA interactions. Nat. Rev. Genet., 11, 751-760.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 751-760
    • Stormo, G.D.1    Zhao, Y.2
  • 3
    • 68949213578 scopus 로고    scopus 로고
    • Insights from genomic profiling of transcription factors
    • Farnham, P.J. (2009) Insights from genomic profiling of transcription factors. Nat Rev Genet, 10, 605-616.
    • (2009) Nat Rev Genet , vol.10 , pp. 605-616
    • Farnham, P.J.1
  • 4
    • 84871891211 scopus 로고    scopus 로고
    • Dendrimer functionalization of gold surface improves the measurement of protein-DNA interactions by surface plasmon resonance imaging
    • Pillet, F., Sanchez, A., Formosa, C., Severac, M., Trevisiol, E., Bouet, J.Y. and Anton Leberre, V. (2013) Dendrimer functionalization of gold surface improves the measurement of protein-DNA interactions by surface plasmon resonance imaging. Biosens. Bioelectron., 43, 148-154.
    • (2013) Biosens. Bioelectron. , vol.43 , pp. 148-154
    • Pillet, F.1    Sanchez, A.2    Formosa, C.3    Severac, M.4    Trevisiol, E.5    Bouet, J.Y.6    Anton Leberre, V.7
  • 5
    • 84897893577 scopus 로고    scopus 로고
    • A force-based, parallel assay for the quantification of protein-DNA interactions
    • Limmer, K., Pippig, D.A., Aschenbrenner, D. and Gaub, H.E. (2014) A force-based, parallel assay for the quantification of protein-DNA interactions. PLoS One, 9, e89626.
    • (2014) PLoS One , vol.9 , pp. e89626
    • Limmer, K.1    Pippig, D.A.2    Aschenbrenner, D.3    Gaub, H.E.4
  • 6
    • 79960277492 scopus 로고    scopus 로고
    • Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument
    • Nutiu, R., Friedman, R. and Luo, S. (2011) Direct measurement of DNA affinity landscapes on a high-throughput sequencing instrument. Nat. Biotechnol., 29, 659-664.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 659-664
    • Nutiu, R.1    Friedman, R.2    Luo, S.3
  • 8
    • 33746691336 scopus 로고    scopus 로고
    • Extensive low-affinity transcriptional interactions in the yeast genome Extensive low-affinity transcriptional interactions in the yeast genome
    • Tanay, A. (2006) Extensive low-affinity transcriptional interactions in the yeast genome Extensive low-affinity transcriptional interactions in the yeast genome. Genome Res., 8, 962-972.
    • (2006) Genome Res. , vol.8 , pp. 962-972
    • Tanay, A.1
  • 9
    • 38749127589 scopus 로고    scopus 로고
    • Predicting expression patterns from regulatory sequence in Drosophila segmentation
    • Segal, E., Raveh-Sadka, T., Schroeder, M., Unnerstall, U. and Gaul, U. (2008) Predicting expression patterns from regulatory sequence in Drosophila segmentation. Nature, 451, 535-540.
    • (2008) Nature , vol.451 , pp. 535-540
    • Segal, E.1    Raveh-Sadka, T.2    Schroeder, M.3    Unnerstall, U.4    Gaul, U.5
  • 10
    • 77956654773 scopus 로고    scopus 로고
    • De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis
    • Fordyce, P.M., Gerber, D., Tran, D., Zheng, J., Li, H., DeRisi, J.L. and Quake, S.R. (2010) De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis. Nat. Biotechnol., 28, 962-967.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 962-967
    • Fordyce, P.M.1    Gerber, D.2    Tran, D.3    Zheng, J.4    Li, H.5    DeRisi, J.L.6    Quake, S.R.7
  • 13
    • 58149354385 scopus 로고    scopus 로고
    • Analysis of combinatorial cis-regulation in synthetic and genomic promoters
    • Gertz, J., Siggia, E.D. and Cohen, B.A. (2009) Analysis of combinatorial cis-regulation in synthetic and genomic promoters. Nature, 457, 215-218.
    • (2009) Nature , vol.457 , pp. 215-218
    • Gertz, J.1    Siggia, E.D.2    Cohen, B.A.3
  • 14
    • 55549113874 scopus 로고    scopus 로고
    • A quantitative model of transcription factor-activated gene expression
    • Kim, H.D. and O'Shea, E.K. (2008) A quantitative model of transcription factor-activated gene expression. Nat. Struct. Mol. Biol., 15, 1192-1198.
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 1192-1198
    • Kim, H.D.1    O'Shea, E.K.2
  • 15
    • 67649826220 scopus 로고    scopus 로고
    • From DNA sequence to transcriptional behaviour: A quantitative approach
    • Segal, E. and Widom, J. (2009) From DNA sequence to transcriptional behaviour: a quantitative approach. Nat. Rev. Genet., 10, 443-456.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 443-456
    • Segal, E.1    Widom, J.2
  • 16
    • 0035094449 scopus 로고    scopus 로고
    • Cis-regulatory logic in the endo16 gene: Switching from a specification to a differentiation mode of control
    • Yuh, C.H., Bolouri, H. and Davidson, E.H. (2001) Cis-regulatory logic in the endo16 gene: switching from a specification to a differentiation mode of control. Development, 128, 617-629.
    • (2001) Development , vol.128 , pp. 617-629
    • Yuh, C.H.1    Bolouri, H.2    Davidson, E.H.3
  • 18
    • 34250159524 scopus 로고    scopus 로고
    • Genome-wide mapping of in vivo protein-DNA interactions
    • Johnson, D.S., Mortazavi, A., Myers, R.M. and Wold, B. (2007) Genome-wide mapping of in vivo protein-DNA interactions. Science, 316, 1497-1502.
    • (2007) Science , vol.316 , pp. 1497-1502
    • Johnson, D.S.1    Mortazavi, A.2    Myers, R.M.3    Wold, B.4
  • 19
    • 83255164884 scopus 로고    scopus 로고
    • Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution
    • Rhee, H.S. and Pugh, B.F. (2011) Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution. Cell, 147, 1408-1419.
    • (2011) Cell , vol.147 , pp. 1408-1419
    • Rhee, H.S.1    Pugh, B.F.2
  • 20
    • 0018199224 scopus 로고
    • DNAse footprinting: A simple method for the detection of protein-DNA binding specificity
    • Galas, D.J. and Schmitz, A. (1978) DNAse footprinting: a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res., 5, 3157-3170.
    • (1978) Nucleic Acids Res. , vol.5 , pp. 3157-3170
    • Galas, D.J.1    Schmitz, A.2
  • 21
    • 0019877067 scopus 로고
    • A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: Application to components of the Escherichia coli lactose operon regulatory system
    • Garner, M.M. and Revzin, A. (1981) A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: Application to components of the Escherichia coli lactose operon regulatory system. Nucleic Acids Res., 9, 3047-3060.
    • (1981) Nucleic Acids Res. , vol.9 , pp. 3047-3060
    • Garner, M.M.1    Revzin, A.2
  • 22
    • 33847770317 scopus 로고    scopus 로고
    • SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics
    • Campbell, C.T. and Kim, G. (2007) SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics. Biomaterials, 28, 2380-2392.
    • (2007) Biomaterials , vol.28 , pp. 2380-2392
    • Campbell, C.T.1    Kim, G.2
  • 23
    • 1842580880 scopus 로고    scopus 로고
    • Parallel, quantitative measurement of protein binding to a 120-element double-stranded DNA array in real time using surface plasmon resonance microscopy
    • Shumaker-Parry, J.S., Aebersold, R. and Campbell, C.T. (2004) Parallel, quantitative measurement of protein binding to a 120-element double-stranded DNA array in real time using surface plasmon resonance microscopy. Anal. Chem., 76, 2071-2082.
    • (2004) Anal. Chem. , vol.76 , pp. 2071-2082
    • Shumaker-Parry, J.S.1    Aebersold, R.2    Campbell, C.T.3
  • 24
    • 34250661506 scopus 로고    scopus 로고
    • Identifying DNA sequences recognized by a transcription factor using a bacterial one-hybrid system
    • Meng, X. and Wolfe, S.A. (2006) Identifying DNA sequences recognized by a transcription factor using a bacterial one-hybrid system. Nat. Protoc., 1, 30-45.
    • (2006) Nat. Protoc. , vol.1 , pp. 30-45
    • Meng, X.1    Wolfe, S.A.2
  • 25
    • 23444446753 scopus 로고    scopus 로고
    • A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors
    • Meng, X., Brodsky, M.H. and Wolfe, S.A. (2005) A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors. Nat. Biotechnol., 23, 988-994.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 988-994
    • Meng, X.1    Brodsky, M.H.2    Wolfe, S.A.3
  • 28
    • 74549209548 scopus 로고    scopus 로고
    • Inferring binding energies from selected binding sites
    • Zhao, Y., Granas, D. and Stormo, G.D. (2009) Inferring binding energies from selected binding sites. PLoS Comput. Biol., 5, 1-8.
    • (2009) PLoS Comput. Biol. , vol.5 , pp. 1-8
    • Zhao, Y.1    Granas, D.2    Stormo, G.D.3
  • 30
    • 33750882505 scopus 로고    scopus 로고
    • Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities
    • Berger, M.F., Philippakis, A.A., Qureshi, A.M., He, F.S., Estep, P.W. and Bulyk, M.L. (2006) Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nat. Biotechnol., 24, 1429-1435.
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1429-1435
    • Berger, M.F.1    Philippakis, A.A.2    Qureshi, A.M.3    He, F.S.4    Estep, P.W.5    Bulyk, M.L.6
  • 32
    • 0035912721 scopus 로고    scopus 로고
    • Exploring the DNA-binding specificities of zinc fingers with DNA microarrays
    • Bulyk, M.L., Huang, X., Choo, Y. and Church, G.M. (2001) Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc. Natl. Acad. Sci. U.S.A., 98, 7158-7163.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 7158-7163
    • Bulyk, M.L.1    Huang, X.2    Choo, Y.3    Church, G.M.4
  • 33
    • 84891768983 scopus 로고    scopus 로고
    • TFBSshape: A motif database for DNA shape features of transcription factor binding sites
    • Yang, L., Zhou, T., Dror, I., Mathelier, A., Wasserman, W.W., Gord?an, R. and Rohs, R. (2014) TFBSshape: a motif database for DNA shape features of transcription factor binding sites. Nucleic Acids Res., 42, D148-D155.
    • (2014) Nucleic Acids Res. , vol.42 , pp. D148-D155
    • Yang, L.1    Zhou, T.2    Dror, I.3    Mathelier, A.4    Wasserman, W.W.5    Gordan, R.6    Rohs, R.7
  • 34
    • 84876955991 scopus 로고    scopus 로고
    • Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape
    • Gord?an, R., Shen, N., Dror, I., Zhou, T., Horton, J., Rohs, R. and Bulyk, M.L. (2013) Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape. Cell Rep., 3, 1093-1104.
    • (2013) Cell Rep. , vol.3 , pp. 1093-1104
    • Gordan, R.1    Shen, N.2    Dror, I.3    Zhou, T.4    Horton, J.5    Rohs, R.6    Bulyk, M.L.7
  • 35
    • 34548169696 scopus 로고    scopus 로고
    • Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions
    • Hellman, L.M. and Fried, M.G. (2007) Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat. Protoc., 2, 1849-1861.
    • (2007) Nat. Protoc. , vol.2 , pp. 1849-1861
    • Hellman, L.M.1    Fried, M.G.2
  • 36
    • 84867053770 scopus 로고    scopus 로고
    • Advances in the study of protein-DNA interaction
    • Cai, Y.-H. and Huang, H. (2012) Advances in the study of protein-DNA interaction. Amino Acids, 43, 1141-1146.
    • (2012) Amino Acids , vol.43 , pp. 1141-1146
    • Cai, Y.-H.1    Huang, H.2
  • 37
    • 0026490544 scopus 로고
    • Use of gel retardation to analyze protein-nucleic acid interactions
    • Lane, D., Prentki, P. and Chandler, M. (1992) Use of gel retardation to analyze protein-nucleic acid interactions. Microbiol. Rev., 56, 509-528.
    • (1992) Microbiol. Rev. , vol.56 , pp. 509-528
    • Lane, D.1    Prentki, P.2    Chandler, M.3
  • 38
    • 4444274983 scopus 로고    scopus 로고
    • Mass spectrometric identification of RNA binding proteins from dried EMSA gels
    • Stenger, D., Gruissem, W. and Baginsky, S. (2004) Mass Spectrometric Identification of RNA Binding Proteins from Dried EMSA Gels. J. Proteome Res., 3, 662-664.
    • (2004) J. Proteome Res. , vol.3 , pp. 662-664
    • Stenger, D.1    Gruissem, W.2    Baginsky, S.3
  • 39
    • 58149112132 scopus 로고    scopus 로고
    • Characterization of DNA-binding proteins using multiplexed competitor EMSA
    • Smith, A.J.P. and Humphries, S.E. (2009) Characterization of DNA-binding proteins using multiplexed competitor EMSA. J. Mol. Biol., 385, 714-717.
    • (2009) J. Mol. Biol. , vol.385 , pp. 714-717
    • Smith, A.J.P.1    Humphries, S.E.2
  • 40
    • 0030576613 scopus 로고    scopus 로고
    • Design and optimization of a capillary electrophoretic mobility shift assay involving trp repressor-DNA complexes
    • Stebbins, M.A., Hoyt, A.M., Sepaniak, M.J. and Hurlburt, B.K. (1996) Design and optimization of a capillary electrophoretic mobility shift assay involving trp repressor-DNA complexes. J. Chromatogr. B Biomed. Sci. Appl., 683, 77-84.
    • (1996) J. Chromatogr. B Biomed. Sci. Appl. , vol.683 , pp. 77-84
    • Stebbins, M.A.1    Hoyt, A.M.2    Sepaniak, M.J.3    Hurlburt, B.K.4
  • 41
    • 0032530598 scopus 로고    scopus 로고
    • A capillary electrophoresis mobility shift assay for protein-DNA binding affinities free in solution
    • Foulds, G.J. and Etzkorn, F.A. (1998) A capillary electrophoresis mobility shift assay for protein-DNA binding affinities free in solution. Nucleic Acids Res., 26, 4304-4305.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 4304-4305
    • Foulds, G.J.1    Etzkorn, F.A.2
  • 42
    • 84874611408 scopus 로고    scopus 로고
    • Microfluidic screening of electrophoretic mobility shifts elucidates riboswitch binding function
    • Karns, K., Vogan, J.M., Qin, Q., Hickey, S.F., Wilson, S.C., Hammond, M.C. and Herr, A.E. (2013) Microfluidic screening of electrophoretic mobility shifts elucidates riboswitch binding function. J. Am. Chem. Soc., 135, 3136-3143.
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 3136-3143
    • Karns, K.1    Vogan, J.M.2    Qin, Q.3    Hickey, S.F.4    Wilson, S.C.5    Hammond, M.C.6    Herr, A.E.7
  • 43
    • 0035288179 scopus 로고    scopus 로고
    • Exploiting sensitive laser-induced fluorescence detection on electrophoretic microchips for executing rapid clinical diagnostics
    • Ferrance, J. and Landers, J.P. (2001) Exploiting sensitive laser-induced fluorescence detection on electrophoretic microchips for executing rapid clinical diagnostics. Luminescence, 16, 79-88.
    • (2001) Luminescence , vol.16 , pp. 79-88
    • Ferrance, J.1    Landers, J.P.2
  • 44
    • 0035449448 scopus 로고    scopus 로고
    • Temperature measurement in microfluidic systems using a temperature-dependent fluorescent dye
    • Ross, D., Gaitan, M. and Locascio, L.E. (2001) Temperature measurement in microfluidic systems using a temperature-dependent fluorescent dye. Anal. Chem., 73, 4117-4123.
    • (2001) Anal. Chem. , vol.73 , pp. 4117-4123
    • Ross, D.1    Gaitan, M.2    Locascio, L.E.3
  • 45
    • 0036789387 scopus 로고    scopus 로고
    • Microfabricated 384-lane capillary array electrophoresis bioanalyzer for ultrahigh-throughput genetic analysis
    • Emrich, C.A., Tian, H., Medintz, I.L. and Mathies, R.A. (2002) Microfabricated 384-lane capillary array electrophoresis bioanalyzer for ultrahigh-throughput genetic analysis. Anal. Chem., 74, 5076-5083.
    • (2002) Anal. Chem. , vol.74 , pp. 5076-5083
    • Emrich, C.A.1    Tian, H.2    Medintz, I.L.3    Mathies, R.A.4
  • 46
    • 84910627244 scopus 로고    scopus 로고
    • High-throughput electrophoretic mobility shift assays for quantitative analysis of molecular binding reactions
    • Pan, Y., Duncombe, T.A., Kellenberger, C.A., Hammond, M.C. and Herr, A.E. (2014) High-Throughput Electrophoretic Mobility Shift Assays for Quantitative Analysis of Molecular Binding Reactions.Anal. Chem., 86, 10357-10364.
    • (2014) Anal. Chem. , vol.86 , pp. 10357-10364
    • Pan, Y.1    Duncombe, T.A.2    Kellenberger, C.A.3    Hammond, M.C.4    Herr, A.E.5
  • 47
    • 84867372779 scopus 로고    scopus 로고
    • Massively parallel measurements of molecular interaction kinetics on a microfluidic platform
    • Geertz, M., Shore, D. and Maerkl, S.J. (2012) Massively parallel measurements of molecular interaction kinetics on a microfluidic platform. Proc. Natl. Acad. Sci. U.S.A., 109, 16540-16545.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 16540-16545
    • Geertz, M.1    Shore, D.2    Maerkl, S.J.3
  • 48
    • 0038185273 scopus 로고    scopus 로고
    • Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness
    • Conkright, M.D., Guzmen, E., Flechner, L., Su, A.I., Hogenesch, J.B. and Montminy, M. (2003) Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol. Cell, 11, 1101-1108.
    • (2003) Mol. Cell , vol.11 , pp. 1101-1108
    • Conkright, M.D.1    Guzmen, E.2    Flechner, L.3    Su, A.I.4    Hogenesch, J.B.5    Montminy, M.6
  • 49
    • 0037101970 scopus 로고    scopus 로고
    • Function and regulation of CREB family transcription factors in the nervous system
    • Lonze, B.E. and Ginty, D.D. (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron, 35, 605-623.
    • (2002) Neuron , vol.35 , pp. 605-623
    • Lonze, B.E.1    Ginty, D.D.2
  • 50
    • 0030972807 scopus 로고    scopus 로고
    • Transcriptional regulation by cyclic AMP
    • Montminy, M. (1997) Transcriptional regulation by cyclic AMP. Annu. Rev. Biochem., 66, 807-822.
    • (1997) Annu. Rev. Biochem. , vol.66 , pp. 807-822
    • Montminy, M.1
  • 51
    • 0023798751 scopus 로고
    • Fos and jun: The AP-1 connection
    • Curran, T. and Franza, B.R. (1988) Fos and jun: The AP-1 connection. Cell, 55, 395-397.
    • (1988) Cell , vol.55 , pp. 395-397
    • Curran, T.1    Franza, B.R.2
  • 52
    • 0028321474 scopus 로고
    • Different binding specificities and transactivation of variant CRE's by CREB complexes
    • Benbrook, D.M. and Jones, N.C. (1994) Different binding specificities and transactivation of variant CRE's by CREB complexes. Nucleic Acids Res., 22, 1463-1469.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 1463-1469
    • Benbrook, D.M.1    Jones, N.C.2
  • 54
    • 0023771685 scopus 로고
    • C-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
    • Halazonetis, T.D., Georgopoulos, K., Greenberg, M.E. and Leder, P. (1988) c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell, 55, 917-924.
    • (1988) Cell , vol.55 , pp. 917-924
    • Halazonetis, T.D.1    Georgopoulos, K.2    Greenberg, M.E.3    Leder, P.4
  • 55
    • 33846467150 scopus 로고    scopus 로고
    • A systems approach to measuring the binding energy landscapes of transcription factors
    • Maerkl, S.J. and Quake, S.R. (2007) A systems approach to measuring the binding energy landscapes of transcription factors. Science, 315, 233-237.
    • (2007) Science , vol.315 , pp. 233-237
    • Maerkl, S.J.1    Quake, S.R.2
  • 56
    • 84868288217 scopus 로고    scopus 로고
    • High-throughput protein expression generator using a microfluidic platform
    • Glick, Y., Avrahami, D., Michaely, E. and Gerber, D. (2012) High-throughput protein expression generator using a microfluidic platform. J Vis Exp, 23, e3849.
    • (2012) J Vis Exp , vol.23 , pp. e3849
    • Glick, Y.1    Avrahami, D.2    Michaely, E.3    Gerber, D.4
  • 58
    • 84883590358 scopus 로고    scopus 로고
    • DNAshape: A method for the high-throughput prediction of DNA structural features on a genomic scale
    • Zhou, T., Yang, L., Lu, Y., Dror, I., Machado, A.C.D., Ghane, T., Di Felice, R. and Rohs, R. (2013) DNAshape: a method for the high-throughput prediction of DNA structural features on a genomic scale. Nucleic Acids Res., 41, 56-62.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 56-62
    • Zhou, T.1    Yang, L.2    Lu, Y.3    Dror, I.4    Machado, A.C.D.5    Ghane, T.6    Di Felice, R.7    Rohs, R.8
  • 59
    • 7444260846 scopus 로고    scopus 로고
    • The ENCODE (ENCyclopedia of DNA elements) project
    • The ENCODE Project Consortium.
    • The ENCODE Project Consortium. (2004) The ENCODE (ENCyclopedia of DNA elements) project. Science, 306, 636-640.
    • (2004) Science , vol.306 , pp. 636-640
  • 60
    • 58149229162 scopus 로고    scopus 로고
    • An in vitro microfluidic approach to generating protein-interaction networks
    • Gerber, D., Maerkl, S.J. and Quake, S.R. (2008) An in vitro microfluidic approach to generating protein-interaction networks. Nat. Methods, 6, 71-74.
    • (2008) Nat. Methods , vol.6 , pp. 71-74
    • Gerber, D.1    Maerkl, S.J.2    Quake, S.R.3
  • 61
    • 0037131390 scopus 로고    scopus 로고
    • Microfluidic large-scale integration
    • Thorsen, T., Maerkl, S.J. and Quake, S.R. (2002) Microfluidic large-scale integration. Science, 298, 580-584.
    • (2002) Science , vol.298 , pp. 580-584
    • Thorsen, T.1    Maerkl, S.J.2    Quake, S.R.3
  • 62
    • 84899799231 scopus 로고    scopus 로고
    • A comparative analysis of transcription factor binding models learned from PBM, HT-SELEX and ChIP data
    • Orenstein, Y. and Shamir, R. (2014) A comparative analysis of transcription factor binding models learned from PBM, HT-SELEX and ChIP data. Nucleic Acids Res., 42, 1-10.
    • (2014) Nucleic Acids Res. , vol.42 , pp. 1-10
    • Orenstein, Y.1    Shamir, R.2
  • 63
    • 84879971887 scopus 로고    scopus 로고
    • RAP: Accurate and fast motif finding based on protein-binding microarray data
    • Orenstein, Y., Mick, E. and Shamir, R. (2013) RAP: accurate and fast motif finding based on protein-binding microarray data. J. Comput. Biol., 20, 375-382.
    • (2013) J. Comput. Biol. , vol.20 , pp. 375-382
    • Orenstein, Y.1    Mick, E.2    Shamir, R.3
  • 66
    • 0038750887 scopus 로고    scopus 로고
    • Manual 768 or 384 well microplate gel 'dry' electrophoresis for PCR checking and SNP genotyping
    • 48e-48
    • Gaunt, T.R., Hinks, L.J., Rassoulian, H. and Day, I.N.M. (2003) Manual 768 or 384 well microplate gel 'dry' electrophoresis for PCR checking and SNP genotyping. Nucleic Acids Res., 31, 48e-48.
    • (2003) Nucleic Acids Res. , vol.31
    • Gaunt, T.R.1    Hinks, L.J.2    Rassoulian, H.3    Day, I.N.M.4
  • 67
    • 33747117373 scopus 로고    scopus 로고
    • The origins and the future of microfluidics
    • Whitesides, G.M. (2006) The origins and the future of microfluidics. Nature, 442, 368-373.
    • (2006) Nature , vol.442 , pp. 368-373
    • Whitesides, G.M.1
  • 68
    • 0035298821 scopus 로고    scopus 로고
    • Concentration and separation of proteins in microfluidic channels on the basis of transverse IEF
    • Macounova, K., Cabrera, C.R. and Yager, P. (2001) Concentration and separation of proteins in microfluidic channels on the basis of transverse IEF. Anal. Chem., 73, 1627-1633.
    • (2001) Anal. Chem. , vol.73 , pp. 1627-1633
    • Macounova, K.1    Cabrera, C.R.2    Yager, P.3
  • 69
    • 84856415994 scopus 로고    scopus 로고
    • On-line sample pre-concentration in microfluidic devices: A review
    • Giordano, B.C., Burgi, D.S., Hart, S.J. and Terray, A. (2012) On-line sample pre-concentration in microfluidic devices: A review. Anal. Chim. Acta, 718, 11-24.
    • (2012) Anal. Chim. Acta , vol.718 , pp. 11-24
    • Giordano, B.C.1    Burgi, D.S.2    Hart, S.J.3    Terray, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.